UniProtKB - P63104 (1433Z_HUMAN)
14-3-3 protein zeta/delta
YWHAZ
Functioni
Caution
GO - Molecular functioni
- cadherin binding Source: BHF-UCL
- identical protein binding Source: IntAct
- ion channel binding Source: SynGO-UCL
- protein kinase binding Source: UniProtKB
- RNA binding Source: UniProtKB
- transcription factor binding Source: UniProtKB
- ubiquitin protein ligase binding Source: ParkinsonsUK-UCL
GO - Biological processi
- cytokine-mediated signaling pathway Source: Reactome
- establishment of Golgi localization Source: UniProtKB
- Golgi reassembly Source: UniProtKB
- membrane organization Source: Reactome
- negative regulation of apoptotic process Source: ProtInc
- platelet activation Source: Reactome
- positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway Source: Reactome
- protein phosphorylation Source: UniProtKB
- regulation of ERK1 and ERK2 cascade Source: UniProtKB
- regulation of mRNA stability Source: Reactome
- regulation of synapse maturation Source: SynGO
- signal transduction Source: UniProtKB
Enzyme and pathway databases
PathwayCommonsi | P63104 |
Reactomei | R-HSA-111447, Activation of BAD and translocation to mitochondria R-HSA-1445148, Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-3769402, Deactivation of the beta-catenin transactivating complex R-HSA-392517, Rap1 signalling R-HSA-430116, GP1b-IX-V activation signalling R-HSA-450604, KSRP (KHSRP) binds and destabilizes mRNA R-HSA-512988, Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-5625740, RHO GTPases activate PKNs R-HSA-5628897, TP53 Regulates Metabolic Genes R-HSA-75035, Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-9013700, NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9604323, Negative regulation of NOTCH4 signaling R-HSA-9614399, Regulation of localization of FOXO transcription factors |
SignaLinki | P63104 |
SIGNORi | P63104 |
Protein family/group databases
MoonDBi | P63104, Predicted |
TCDBi | 8.A.98.1.2, the 14-3-3 protein (14-3-3) family |
Names & Taxonomyi
Protein namesi | Recommended name: 14-3-3 protein zeta/deltaAlternative name(s): Protein kinase C inhibitor protein 1 Short name: KCIP-1 |
Gene namesi | Name:YWHAZ |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:12855, YWHAZ |
MIMi | 601288, gene |
neXtProti | NX_P63104 |
VEuPathDBi | HostDB:ENSG00000164924.17 |
Subcellular locationi
Other locations
- Cytoplasm 1 Publication
- Melanosome 1 Publication
Note: Located to stage I to stage IV melanosomes.
Cytosol
- cytosol Source: Reactome
Extracellular region or secreted
- blood microparticle Source: UniProtKB
- extracellular exosome Source: UniProtKB
- extracellular space Source: UniProtKB
Mitochondrion
- mitochondrion Source: GOC
Nucleus
- nucleoplasm Source: Reactome
- nucleus Source: UniProtKB
Other locations
- cytoplasm Source: ProtInc
- focal adhesion Source: UniProtKB
- glutamatergic synapse Source: SynGO
- melanosome Source: UniProtKB-SubCell
- vesicle Source: UniProtKB
Keywords - Cellular componenti
CytoplasmPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 49 | K → E: Loss of interaction with NOXA1. 1 Publication | 1 | |
Mutagenesisi | 56 – 60 | RSSWR → ASSWA: Abolishes lamellipodia formation and induces filopodia formation. 1 Publication | 5 | |
Mutagenesisi | 58 | S → A: Loss of sphingosine-activated PKA phosphorylation. Promotes homodimerization and heterodimerization with YWHAE. Enhanced transcriptional activity of P53. 2 Publications | 1 | |
Mutagenesisi | 58 | S → E: Loss of homodimerization. Reduced dimerization with YWHAE. Significantly reduced interaction with P53. No enhancement of P53 transcriptional activity. 2 Publications | 1 | |
Mutagenesisi | 184 | S → A: On DNA damage, loss of MAPK8-mediated phosphorylation. Loss of binding ABL1. Attenuates ABL1-mediated apoptosis. No loss of interaction with BAX under stress conditions. Inhibits translocation of BAX to mitochondria. 2 Publications | 1 | |
Mutagenesisi | 232 | T → A: Loss of phosphorylation by CK1. 1 Publication | 1 |
Keywords - Diseasei
Disease variantOrganism-specific databases
DisGeNETi | 7534 |
OpenTargetsi | ENSG00000164924 |
PharmGKBi | PA37444 |
Miscellaneous databases
Pharosi | P63104, Tbio |
Chemistry databases
ChEMBLi | CHEMBL4105899 |
DrugBanki | DB12695, Phenethyl Isothiocyanate |
Genetic variation databases
BioMutai | YWHAZ |
DMDMi | 52000887 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000058627 | 1 – 245 | 14-3-3 protein zeta/deltaAdd BLAST | 245 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 1 | N-acetylmethionineCombined sources1 Publication | 1 | |
Modified residuei | 3 | N6-acetyllysineCombined sources | 1 | |
Modified residuei | 58 | Phosphoserine; by PKA and PKB/AKT14 Publications | 1 | |
Modified residuei | 68 | N6-acetyllysineCombined sources | 1 | |
Modified residuei | 184 | Phosphoserine; by MAPK82 Publications | 1 | |
Modified residuei | 207 | PhosphoserineCombined sources | 1 | |
Modified residuei | 210 | PhosphoserineBy similarity | 1 | |
Modified residuei | 232 | Phosphothreonine; by CK1Combined sources2 Publications | 1 |
Post-translational modificationi
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | P63104 |
jPOSTi | P63104 |
MassIVEi | P63104 |
MaxQBi | P63104 |
PaxDbi | P63104 |
PeptideAtlasi | P63104 |
PRIDEi | P63104 |
ProteomicsDBi | 57477 |
TopDownProteomicsi | P63104-1 [P63104-1] |
2D gel databases
DOSAC-COBS-2DPAGEi | P63104 |
OGPi | P63104 |
UCD-2DPAGEi | P63104 |
PTM databases
iPTMneti | P63104 |
MetOSitei | P63104 |
PhosphoSitePlusi | P63104 |
SwissPalmi | P63104 |
Expressioni
Gene expression databases
Bgeei | ENSG00000164924, Expressed in frontal cortex and 247 other tissues |
ExpressionAtlasi | P63104, baseline and differential |
Genevisiblei | P63104, HS |
Organism-specific databases
HPAi | ENSG00000164924, Low tissue specificity |
Interactioni
Subunit structurei
Interacts with CDK16 and BSPRY (By similarity).
Interacts with WEE1 (C-terminal).
Interacts with SAMSN1 (By similarity).
Interacts with MLF1 (phosphorylated form); the interaction retains it in the cytoplasm (By similarity).
Interacts with Thr-phosphorylated ITGB2 (By similarity).
Interacts with BCL2L11 (By similarity). Homodimer. Heterodimerizes with YWHAE. Homo- and heterodimerization is inhibited by phosphorylation on Ser-58.
Interacts with FOXO4, NOXA1, SSH1 and ARHGEF2.
Interacts with Pseudomonas aeruginosa exoS (unphosphorylated form).
Interacts with BAX; the interaction occurs in the cytoplasm. Under stress conditions, MAPK8-mediated phosphorylation releases BAX to mitochondria.
Interacts with phosphorylated RAF1; the interaction is inhibited when YWHAZ is phosphorylated on Thr-232 (PubMed:31024343).
Interacts with BRAF (PubMed:31024343).
Interacts with TP53; the interaction enhances p53 transcriptional activity. The Ser-58 phosphorylated form inhibits this interaction and p53 transcriptional activity.
Interacts with ABL1 (phosphorylated form); the interaction retains ABL1 in the cytoplasm.
Interacts with PKA-phosphorylated AANAT; the interaction modulates AANAT enzymatic activity by increasing affinity for arylalkylamines and acetyl-CoA and protecting the enzyme from dephosphorylation and proteasomal degradation. It may also prevent thiol-dependent inactivation.
Interacts with AKT1; the interaction phosphorylates YWHAZ and modulates dimerization.
Interacts with GAB2 and TLK2.
Interacts with the 'Thr-369' phosphorylated form of DAPK2 (PubMed:26047703).
Interacts with PI4KB, TBC1D22A and TBC1D22B (PubMed:23572552).
Interacts with ZFP36L1 (via phosphorylated form); this interaction occurs in a p38 MAPK- and AKT-signaling pathways (By similarity).
Interacts with SLITRK1 (PubMed:19640509).
Interacts with AK5, LDB1, MADD, MARK3, PDE1A and SMARCB1 (PubMed:16959763).
By similarity23 PublicationsSites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 56 | Interaction with phosphoserine on interacting proteinBy similarity | 1 | |
Sitei | 127 | Interaction with phosphoserine on interacting proteinBy similarity | 1 |
Binary interactionsi
P63104
GO - Molecular functioni
- cadherin binding Source: BHF-UCL
- identical protein binding Source: IntAct
- ion channel binding Source: SynGO-UCL
- protein kinase binding Source: UniProtKB
- transcription factor binding Source: UniProtKB
- ubiquitin protein ligase binding Source: ParkinsonsUK-UCL
Protein-protein interaction databases
BioGRIDi | 113366, 621 interactors |
ComplexPortali | CPX-1147, FOXO3-YWHAZ complex |
CORUMi | P63104 |
DIPi | DIP-563N |
ELMi | P63104 |
IntActi | P63104, 713 interactors |
MINTi | P63104 |
STRINGi | 9606.ENSP00000379287 |
Chemistry databases
BindingDBi | P63104 |
Miscellaneous databases
RNActi | P63104, protein |
Structurei
Secondary structure
3D structure databases
BMRBi | P63104 |
SMRi | P63104 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P63104 |
Family & Domainsi
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG0841, Eukaryota |
GeneTreei | ENSGT01000000214500 |
InParanoidi | P63104 |
PhylomeDBi | P63104 |
TreeFami | TF102003 |
Family and domain databases
Gene3Di | 1.20.190.20, 1 hit |
IDEALi | IID00061 |
InterProi | View protein in InterPro IPR000308, 14-3-3 IPR023409, 14-3-3_CS IPR036815, 14-3-3_dom_sf IPR023410, 14-3-3_domain |
PANTHERi | PTHR18860, PTHR18860, 1 hit |
Pfami | View protein in Pfam PF00244, 14-3-3, 1 hit |
PIRSFi | PIRSF000868, 14-3-3, 1 hit |
PRINTSi | PR00305, 1433ZETA |
SMARTi | View protein in SMART SM00101, 14_3_3, 1 hit |
SUPFAMi | SSF48445, SSF48445, 1 hit |
PROSITEi | View protein in PROSITE PS00796, 1433_1, 1 hit PS00797, 1433_2, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 9 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MDKNELVQKA KLAEQAERYD DMAACMKSVT EQGAELSNEE RNLLSVAYKN
60 70 80 90 100
VVGARRSSWR VVSSIEQKTE GAEKKQQMAR EYREKIETEL RDICNDVLSL
110 120 130 140 150
LEKFLIPNAS QAESKVFYLK MKGDYYRYLA EVAAGDDKKG IVDQSQQAYQ
160 170 180 190 200
EAFEISKKEM QPTHPIRLGL ALNFSVFYYE ILNSPEKACS LAKTAFDEAI
210 220 230 240
AELDTLSEES YKDSTLIMQL LRDNLTLWTS DTQGDEAEAG EGGEN
Computationally mapped potential isoform sequencesi
There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketE7EX29 | E7EX29_HUMAN | 14-3-3 protein zeta/delta | YWHAZ | 246 | Annotation score: | ||
E7ESK7 | E7ESK7_HUMAN | 14-3-3 protein zeta/delta | YWHAZ | 137 | Annotation score: | ||
E7EVZ2 | E7EVZ2_HUMAN | 14-3-3 protein zeta/delta | YWHAZ | 98 | Annotation score: | ||
E9PD24 | E9PD24_HUMAN | 14-3-3 protein zeta/delta | YWHAZ | 92 | Annotation score: | ||
B7Z2E6 | B7Z2E6_HUMAN | 14-3-3 protein zeta/delta | YWHAZ | 125 | Annotation score: | ||
B0AZS6 | B0AZS6_HUMAN | 14-3-3 protein zeta/delta | YWHAZ | 168 | Annotation score: | ||
H0YB80 | H0YB80_HUMAN | 14-3-3 protein zeta/delta | YWHAZ | 130 | Annotation score: | ||
E5RIR4 | E5RIR4_HUMAN | 14-3-3 protein zeta/delta | YWHAZ | 75 | Annotation score: | ||
E5RGE1 | E5RGE1_HUMAN | 14-3-3 protein zeta/delta | YWHAZ | 51 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 22 | M → V in AAH68456 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 136 | D → G in BAH12451 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_082640 | 14 – 245 | Missing Found in a patient with a neurodevelopmental disorder; unknown pathological significance. 1 PublicationAdd BLAST | 232 | |
Natural variantiVAR_082641 | 53 | G → R Found in a patient with a neurodevelopmental disorder; unknown pathological significance. 1 Publication | 1 | |
Natural variantiVAR_082642 | 145 | S → L Found in a patient with a neurodevelopmental disorder; unknown pathological significance. 1 Publication | 1 | |
Natural variantiVAR_082643 | 230 | S → W Found in a patient with a neurodevelopmental disorder; unknown pathological significance; gain-of-function mutation in signal transduction; changed regulation of ERK1 and ERK2 cascade; increased interaction with BRAF; increased interaction with RAF1; loss of phosphorylation by CK1 at Thr-232. 1 Publication | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_047505 | 1 – 98 | MDKNE…CNDVL → MSQPCRKLWRHNYETSSCIE FLK in isoform 2. 1 PublicationAdd BLAST | 98 |
Sequence databases
Genome annotation databases
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1IB1 | X-ray | 2.70 | A/B/C/D | 1-245 | [»] | |
1QJA | X-ray | 2.00 | A/B | 1-245 | [»] | |
1QJB | X-ray | 2.00 | A/B | 1-245 | [»] | |
2C1J | X-ray | 2.60 | A/B | 1-245 | [»] | |
2C1N | X-ray | 2.00 | A/B | 1-245 | [»] | |
2O02 | X-ray | 1.50 | A/B | 1-230 | [»] | |
2WH0 | X-ray | 2.25 | A/B/C/D | 1-245 | [»] | |
3CU8 | X-ray | 2.40 | A/B | 1-245 | [»] | |
3NKX | X-ray | 2.40 | A/B | 1-245 | [»] | |
3RDH | X-ray | 2.39 | A/B/C/D | 1-245 | [»] | |
4BG6 | X-ray | 2.30 | A/B | 1-245 | [»] | |
4FJ3 | X-ray | 1.95 | A/B | 1-230 | [»] | |
4HKC | X-ray | 2.20 | A | 1-245 | [»] | |
4IHL | X-ray | 2.20 | A/B | 1-230 | [»] | |
4N7G | X-ray | 2.25 | A | 1-230 | [»] | |
4N7Y | X-ray | 2.16 | A/B | 1-230 | [»] | |
4N84 | X-ray | 2.50 | A/B | 1-230 | [»] | |
4WRQ | X-ray | 2.41 | A/B | 1-245 | [»] | |
4ZDR | X-ray | 2.90 | A/B | 1-230 | [»] | |
5D2D | X-ray | 2.10 | A/B | 1-230 | [»] | |
5D3F | X-ray | 2.74 | A/B | 1-230 | [»] | |
5EWZ | X-ray | 2.34 | A/B | 1-230 | [»] | |
5EXA | X-ray | 1.95 | A/B | 1-230 | [»] | |
5J31 | X-ray | 2.40 | A/B | 1-230 | [»] | |
5JM4 | X-ray | 2.34 | A/B | 1-229 | [»] | |
5M35 | X-ray | 2.38 | A/B | 2-230 | [»] | |
5M36 | X-ray | 2.45 | A/B | 2-230 | [»] | |
5M37 | X-ray | 2.35 | A/B | 1-230 | [»] | |
5NAS | X-ray | 2.08 | A/B | 1-230 | [»] | |
5ULO | X-ray | 2.14 | A/B | 1-245 | [»] | |
5WXN | X-ray | 2.93 | A/B | 1-245 | [»] | |
5XY9 | X-ray | 2.30 | A/B | 1-245 | [»] | |
6EF5 | X-ray | 2.44 | A/B/C/D | 1-245 | [»] | |
6EJL | X-ray | 2.38 | A/B | 1-230 | [»] | |
6EWW | X-ray | 2.68 | A/B/C/D | 1-230 | [»] | |
6F08 | X-ray | 1.90 | A/B/I/J | 1-230 | [»] | |
6F09 | X-ray | 1.59 | P/Q/R/S | 1-230 | [»] | |
6FN9 | X-ray | 2.27 | A/B | 1-230 | [»] | |
6FNA | X-ray | 2.12 | A/B | 1-230 | [»] | |
6FNB | X-ray | 2.30 | A/B | 1-230 | [»] | |
6FNC | X-ray | 2.12 | A/B | 1-230 | [»] | |
6Q0K | electron microscopy | 6.80 | X/Y | 1-245 | [»] | |
6RLZ | X-ray | 3.70 | A/B | 1-230 | [»] | |
6U2H | X-ray | 2.50 | A/B | 1-230 | [»] | |
6XAG | X-ray | 3.30 | A/B | 1-230 | [»] | |
BMRBi | P63104 | |||||
SMRi | P63104 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 113366, 621 interactors |
ComplexPortali | CPX-1147, FOXO3-YWHAZ complex |
CORUMi | P63104 |
DIPi | DIP-563N |
ELMi | P63104 |
IntActi | P63104, 713 interactors |
MINTi | P63104 |
STRINGi | 9606.ENSP00000379287 |
Chemistry databases
BindingDBi | P63104 |
ChEMBLi | CHEMBL4105899 |
DrugBanki | DB12695, Phenethyl Isothiocyanate |
Protein family/group databases
MoonDBi | P63104, Predicted |
TCDBi | 8.A.98.1.2, the 14-3-3 protein (14-3-3) family |
PTM databases
iPTMneti | P63104 |
MetOSitei | P63104 |
PhosphoSitePlusi | P63104 |
SwissPalmi | P63104 |
Genetic variation databases
BioMutai | YWHAZ |
DMDMi | 52000887 |
2D gel databases
DOSAC-COBS-2DPAGEi | P63104 |
OGPi | P63104 |
UCD-2DPAGEi | P63104 |
Proteomic databases
EPDi | P63104 |
jPOSTi | P63104 |
MassIVEi | P63104 |
MaxQBi | P63104 |
PaxDbi | P63104 |
PeptideAtlasi | P63104 |
PRIDEi | P63104 |
ProteomicsDBi | 57477 |
TopDownProteomicsi | P63104-1 [P63104-1] |
Protocols and materials databases
Antibodypediai | 3905, 953 antibodies |
DNASUi | 7534 |
Genome annotation databases
Organism-specific databases
CTDi | 7534 |
DisGeNETi | 7534 |
GeneCardsi | YWHAZ |
HGNCi | HGNC:12855, YWHAZ |
HPAi | ENSG00000164924, Low tissue specificity |
MIMi | 601288, gene |
neXtProti | NX_P63104 |
OpenTargetsi | ENSG00000164924 |
PharmGKBi | PA37444 |
VEuPathDBi | HostDB:ENSG00000164924.17 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0841, Eukaryota |
GeneTreei | ENSGT01000000214500 |
InParanoidi | P63104 |
PhylomeDBi | P63104 |
TreeFami | TF102003 |
Enzyme and pathway databases
PathwayCommonsi | P63104 |
Reactomei | R-HSA-111447, Activation of BAD and translocation to mitochondria R-HSA-1445148, Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-3769402, Deactivation of the beta-catenin transactivating complex R-HSA-392517, Rap1 signalling R-HSA-430116, GP1b-IX-V activation signalling R-HSA-450604, KSRP (KHSRP) binds and destabilizes mRNA R-HSA-512988, Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-5625740, RHO GTPases activate PKNs R-HSA-5628897, TP53 Regulates Metabolic Genes R-HSA-75035, Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-9013700, NOTCH4 Activation and Transmission of Signal to the Nucleus R-HSA-9604323, Negative regulation of NOTCH4 signaling R-HSA-9614399, Regulation of localization of FOXO transcription factors |
SignaLinki | P63104 |
SIGNORi | P63104 |
Miscellaneous databases
BioGRID-ORCSi | 7534, 154 hits in 860 CRISPR screens |
ChiTaRSi | YWHAZ, human |
EvolutionaryTracei | P63104 |
GeneWikii | YWHAZ |
GenomeRNAii | 7534 |
Pharosi | P63104, Tbio |
PROi | PR:P63104 |
RNActi | P63104, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000164924, Expressed in frontal cortex and 247 other tissues |
ExpressionAtlasi | P63104, baseline and differential |
Genevisiblei | P63104, HS |
Family and domain databases
Gene3Di | 1.20.190.20, 1 hit |
IDEALi | IID00061 |
InterProi | View protein in InterPro IPR000308, 14-3-3 IPR023409, 14-3-3_CS IPR036815, 14-3-3_dom_sf IPR023410, 14-3-3_domain |
PANTHERi | PTHR18860, PTHR18860, 1 hit |
Pfami | View protein in Pfam PF00244, 14-3-3, 1 hit |
PIRSFi | PIRSF000868, 14-3-3, 1 hit |
PRINTSi | PR00305, 1433ZETA |
SMARTi | View protein in SMART SM00101, 14_3_3, 1 hit |
SUPFAMi | SSF48445, SSF48445, 1 hit |
PROSITEi | View protein in PROSITE PS00796, 1433_1, 1 hit PS00797, 1433_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | 1433Z_HUMAN | |
Accessioni | P63104Primary (citable) accession number: P63104 Secondary accession number(s): A8K1N0 Q86V33 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 13, 2004 |
Last sequence update: | September 13, 2004 | |
Last modified: | February 10, 2021 | |
This is version 197 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 8
Human chromosome 8: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families