Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Protein S100-A5

Gene

S100a5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Binds calcium, zinc and copper. One subunit can simultaneously bind 2 calcium ions or 2 copper ions plus 1 zinc ion. Calcium and copper ions compete for the same binding sites (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi20 – 331; low affinityPROSITE-ProRule annotationAdd BLAST14
Calcium bindingi61 – 722; high affinityPROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

Keywordsi

LigandCalcium, Copper, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Protein S100-A5
Alternative name(s):
Protein S-100D
S100 calcium-binding protein A5
Gene namesi
Name:S100a5
Synonyms:S100d
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1338915 S100a5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001439811 – 93Protein S100-A5Add BLAST93

Proteomic databases

EPDiP63084
PaxDbiP63084
PeptideAtlasiP63084
PRIDEiP63084

PTM databases

PhosphoSitePlusiP63084

Expressioni

Gene expression databases

BgeeiENSMUSG00000001023 Expressed in 38 organ(s), highest expression level in olfactory epithelium
CleanExiMM_S100A5
ExpressionAtlasiP63084 baseline and differential
GenevisibleiP63084 MM

Interactioni

Subunit structurei

Homodimer.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000001049

Structurei

3D structure databases

ProteinModelPortaliP63084
SMRiP63084
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini12 – 47EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini48 – 83EF-hand 2PROSITE-ProRule annotationAdd BLAST36

Sequence similaritiesi

Belongs to the S-100 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IZNS Eukaryota
ENOG4111EF4 LUCA
GeneTreeiENSGT00760000119034
HOGENOMiHOG000246968
HOVERGENiHBG001479
InParanoidiP63084
OMAiNDFFLEE
OrthoDBiEOG091G10JX
PhylomeDBiP63084
TreeFamiTF332727

Family and domain databases

CDDicd00213 S-100, 1 hit
InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
IPR034325 S-100_dom
IPR028497 S100-A5
IPR001751 S100/CaBP-9k_CS
IPR013787 S100_Ca-bd_sub
PANTHERiPTHR11639:SF65 PTHR11639:SF65, 1 hit
PfamiView protein in Pfam
PF01023 S_100, 1 hit
SMARTiView protein in SMART
SM00054 EFh, 1 hit
SM01394 S_100, 1 hit
SUPFAMiSSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 1 hit
PS50222 EF_HAND_2, 1 hit
PS00303 S100_CABP, 1 hit

Sequencei

Sequence statusi: Complete.

P63084-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
METPLEKALT TMVTTFHKYS GREGSKLTLS RKELKELIKT ELSLAEKMKE
60 70 80 90
SSIDNLMKSL DKNSDQEIDF KEYSVFLTTL CMAYNDFFLE DNK
Length:93
Mass (Da):10,812
Last modified:September 13, 2004 - v1
Checksum:i9A922E1898D202A4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF087469 mRNA Translation: AAC64106.1
CCDSiCCDS38505.1
RefSeqiNP_035442.1, NM_011312.2
XP_006501242.1, XM_006501179.1
XP_006501243.1, XM_006501180.2
XP_006501244.1, XM_006501181.2
UniGeneiMm.19946

Genome annotation databases

EnsembliENSMUST00000001049; ENSMUSP00000001049; ENSMUSG00000001023
ENSMUST00000107329; ENSMUSP00000102952; ENSMUSG00000001023
GeneIDi20199
KEGGimmu:20199
UCSCiuc008qda.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF087469 mRNA Translation: AAC64106.1
CCDSiCCDS38505.1
RefSeqiNP_035442.1, NM_011312.2
XP_006501242.1, XM_006501179.1
XP_006501243.1, XM_006501180.2
XP_006501244.1, XM_006501181.2
UniGeneiMm.19946

3D structure databases

ProteinModelPortaliP63084
SMRiP63084
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000001049

PTM databases

PhosphoSitePlusiP63084

Proteomic databases

EPDiP63084
PaxDbiP63084
PeptideAtlasiP63084
PRIDEiP63084

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000001049; ENSMUSP00000001049; ENSMUSG00000001023
ENSMUST00000107329; ENSMUSP00000102952; ENSMUSG00000001023
GeneIDi20199
KEGGimmu:20199
UCSCiuc008qda.1 mouse

Organism-specific databases

CTDi6276
MGIiMGI:1338915 S100a5

Phylogenomic databases

eggNOGiENOG410IZNS Eukaryota
ENOG4111EF4 LUCA
GeneTreeiENSGT00760000119034
HOGENOMiHOG000246968
HOVERGENiHBG001479
InParanoidiP63084
OMAiNDFFLEE
OrthoDBiEOG091G10JX
PhylomeDBiP63084
TreeFamiTF332727

Miscellaneous databases

PROiPR:P63084
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000001023 Expressed in 38 organ(s), highest expression level in olfactory epithelium
CleanExiMM_S100A5
ExpressionAtlasiP63084 baseline and differential
GenevisibleiP63084 MM

Family and domain databases

CDDicd00213 S-100, 1 hit
InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
IPR034325 S-100_dom
IPR028497 S100-A5
IPR001751 S100/CaBP-9k_CS
IPR013787 S100_Ca-bd_sub
PANTHERiPTHR11639:SF65 PTHR11639:SF65, 1 hit
PfamiView protein in Pfam
PF01023 S_100, 1 hit
SMARTiView protein in SMART
SM00054 EFh, 1 hit
SM01394 S_100, 1 hit
SUPFAMiSSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 1 hit
PS50222 EF_HAND_2, 1 hit
PS00303 S100_CABP, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiS10A5_MOUSE
AccessioniPrimary (citable) accession number: P63084
Secondary accession number(s): O88945, P82540
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 13, 2004
Last sequence update: September 13, 2004
Last modified: November 7, 2018
This is version 107 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again