Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

V-type proton ATPase 16 kDa proteolipid subunit

Gene

Atp6v0c

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei139Essential for proton translocationBy similarity1

GO - Molecular functioni

GO - Biological processi

  • ATP hydrolysis coupled proton transport Source: InterPro
  • lysosomal lumen acidification Source: MGI
  • positive regulation of Wnt signaling pathway Source: MGI
  • vacuolar acidification Source: MGI

Keywordsi

Biological processHydrogen ion transport, Ion transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-1222556 ROS, RNS production in phagocytes
R-MMU-6798695 Neutrophil degranulation
R-MMU-77387 Insulin receptor recycling
R-MMU-917977 Transferrin endocytosis and recycling
R-MMU-983712 Ion channel transport

Protein family/group databases

TCDBi3.A.2.2.6 the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily

Names & Taxonomyi

Protein namesi
Recommended name:
V-type proton ATPase 16 kDa proteolipid subunit
Short name:
V-ATPase 16 kDa proteolipid subunit
Alternative name(s):
PL16
Vacuolar proton pump 16 kDa proteolipid subunit
Gene namesi
Name:Atp6v0c
Synonyms:Atp6c, Atp6l, Atpl, Mvp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:88116 Atp6v0c

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 10LumenalSequence analysis10
Transmembranei11 – 33HelicalSequence analysisAdd BLAST23
Topological domaini34 – 55CytoplasmicSequence analysisAdd BLAST22
Transmembranei56 – 76HelicalSequence analysisAdd BLAST21
Topological domaini77 – 92LumenalSequence analysisAdd BLAST16
Transmembranei93 – 114HelicalSequence analysisAdd BLAST22
Topological domaini115 – 131CytoplasmicSequence analysisAdd BLAST17
Transmembranei132 – 152HelicalSequence analysisAdd BLAST21
Topological domaini153 – 155LumenalSequence analysis3

Keywords - Cellular componenti

Membrane, Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000717441 – 155V-type proton ATPase 16 kDa proteolipid subunitAdd BLAST155

Post-translational modificationi

Ubiquitinated by RNF182, leading to its degradation via the ubiquitin-proteasome pathway.By similarity

Keywords - PTMi

Ubl conjugation

Proteomic databases

MaxQBiP63082
PaxDbiP63082
PRIDEiP63082
TopDownProteomicsiP63082

PTM databases

iPTMnetiP63082
PhosphoSitePlusiP63082

Expressioni

Gene expression databases

BgeeiENSMUSG00000024121
CleanExiMM_ATP6V0C
MM_MVP
ExpressionAtlasiP63082 baseline and differential
GenevisibleiP63082 MM

Interactioni

Subunit structurei

V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (main components: subunits A, B, C, D, E, and F) attached to an integral membrane V0 proton pore complex (main component: the proteolipid protein; which is present as a hexamer that forms the proton-conducting pore). Interacts with RNF182; this interaction leads to ubiquitination and degradation via the proteasome pathway (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi198274, 4 interactors
IntActiP63082, 2 interactors
STRINGi10090.ENSMUSP00000024932

Structurei

3D structure databases

ProteinModelPortaliP63082
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0232 Eukaryota
COG0636 LUCA
GeneTreeiENSGT00550000074873
HOVERGENiHBG002712
InParanoidiP63082
KOiK02155
OMAiDMFARGI
OrthoDBiEOG091G0U1Y
PhylomeDBiP63082
TreeFamiTF300025

Family and domain databases

InterProiView protein in InterPro
IPR002379 ATPase_proteolipid_c-like_dom
IPR000245 ATPase_proteolipid_csu
IPR011555 ATPase_proteolipid_su_C_euk
IPR035921 F/V-ATP_Csub_sf
PfamiView protein in Pfam
PF00137 ATP-synt_C, 2 hits
PRINTSiPR00122 VACATPASE
SUPFAMiSSF81333 SSF81333, 2 hits
TIGRFAMsiTIGR01100 V_ATP_synt_C, 1 hit

Sequencei

Sequence statusi: Complete.

P63082-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADIKNNPEY SSFFGVMGAS SAMVFSAMGA AYGTAKSGTG IAAMSVMRPE
60 70 80 90 100
LIMKSIIPVV MAGIIAIYGL VVAVLIANSL TDGITLYRSF LQLGAGLSVG
110 120 130 140 150
LSGLAAGFAI GIVGDAGVRG TAQQPRLFVG MILILIFAEV LGLYGLIVAL

ILSTK
Length:155
Mass (Da):15,808
Last modified:September 13, 2004 - v1
Checksum:i880C280C5AEB0C5C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M64298 mRNA Translation: AAA39775.1
U13842 Genomic DNA Translation: AAC52413.1
AB059662 Genomic DNA Translation: BAB64538.1
AF356008 Genomic DNA Translation: AAL02098.1
AK002570 mRNA Translation: BAB22195.1
AK002871 mRNA Translation: BAB22419.1
AK170346 mRNA Translation: BAE41735.1
CCDSiCCDS28476.1
PIRiJN0063
RefSeqiNP_033859.1, NM_009729.3
UniGeneiMm.294761
Mm.30155
Mm.320896

Genome annotation databases

EnsembliENSMUST00000024932; ENSMUSP00000024932; ENSMUSG00000024121
ENSMUST00000098862; ENSMUSP00000111059; ENSMUSG00000024121
GeneIDi11984
KEGGimmu:11984
UCSCiuc008aup.2 mouse

Similar proteinsi

Entry informationi

Entry nameiVATL_MOUSE
AccessioniPrimary (citable) accession number: P63082
Secondary accession number(s): P23967, Q3TD69
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 13, 2004
Last sequence update: September 13, 2004
Last modified: June 20, 2018
This is version 129 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health