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Entry version 197 (10 Feb 2021)
Sequence version 1 (13 Sep 2004)
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Protein

14-3-3 protein zeta/delta

Gene

YWHAZ

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Induces ARHGEF7 activity on RAC1 as well as lamellipodia and membrane ruffle formation (PubMed:16959763). In neurons, regulates spine maturation through the modulation of ARHGEF7 activity (By similarity).By similarity7 Publications

Caution

Was originally thought to have phospholipase A2 activity.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

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PathwayCommonsi
P63104

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-111447, Activation of BAD and translocation to mitochondria
R-HSA-1445148, Translocation of SLC2A4 (GLUT4) to the plasma membrane
R-HSA-3769402, Deactivation of the beta-catenin transactivating complex
R-HSA-392517, Rap1 signalling
R-HSA-430116, GP1b-IX-V activation signalling
R-HSA-450604, KSRP (KHSRP) binds and destabilizes mRNA
R-HSA-512988, Interleukin-3, Interleukin-5 and GM-CSF signaling
R-HSA-5625740, RHO GTPases activate PKNs
R-HSA-5628897, TP53 Regulates Metabolic Genes
R-HSA-75035, Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
R-HSA-9013700, NOTCH4 Activation and Transmission of Signal to the Nucleus
R-HSA-9604323, Negative regulation of NOTCH4 signaling
R-HSA-9614399, Regulation of localization of FOXO transcription factors

SignaLink: a signaling pathway resource with multi-layered regulatory networks

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SignaLinki
P63104

SIGNOR Signaling Network Open Resource

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SIGNORi
P63104

Protein family/group databases

MoonDB Database of extreme multifunctional and moonlighting proteins

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MoonDBi
P63104, Predicted

Transport Classification Database

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TCDBi
8.A.98.1.2, the 14-3-3 protein (14-3-3) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
14-3-3 protein zeta/delta
Alternative name(s):
Protein kinase C inhibitor protein 1
Short name:
KCIP-1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:YWHAZ
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:12855, YWHAZ

Online Mendelian Inheritance in Man (OMIM)

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MIMi
601288, gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_P63104

Eukaryotic Pathogen, Vector and Host Database Resources

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VEuPathDBi
HostDB:ENSG00000164924.17

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi49K → E: Loss of interaction with NOXA1. 1 Publication1
Mutagenesisi56 – 60RSSWR → ASSWA: Abolishes lamellipodia formation and induces filopodia formation. 1 Publication5
Mutagenesisi58S → A: Loss of sphingosine-activated PKA phosphorylation. Promotes homodimerization and heterodimerization with YWHAE. Enhanced transcriptional activity of P53. 2 Publications1
Mutagenesisi58S → E: Loss of homodimerization. Reduced dimerization with YWHAE. Significantly reduced interaction with P53. No enhancement of P53 transcriptional activity. 2 Publications1
Mutagenesisi184S → A: On DNA damage, loss of MAPK8-mediated phosphorylation. Loss of binding ABL1. Attenuates ABL1-mediated apoptosis. No loss of interaction with BAX under stress conditions. Inhibits translocation of BAX to mitochondria. 2 Publications1
Mutagenesisi232T → A: Loss of phosphorylation by CK1. 1 Publication1

Keywords - Diseasei

Disease variant

Organism-specific databases

DisGeNET

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DisGeNETi
7534

Open Targets

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OpenTargetsi
ENSG00000164924

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA37444

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

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Pharosi
P63104, Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

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ChEMBLi
CHEMBL4105899

Drug and drug target database

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DrugBanki
DB12695, Phenethyl Isothiocyanate

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
YWHAZ

Domain mapping of disease mutations (DMDM)

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DMDMi
52000887

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000586271 – 24514-3-3 protein zeta/deltaAdd BLAST245

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineCombined sources1 Publication1
Modified residuei3N6-acetyllysineCombined sources1
Modified residuei58Phosphoserine; by PKA and PKB/AKT14 Publications1
Modified residuei68N6-acetyllysineCombined sources1
Modified residuei184Phosphoserine; by MAPK82 Publications1
Modified residuei207PhosphoserineCombined sources1
Modified residuei210PhosphoserineBy similarity1
Modified residuei232Phosphothreonine; by CK1Combined sources2 Publications1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

The delta, brain-specific form differs from the zeta form in being phosphorylated (By similarity). Phosphorylation on Ser-184 by MAPK8; promotes dissociation of BAX and translocation of BAX to mitochondria. Phosphorylation on Thr-232; inhibits binding of RAF1. Phosphorylated on Ser-58 by PKA and protein kinase C delta type catalytic subunit in a sphingosine-dependent fashion. Phosphorylation on Ser-58 by PKA; disrupts homodimerization and heterodimerization with YHAE and TP53.By similarity7 Publications

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
P63104

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
P63104

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
P63104

MaxQB - The MaxQuant DataBase

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MaxQBi
P63104

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P63104

PeptideAtlas

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PeptideAtlasi
P63104

PRoteomics IDEntifications database

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PRIDEi
P63104

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
57477

Consortium for Top Down Proteomics

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TopDownProteomicsi
P63104-1 [P63104-1]

2D gel databases

DOSAC-COBS 2D-PAGE database

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DOSAC-COBS-2DPAGEi
P63104

USC-OGP 2-DE database

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OGPi
P63104

University College Dublin 2-DE Proteome Database

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UCD-2DPAGEi
P63104

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P63104

MetOSite database of methionine sulfoxide sites

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MetOSitei
P63104

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P63104

SwissPalm database of S-palmitoylation events

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SwissPalmi
P63104

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000164924, Expressed in frontal cortex and 247 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P63104, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P63104, HS

Organism-specific databases

Human Protein Atlas

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HPAi
ENSG00000164924, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with CDK16 and BSPRY (By similarity).

Interacts with WEE1 (C-terminal).

Interacts with SAMSN1 (By similarity).

Interacts with MLF1 (phosphorylated form); the interaction retains it in the cytoplasm (By similarity).

Interacts with Thr-phosphorylated ITGB2 (By similarity).

Interacts with BCL2L11 (By similarity). Homodimer. Heterodimerizes with YWHAE. Homo- and heterodimerization is inhibited by phosphorylation on Ser-58.

Interacts with FOXO4, NOXA1, SSH1 and ARHGEF2.

Interacts with Pseudomonas aeruginosa exoS (unphosphorylated form).

Interacts with BAX; the interaction occurs in the cytoplasm. Under stress conditions, MAPK8-mediated phosphorylation releases BAX to mitochondria.

Interacts with phosphorylated RAF1; the interaction is inhibited when YWHAZ is phosphorylated on Thr-232 (PubMed:31024343).

Interacts with BRAF (PubMed:31024343).

Interacts with TP53; the interaction enhances p53 transcriptional activity. The Ser-58 phosphorylated form inhibits this interaction and p53 transcriptional activity.

Interacts with ABL1 (phosphorylated form); the interaction retains ABL1 in the cytoplasm.

Interacts with PKA-phosphorylated AANAT; the interaction modulates AANAT enzymatic activity by increasing affinity for arylalkylamines and acetyl-CoA and protecting the enzyme from dephosphorylation and proteasomal degradation. It may also prevent thiol-dependent inactivation.

Interacts with AKT1; the interaction phosphorylates YWHAZ and modulates dimerization.

Interacts with GAB2 and TLK2.

Interacts with the 'Thr-369' phosphorylated form of DAPK2 (PubMed:26047703).

Interacts with PI4KB, TBC1D22A and TBC1D22B (PubMed:23572552).

Interacts with ZFP36L1 (via phosphorylated form); this interaction occurs in a p38 MAPK- and AKT-signaling pathways (By similarity).

Interacts with SLITRK1 (PubMed:19640509).

Interacts with AK5, LDB1, MADD, MARK3, PDE1A and SMARCB1 (PubMed:16959763).

By similarity23 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei56Interaction with phosphoserine on interacting proteinBy similarity1
Sitei127Interaction with phosphoserine on interacting proteinBy similarity1

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

P63104
With#Exp.IntAct
ABL1 [P00519]3EBI-347088,EBI-375543
ACTB [P60709]3EBI-347088,EBI-353944
ADAM22 [Q9P0K1]3EBI-347088,EBI-1567236
ADAM22 - isoform 3 [Q9P0K1-3]3EBI-347088,EBI-1567267
AKAP13 [Q12802]2EBI-347088,EBI-1373806
ARAF [P10398]6EBI-347088,EBI-365961
ARHGAP21 [Q5T5U3]2EBI-347088,EBI-1642518
ARHGEF16 [Q5VV41]2EBI-347088,EBI-1057448
ARHGEF2 [Q92974]3EBI-347088,EBI-302405
ATP5F1A [P25705]3EBI-347088,EBI-351437
ATP5F1B [P06576]2EBI-347088,EBI-356231
ATXN1 [P54253]8EBI-347088,EBI-930964
BAD [Q92934]8EBI-347088,EBI-700771
BAIAP2 [Q9UQB8]3EBI-347088,EBI-525456
BRAF [P15056]8EBI-347088,EBI-365980
CALM3 [P62158]2EBI-347088,EBI-397435
CBX4 - isoform 2 [O00257-3]2EBI-347088,EBI-4392727
CBY1 [Q9Y3M2]3EBI-347088,EBI-947308
CCDC125 [Q86Z20]3EBI-347088,EBI-11977221
CDC25A [P30304]2EBI-347088,EBI-747671
CDC25B [P30305]7EBI-347088,EBI-1051746
CDK17 [Q00537]3EBI-347088,EBI-624648
CDK18 [Q07002]2EBI-347088,EBI-746238
CFL1 [P23528]3EBI-347088,EBI-352733
CGN [Q9P2M7]3EBI-347088,EBI-79537
CPS1 [P31327]2EBI-347088,EBI-536811
DENND4A [Q7Z401]2EBI-347088,EBI-1046479
DISC1 [Q9NRI5]3EBI-347088,EBI-529989
EEF1A1 [P68104]2EBI-347088,EBI-352162
EGFR [P00533]6EBI-347088,EBI-297353
ENO1 [P06733]2EBI-347088,EBI-353877
FOXO1 [Q12778]3EBI-347088,EBI-1108782
FOXO3 [O43524]3EBI-347088,EBI-1644164
FSCN1 [Q16658]3EBI-347088,EBI-351076
GCH1 [P30793]4EBI-347088,EBI-958183
GPSM3 [Q9Y4H4]5EBI-347088,EBI-347538
GSK3B [P49841]4EBI-347088,EBI-373586
H2AC17 [P0C0S8]2EBI-347088,EBI-1390628
H3C12 [P68431]3EBI-347088,EBI-79722
H4C9 [P62805]3EBI-347088,EBI-302023
HDAC4 [P56524]6EBI-347088,EBI-308629
HDAC5 [Q9UQL6]3EBI-347088,EBI-715576
HDAC7 [Q8WUI4]4EBI-347088,EBI-1048378
HECTD4 [Q9Y4D8]2EBI-347088,EBI-7195436
HNRNPC [P07910]2EBI-347088,EBI-357966
HSPB1 [P04792]4EBI-347088,EBI-352682
IRS2 [Q9Y4H2]3EBI-347088,EBI-1049582
KIF23 [Q02241]6EBI-347088,EBI-306852
KIF5B [P33176]2EBI-347088,EBI-355878
KLC2 [Q9H0B6]2EBI-347088,EBI-726994
KLC3 [Q6P597]2EBI-347088,EBI-1643885
LMNA [P02545]2EBI-347088,EBI-351935
LNX1 [Q8TBB1]3EBI-347088,EBI-739832
LRRK2 [Q5S007]11EBI-347088,EBI-5323863
MAP3K20 [Q9NYL2]5EBI-347088,EBI-602273
MAP3K3 [Q99759]2EBI-347088,EBI-307281
MAP3K5 [Q99683]4EBI-347088,EBI-476263
MAPT [P10636]8EBI-347088,EBI-366182
MAPT - isoform Fetal-tau [P10636-2]2EBI-347088,EBI-7796412
MAPT - isoform Tau-A [P10636-3]9EBI-347088,EBI-7145070
MARK2 [Q7KZI7]7EBI-347088,EBI-516560
MARK3 [P27448]11EBI-347088,EBI-707595
MDM4 [O15151]2EBI-347088,EBI-398437
MPRIP [Q6WCQ1]2EBI-347088,EBI-1022605
MYCBP2 [O75592]2EBI-347088,EBI-1043774
NADK [O95544]2EBI-347088,EBI-743949
NCL [P19338]2EBI-347088,EBI-346967
NPM1 [P06748]2EBI-347088,EBI-78579
PAK4 [O96013]2EBI-347088,EBI-713738
PARD3 [Q8TEW0]5EBI-347088,EBI-81968
PFKFB2 [O60825]2EBI-347088,EBI-764425
PIK3C2B [O00750]2EBI-347088,EBI-641107
PPP1R3D [O95685]3EBI-347088,EBI-1045661
PRKCE [Q02156]7EBI-347088,EBI-706254
PRLR [P16471]3EBI-347088,EBI-476182
PRMT5 [O14744]2EBI-347088,EBI-351098
PTPN3 [P26045]4EBI-347088,EBI-1047946
RAF1 [P04049]15EBI-347088,EBI-365996
RAI14 [Q9P0K7]2EBI-347088,EBI-1023749
REPS2 - isoform 2 [Q8NFH8-2]2EBI-347088,EBI-8029141
RND3 [P61587]11EBI-347088,EBI-1111534
RPS3 [P23396]2EBI-347088,EBI-351193
SAMD4B [Q5PRF9]2EBI-347088,EBI-1047489
SFN [P31947]3EBI-347088,EBI-476295
SH3BP5L [Q7L8J4]2EBI-347088,EBI-747389
SIK1 [P57059]4EBI-347088,EBI-1181640
SIK3 [Q9Y2K2]5EBI-347088,EBI-1181460
SIPA1L3 [O60292]2EBI-347088,EBI-2559690
SORBS2 [O94875]2EBI-347088,EBI-311323
SRGAP1 [Q7Z6B7]2EBI-347088,EBI-2481729
SRGAP2 [O75044]2EBI-347088,EBI-1051034
STK11 [Q15831]6EBI-347088,EBI-306838
STK25 [O00506]2EBI-347088,EBI-618295
TBC1D4 [O60343]2EBI-347088,EBI-522028
TGFBR1 [P36897]4EBI-347088,EBI-1027557
TP53 [P04637]2EBI-347088,EBI-366083
TP53BP2 [Q13625]3EBI-347088,EBI-77642
TSC2 [P49815]7EBI-347088,EBI-396587
USP8 [P40818]2EBI-347088,EBI-1050865
VCP [P55072]2EBI-347088,EBI-355164
VIM [P08670]2EBI-347088,EBI-353844
WEE1 [P30291]3EBI-347088,EBI-914695
XPO1 [O14980]2EBI-347088,EBI-355867
YAP1 [P46937]9EBI-347088,EBI-1044059
YWHAE [P62258]9EBI-347088,EBI-356498
itself3EBI-347088,EBI-347088
AANAT [Q29495] from Ovis aries.3EBI-347088,EBI-446413
Bad [Q61337] from Mus musculus.3EBI-347088,EBI-400328
CSNK1A1 [P67828] from Oryctolagus cuniculus.4EBI-347088,EBI-7540603
Hap1 - isoform A [P54256-2] from Rattus norvegicus.4EBI-347088,EBI-994554
MAPT [P29172] from Bos taurus.2EBI-347088,EBI-7291149
Rnd3 [P61588] from Mus musculus.3EBI-347088,EBI-6930266

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
113366, 621 interactors

ComplexPortal: manually curated resource of macromolecular complexes

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ComplexPortali
CPX-1147, FOXO3-YWHAZ complex

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
P63104

Database of interacting proteins

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DIPi
DIP-563N

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

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ELMi
P63104

Protein interaction database and analysis system

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IntActi
P63104, 713 interactors

Molecular INTeraction database

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MINTi
P63104

STRING: functional protein association networks

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STRINGi
9606.ENSP00000379287

Chemistry databases

BindingDB database of measured binding affinities

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BindingDBi
P63104

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

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RNActi
P63104, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1245
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Biological Magnetic Resonance Data Bank

More...
BMRBi
P63104

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P63104

Database of comparative protein structure models

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ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

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PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P63104

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the 14-3-3 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG0841, Eukaryota

Ensembl GeneTree

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GeneTreei
ENSGT01000000214500

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P63104

Database for complete collections of gene phylogenies

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PhylomeDBi
P63104

TreeFam database of animal gene trees

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TreeFami
TF102003

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.20.190.20, 1 hit

Intrinsically Disordered proteins with Extensive Annotations and Literature

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IDEALi
IID00061

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR000308, 14-3-3
IPR023409, 14-3-3_CS
IPR036815, 14-3-3_dom_sf
IPR023410, 14-3-3_domain

The PANTHER Classification System

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PANTHERi
PTHR18860, PTHR18860, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF00244, 14-3-3, 1 hit

PIRSF; a whole-protein classification database

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PIRSFi
PIRSF000868, 14-3-3, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR00305, 1433ZETA

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00101, 14_3_3, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48445, SSF48445, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00796, 1433_1, 1 hit
PS00797, 1433_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 9 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P63104-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDKNELVQKA KLAEQAERYD DMAACMKSVT EQGAELSNEE RNLLSVAYKN
60 70 80 90 100
VVGARRSSWR VVSSIEQKTE GAEKKQQMAR EYREKIETEL RDICNDVLSL
110 120 130 140 150
LEKFLIPNAS QAESKVFYLK MKGDYYRYLA EVAAGDDKKG IVDQSQQAYQ
160 170 180 190 200
EAFEISKKEM QPTHPIRLGL ALNFSVFYYE ILNSPEKACS LAKTAFDEAI
210 220 230 240
AELDTLSEES YKDSTLIMQL LRDNLTLWTS DTQGDEAEAG EGGEN
Length:245
Mass (Da):27,745
Last modified:September 13, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD464DF2286BBFE60
GO
Isoform 2 (identifier: P63104-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-98: MDKNELVQKA...ELRDICNDVL → MSQPCRKLWRHNYETSSCIEFLK

Show »
Length:170
Mass (Da):19,333
Checksum:iBE97CE3F0A74C75C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E7EX29E7EX29_HUMAN
14-3-3 protein zeta/delta
YWHAZ
246Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7ESK7E7ESK7_HUMAN
14-3-3 protein zeta/delta
YWHAZ
137Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7EVZ2E7EVZ2_HUMAN
14-3-3 protein zeta/delta
YWHAZ
98Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PD24E9PD24_HUMAN
14-3-3 protein zeta/delta
YWHAZ
92Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B7Z2E6B7Z2E6_HUMAN
14-3-3 protein zeta/delta
YWHAZ
125Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B0AZS6B0AZS6_HUMAN
14-3-3 protein zeta/delta
YWHAZ
168Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YB80H0YB80_HUMAN
14-3-3 protein zeta/delta
YWHAZ
130Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RIR4E5RIR4_HUMAN
14-3-3 protein zeta/delta
YWHAZ
75Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RGE1E5RGE1_HUMAN
14-3-3 protein zeta/delta
YWHAZ
51Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH51814 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence AAH73141 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti22M → V in AAH68456 (PubMed:15489334).Curated1
Sequence conflicti136D → G in BAH12451 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_08264014 – 245Missing Found in a patient with a neurodevelopmental disorder; unknown pathological significance. 1 PublicationAdd BLAST232
Natural variantiVAR_08264153G → R Found in a patient with a neurodevelopmental disorder; unknown pathological significance. 1 Publication1
Natural variantiVAR_082642145S → L Found in a patient with a neurodevelopmental disorder; unknown pathological significance. 1 Publication1
Natural variantiVAR_082643230S → W Found in a patient with a neurodevelopmental disorder; unknown pathological significance; gain-of-function mutation in signal transduction; changed regulation of ERK1 and ERK2 cascade; increased interaction with BRAF; increased interaction with RAF1; loss of phosphorylation by CK1 at Thr-232. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0475051 – 98MDKNE…CNDVL → MSQPCRKLWRHNYETSSCIE FLK in isoform 2. 1 PublicationAdd BLAST98

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M86400 mRNA Translation: AAA36446.1
U28964 mRNA Translation: AAC52052.1
AK289945 mRNA Translation: BAF82634.1
AK296902 mRNA Translation: BAH12451.1
CH471060 Genomic DNA Translation: EAW91823.1
BC003623 mRNA Translation: AAH03623.3
BC051814 mRNA Translation: AAH51814.1 Different initiation.
BC063824 mRNA Translation: AAH63824.2
BC068456 mRNA Translation: AAH68456.2
BC072426 mRNA Translation: AAH72426.2
BC073141 mRNA Translation: AAH73141.1 Different initiation.
BC083508 mRNA Translation: AAH83508.2
BC099904 mRNA Translation: AAH99904.1
BC101483 mRNA Translation: AAI01484.1
BC108281 mRNA Translation: AAI08282.1
BC111951 mRNA Translation: AAI11952.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS6290.1 [P63104-1]

Protein sequence database of the Protein Information Resource

More...
PIRi
A38246, PSHUAM

NCBI Reference Sequences

More...
RefSeqi
NP_001129171.1, NM_001135699.1 [P63104-1]
NP_001129172.1, NM_001135700.1 [P63104-1]
NP_001129173.1, NM_001135701.1 [P63104-1]
NP_001129174.1, NM_001135702.1 [P63104-1]
NP_003397.1, NM_003406.3 [P63104-1]
NP_663723.1, NM_145690.2 [P63104-1]
XP_005251118.1, XM_005251061.3 [P63104-1]
XP_005251120.1, XM_005251063.3 [P63104-1]
XP_016869299.1, XM_017013810.1 [P63104-1]
XP_016869300.1, XM_017013811.1 [P63104-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000353245; ENSP00000309503; ENSG00000164924 [P63104-1]
ENST00000395951; ENSP00000379281; ENSG00000164924 [P63104-1]
ENST00000395953; ENSP00000379283; ENSG00000164924 [P63104-1]
ENST00000395956; ENSP00000379286; ENSG00000164924 [P63104-1]
ENST00000395957; ENSP00000379287; ENSG00000164924 [P63104-1]
ENST00000395958; ENSP00000379288; ENSG00000164924 [P63104-1]
ENST00000419477; ENSP00000395114; ENSG00000164924 [P63104-1]
ENST00000457309; ENSP00000398599; ENSG00000164924 [P63104-1]
ENST00000522542; ENSP00000430072; ENSG00000164924 [P63104-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
7534

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:7534

UCSC genome browser

More...
UCSCi
uc003yjv.3, human [P63104-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M86400 mRNA Translation: AAA36446.1
U28964 mRNA Translation: AAC52052.1
AK289945 mRNA Translation: BAF82634.1
AK296902 mRNA Translation: BAH12451.1
CH471060 Genomic DNA Translation: EAW91823.1
BC003623 mRNA Translation: AAH03623.3
BC051814 mRNA Translation: AAH51814.1 Different initiation.
BC063824 mRNA Translation: AAH63824.2
BC068456 mRNA Translation: AAH68456.2
BC072426 mRNA Translation: AAH72426.2
BC073141 mRNA Translation: AAH73141.1 Different initiation.
BC083508 mRNA Translation: AAH83508.2
BC099904 mRNA Translation: AAH99904.1
BC101483 mRNA Translation: AAI01484.1
BC108281 mRNA Translation: AAI08282.1
BC111951 mRNA Translation: AAI11952.1
CCDSiCCDS6290.1 [P63104-1]
PIRiA38246, PSHUAM
RefSeqiNP_001129171.1, NM_001135699.1 [P63104-1]
NP_001129172.1, NM_001135700.1 [P63104-1]
NP_001129173.1, NM_001135701.1 [P63104-1]
NP_001129174.1, NM_001135702.1 [P63104-1]
NP_003397.1, NM_003406.3 [P63104-1]
NP_663723.1, NM_145690.2 [P63104-1]
XP_005251118.1, XM_005251061.3 [P63104-1]
XP_005251120.1, XM_005251063.3 [P63104-1]
XP_016869299.1, XM_017013810.1 [P63104-1]
XP_016869300.1, XM_017013811.1 [P63104-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1IB1X-ray2.70A/B/C/D1-245[»]
1QJAX-ray2.00A/B1-245[»]
1QJBX-ray2.00A/B1-245[»]
2C1JX-ray2.60A/B1-245[»]
2C1NX-ray2.00A/B1-245[»]
2O02X-ray1.50A/B1-230[»]
2WH0X-ray2.25A/B/C/D1-245[»]
3CU8X-ray2.40A/B1-245[»]
3NKXX-ray2.40A/B1-245[»]
3RDHX-ray2.39A/B/C/D1-245[»]
4BG6X-ray2.30A/B1-245[»]
4FJ3X-ray1.95A/B1-230[»]
4HKCX-ray2.20A1-245[»]
4IHLX-ray2.20A/B1-230[»]
4N7GX-ray2.25A1-230[»]
4N7YX-ray2.16A/B1-230[»]
4N84X-ray2.50A/B1-230[»]
4WRQX-ray2.41A/B1-245[»]
4ZDRX-ray2.90A/B1-230[»]
5D2DX-ray2.10A/B1-230[»]
5D3FX-ray2.74A/B1-230[»]
5EWZX-ray2.34A/B1-230[»]
5EXAX-ray1.95A/B1-230[»]
5J31X-ray2.40A/B1-230[»]
5JM4X-ray2.34A/B1-229[»]
5M35X-ray2.38A/B2-230[»]
5M36X-ray2.45A/B2-230[»]
5M37X-ray2.35A/B1-230[»]
5NASX-ray2.08A/B1-230[»]
5ULOX-ray2.14A/B1-245[»]
5WXNX-ray2.93A/B1-245[»]
5XY9X-ray2.30A/B1-245[»]
6EF5X-ray2.44A/B/C/D1-245[»]
6EJLX-ray2.38A/B1-230[»]
6EWWX-ray2.68A/B/C/D1-230[»]
6F08X-ray1.90A/B/I/J1-230[»]
6F09X-ray1.59P/Q/R/S1-230[»]
6FN9X-ray2.27A/B1-230[»]
6FNAX-ray2.12A/B1-230[»]
6FNBX-ray2.30A/B1-230[»]
6FNCX-ray2.12A/B1-230[»]
6Q0Kelectron microscopy6.80X/Y1-245[»]
6RLZX-ray3.70A/B1-230[»]
6U2HX-ray2.50A/B1-230[»]
6XAGX-ray3.30A/B1-230[»]
BMRBiP63104
SMRiP63104
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi113366, 621 interactors
ComplexPortaliCPX-1147, FOXO3-YWHAZ complex
CORUMiP63104
DIPiDIP-563N
ELMiP63104
IntActiP63104, 713 interactors
MINTiP63104
STRINGi9606.ENSP00000379287

Chemistry databases

BindingDBiP63104
ChEMBLiCHEMBL4105899
DrugBankiDB12695, Phenethyl Isothiocyanate

Protein family/group databases

MoonDBiP63104, Predicted
TCDBi8.A.98.1.2, the 14-3-3 protein (14-3-3) family

PTM databases

iPTMnetiP63104
MetOSiteiP63104
PhosphoSitePlusiP63104
SwissPalmiP63104

Genetic variation databases

BioMutaiYWHAZ
DMDMi52000887

2D gel databases

DOSAC-COBS-2DPAGEiP63104
OGPiP63104
UCD-2DPAGEiP63104

Proteomic databases

EPDiP63104
jPOSTiP63104
MassIVEiP63104
MaxQBiP63104
PaxDbiP63104
PeptideAtlasiP63104
PRIDEiP63104
ProteomicsDBi57477
TopDownProteomicsiP63104-1 [P63104-1]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
3905, 953 antibodies

The DNASU plasmid repository

More...
DNASUi
7534

Genome annotation databases

EnsembliENST00000353245; ENSP00000309503; ENSG00000164924 [P63104-1]
ENST00000395951; ENSP00000379281; ENSG00000164924 [P63104-1]
ENST00000395953; ENSP00000379283; ENSG00000164924 [P63104-1]
ENST00000395956; ENSP00000379286; ENSG00000164924 [P63104-1]
ENST00000395957; ENSP00000379287; ENSG00000164924 [P63104-1]
ENST00000395958; ENSP00000379288; ENSG00000164924 [P63104-1]
ENST00000419477; ENSP00000395114; ENSG00000164924 [P63104-1]
ENST00000457309; ENSP00000398599; ENSG00000164924 [P63104-1]
ENST00000522542; ENSP00000430072; ENSG00000164924 [P63104-2]
GeneIDi7534
KEGGihsa:7534
UCSCiuc003yjv.3, human [P63104-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
7534
DisGeNETi7534

GeneCards: human genes, protein and diseases

More...
GeneCardsi
YWHAZ
HGNCiHGNC:12855, YWHAZ
HPAiENSG00000164924, Low tissue specificity
MIMi601288, gene
neXtProtiNX_P63104
OpenTargetsiENSG00000164924
PharmGKBiPA37444
VEuPathDBiHostDB:ENSG00000164924.17

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0841, Eukaryota
GeneTreeiENSGT01000000214500
InParanoidiP63104
PhylomeDBiP63104
TreeFamiTF102003

Enzyme and pathway databases

PathwayCommonsiP63104
ReactomeiR-HSA-111447, Activation of BAD and translocation to mitochondria
R-HSA-1445148, Translocation of SLC2A4 (GLUT4) to the plasma membrane
R-HSA-3769402, Deactivation of the beta-catenin transactivating complex
R-HSA-392517, Rap1 signalling
R-HSA-430116, GP1b-IX-V activation signalling
R-HSA-450604, KSRP (KHSRP) binds and destabilizes mRNA
R-HSA-512988, Interleukin-3, Interleukin-5 and GM-CSF signaling
R-HSA-5625740, RHO GTPases activate PKNs
R-HSA-5628897, TP53 Regulates Metabolic Genes
R-HSA-75035, Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
R-HSA-9013700, NOTCH4 Activation and Transmission of Signal to the Nucleus
R-HSA-9604323, Negative regulation of NOTCH4 signaling
R-HSA-9614399, Regulation of localization of FOXO transcription factors
SignaLinkiP63104
SIGNORiP63104

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
7534, 154 hits in 860 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
YWHAZ, human
EvolutionaryTraceiP63104

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
YWHAZ

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
7534
PharosiP63104, Tbio

Protein Ontology

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PROi
PR:P63104
RNActiP63104, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000164924, Expressed in frontal cortex and 247 other tissues
ExpressionAtlasiP63104, baseline and differential
GenevisibleiP63104, HS

Family and domain databases

Gene3Di1.20.190.20, 1 hit
IDEALiIID00061
InterProiView protein in InterPro
IPR000308, 14-3-3
IPR023409, 14-3-3_CS
IPR036815, 14-3-3_dom_sf
IPR023410, 14-3-3_domain
PANTHERiPTHR18860, PTHR18860, 1 hit
PfamiView protein in Pfam
PF00244, 14-3-3, 1 hit
PIRSFiPIRSF000868, 14-3-3, 1 hit
PRINTSiPR00305, 1433ZETA
SMARTiView protein in SMART
SM00101, 14_3_3, 1 hit
SUPFAMiSSF48445, SSF48445, 1 hit
PROSITEiView protein in PROSITE
PS00796, 1433_1, 1 hit
PS00797, 1433_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry namei1433Z_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P63104
Secondary accession number(s): A8K1N0
, B7Z465, P29213, P29312, Q32P43, Q5XJ08, Q6GPI2, Q6IN74, Q6NUR9, Q6P3U9, Q86V33
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 13, 2004
Last sequence update: September 13, 2004
Last modified: February 10, 2021
This is version 197 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Human entries with genetic variants
    List of human entries with genetic variants
  2. Human variants curated from literature reports
    Index of human variants curated from literature reports
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families
  6. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
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