Ppp1cc

Functionⁱ

Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Dephosphorylates RPS6KB1. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca²⁺/calmodulin dependent protein kinase II. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. May dephosphorylate CSNK1D and CSNK1E.2 Publications

Isoform 2: Required for normal male fertility.1 Publication

Catalytic activityⁱ

[a protein]-serine/threonine phosphate + H₂O = [a protein]-serine/threonine + phosphate.

Cofactorⁱ

Mn²⁺By similarityNote: Binds 2 manganese ions per subunit.By similarity

Activity regulationⁱ

Inactivated by binding to URI1.By similarity

Sites

Feature key	Position(s)	DescriptionActions	Length
Metal bindingⁱ	64	Manganese 1By similarity	1
Metal bindingⁱ	66	Manganese 1By similarity	1
Metal bindingⁱ	92	Manganese 1By similarity	1
Metal bindingⁱ	92	Manganese 2By similarity	1
Metal bindingⁱ	124	Manganese 2By similarity	1
Active siteⁱ	125	Proton donorBy similarity	1
Metal bindingⁱ	173	Manganese 2By similarity	1
Metal bindingⁱ	248	Manganese 2By similarity	1

GO - Molecular functionⁱ

lamin binding Source: MGI
metal ion binding Source: UniProtKB-KW
phosphatase activity
Source: UniProtKB
Inferred from direct assayⁱ
- 21930935
protein-containing complex binding Source: MGI
protein C-terminus binding Source: MGI
protein domain specific binding Source: MGI
protein kinase binding Source: Ensembl
protein N-terminus binding
Source: MGI
Inferred from sequence orthologyⁱ
- 23789093
protein phosphatase 1 binding Source: MGI
protein phosphatase binding Source: MGI
protein serine/threonine phosphatase activity
Source: MGI
Inferred from direct assayⁱ
- 14640981
- 17369396

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cell cycle Source: UniProtKB-KW
cell division Source: UniProtKB-KW
circadian regulation of gene expression
Source: UniProtKB
Inferred from direct assayⁱ
- 21930935
entrainment of circadian clock by photoperiod
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 21712997
glycogen metabolic process Source: UniProtKB-KW
neuron differentiation
Source: MGI
Inferred from sequence or structural similarityⁱ
- 17202132
positive regulation of glial cell proliferation Source: MGI
protein dephosphorylation
Source: UniProtKB
Inferred from direct assayⁱ
- 21930935
regulation of circadian rhythm
Source: UniProtKB
Inferred from direct assayⁱ
- 21930935
regulation of nucleocytoplasmic transport
Source: MGI
Inferred from mutant phenotypeⁱ
- 17369396

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Hydrolase, Protein phosphatase
Biological process	Biological rhythms, Carbohydrate metabolism, Cell cycle, Cell division, Glycogen metabolism
Ligand	Manganese, Metal-binding

Enzyme and pathway databases

Reactomeⁱ	R-MMU-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-MMU-2467813 Separation of Sister Chromatids R-MMU-2500257 Resolution of Sister Chromatid Cohesion R-MMU-5663220 RHO GTPases Activate Formins R-MMU-68877 Mitotic Prometaphase

Reactomeⁱ

R-MMU-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
R-MMU-2467813 Separation of Sister Chromatids
R-MMU-2500257 Resolution of Sister Chromatid Cohesion
R-MMU-5663220 RHO GTPases Activate Formins
R-MMU-68877 Mitotic Prometaphase

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Serine/threonine-protein phosphatase PP1-gamma catalytic subunit (EC:3.1.3.16) Short name: PP-1G Alternative name(s): Protein phosphatase 1C catalytic subunit
Gene namesⁱ	Name:Ppp1cc
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 5

Organism-specific databases

MGIⁱ	MGI:104872 Ppp1cc

Keywords - Cellular componentⁱ

Centromere, Chromosome, Cytoplasm, Kinetochore, Mitochondrion, Nucleus

Pathology & Biotechⁱ

Disruption phenotypeⁱ

Deficient mice exhibit male infertility due to severely impaired spermiogenesis beginning at the round spermatid stage. Females are fertile.2 Publications

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		RemovedBy similarity
ChainⁱPRO_0000058788	2 – 323	Serine/threonine-protein phosphatase PP1-gamma catalytic subunitAdd BLAST		322

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	2	N-acetylalanineBy similarity	1
Modified residueⁱ	307	PhosphothreonineBy similarity	1
Modified residueⁱ	311	PhosphothreonineBy similarity	1

Post-translational modificationⁱ

Phosphorylated by NEK2.By similarity

Keywords - PTMⁱ

Acetylation, Phosphoprotein

Proteomic databases

EPDⁱ	P63087
PaxDbⁱ	P63087
PeptideAtlas More...PeptideAtlasⁱ	P63087
PRIDEⁱ	P63087

PTM databases

iPTMnetⁱ	P63087
PhosphoSitePlusⁱ	P63087
SwissPalmⁱ	P63087

Expressionⁱ

Tissue specificityⁱ

Isoform 1 is widely expressed (PubMed:9339378). Isoform 2 is highly enriched in testis, mainly restricted to meiotic and postmeiotic germ cells (PubMed:9339378).1 Publication

Gene expression databases

Bgeeⁱ	ENSMUSG00000004455 Expressed in 52 organ(s), highest expression level in cerebellum
ExpressionAtlasⁱ	P63087 baseline and differential
Genevisibleⁱ	P63087 MM

Interactionⁱ

Subunit structureⁱ

PP1 comprises a catalytic subunit, PPP1CA, PPP1CB or PPP1CC, which is folded into its native form by inhibitor 2 and glycogen synthetase kinase 3, and then complexed to one or several targeting or regulatory subunits. PPP1R12A, PPP1R12B and PPP1R12C mediate binding to myosin. PPP1R3A (in skeletal muscle), PPP1R3B (in liver), PPP1R3C, PPP1R3D and PPP1R3F (in brain) mediate binding to glycogen. Interacts with PPP1R3B, PPP1R7 and CDCA2 (By similarity). Isoform 2 interacts with SPZ1. This interaction can prevent SPZ1 binding to the E-box and inhibits PPP1CC activity. PPP1R15A and PPP1R15B mediate binding to EIF2S1. Part of a complex containing PPP1R15B, PP1 and NCK1/2. Interacts with IKFZ1; the interaction targets PPP1CC to pericentromeric heterochromatin, dephosphorylates IKAROS, stabilizes it and prevents it from degradation. Interacts with NOM1 and PPP1R8. Component of the PTW/PP1 phosphatase complex, composed of PPP1R10/PNUTS, TOX4, WDR82, and PPP1CA or PPP1CB or PPP1CC. Interacts with PPP1R8. Interacts with NEK2. Interacts with NEK2. Interacts with URI1; the interaction is phosphorylation-dependent and occurs in a growth factor-dependent manner (By similarity). Isoform 2 interacts with PPP1R42; the interaction is direct. Interacts with FOXP3 (By similarity). Isoform 2 interacts with TMEM225 (via RVxF motif) (PubMed:25605614). Isoform 2, but not isoform 1, interacts with Sh3glb1 testis-specific isoform 3; this interaction leads to the inhibition of phosphatase activity (PubMed:17381077). Interacts with MKI67 (By similarity). Interacts with RRP1B; this targets PPP1CC to the nucleolus (By similarity). Found in a complex with PPP1CA, PPP1CC, SHC1 and PEAK1 (By similarity).By similarity7 Publications

GO - Molecular functionⁱ

lamin binding Source: MGI
protein C-terminus binding Source: MGI
protein domain specific binding Source: MGI
protein kinase binding Source: Ensembl
protein N-terminus binding
Source: MGI
Inferred from sequence orthologyⁱ
- 23789093
protein phosphatase 1 binding Source: MGI
protein phosphatase binding Source: MGI

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	202337, 40 interactors 241685, 1 interactor
IntActⁱ	P63087, 27 interactors
Molecular INTeraction database More...MINTⁱ	P63087
STRINGⁱ	10090.ENSMUSP00000099587

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	9 – 17	Combined sources	9
Turnⁱ	18 – 21	Combined sources	4
Helixⁱ	32 – 48	Combined sources	17
Beta strandⁱ	51 – 55	Combined sources	5
Beta strandⁱ	57 – 62	Combined sources	6
Helixⁱ	69 – 79	Combined sources	11
Beta strandⁱ	87 – 89	Combined sources	3
Beta strandⁱ	94 – 98	Combined sources	5
Helixⁱ	100 – 113	Combined sources	14
Turnⁱ	115 – 117	Combined sources	3
Beta strandⁱ	118 – 120	Combined sources	3
Helixⁱ	128 – 131	Combined sources	4
Helixⁱ	136 – 143	Combined sources	8
Helixⁱ	146 – 156	Combined sources	11
Beta strandⁱ	162 – 165	Combined sources	4
Turnⁱ	166 – 168	Combined sources	3
Beta strandⁱ	169 – 174	Combined sources	6
Helixⁱ	184 – 187	Combined sources	4
Beta strandⁱ	197 – 199	Combined sources	3
Helixⁱ	200 – 206	Combined sources	7
Beta strandⁱ	214 – 218	Combined sources	5
Beta strandⁱ	222 – 227	Combined sources	6
Helixⁱ	229 – 239	Combined sources	11
Beta strandⁱ	242 – 246	Combined sources	5
Beta strandⁱ	254 – 258	Combined sources	5
Turnⁱ	259 – 262	Combined sources	4
Beta strandⁱ	263 – 267	Combined sources	5
Helixⁱ	272 – 274	Combined sources	3
Beta strandⁱ	280 – 285	Combined sources	6
Beta strandⁱ	290 – 298	Combined sources	9

Show more details

3D structure databases

ProteinModelPortalⁱ	P63087
SMRⁱ	P63087
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the PPP phosphatase family. PP-1 subfamily.Curated

Phylogenomic databases

eggNOGⁱ	ENOG410IN85 Eukaryota ENOG410XPVF LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000062911
HOGENOMⁱ	HOG000172697
HOVERGENⁱ	HBG000216
InParanoidⁱ	P63087
KEGG Orthology (KO) More...KOⁱ	K06269
OMAⁱ	LICDLVW
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0EKF
PhylomeDBⁱ	P63087
TreeFamⁱ	TF354243

Family and domain databases

Gene3Dⁱ	3.60.21.10, 1 hit
InterProⁱ	View protein in InterPro IPR004843 Calcineurin-like_PHP_ApaH IPR029052 Metallo-depent_PP-like IPR037981 PPP1CC IPR006186 Ser/Thr-sp_prot-phosphatase IPR031675 STPPase_N
PANTHERⁱ	PTHR11668:SF204 PTHR11668:SF204, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00149 Metallophos, 1 hit PF16891 STPPase_N, 1 hit
PRINTSⁱ	PR00114 STPHPHTASE
SMARTⁱ	View protein in SMART SM00156 PP2Ac, 1 hit
PROSITEⁱ	View protein in PROSITE PS00125 SER_THR_PHOSPHATASE, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: P63087-1) [UniParc]FASTA Add to basket

Also known as: Gamma-1, Pppcc1

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MADIDKLNID SIIQRLLEVR GSKPGKNVQL QENEIRGLCL KSREIFLSQP 
        60         70         80         90        100
ILLELEAPLK ICGDIHGQYY DLLRLFEYGG FPPESNYLFL GDYVDRGKQS 
       110        120        130        140        150
LETICLLLAY KIKYPENFFL LRGNHECASI NRIYGFYDEC KRRYNIKLWK 
       160        170        180        190        200
TFTDCFNCLP IAAIVDEKIF CCHGGLSPDL QSMEQIRRIM RPTDVPDQGL 
       210        220        230        240        250
LCDLLWSDPD KDVLGWGEND RGVSFTFGAE VVAKFLHKHD LDLICRAHQV 
       260        270        280        290        300
VEDGYEFFAK RQLVTLFSAP NYCGEFDNAG AMMSVDETLM CSFQILKPAE 
       310        320 
KKKPNATRPV TPPRGMITKQ AKK

Length:323

Mass (Da):36,984

Last modified:September 13, 2004 - v1

Checksum:ⁱ4E28412C16898615

GO

Isoform 2 (identifier: P63087-2) [UniParc]FASTA Add to basket

Also known as: Gamma-2, Pppcc2

The sequence of this isoform differs from the canonical sequence as follows:
315-323: GMITKQAKK → VGSGLNPSIQKASNYRNNTVLYE

« Hide

        10         20         30         40         50
MADIDKLNID SIIQRLLEVR GSKPGKNVQL QENEIRGLCL KSREIFLSQP 
        60         70         80         90        100
ILLELEAPLK ICGDIHGQYY DLLRLFEYGG FPPESNYLFL GDYVDRGKQS 
       110        120        130        140        150
LETICLLLAY KIKYPENFFL LRGNHECASI NRIYGFYDEC KRRYNIKLWK 
       160        170        180        190        200
TFTDCFNCLP IAAIVDEKIF CCHGGLSPDL QSMEQIRRIM RPTDVPDQGL 
       210        220        230        240        250
LCDLLWSDPD KDVLGWGEND RGVSFTFGAE VVAKFLHKHD LDLICRAHQV 
       260        270        280        290        300
VEDGYEFFAK RQLVTLFSAP NYCGEFDNAG AMMSVDETLM CSFQILKPAE 
       310        320        330 
KKKPNATRPV TPPRVGSGLN PSIQKASNYR NNTVLYE

Show »

Length:337

Mass (Da):38,504

Checksum:ⁱE6F271155E0E67D7

GO

Computationally mapped potential isoform sequencesⁱ

There are 5 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

A0A0G2JFF1	A0A0G2JFF1_MOUSE	Serine/threonine-protein phosphatas... Serine/threonine-protein phosphatase, EC 3.1.3.16	Ppp1cc	292	Annotation score:
A0A0G2JGC1	A0A0G2JGC1_MOUSE	Serine/threonine-protein phosphatas... Serine/threonine-protein phosphatase, EC 3.1.3.16	Ppp1cc	273	Annotation score:
A0A0G2JF34	A0A0G2JF34_MOUSE	Serine/threonine-protein phosphatas... Serine/threonine-protein phosphatase PP1-gamma catalytic subunit	Ppp1cc	87	Annotation score:
A0A0G2JE42	A0A0G2JE42_MOUSE	Serine/threonine-protein phosphatas... Serine/threonine-protein phosphatase PP1-gamma catalytic subunit	Ppp1cc	27	Annotation score:
A0A0G2JEB0	A0A0G2JEB0_MOUSE	Serine/threonine-protein phosphatas... Serine/threonine-protein phosphatase PP1-gamma catalytic subunit	Ppp1cc	26	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	316 – 317	MI → IV in AAC53383 (PubMed:9339378).Curated	2
Sequence conflictⁱ	316 – 317	MI → IV in AAC53384 (PubMed:9339378).Curated	2
Sequence conflictⁱ	316 – 317	MI → IV in BAA19729 (Ref. 3) Curated	2

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_005095	315 – 323	GMITKQAKK → VGSGLNPSIQKASNYRNNTV LYE in isoform 2. 2 Publications		9

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M27071 mRNA Translation: AAA37526.1 U53456 mRNA Translation: AAC53383.1 U53276 , U53271, U53272, U53273, U53275 Genomic DNA Translation: AAC53384.1 U53276 , U53271, U53272, U53273, U53275 Genomic DNA Translation: AAC53385.1 D85137 mRNA Translation: BAA19729.1 BC010613 mRNA Translation: AAH10613.1 BC021646 mRNA Translation: AAH21646.1 BC085496 mRNA Translation: AAH85496.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS19643.1 [P63087-1]
PIRⁱ	C32550
NCBI Reference Sequences More...RefSeqⁱ	NP_038664.2, NM_013636.3 [P63087-1] XP_006508478.1, XM_006508415.3 [P63087-2] XP_006530263.1, XM_006530200.2 [P63087-2]
UniGeneⁱ	Mm.280784 Mm.334198

Genome annotation databases

Ensemblⁱ	ENSMUST00000086294; ENSMUSP00000083474; ENSMUSG00000004455 [P63087-2] ENSMUST00000102528; ENSMUSP00000099587; ENSMUSG00000004455 [P63087-1]
GeneIDⁱ	19047 434233
KEGGⁱ	mmu:19047 mmu:434233
UCSC genome browser More...UCSCⁱ	uc008zks.1 mouse [P63087-1] uc008zkt.1 mouse [P63087-2]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P63087	Serine/threonine-protein phosphatase PP1-gamma catalytic subunit		BOVIN		323	UniRef100_P63087
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit	)	RAT		323
Serine/threonine-protein phosphatase		PIG		323
serine/threonine-protein phosphatase PP1-gamma catalytic subunit isoform X1		BALAS		323
Serine/threonine-protein phosphatase		DELLE		323
+12
P63087-2	Serine/threonine-protein phosphatase		RAT		337	UniRef100_Q6AYZ4
Serine/threonine-protein phosphatase		ICTTR		337
UPI000454905C		CRIGR		335
Isoform 2 of Serine/threonine-protein phosphatase PP1-gamma catalytic subunit		RAT		337

Protein	Similar proteins		Species	Score	Length	Source
P63087	Serine/threonine-protein phosphatase PP1-gamma catalytic subunit		BOVIN		323	UniRef90_P63087
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit	)	RAT		323
Serine/threonine-protein phosphatase		PIG		323
serine/threonine-protein phosphatase PP1-gamma catalytic subunit isoform X1		BALAS		323
Serine/threonine-protein phosphatase		DELLE		323
+103

Protein	Similar proteins		Species	Score	Length	Source
P63087	Serine/threonine-protein phosphatase PP1-2		YEAST		312	UniRef50_P32598
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit		BOVIN		323
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit	)	RAT		323
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit		CANLF		323
Serine/threonine-protein phosphatase alpha-2 isoform		DROME		302
+1209

Cross-referencesⁱ

Web resourcesⁱ

Protein Spotlight

The things we forget - Issue 32 of March 2003

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M27071 mRNA Translation: AAA37526.1 U53456 mRNA Translation: AAC53383.1 U53276 , U53271, U53272, U53273, U53275 Genomic DNA Translation: AAC53384.1 U53276 , U53271, U53272, U53273, U53275 Genomic DNA Translation: AAC53385.1 D85137 mRNA Translation: BAA19729.1 BC010613 mRNA Translation: AAH10613.1 BC021646 mRNA Translation: AAH21646.1 BC085496 mRNA Translation: AAH85496.1
CCDSⁱ	CCDS19643.1 [P63087-1]
PIRⁱ	C32550
RefSeqⁱ	NP_038664.2, NM_013636.3 [P63087-1] XP_006508478.1, XM_006508415.3 [P63087-2] XP_006530263.1, XM_006530200.2 [P63087-2]
UniGeneⁱ	Mm.280784 Mm.334198

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	4V0U	X-ray	7.88	D/F/H/J/N	1-323	[»]
	4V0V	X-ray	1.61	A/C	7-300	[»]
	4V0W	X-ray	1.55	A/C	7-300	[»]
	4V0X	X-ray	1.85	A	7-300	[»]
ProteinModelPortalⁱ	P63087
SMRⁱ	P63087
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	202337, 40 interactors 241685, 1 interactor
IntActⁱ	P63087, 27 interactors
MINTⁱ	P63087
STRINGⁱ	10090.ENSMUSP00000099587

PTM databases

iPTMnetⁱ	P63087
PhosphoSitePlusⁱ	P63087
SwissPalmⁱ	P63087

Proteomic databases

EPDⁱ	P63087
PaxDbⁱ	P63087
PeptideAtlasⁱ	P63087
PRIDEⁱ	P63087

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000086294; ENSMUSP00000083474; ENSMUSG00000004455 [P63087-2] ENSMUST00000102528; ENSMUSP00000099587; ENSMUSG00000004455 [P63087-1]
GeneIDⁱ	19047 434233
KEGGⁱ	mmu:19047 mmu:434233
UCSCⁱ	uc008zks.1 mouse [P63087-1] uc008zkt.1 mouse [P63087-2]

Organism-specific databases

CTDⁱ	434233 5501
MGIⁱ	MGI:104872 Ppp1cc

Phylogenomic databases

eggNOGⁱ	ENOG410IN85 Eukaryota ENOG410XPVF LUCA
GeneTreeⁱ	ENSGT00530000062911
HOGENOMⁱ	HOG000172697
HOVERGENⁱ	HBG000216
InParanoidⁱ	P63087
KOⁱ	K06269
OMAⁱ	LICDLVW
OrthoDBⁱ	EOG091G0EKF
PhylomeDBⁱ	P63087
TreeFamⁱ	TF354243

Enzyme and pathway databases

Reactomeⁱ	R-MMU-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-MMU-2467813 Separation of Sister Chromatids R-MMU-2500257 Resolution of Sister Chromatid Cohesion R-MMU-5663220 RHO GTPases Activate Formins R-MMU-68877 Mitotic Prometaphase

Reactomeⁱ

R-MMU-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
R-MMU-2467813 Separation of Sister Chromatids
R-MMU-2500257 Resolution of Sister Chromatid Cohesion
R-MMU-5663220 RHO GTPases Activate Formins
R-MMU-68877 Mitotic Prometaphase

Miscellaneous databases

ChiTaRSⁱ	Ppp1cc mouse
Protein Ontology More...PROⁱ	PR:P63087
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000004455 Expressed in 52 organ(s), highest expression level in cerebellum
ExpressionAtlasⁱ	P63087 baseline and differential
Genevisibleⁱ	P63087 MM

Family and domain databases

Gene3Dⁱ	3.60.21.10, 1 hit
InterProⁱ	View protein in InterPro IPR004843 Calcineurin-like_PHP_ApaH IPR029052 Metallo-depent_PP-like IPR037981 PPP1CC IPR006186 Ser/Thr-sp_prot-phosphatase IPR031675 STPPase_N
PANTHERⁱ	PTHR11668:SF204 PTHR11668:SF204, 1 hit
Pfamⁱ	View protein in Pfam PF00149 Metallophos, 1 hit PF16891 STPPase_N, 1 hit
PRINTSⁱ	PR00114 STPHPHTASE
SMARTⁱ	View protein in SMART SM00156 PP2Ac, 1 hit
PROSITEⁱ	View protein in PROSITE PS00125 SER_THR_PHOSPHATASE, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	PP1G_MOUSE
Accessionⁱ	P63087Primary (citable) accession number: P63087 Secondary accession number(s): O09186 , O09189, P37139, Q64679
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	September 13, 2004
	Last sequence update:	September 13, 2004
	Last modified:	November 7, 2018
	This is version 152 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Protein Spotlight
Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries

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Supporting data

UniProtKB - P63087 (PP1G_MOUSE)

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Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Mitochondrion

Nucleus

Other locations

Mitochondrion

Nucleus

Plasma Membrane

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ