UniProtKB - P63096 (GNAI1_HUMAN)
Guanine nucleotide-binding protein G(i) subunit alpha-1
GNAI1
Functioni
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 47 | MagnesiumCombined sources2 Publications | 1 | |
Binding sitei | 151 | GTPCombined sources | 1 | |
Metal bindingi | 181 | MagnesiumCombined sources2 Publications | 1 | |
Binding sitei | 326 | GTP; via amide nitrogenCombined sources | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 43 – 48 | GTPCombined sources1 Publication | 6 | |
Nucleotide bindingi | 175 – 181 | GTPCombined sources | 7 | |
Nucleotide bindingi | 200 – 204 | GTP1 Publication | 5 | |
Nucleotide bindingi | 269 – 272 | GTPCombined sources1 Publication | 4 |
GO - Molecular functioni
- GDP binding Source: UniProtKB
- G-protein beta/gamma-subunit complex binding Source: GO_Central
- G protein-coupled receptor binding Source: UniProtKB
- G protein-coupled serotonin receptor binding Source: GO_Central
- GTPase activating protein binding Source: Ensembl
- GTPase activity Source: UniProtKB
- GTP binding Source: UniProtKB
- magnesium ion binding Source: UniProtKB
GO - Biological processi
- adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway Source: Reactome
- adenylate cyclase-modulating G protein-coupled receptor signaling pathway Source: GO_Central
- cell cycle Source: UniProtKB-KW
- cell division Source: UniProtKB
- cellular response to forskolin Source: UniProtKB
- G protein-coupled receptor signaling pathway Source: UniProtKB
- negative regulation of synaptic transmission Source: Ensembl
- positive regulation of protein localization to cell cortex Source: UniProtKB
- protein folding Source: Reactome
- regulation of cAMP-mediated signaling Source: UniProtKB
- regulation of mitotic spindle organization Source: UniProtKB
- response to peptide hormone Source: BHF-UCL
Keywordsi
Molecular function | Transducer |
Biological process | Cell cycle, Cell division, Mitosis, Transport |
Ligand | GTP-binding, Magnesium, Metal-binding, Nucleotide-binding |
Enzyme and pathway databases
PathwayCommonsi | P63096 |
Reactomei | R-HSA-112043, PLC beta mediated events R-HSA-170670, Adenylate cyclase inhibitory pathway R-HSA-202040, G-protein activation R-HSA-392170, ADP signalling through P2Y purinoceptor 12 R-HSA-400042, Adrenaline,noradrenaline inhibits insulin secretion R-HSA-418555, G alpha (s) signalling events R-HSA-418594, G alpha (i) signalling events R-HSA-418597, G alpha (z) signalling events R-HSA-422356, Regulation of insulin secretion R-HSA-6814122, Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-9009391, Extra-nuclear estrogen signaling R-HSA-9660821, ADORA2B mediated anti-inflammatory cytokines production |
SignaLinki | P63096 |
SIGNORi | P63096 |
Names & Taxonomyi
Protein namesi | Recommended name: Guanine nucleotide-binding protein G(i) subunit alpha-1Alternative name(s): Adenylate cyclase-inhibiting G alpha protein |
Gene namesi | Name:GNAI1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000127955.15 |
HGNCi | HGNC:4384, GNAI1 |
MIMi | 139310, gene |
neXtProti | NX_P63096 |
Subcellular locationi
Plasma membrane
- Cell membrane 2 Publications; Peripheral membrane protein By similarity; Cytoplasmic side By similarity
Cytoskeleton
- centrosome 1 Publication
Nucleus
- Nucleus By similarity
Other locations
- Cytoplasm 1 Publication
- cell cortex 1 Publication
- Membrane By similarity; Lipid-anchor 2 Publications
Note: Localizes in the centrosomes of interphase and mitotic cells, but not in centrosomes during cytokinesis. Detected at the cleavage furrow or the midbody (PubMed:17635935). Localized at the plasma membrane throughout mitosis. Colocalizes with RIC8A and RGS14 at the plasma membrane.By similarity1 Publication
Cytoskeleton
- centrosome Source: UniProtKB
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
Lysosome
- lysosomal membrane Source: UniProtKB
Nucleus
- nucleus Source: UniProtKB-SubCell
Plasma Membrane
- heterotrimeric G-protein complex Source: GO_Central
- plasma membrane Source: UniProtKB
Other locations
- cell cortex region Source: UniProtKB
- cytoplasm Source: UniProtKB
- membrane raft Source: Ensembl
- midbody Source: UniProtKB
Keywords - Cellular componenti
Cell membrane, Cytoplasm, Cytoskeleton, Membrane, NucleusPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 42 | G → R: Abolishes switch to an activated conformation and dissociation from beta and gamma subunits upon GTP binding. Abolishes interaction with RGS family members. 1 Publication | 1 | |
Mutagenesisi | 116 | E → L: Enhances interaction (inactive GDP-bound) with RGS14. 2 Publications | 1 | |
Mutagenesisi | 147 | Q → L: Enhances interaction (inactive GDP-bound) with RGS14. 2 Publications | 1 | |
Mutagenesisi | 245 | E → L: Enhances interaction (inactive GDP-bound) with RGS14. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 2770 |
OpenTargetsi | ENSG00000127955 |
PharmGKBi | PA172 |
Miscellaneous databases
Pharosi | P63096, Tbio |
Chemistry databases
ChEMBLi | CHEMBL4741 |
DrugBanki | DB04315, Guanosine-5'-Diphosphate DB04444, Tetrafluoroaluminate Ion |
Polymorphism and mutation databases
BioMutai | GNAI1 |
DMDMi | 52000964 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | Removed2 Publications | |||
ChainiPRO_0000203671 | 2 – 354 | Guanine nucleotide-binding protein G(i) subunit alpha-1Add BLAST | 353 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Lipidationi | 2 | N-myristoyl glycine2 Publications | 1 | |
Lipidationi | 3 | S-palmitoyl cysteineBy similarity | 1 | |
Modified residuei | 178 | ADP-ribosylarginine; by cholera toxinBy similarity | 1 | |
Modified residuei | 204 | Deamidated glutamine; by Photorhabdus PAU_022301 Publication | 1 | |
Modified residuei | 351 | ADP-ribosylcysteine; by pertussis toxinBy similarity | 1 |
Post-translational modificationi
Keywords - PTMi
ADP-ribosylation, Lipoprotein, Myristate, PalmitateProteomic databases
CPTACi | CPTAC-1243 CPTAC-1244 |
EPDi | P63096 |
jPOSTi | P63096 |
MassIVEi | P63096 |
MaxQBi | P63096 |
PaxDbi | P63096 |
PeptideAtlasi | P63096 |
PRIDEi | P63096 |
ProteomicsDBi | 57475 [P63096-1] 5853 |
PTM databases
iPTMneti | P63096 |
PhosphoSitePlusi | P63096 |
SwissPalmi | P63096 |
Expressioni
Gene expression databases
Bgeei | ENSG00000127955, Expressed in corpus callosum and 233 other tissues |
ExpressionAtlasi | P63096, baseline and differential |
Genevisiblei | P63096, HS |
Organism-specific databases
HPAi | ENSG00000127955, Low tissue specificity |
Interactioni
Subunit structurei
Heterotrimeric G proteins are composed of 3 units; alpha, beta and gamma.
Part of a spindle orientation complex at least composed of GNAI1, GPSM2 and NUMA1 (PubMed:26766442). The alpha chain contains the guanine nucleotide binding site. Identified in complex with the beta subunit GNB1 and the gamma subunit GNG1 (PubMed:22383884). Identified in complex with the beta subunit GNB1 and the gamma subunit GNG2 (PubMed:18434541). GTP binding causes dissociation of the heterotrimer, liberating the individual subunits so that they can interact with downstream effector proteins (PubMed:22383884).
Interacts (GDP-bound form) with GPSM1; this inhibits guanine nucleotide exchange and GTP binding (By similarity).
Interacts (GDP-bound form) with GPSM2 (via GoLoco domains); this inhibits guanine nucleotide exchange (PubMed:22952234).
Interacts with RGS10; this strongly enhances GTP hydrolysis (PubMed:8774883, PubMed:18434541).
Interacts with RGS1 and RGS16; this strongly enhances GTPase activity (PubMed:18434541).
Interacts with RGS4 (PubMed:18434541).
Interacts with RGS12 (PubMed:18434541).
Interacts (via active GTP- or inactive GDP-bound forms) with RGS14 (via RGS and GoLoco domains) (PubMed:11976690, PubMed:18434541, PubMed:21115486, PubMed:22383884).
Interacts with RGS3, RGS6, RGS7, RGS8, RGS17, RGS18 and RGS20 (in vitro) (PubMed:18434541).
Interacts (GDP-bound form) with RIC8A (via C-terminus) (By similarity).
Interacts (inactive GDP-bound form) with NUCB1 (via GBA motif); the interaction leads to activation of GNAI1 (By similarity).
Interacts (inactive GDP-bound form) with CCDC88C/DAPLE (via GBA motif); the interaction leads to activation of GNAI1 (PubMed:26126266).
Interacts (inactive GDP-bound form) with CCDC8A/GIV (via GBA motif) (PubMed:19211784).
By similarity11 PublicationsBinary interactionsi
Hide detailsP63096
GO - Molecular functioni
- G protein-coupled receptor binding Source: UniProtKB
- G protein-coupled serotonin receptor binding Source: GO_Central
- GTPase activating protein binding Source: Ensembl
Protein-protein interaction databases
BioGRIDi | 109032, 96 interactors |
CORUMi | P63096 |
ELMi | P63096 |
IntActi | P63096, 55 interactors |
MINTi | P63096 |
STRINGi | 9606.ENSP00000343027 |
Chemistry databases
BindingDBi | P63096 |
Miscellaneous databases
RNActi | P63096, protein |
Structurei
Secondary structure
3D structure databases
SMRi | P63096 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P63096 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 32 – 354 | G-alphaPROSITE-ProRule annotationAdd BLAST | 323 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 35 – 48 | G1 motifPROSITE-ProRule annotationAdd BLAST | 14 | |
Regioni | 173 – 181 | G2 motifPROSITE-ProRule annotation | 9 | |
Regioni | 196 – 205 | G3 motifPROSITE-ProRule annotation | 10 | |
Regioni | 265 – 272 | G4 motifPROSITE-ProRule annotation | 8 | |
Regioni | 324 – 329 | G5 motifPROSITE-ProRule annotation | 6 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG0082, Eukaryota |
GeneTreei | ENSGT00940000153567 |
HOGENOMi | CLU_014184_6_0_1 |
InParanoidi | P63096 |
OMAi | RIAQTSY |
OrthoDBi | 754573at2759 |
PhylomeDBi | P63096 |
TreeFami | TF300673 |
Family and domain databases
CDDi | cd00066, G-alpha, 1 hit |
Gene3Di | 1.10.400.10, 1 hit |
IDEALi | IID00608 |
InterProi | View protein in InterPro IPR001408, Gprotein_alpha_I IPR001019, Gprotein_alpha_su IPR011025, GproteinA_insert IPR027417, P-loop_NTPase |
PANTHERi | PTHR10218, PTHR10218, 1 hit |
Pfami | View protein in Pfam PF00503, G-alpha, 1 hit |
PRINTSi | PR00318, GPROTEINA PR00441, GPROTEINAI |
SMARTi | View protein in SMART SM00275, G_alpha, 1 hit |
SUPFAMi | SSF47895, SSF47895, 1 hit SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS51882, G_ALPHA, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MGCTLSAEDK AAVERSKMID RNLREDGEKA AREVKLLLLG AGESGKSTIV
60 70 80 90 100
KQMKIIHEAG YSEEECKQYK AVVYSNTIQS IIAIIRAMGR LKIDFGDSAR
110 120 130 140 150
ADDARQLFVL AGAAEEGFMT AELAGVIKRL WKDSGVQACF NRSREYQLND
160 170 180 190 200
SAAYYLNDLD RIAQPNYIPT QQDVLRTRVK TTGIVETHFT FKDLHFKMFD
210 220 230 240 250
VGGQRSERKK WIHCFEGVTA IIFCVALSDY DLVLAEDEEM NRMHESMKLF
260 270 280 290 300
DSICNNKWFT DTSIILFLNK KDLFEEKIKK SPLTICYPEY AGSNTYEEAA
310 320 330 340 350
AYIQCQFEDL NKRKDTKEIY THFTCATDTK NVQFVFDAVT DVIIKNNLKD
CGLF
Computationally mapped potential isoform sequencesi
There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A3B3ITM0 | A0A3B3ITM0_HUMAN | Guanine nucleotide-binding protein ... | GNAI1 | 168 | Annotation score: | ||
A0A3B3ITX3 | A0A3B3ITX3_HUMAN | Guanine nucleotide-binding protein ... | GNAI1 | 60 | Annotation score: | ||
A0A3B3IUA8 | A0A3B3IUA8_HUMAN | Guanine nucleotide-binding protein ... | GNAI1 | 148 | Annotation score: | ||
A0A3B3IRK0 | A0A3B3IRK0_HUMAN | Guanine nucleotide-binding protein ... | GNAI1 | 40 | Annotation score: | ||
A0A3B3IS42 | A0A3B3IS42_HUMAN | Guanine nucleotide-binding protein ... | GNAI1 | 47 | Annotation score: | ||
A0A3B3ITG4 | A0A3B3ITG4_HUMAN | Guanine nucleotide-binding protein ... | GNAI1 | 40 | Annotation score: | ||
A0A3B3IU77 | A0A3B3IU77_HUMAN | Guanine nucleotide-binding protein ... | GNAI1 | 43 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 138 | A → G in CAB43212 (PubMed:11230166).Curated | 1 | |
Sequence conflicti | 219 | T → A in AAH26326 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 244 | H → Y in AAV38580 (Ref. 4) Curated | 1 | |
Sequence conflicti | 249 | L → M in AAV38580 (Ref. 4) Curated | 1 | |
Sequence conflicti | 288 | P → Q in AAH26326 (PubMed:15489334).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_045215 | 1 – 52 | Missing in isoform 2. 1 PublicationAdd BLAST | 52 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF493905 mRNA Translation: AAM12619.1 AF055013 mRNA Translation: AAC09361.1 AL049933 mRNA Translation: CAB43212.2 BT019775 mRNA Translation: AAV38580.1 AK292953 mRNA Translation: BAF85642.1 AK304442 mRNA Translation: BAG65263.1 AC004159 Genomic DNA No translation available. AC080066 Genomic DNA No translation available. CH471091 Genomic DNA Translation: EAW77011.1 BC026326 mRNA Translation: AAH26326.1 M20596, M20594, M20595 Genomic DNA Translation: AAA35893.1 M17219 mRNA Translation: AAA52581.1 |
CCDSi | CCDS5595.1 [P63096-1] CCDS59061.1 [P63096-2] |
PIRi | A28318, RGHUI1 |
RefSeqi | NP_001243343.1, NM_001256414.1 [P63096-2] NP_002060.4, NM_002069.5 [P63096-1] |
Genome annotation databases
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF493905 mRNA Translation: AAM12619.1 AF055013 mRNA Translation: AAC09361.1 AL049933 mRNA Translation: CAB43212.2 BT019775 mRNA Translation: AAV38580.1 AK292953 mRNA Translation: BAF85642.1 AK304442 mRNA Translation: BAG65263.1 AC004159 Genomic DNA No translation available. AC080066 Genomic DNA No translation available. CH471091 Genomic DNA Translation: EAW77011.1 BC026326 mRNA Translation: AAH26326.1 M20596, M20594, M20595 Genomic DNA Translation: AAA35893.1 M17219 mRNA Translation: AAA52581.1 |
CCDSi | CCDS5595.1 [P63096-1] CCDS59061.1 [P63096-2] |
PIRi | A28318, RGHUI1 |
RefSeqi | NP_001243343.1, NM_001256414.1 [P63096-2] NP_002060.4, NM_002069.5 [P63096-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1KJY | X-ray | 2.70 | A/C | 30-354 | [»] | |
1Y3A | X-ray | 2.50 | A/B/C/D | 26-354 | [»] | |
2G83 | X-ray | 2.80 | A/B | 33-345 | [»] | |
2GTP | X-ray | 2.55 | A/B | 32-354 | [»] | |
2IK8 | X-ray | 2.71 | A/C | 31-354 | [»] | |
2OM2 | X-ray | 2.20 | A/C | 31-354 | [»] | |
2XNS | X-ray | 3.41 | A/B | 30-354 | [»] | |
3ONW | X-ray | 2.38 | A/B | 31-354 | [»] | |
3QE0 | X-ray | 3.00 | A/B/C | 33-354 | [»] | |
3QI2 | X-ray | 2.80 | A/B | 31-354 | [»] | |
3UMR | X-ray | 2.24 | A | 1-354 | [»] | |
3UMS | X-ray | 2.60 | A | 1-354 | [»] | |
4G5Q | X-ray | 2.90 | A/B/C/D | 25-354 | [»] | |
5JS7 | NMR | - | A | 30-354 | [»] | |
5JS8 | NMR | - | A | 30-354 | [»] | |
5TDH | X-ray | 3.00 | A/H | 1-354 | [»] | |
6CMO | electron microscopy | 4.50 | A | 1-354 | [»] | |
6CRK | X-ray | 2.00 | A | 2-354 | [»] | |
6DDE | electron microscopy | 3.50 | A | 1-354 | [»] | |
6DDF | electron microscopy | 3.50 | A | 1-354 | [»] | |
6KPF | electron microscopy | 2.90 | A | 1-354 | [»] | |
6KPG | electron microscopy | 3.00 | A | 2-354 | [»] | |
6LFM | electron microscopy | 3.50 | A | 2-354 | [»] | |
6LFO | electron microscopy | 3.40 | A | 2-354 | [»] | |
6LML | electron microscopy | 3.90 | A | 1-354 | [»] | |
6N4B | electron microscopy | 3.00 | A | 1-354 | [»] | |
6OMM | electron microscopy | 3.17 | A | 2-354 | [»] | |
6OS9 | electron microscopy | 3.00 | A | 1-354 | [»] | |
6OSA | electron microscopy | 3.00 | A | 1-354 | [»] | |
6OT0 | electron microscopy | 3.90 | A | 1-354 | [»] | |
6PB0 | electron microscopy | 3.00 | A | 61-184 | [»] | |
6PB1 | electron microscopy | 2.80 | A | 61-184 | [»] | |
6PT0 | electron microscopy | 3.20 | A | 1-354 | [»] | |
6QNO | electron microscopy | 4.38 | A | 1-354 | [»] | |
6VU8 | electron microscopy | 4.14 | B | 2-354 | [»] | |
SMRi | P63096 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 109032, 96 interactors |
CORUMi | P63096 |
ELMi | P63096 |
IntActi | P63096, 55 interactors |
MINTi | P63096 |
STRINGi | 9606.ENSP00000343027 |
Chemistry databases
BindingDBi | P63096 |
ChEMBLi | CHEMBL4741 |
DrugBanki | DB04315, Guanosine-5'-Diphosphate DB04444, Tetrafluoroaluminate Ion |
PTM databases
iPTMneti | P63096 |
PhosphoSitePlusi | P63096 |
SwissPalmi | P63096 |
Polymorphism and mutation databases
BioMutai | GNAI1 |
DMDMi | 52000964 |
Proteomic databases
CPTACi | CPTAC-1243 CPTAC-1244 |
EPDi | P63096 |
jPOSTi | P63096 |
MassIVEi | P63096 |
MaxQBi | P63096 |
PaxDbi | P63096 |
PeptideAtlasi | P63096 |
PRIDEi | P63096 |
ProteomicsDBi | 57475 [P63096-1] 5853 |
Protocols and materials databases
ABCDi | P63096, 2 sequenced antibodies |
Antibodypediai | 15099, 293 antibodies |
DNASUi | 2770 |
Genome annotation databases
Organism-specific databases
CTDi | 2770 |
DisGeNETi | 2770 |
EuPathDBi | HostDB:ENSG00000127955.15 |
GeneCardsi | GNAI1 |
HGNCi | HGNC:4384, GNAI1 |
HPAi | ENSG00000127955, Low tissue specificity |
MIMi | 139310, gene |
neXtProti | NX_P63096 |
OpenTargetsi | ENSG00000127955 |
PharmGKBi | PA172 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0082, Eukaryota |
GeneTreei | ENSGT00940000153567 |
HOGENOMi | CLU_014184_6_0_1 |
InParanoidi | P63096 |
OMAi | RIAQTSY |
OrthoDBi | 754573at2759 |
PhylomeDBi | P63096 |
TreeFami | TF300673 |
Enzyme and pathway databases
PathwayCommonsi | P63096 |
Reactomei | R-HSA-112043, PLC beta mediated events R-HSA-170670, Adenylate cyclase inhibitory pathway R-HSA-202040, G-protein activation R-HSA-392170, ADP signalling through P2Y purinoceptor 12 R-HSA-400042, Adrenaline,noradrenaline inhibits insulin secretion R-HSA-418555, G alpha (s) signalling events R-HSA-418594, G alpha (i) signalling events R-HSA-418597, G alpha (z) signalling events R-HSA-422356, Regulation of insulin secretion R-HSA-6814122, Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-9009391, Extra-nuclear estrogen signaling R-HSA-9660821, ADORA2B mediated anti-inflammatory cytokines production |
SignaLinki | P63096 |
SIGNORi | P63096 |
Miscellaneous databases
BioGRID-ORCSi | 2770, 2 hits in 846 CRISPR screens |
ChiTaRSi | GNAI1, human |
EvolutionaryTracei | P63096 |
GeneWikii | GNAI1 |
GenomeRNAii | 2770 |
Pharosi | P63096, Tbio |
PROi | PR:P63096 |
RNActi | P63096, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000127955, Expressed in corpus callosum and 233 other tissues |
ExpressionAtlasi | P63096, baseline and differential |
Genevisiblei | P63096, HS |
Family and domain databases
CDDi | cd00066, G-alpha, 1 hit |
Gene3Di | 1.10.400.10, 1 hit |
IDEALi | IID00608 |
InterProi | View protein in InterPro IPR001408, Gprotein_alpha_I IPR001019, Gprotein_alpha_su IPR011025, GproteinA_insert IPR027417, P-loop_NTPase |
PANTHERi | PTHR10218, PTHR10218, 1 hit |
Pfami | View protein in Pfam PF00503, G-alpha, 1 hit |
PRINTSi | PR00318, GPROTEINA PR00441, GPROTEINAI |
SMARTi | View protein in SMART SM00275, G_alpha, 1 hit |
SUPFAMi | SSF47895, SSF47895, 1 hit SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS51882, G_ALPHA, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | GNAI1_HUMAN | |
Accessioni | P63096Primary (citable) accession number: P63096 Secondary accession number(s): A8KA88 Q9UGA4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 13, 1987 |
Last sequence update: | January 23, 2007 | |
Last modified: | December 2, 2020 | |
This is version 179 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 7
Human chromosome 7: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families