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Entry version 134 (02 Jun 2021)
Sequence version 1 (13 Sep 2004)
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Protein

Pleiotrophin

Gene

Ptn

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Secreted growth factor that mediates its signal through cell-surface proteoglycan and non-proteoglycan receptors (By similarity).

Binds cell-surface proteoglycan receptor via their chondroitin sulfate (CS) groups (By similarity).

Thereby regulates many processes like cell proliferation, cell survival, cell growth, cell differentiation and cell migration in several tissues namely neuron and bone (PubMed:15121180, PubMed:30497772, PubMed:27445335, PubMed:19442624).

Also plays a role in synaptic plasticity and learning-related behavior by inhibiting long-term synaptic potentiation (PubMed:11414790, PubMed:25000129).

Binds PTPRZ1, leading to neutralization of the negative charges of the CS chains of PTPRZ1, inducing PTPRZ1 clustering, thereby causing the dimerization and inactivation of its phosphatase activity leading to increased tyrosine phosphorylation of each of the PTPRZ1 substrates like ALK or AFAP1L2 in order to activate the PI3K-AKT pathway (PubMed:27445335).

Through PTPRZ1 binding controls oligodendrocyte precursor cell differentiation by enhancing the phosphorylation of AFAP1L2 in order to activate the PI3K-AKT pathway (PubMed:27445335).

Forms a complex with PTPRZ1 and integrin alpha-V/beta-3 (ITGAV:ITGB3) that stimulates endothelial cell migration through SRC dephosphorylation and activation that consequently leads to ITGB3 'Tyr-773' phosphorylation (By similarity).

In adult hippocampus promotes dendritic arborization, spine development, and functional integration and connectivity of newborn granule neurons through ALK by activating AKT signaling pathway (PubMed:30497772).

Binds GPC2 and chondroitin sulfate proteoglycans (CSPGs) at the neuron surface, leading to abrogation of binding between PTPRS and CSPGs and neurite outgrowth promotion (By similarity).

Binds SDC3 and mediates bone formation by recruiting and attaching osteoblasts/osteoblast precursors to the sites for new bone deposition (By similarity).

Binds ALK and promotes cell survival and cell proliferation through MAPK pathway activation (By similarity).

Inhibits proliferation and enhances differentiation of neural stem cells by inhibiting FGF2-induced fibroblast growth factor receptor signaling pathway (PubMed:15121180).

Mediates regulatory mechanisms in normal hemostasis and in hematopoietic regeneration and in maintaining the balance of myeloid and lymphoid regeneration (PubMed:21791434).

In addition may play a role in the female reproductive system, auditory response and the progesterone-induced decidualization pathway (PubMed:17121547, PubMed:28657144, PubMed:16619002).

By similarity10 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGrowth factor, Heparin-binding, Mitogen

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
PleiotrophinBy similarity
Short name:
PTNBy similarity
Alternative name(s):
Heparin-binding brain mitogenBy similarity
Short name:
HBBMBy similarity
Heparin-binding growth factor 8By similarity
Short name:
HBGF-8By similarity
Heparin-binding growth-associated moleculeBy similarity
Short name:
HB-GAMBy similarity
Heparin-binding neutrophic factorBy similarity
Short name:
HBNFBy similarity
Osteoblast-specific factor 11 Publication
Short name:
OSF-11 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PtnImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:97804, Ptn

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Homozygous PTN knockout mice are viable and fertile and show no gross anatomical abnormalities. The hippocampal structure as well as basal excitatory synaptic transmission in the area CA1 appear normal. The skeletal structure of homozygous PTN knockout mice develops normally. However, a growth retardation of the weight-bearing bones is observed by 2 months of age. Adult homozygous PTN knockout mice are characterized by low bone formation and osteopenia, as well as resistance to immobilization-dependent bone remodeling (PubMed:11414790, PubMed:12093164). Mice show faster learning in water maze and decreased anxiety in elevated plus-maze test (PubMed:12093164). Homozygous PTN knockout mice exhibit cognitive rigidity, heightened anxiety, behavioral reticence in novel contexts and novel social interactions. Initial learning of spatial and other associative tasks, as well as vascular density in the lateral entorhinal cortex, are normal (PubMed:25000129). PTN and MDK double knockout mice are born in only one third the number expected by Mendelian segregation and 4 weeks after birth weigh about half as much as wild-type mice. Most of the female are infertile. Both male and female one-month-old mice show a defect in spontaneous locomotive activity of 50-60% of that of wild-type mice. Although the difference in activity decrease with age, the activity of 3-month-old male double knockout mice is still about 80% of that of the wild-type mice. The diestrus and proestrus periods are long and the estrus period is short. Furthermore, vaginal abnormality is found in about half of the double deficient mice (PubMed:17121547). PTN and MDK double knockout mice have a deficit of auditory response (PubMed:16619002).5 Publications

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 32Add BLAST32
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000002466033 – 168PleiotrophinAdd BLAST136

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi47 ↔ 76By similarity
Disulfide bondi55 ↔ 85By similarity
Disulfide bondi62 ↔ 89By similarity
Disulfide bondi99 ↔ 131By similarity
Disulfide bondi109 ↔ 141By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated by NEK6.By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P63089

PRoteomics IDEntifications database

More...
PRIDEi
P63089

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
301960

PTM databases

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P63089

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Osteoblast and brain (PubMed:1701634, PubMed:1768439). Expressed in the follicular epithelium and granulosa cells of the ovary. Strongly expressed in the uterus of newborn mice, and the degree of expression decreased in one-week-old mice, although the expression continues even in the uteri of adult mice. Expression gradually increases from proestrus to estrus, then decreases sharply, and thereafter gradually increased again (PubMed:17121547). strongly expressed in the cochlea of WT mice 1 week after birth, and then the expression decreased and was undetectable by week 8 after birth (PubMed:16619002). Expressed around the cell soma of osteocytes and apparently captured in the unmineralized interstitial matrix surrounding the cells. Furthermore distributed throughout the intraosseous canalicular porosity, being localized in the unmineralized matrix around the cell processes. Strongly expressed in the innermost layer of the periosteum (PubMed:19442624).5 Publications

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

NoT detected in the uteri from days 1-3 of pregnancy. On day 4 of pregnancy, localizes in the luminal and glandular epithelium as well as in the uterine stromal cells. On day 5, a high level is observed in the subluminal stroma surrounding the implanting blastocyst, while there is no expression at the inter-implantation sites. From day 6-8 of pregnancy, strongly expressed in the decidua. Expression is gradually increased as the progression of pregnancy and reached a maximum on day 8. Elevated expression is observed at implantation sites from days 5-8 of pregnancy.1 Publication

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Enhanced up to 3 days after the administration of chorionic gonadotropin to induce ovulation (PubMed:17121547). Up-regulated by progesterone in the uterine stromal cells through cAMP (PubMed:28657144).2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000029838, Expressed in pineal body and 331 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P63089, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P63089, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with ALK and NEK6.

Interacts with PTPRZ1 (via chondroitin sulfate groups); promotes formation of homooligomers; oligomerization impairs tyrosine phosphatase activity.

Forms a complex with PTPRZ1 and CTNNB1; this complex inactivates PTPRZ1 protein tyrosine phosphatase activity through PTN interaction and stimulates tyrosine phosphorylation of CTNNB1.

Interacts with ITGB3 AND ITGA5.

Forms a complex with PTPRZ1 and integrin alpha-V/beta-3 (ITGAV:ITGB3) that stimulates endothelial cell migration through ITGB3 'Tyr-773' phosphorylation (By similarity).

Interacts with SDC3 (via heparan sulfate chains); this interaction mediates the neurite outgrowth-promoting signal from PTN to the cytoskeleton of growing neurites; this interaction mediates osteoblast recruitment.

Interacts with GPC2 (via heparan sulfate); this interaction promotes neurite outgrowth through binding of PTN with chondroitin sulfate of proteoglycans, thereby releasing PTPRS of chondroitin sulfate proteoglycans (CSPGs) and leading to binding with heparan sulfate of GPC2 (By similarity).

By similarity

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
202472, 8 interactors

Protein interaction database and analysis system

More...
IntActi
P63089, 2 interactors

Molecular INTeraction database

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MINTi
P63089

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000099073

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

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RNActi
P63089, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni92 – 99Chondroitin sulfate bindingBy similarity8
Regioni123 – 131Chondroitin sulfate bindingBy similarity9
Regioni139 – 168DisorderedSequence analysisAdd BLAST30
Regioni147 – 168Chondroitin sulfate A bindingBy similarityAdd BLAST22

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi148 – 168Basic and acidic residuesSequence analysisAdd BLAST21

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the pleiotrophin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG502RXV7, Eukaryota

Ensembl GeneTree

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GeneTreei
ENSGT00390000007640

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
CLU_136864_1_0_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P63089

Identification of Orthologs from Complete Genome Data

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OMAi
KRERTQM

Database of Orthologous Groups

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OrthoDBi
1489280at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
P63089

TreeFam database of animal gene trees

More...
TreeFami
TF332376

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
2.20.60.10, 1 hit
2.30.90.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000762, Midkine_heparin-bd_GF
IPR020090, PTN/MK_C_dom
IPR038130, PTN/MK_C_dom_sf
IPR020091, PTN/MK_diS_sf
IPR020089, PTN/MK_N_dom
IPR037122, PTN/MK_N_dom_sf
IPR020092, PTN_MK_heparin-bd_GF_CS

The PANTHER Classification System

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PANTHERi
PTHR13850, PTHR13850, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF01091, PTN_MK_C, 1 hit
PF05196, PTN_MK_N, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR00269, PTNMIDKINE

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00193, PTN, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF57288, SSF57288, 2 hits

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS00619, PTN_MK_1, 1 hit
PS00620, PTN_MK_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P63089-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSQQYQQQR RKFAAAFLAL IFILAAVDTA EAGKKEKPEK KVKKSDCGEW
60 70 80 90 100
QWSVCVPTSG DCGLGTREGT RTGAECKQTM KTQRCKIPCN WKKQFGAECK
110 120 130 140 150
YQFQAWGECD LNTALKTRTG SLKRALHNAD CQKTVTISKP CGKLTKPKPQ
160
AESKKKKKEG KKQEKMLD
Length:168
Mass (Da):18,869
Last modified:September 13, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2127DA167D2DD33D
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q3UZI5Q3UZI5_MOUSE
Pleiotrophin
Ptn
156Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
D90225 mRNA Translation: BAA14260.1
S52357 S52353 Genomic DNA Translation: AAB24477.1
AK011346 mRNA Translation: BAB27557.1
BC002064 mRNA Translation: AAH02064.1
BC061695 mRNA Translation: AAH61695.1
S88460 Genomic DNA No translation available.
S88462 Genomic DNA No translation available.
S88464 Genomic DNA No translation available.
S88466 Genomic DNA No translation available.
S88468 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

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CCDSi
CCDS20005.1

Protein sequence database of the Protein Information Resource

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PIRi
A37087

NCBI Reference Sequences

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RefSeqi
NP_032999.1, NM_008973.2
XP_006505820.2, XM_006505757.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000101534; ENSMUSP00000099073; ENSMUSG00000029838

Database of genes from NCBI RefSeq genomes

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GeneIDi
19242

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:19242

UCSC genome browser

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UCSCi
uc009bja.1, mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D90225 mRNA Translation: BAA14260.1
S52357 S52353 Genomic DNA Translation: AAB24477.1
AK011346 mRNA Translation: BAB27557.1
BC002064 mRNA Translation: AAH02064.1
BC061695 mRNA Translation: AAH61695.1
S88460 Genomic DNA No translation available.
S88462 Genomic DNA No translation available.
S88464 Genomic DNA No translation available.
S88466 Genomic DNA No translation available.
S88468 Genomic DNA No translation available.
CCDSiCCDS20005.1
PIRiA37087
RefSeqiNP_032999.1, NM_008973.2
XP_006505820.2, XM_006505757.3

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi202472, 8 interactors
IntActiP63089, 2 interactors
MINTiP63089
STRINGi10090.ENSMUSP00000099073

PTM databases

PhosphoSitePlusiP63089

Proteomic databases

PaxDbiP63089
PRIDEiP63089
ProteomicsDBi301960

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
4323, 544 antibodies

The DNASU plasmid repository

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DNASUi
19242

Genome annotation databases

EnsembliENSMUST00000101534; ENSMUSP00000099073; ENSMUSG00000029838
GeneIDi19242
KEGGimmu:19242
UCSCiuc009bja.1, mouse

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
5764
MGIiMGI:97804, Ptn

Phylogenomic databases

eggNOGiENOG502RXV7, Eukaryota
GeneTreeiENSGT00390000007640
HOGENOMiCLU_136864_1_0_1
InParanoidiP63089
OMAiKRERTQM
OrthoDBi1489280at2759
PhylomeDBiP63089
TreeFamiTF332376

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
19242, 0 hits in 52 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Ptn, mouse

Protein Ontology

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PROi
PR:P63089
RNActiP63089, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSMUSG00000029838, Expressed in pineal body and 331 other tissues
ExpressionAtlasiP63089, baseline and differential
GenevisibleiP63089, MM

Family and domain databases

Gene3Di2.20.60.10, 1 hit
2.30.90.10, 1 hit
InterProiView protein in InterPro
IPR000762, Midkine_heparin-bd_GF
IPR020090, PTN/MK_C_dom
IPR038130, PTN/MK_C_dom_sf
IPR020091, PTN/MK_diS_sf
IPR020089, PTN/MK_N_dom
IPR037122, PTN/MK_N_dom_sf
IPR020092, PTN_MK_heparin-bd_GF_CS
PANTHERiPTHR13850, PTHR13850, 1 hit
PfamiView protein in Pfam
PF01091, PTN_MK_C, 1 hit
PF05196, PTN_MK_N, 1 hit
PRINTSiPR00269, PTNMIDKINE
SMARTiView protein in SMART
SM00193, PTN, 1 hit
SUPFAMiSSF57288, SSF57288, 2 hits
PROSITEiView protein in PROSITE
PS00619, PTN_MK_1, 1 hit
PS00620, PTN_MK_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPTN_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P63089
Secondary accession number(s): P20935
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 13, 2004
Last sequence update: September 13, 2004
Last modified: June 2, 2021
This is version 134 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
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