Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

UniProtKB - P63104 (1433Z_HUMAN)

Entry version 191 (26 Feb 2020)
Sequence version 1 (13 Sep 2004)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

14-3-3 protein zeta/delta

Gene

YWHAZ

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Induces ARHGEF7 activity on RAC1 as well as lamellipodia and membrane ruffle formation (PubMed:16959763). In neurons, regulates spine maturation through the modulation of ARHGEF7 activity (By similarity).By similarity7 Publications

Caution

Was originally thought to have phospholipase A2 activity.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-111447 Activation of BAD and translocation to mitochondria
R-HSA-1445148 Translocation of SLC2A4 (GLUT4) to the plasma membrane
R-HSA-3769402 Deactivation of the beta-catenin transactivating complex
R-HSA-392517 Rap1 signalling
R-HSA-430116 GP1b-IX-V activation signalling
R-HSA-450604 KSRP (KHSRP) binds and destabilizes mRNA
R-HSA-512988 Interleukin-3, Interleukin-5 and GM-CSF signaling
R-HSA-5625740 RHO GTPases activate PKNs
R-HSA-5628897 TP53 Regulates Metabolic Genes
R-HSA-75035 Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
R-HSA-9013700 NOTCH4 Activation and Transmission of Signal to the Nucleus
R-HSA-9604323 Negative regulation of NOTCH4 signaling
R-HSA-9614399 Regulation of localization of FOXO transcription factors

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		P63104

SIGNOR Signaling Network Open Resource

More...SIGNORi		P63104

Protein family/group databases

MoonDB Database of extreme multifunctional and moonlighting proteins

More...MoonDBi		P63104 Predicted

Transport Classification Database

More...TCDBi		8.A.98.1.2 the 14-3-3 protein (14-3-3) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
14-3-3 protein zeta/delta
Alternative name(s):
Protein kinase C inhibitor protein 1
Short name:
KCIP-1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:YWHAZ
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:12855 YWHAZ

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		601288 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P63104

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi49K → E: Loss of interaction with NOXA1. 1 Publication1
Mutagenesisi56 – 60RSSWR → ASSWA: Abolishes lamellipodia formation and induces filopodia formation. 1 Publication5
Mutagenesisi58S → A: Loss of sphingosine-activated PKA phosphorylation. Promotes homodimerization and heterodimerization with YWHAE. Enhanced transcriptional activity of P53. 2 Publications1
Mutagenesisi58S → E: Loss of homodimerization. Reduced dimerization with YWHAE. Significantly reduced interaction with P53. No enhancement of P53 transcriptional activity. 2 Publications1
Mutagenesisi184S → A: On DNA damage, loss of MAPK8-mediated phosphorylation. Loss of binding ABL1. Attenuates ABL1-mediated apoptosis. No loss of interaction with BAX under stress conditions. Inhibits translocation of BAX to mitochondria. 2 Publications1
Mutagenesisi232T → A: Loss of phosphorylation by CK1. 1 Publication1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNET

More...DisGeNETi		7534

MalaCards human disease database

More...MalaCardsi		YWHAZ

Open Targets

More...OpenTargetsi		ENSG00000164924

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA37444

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P63104 Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL4105899

Drug and drug target database

More...DrugBanki		DB12695 Phenethyl Isothiocyanate

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		YWHAZ

Domain mapping of disease mutations (DMDM)

More...DMDMi		52000887

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000586271 – 24514-3-3 protein zeta/deltaAdd BLAST245

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineCombined sources1 Publication1
Modified residuei3N6-acetyllysineCombined sources1
Modified residuei58Phosphoserine; by PKA and PKB/AKT14 Publications1
Modified residuei68N6-acetyllysineCombined sources1
Modified residuei184Phosphoserine; by MAPK82 Publications1
Modified residuei207PhosphoserineCombined sources1
Modified residuei210PhosphoserineBy similarity1
Modified residuei232Phosphothreonine; by CK1Combined sources2 Publications1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

The delta, brain-specific form differs from the zeta form in being phosphorylated (By similarity). Phosphorylation on Ser-184 by MAPK8; promotes dissociation of BAX and translocation of BAX to mitochondria. Phosphorylation on Thr-232; inhibits binding of RAF1. Phosphorylated on Ser-58 by PKA and protein kinase C delta type catalytic subunit in a sphingosine-dependent fashion. Phosphorylation on Ser-58 by PKA; disrupts homodimerization and heterodimerization with YHAE and TP53.By similarity7 Publications

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		P63104

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P63104

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P63104

MaxQB - The MaxQuant DataBase

More...MaxQBi		P63104

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P63104

PeptideAtlas

More...PeptideAtlasi		P63104

PRoteomics IDEntifications database

More...PRIDEi		P63104

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		57477

Consortium for Top Down Proteomics

More...TopDownProteomicsi		P63104-1 [P63104-1]

2D gel databases

DOSAC-COBS 2D-PAGE database

More...DOSAC-COBS-2DPAGEi		P63104

USC-OGP 2-DE database

More...OGPi		P63104

University College Dublin 2-DE Proteome Database

More...UCD-2DPAGEi		P63104

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P63104

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P63104

SwissPalm database of S-palmitoylation events

More...SwissPalmi		P63104

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000164924 Expressed in frontal cortex and 233 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P63104 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P63104 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		CAB005065
HPA061603

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with CDK16 and BSPRY (By similarity).

Interacts with WEE1 (C-terminal).

Interacts with SAMSN1 (By similarity).

Interacts with MLF1 (phosphorylated form); the interaction retains it in the cytoplasm (By similarity).

Interacts with Thr-phosphorylated ITGB2 (By similarity).

Interacts with BCL2L11 (By similarity). Homodimer. Heterodimerizes with YWHAE. Homo- and heterodimerization is inhibited by phosphorylation on Ser-58.

Interacts with FOXO4, NOXA1, SSH1 and ARHGEF2.

Interacts with Pseudomonas aeruginosa exoS (unphosphorylated form).

Interacts with BAX; the interaction occurs in the cytoplasm. Under stress conditions, MAPK8-mediated phosphorylation releases BAX to mitochondria.

Interacts with phosphorylated RAF1; the interaction is inhibited when YWHAZ is phosphorylated on Thr-232 (PubMed:31024343).

Interacts with BRAF (PubMed:31024343).

Interacts with TP53; the interaction enhances p53 transcriptional activity. The Ser-58 phosphorylated form inhibits this interaction and p53 transcriptional activity.

Interacts with ABL1 (phosphorylated form); the interaction retains ABL1 in the cytoplasm.

Interacts with PKA-phosphorylated AANAT; the interaction modulates AANAT enzymatic activity by increasing affinity for arylalkylamines and acetyl-CoA and protecting the enzyme from dephosphorylation and proteasomal degradation. It may also prevent thiol-dependent inactivation.

Interacts with AKT1; the interaction phosphorylates YWHAZ and modulates dimerization.

Interacts with GAB2 and TLK2.

Interacts with the 'Thr-369' phosphorylated form of DAPK2 (PubMed:26047703).

Interacts with PI4KB, TBC1D22A and TBC1D22B (PubMed:23572552).

Interacts with ZFP36L1 (via phosphorylated form); this interaction occurs in a p38 MAPK- and AKT-signaling pathways (By similarity).

Interacts with SLITRK1 (PubMed:19640509).

Interacts with AK5, LDB1, MADD, MARK3, PDE1A and SMARCB1 (PubMed:16959763).

By similarity23 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei56Interaction with phosphoserine on interacting proteinBy similarity1
Sitei127Interaction with phosphoserine on interacting proteinBy similarity1

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
itself3EBI-347088,EBI-347088
Q294953EBI-347088,EBI-446413From Ovis aries.
P005193EBI-347088,EBI-375543
P607093EBI-347088,EBI-353944
Q9P0K13EBI-347088,EBI-1567236
Q9P0K1-33EBI-347088,EBI-1567267
Q128022EBI-347088,EBI-1373806
P103985EBI-347088,EBI-365961
Q5T5U32EBI-347088,EBI-1642518
Q5VV412EBI-347088,EBI-1057448
Q929743EBI-347088,EBI-302405
P257053EBI-347088,EBI-351437
P065762EBI-347088,EBI-356231
Q929346EBI-347088,EBI-700771
Q613373EBI-347088,EBI-400328From Mus musculus.
Q9UQB83EBI-347088,EBI-525456
P150566EBI-347088,EBI-365980
P621582EBI-347088,EBI-397435
O00257-32EBI-347088,EBI-4392727
Q9Y3M23EBI-347088,EBI-947308
P303042EBI-347088,EBI-747671
P303057EBI-347088,EBI-1051746
Q005373EBI-347088,EBI-624648
Q070022EBI-347088,EBI-746238
P235283EBI-347088,EBI-352733
Q9P2M73EBI-347088,EBI-79537
P313272EBI-347088,EBI-536811
P678284EBI-347088,EBI-7540603From Oryctolagus cuniculus.
Q7Z4012EBI-347088,EBI-1046479
Q9NRI53EBI-347088,EBI-529989
P681042EBI-347088,EBI-352162
P005335EBI-347088,EBI-297353
P067332EBI-347088,EBI-353877
Q127783EBI-347088,EBI-1108782
O435243EBI-347088,EBI-1644164
Q166583EBI-347088,EBI-351076
P307934EBI-347088,EBI-958183
P498414EBI-347088,EBI-373586
P54256-24EBI-347088,EBI-994554From a different organism.
P565246EBI-347088,EBI-308629
Q9UQL63EBI-347088,EBI-715576
Q8WUI44EBI-347088,EBI-1048378
Q9Y4D82EBI-347088,EBI-7195436
P0C0S82EBI-347088,EBI-1390628
P684313EBI-347088,EBI-79722
P628053EBI-347088,EBI-302023
P079102EBI-347088,EBI-357966
P047924EBI-347088,EBI-352682
Q9Y4H23EBI-347088,EBI-1049582
Q022416EBI-347088,EBI-306852
P331762EBI-347088,EBI-355878
Q9H0B62EBI-347088,EBI-726994
Q6P5972EBI-347088,EBI-1643885
P025452EBI-347088,EBI-351935
Q5S00711EBI-347088,EBI-5323863
Q9NYL25EBI-347088,EBI-602273
Q997592EBI-347088,EBI-307281
Q996834EBI-347088,EBI-476263
P106368EBI-347088,EBI-366182
P10636-22EBI-347088,EBI-7796412
P10636-39EBI-347088,EBI-7145070
P291722EBI-347088,EBI-7291149From Bos taurus.
Q7KZI77EBI-347088,EBI-516560
P2744811EBI-347088,EBI-707595
O151512EBI-347088,EBI-398437
Q6WCQ12EBI-347088,EBI-1022605
O755922EBI-347088,EBI-1043774
O955442EBI-347088,EBI-743949
P193382EBI-347088,EBI-346967
P067482EBI-347088,EBI-78579
O960132EBI-347088,EBI-713738
Q8TEW05EBI-347088,EBI-81968
O608252EBI-347088,EBI-764425
O007502EBI-347088,EBI-641107
Q021565EBI-347088,EBI-706254
P164713EBI-347088,EBI-476182
O147442EBI-347088,EBI-351098
P260454EBI-347088,EBI-1047946
P0404913EBI-347088,EBI-365996
Q9P0K72EBI-347088,EBI-1023749
Q8NFH8-22EBI-347088,EBI-8029141
P6158711EBI-347088,EBI-1111534
P615883EBI-347088,EBI-6930266From Mus musculus.
P233962EBI-347088,EBI-351193
Q5PRF92EBI-347088,EBI-1047489
P319473EBI-347088,EBI-476295
Q7L8J42EBI-347088,EBI-747389
P570594EBI-347088,EBI-1181640
Q9Y2K25EBI-347088,EBI-1181460
O602922EBI-347088,EBI-2559690
O948752EBI-347088,EBI-311323
Q7Z6B72EBI-347088,EBI-2481729
O750442EBI-347088,EBI-1051034
Q158316EBI-347088,EBI-306838
O005062EBI-347088,EBI-618295
O603432EBI-347088,EBI-522028
P368974EBI-347088,EBI-1027557
P046372EBI-347088,EBI-366083
Q136253EBI-347088,EBI-77642
P498157EBI-347088,EBI-396587
P408182EBI-347088,EBI-1050865
P550722EBI-347088,EBI-355164
P086702EBI-347088,EBI-353844
P302913EBI-347088,EBI-914695
O149802EBI-347088,EBI-355867
P469379EBI-347088,EBI-1044059
P622587EBI-347088,EBI-356498

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		113366, 446 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...ComplexPortali		CPX-1147 FOXO3-YWHAZ complex

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		P63104

Database of interacting proteins

More...DIPi		DIP-563N

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...ELMi		P63104

Protein interaction database and analysis system

More...IntActi		P63104, 695 interactors

Molecular INTeraction database

More...MINTi		P63104

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000379287

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P63104 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1245
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P63104

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P63104

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the 14-3-3 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0841 Eukaryota
COG5040 LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00970000193355

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P63104

KEGG Orthology (KO)

More...KOi		K16197

Database of Orthologous Groups

More...OrthoDBi		1176818at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P63104

TreeFam database of animal gene trees

More...TreeFami		TF102003

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.20.190.20, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR000308 14-3-3
IPR023409 14-3-3_CS
IPR036815 14-3-3_dom_sf
IPR023410 14-3-3_domain

The PANTHER Classification System

More...PANTHERi		PTHR18860 PTHR18860, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00244 14-3-3, 1 hit

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF000868 14-3-3, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00305 1433ZETA

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00101 14_3_3, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48445 SSF48445, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00796 1433_1, 1 hit
PS00797 1433_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 9 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P63104-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDKNELVQKA KLAEQAERYD DMAACMKSVT EQGAELSNEE RNLLSVAYKN 
        60         70         80         90        100
VVGARRSSWR VVSSIEQKTE GAEKKQQMAR EYREKIETEL RDICNDVLSL 
       110        120        130        140        150
LEKFLIPNAS QAESKVFYLK MKGDYYRYLA EVAAGDDKKG IVDQSQQAYQ 
       160        170        180        190        200
EAFEISKKEM QPTHPIRLGL ALNFSVFYYE ILNSPEKACS LAKTAFDEAI 
       210        220        230        240 
AELDTLSEES YKDSTLIMQL LRDNLTLWTS DTQGDEAEAG EGGEN
Length:245
Mass (Da):27,745
Last modified:September 13, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD464DF2286BBFE60
GO
Isoform 2 (identifier: P63104-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-98: MDKNELVQKA...ELRDICNDVL → MSQPCRKLWRHNYETSSCIEFLK

Show »
Length:170
Mass (Da):19,333
Checksum:iBE97CE3F0A74C75C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E7EX29E7EX29_HUMAN
14-3-3 protein zeta/delta
YWHAZ
246Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7ESK7E7ESK7_HUMAN
14-3-3 protein zeta/delta
YWHAZ
137Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7EVZ2E7EVZ2_HUMAN
14-3-3 protein zeta/delta
YWHAZ
98Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PD24E9PD24_HUMAN
14-3-3 protein zeta/delta
YWHAZ
92Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B7Z2E6B7Z2E6_HUMAN
14-3-3 protein zeta/delta
YWHAZ
125Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YB80H0YB80_HUMAN
14-3-3 protein zeta/delta
YWHAZ
130Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B0AZS6B0AZS6_HUMAN
14-3-3 protein zeta/delta
YWHAZ
168Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RIR4E5RIR4_HUMAN
14-3-3 protein zeta/delta
YWHAZ
75Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RGE1E5RGE1_HUMAN
14-3-3 protein zeta/delta
YWHAZ
51Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH51814 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence AAH73141 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti22M → V in AAH68456 (PubMed:15489334).Curated1
Sequence conflicti136D → G in BAH12451 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_08264014 – 245Missing Found in a patient with a neurodevelopmental disorder; unknown pathological significance. 1 PublicationAdd BLAST232
Natural variantiVAR_08264153G → R Found in a patient with a neurodevelopmental disorder; unknown pathological significance. 1 Publication1
Natural variantiVAR_082642145S → L Found in a patient with a neurodevelopmental disorder; unknown pathological significance. 1 Publication1
Natural variantiVAR_082643230S → W Found in a patient with a neurodevelopmental disorder; unknown pathological significance; gain-of-function mutation in signal transduction; changed regulation of ERK1 and ERK2 cascade; increased interaction with BRAF; increased interaction with RAF1; loss of phosphorylation by CK1 at Thr-232. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0475051 – 98MDKNE…CNDVL → MSQPCRKLWRHNYETSSCIE FLK in isoform 2. 1 PublicationAdd BLAST98

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
M86400 mRNA Translation: AAA36446.1
U28964 mRNA Translation: AAC52052.1
AK289945 mRNA Translation: BAF82634.1
AK296902 mRNA Translation: BAH12451.1
CH471060 Genomic DNA Translation: EAW91823.1
BC003623 mRNA Translation: AAH03623.3
BC051814 mRNA Translation: AAH51814.1 Different initiation.
BC063824 mRNA Translation: AAH63824.2
BC068456 mRNA Translation: AAH68456.2
BC072426 mRNA Translation: AAH72426.2
BC073141 mRNA Translation: AAH73141.1 Different initiation.
BC083508 mRNA Translation: AAH83508.2
BC099904 mRNA Translation: AAH99904.1
BC101483 mRNA Translation: AAI01484.1
BC108281 mRNA Translation: AAI08282.1
BC111951 mRNA Translation: AAI11952.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS6290.1 [P63104-1]

Protein sequence database of the Protein Information Resource

More...PIRi		A38246 PSHUAM

NCBI Reference Sequences

More...RefSeqi		NP_001129171.1, NM_001135699.1 [P63104-1]
NP_001129172.1, NM_001135700.1 [P63104-1]
NP_001129173.1, NM_001135701.1 [P63104-1]
NP_001129174.1, NM_001135702.1 [P63104-1]
NP_003397.1, NM_003406.3 [P63104-1]
NP_663723.1, NM_145690.2 [P63104-1]
XP_005251118.1, XM_005251061.3 [P63104-1]
XP_005251120.1, XM_005251063.3 [P63104-1]
XP_016869299.1, XM_017013810.1 [P63104-1]
XP_016869300.1, XM_017013811.1 [P63104-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000353245; ENSP00000309503; ENSG00000164924 [P63104-1]
ENST00000395951; ENSP00000379281; ENSG00000164924 [P63104-1]
ENST00000395953; ENSP00000379283; ENSG00000164924 [P63104-1]
ENST00000395956; ENSP00000379286; ENSG00000164924 [P63104-1]
ENST00000395957; ENSP00000379287; ENSG00000164924 [P63104-1]
ENST00000395958; ENSP00000379288; ENSG00000164924 [P63104-1]
ENST00000419477; ENSP00000395114; ENSG00000164924 [P63104-1]
ENST00000457309; ENSP00000398599; ENSG00000164924 [P63104-1]
ENST00000522542; ENSP00000430072; ENSG00000164924 [P63104-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		7534

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:7534

UCSC genome browser

More...UCSCi		uc003yjv.3 human [P63104-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M86400 mRNA Translation: AAA36446.1
U28964 mRNA Translation: AAC52052.1
AK289945 mRNA Translation: BAF82634.1
AK296902 mRNA Translation: BAH12451.1
CH471060 Genomic DNA Translation: EAW91823.1
BC003623 mRNA Translation: AAH03623.3
BC051814 mRNA Translation: AAH51814.1 Different initiation.
BC063824 mRNA Translation: AAH63824.2
BC068456 mRNA Translation: AAH68456.2
BC072426 mRNA Translation: AAH72426.2
BC073141 mRNA Translation: AAH73141.1 Different initiation.
BC083508 mRNA Translation: AAH83508.2
BC099904 mRNA Translation: AAH99904.1
BC101483 mRNA Translation: AAI01484.1
BC108281 mRNA Translation: AAI08282.1
BC111951 mRNA Translation: AAI11952.1
CCDSiCCDS6290.1 [P63104-1]
PIRiA38246 PSHUAM
RefSeqiNP_001129171.1, NM_001135699.1 [P63104-1]
NP_001129172.1, NM_001135700.1 [P63104-1]
NP_001129173.1, NM_001135701.1 [P63104-1]
NP_001129174.1, NM_001135702.1 [P63104-1]
NP_003397.1, NM_003406.3 [P63104-1]
NP_663723.1, NM_145690.2 [P63104-1]
XP_005251118.1, XM_005251061.3 [P63104-1]
XP_005251120.1, XM_005251063.3 [P63104-1]
XP_016869299.1, XM_017013810.1 [P63104-1]
XP_016869300.1, XM_017013811.1 [P63104-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1IB1X-ray2.70A/B/C/D1-245[»]
1QJAX-ray2.00A/B1-245[»]
1QJBX-ray2.00A/B1-245[»]
2C1JX-ray2.60A/B1-245[»]
2C1NX-ray2.00A/B1-245[»]
2O02X-ray1.50A/B1-230[»]
2WH0X-ray2.25A/B/C/D1-245[»]
3CU8X-ray2.40A/B1-245[»]
3NKXX-ray2.40A/B1-245[»]
3RDHX-ray2.39A/B/C/D1-245[»]
4BG6X-ray2.30A/B1-245[»]
4FJ3X-ray1.95A/B1-230[»]
4HKCX-ray2.20A1-245[»]
4IHLX-ray2.20A/B1-230[»]
4N7GX-ray2.25A1-230[»]
4N7YX-ray2.16A/B1-230[»]
4N84X-ray2.50A/B1-230[»]
4WRQX-ray2.41A/B1-245[»]
4ZDRX-ray2.90A/B1-230[»]
5D2DX-ray2.10A/B1-230[»]
5D3FX-ray2.74A/B1-230[»]
5EWZX-ray2.34A/B1-230[»]
5EXAX-ray1.95A/B1-230[»]
5J31X-ray2.40A/B1-230[»]
5JM4X-ray2.34A/B1-229[»]
5M35X-ray2.38A/B2-230[»]
5M36X-ray2.45A/B2-230[»]
5M37X-ray2.35A/B1-230[»]
5NASX-ray2.08A/B1-230[»]
5ULOX-ray2.14A/B1-245[»]
5WXNX-ray2.93A/B1-245[»]
5XY9X-ray2.30A/B1-245[»]
6EF5X-ray2.44A/B/C/D1-245[»]
6EJLX-ray2.38A/B1-230[»]
6EWWX-ray2.68A/B/C/D1-230[»]
6F08X-ray1.90A/B/I/J1-230[»]
6F09X-ray1.59P/Q/R/S1-230[»]
6FN9X-ray2.27A/B1-230[»]
6FNAX-ray2.12A/B1-230[»]
6FNBX-ray2.30A/B1-230[»]
6FNCX-ray2.12A/B1-230[»]
6Q0Kelectron microscopy6.80X/Y1-245[»]
6U2HX-ray2.50A/B1-230[»]
SMRiP63104
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi113366, 446 interactors
ComplexPortaliCPX-1147 FOXO3-YWHAZ complex
CORUMiP63104
DIPiDIP-563N
ELMiP63104
IntActiP63104, 695 interactors
MINTiP63104
STRINGi9606.ENSP00000379287

Chemistry databases

ChEMBLiCHEMBL4105899
DrugBankiDB12695 Phenethyl Isothiocyanate

Protein family/group databases

MoonDBiP63104 Predicted
TCDBi8.A.98.1.2 the 14-3-3 protein (14-3-3) family

PTM databases

iPTMnetiP63104
PhosphoSitePlusiP63104
SwissPalmiP63104

Polymorphism and mutation databases

BioMutaiYWHAZ
DMDMi52000887

2D gel databases

DOSAC-COBS-2DPAGEiP63104
OGPiP63104
UCD-2DPAGEiP63104

Proteomic databases

EPDiP63104
jPOSTiP63104
MassIVEiP63104
MaxQBiP63104
PaxDbiP63104
PeptideAtlasiP63104
PRIDEiP63104
ProteomicsDBi57477
TopDownProteomicsiP63104-1 [P63104-1]

Protocols and materials databases

The DNASU plasmid repository

More...DNASUi		7534

Genome annotation databases

EnsembliENST00000353245; ENSP00000309503; ENSG00000164924 [P63104-1]
ENST00000395951; ENSP00000379281; ENSG00000164924 [P63104-1]
ENST00000395953; ENSP00000379283; ENSG00000164924 [P63104-1]
ENST00000395956; ENSP00000379286; ENSG00000164924 [P63104-1]
ENST00000395957; ENSP00000379287; ENSG00000164924 [P63104-1]
ENST00000395958; ENSP00000379288; ENSG00000164924 [P63104-1]
ENST00000419477; ENSP00000395114; ENSG00000164924 [P63104-1]
ENST00000457309; ENSP00000398599; ENSG00000164924 [P63104-1]
ENST00000522542; ENSP00000430072; ENSG00000164924 [P63104-2]
GeneIDi7534
KEGGihsa:7534
UCSCiuc003yjv.3 human [P63104-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		7534
DisGeNETi7534

GeneCards: human genes, protein and diseases

More...GeneCardsi		YWHAZ
HGNCiHGNC:12855 YWHAZ
HPAiCAB005065
HPA061603
MalaCardsiYWHAZ
MIMi601288 gene
neXtProtiNX_P63104
OpenTargetsiENSG00000164924
PharmGKBiPA37444

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0841 Eukaryota
COG5040 LUCA
GeneTreeiENSGT00970000193355
InParanoidiP63104
KOiK16197
OrthoDBi1176818at2759
PhylomeDBiP63104
TreeFamiTF102003

Enzyme and pathway databases

ReactomeiR-HSA-111447 Activation of BAD and translocation to mitochondria
R-HSA-1445148 Translocation of SLC2A4 (GLUT4) to the plasma membrane
R-HSA-3769402 Deactivation of the beta-catenin transactivating complex
R-HSA-392517 Rap1 signalling
R-HSA-430116 GP1b-IX-V activation signalling
R-HSA-450604 KSRP (KHSRP) binds and destabilizes mRNA
R-HSA-512988 Interleukin-3, Interleukin-5 and GM-CSF signaling
R-HSA-5625740 RHO GTPases activate PKNs
R-HSA-5628897 TP53 Regulates Metabolic Genes
R-HSA-75035 Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
R-HSA-9013700 NOTCH4 Activation and Transmission of Signal to the Nucleus
R-HSA-9604323 Negative regulation of NOTCH4 signaling
R-HSA-9614399 Regulation of localization of FOXO transcription factors
SignaLinkiP63104
SIGNORiP63104

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		YWHAZ human
EvolutionaryTraceiP63104

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		YWHAZ

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		7534
PharosiP63104 Tbio

Protein Ontology

More...PROi		PR:P63104
RNActiP63104 protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000164924 Expressed in frontal cortex and 233 other tissues
ExpressionAtlasiP63104 baseline and differential
GenevisibleiP63104 HS

Family and domain databases

Gene3Di1.20.190.20, 1 hit
InterProiView protein in InterPro
IPR000308 14-3-3
IPR023409 14-3-3_CS
IPR036815 14-3-3_dom_sf
IPR023410 14-3-3_domain
PANTHERiPTHR18860 PTHR18860, 1 hit
PfamiView protein in Pfam
PF00244 14-3-3, 1 hit
PIRSFiPIRSF000868 14-3-3, 1 hit
PRINTSiPR00305 1433ZETA
SMARTiView protein in SMART
SM00101 14_3_3, 1 hit
SUPFAMiSSF48445 SSF48445, 1 hit
PROSITEiView protein in PROSITE
PS00796 1433_1, 1 hit
PS00797 1433_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry namei1433Z_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P63104
Secondary accession number(s): A8K1N0
, B7Z465, P29213, P29312, Q32P43, Q5XJ08, Q6GPI2, Q6IN74, Q6NUR9, Q6P3U9, Q86V33
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 13, 2004
Last sequence update: September 13, 2004
Last modified: February 26, 2020
This is version 191 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again