UniProtKB - P63075 (FGF17_MOUSE)
Protein
Fibroblast growth factor 17
Gene
Fgf17
Organism
Mus musculus (Mouse)
Status
Functioni
Plays an important role in the regulation of embryonic development and as signaling molecule in the induction and patterning of the embryonic brain. Required for normal brain development.
GO - Molecular functioni
- fibroblast growth factor receptor binding Source: GO_Central
- growth factor activity Source: GO_Central
- type 1 fibroblast growth factor receptor binding Source: MGI
- type 2 fibroblast growth factor receptor binding Source: MGI
GO - Biological processi
- animal organ morphogenesis Source: GO_Central
- cell differentiation Source: GO_Central
- fibroblast growth factor receptor signaling pathway Source: MGI
- positive regulation of cell population proliferation Source: MGI
- positive regulation of gene expression Source: GO_Central
- positive regulation of protein phosphorylation Source: GO_Central
- regulation of cell migration Source: GO_Central
Keywordsi
Molecular function | Developmental protein, Growth factor |
Enzyme and pathway databases
Reactomei | R-MMU-109704, PI3K Cascade R-MMU-1257604, PIP3 activates AKT signaling R-MMU-190322, FGFR4 ligand binding and activation R-MMU-190371, FGFR3b ligand binding and activation R-MMU-190372, FGFR3c ligand binding and activation R-MMU-190373, FGFR1c ligand binding and activation R-MMU-190375, FGFR2c ligand binding and activation R-MMU-5654219, Phospholipase C-mediated cascade: FGFR1 R-MMU-5654221, Phospholipase C-mediated cascade, FGFR2 R-MMU-5654227, Phospholipase C-mediated cascade, FGFR3 R-MMU-5654228, Phospholipase C-mediated cascade, FGFR4 R-MMU-5654687, Downstream signaling of activated FGFR1 R-MMU-5654688, SHC-mediated cascade:FGFR1 R-MMU-5654689, PI-3K cascade:FGFR1 R-MMU-5654693, FRS-mediated FGFR1 signaling R-MMU-5654695, PI-3K cascade:FGFR2 R-MMU-5654699, SHC-mediated cascade:FGFR2 R-MMU-5654700, FRS-mediated FGFR2 signaling R-MMU-5654704, SHC-mediated cascade:FGFR3 R-MMU-5654706, FRS-mediated FGFR3 signaling R-MMU-5654710, PI-3K cascade:FGFR3 R-MMU-5654712, FRS-mediated FGFR4 signaling R-MMU-5654719, SHC-mediated cascade:FGFR4 R-MMU-5654720, PI-3K cascade:FGFR4 R-MMU-5654726, Negative regulation of FGFR1 signaling R-MMU-5654727, Negative regulation of FGFR2 signaling R-MMU-5654732, Negative regulation of FGFR3 signaling R-MMU-5654733, Negative regulation of FGFR4 signaling R-MMU-5658623, FGFRL1 modulation of FGFR1 signaling R-MMU-5673001, RAF/MAP kinase cascade R-MMU-6811558, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling |
Names & Taxonomyi
Protein namesi | Recommended name: Fibroblast growth factor 17Short name: FGF-17 |
Gene namesi | Name:Fgf17 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1202401, Fgf17 |
Subcellular locationi
Extracellular region or secreted
- Secreted By similarity
Extracellular region or secreted
- extracellular space Source: GO_Central
Other locations
- cytoplasm Source: GO_Central
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 22 | Sequence analysisAdd BLAST | 22 | |
ChainiPRO_0000008986 | 23 – 216 | Fibroblast growth factor 17Add BLAST | 194 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 137 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
GlycoproteinProteomic databases
PaxDbi | P63075 |
PRIDEi | P63075 |
PTM databases
GlyGeni | P63075, 1 site |
PhosphoSitePlusi | P63075 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000022101, Expressed in embryonic post-anal tail and 93 other tissues |
ExpressionAtlasi | P63075, baseline and differential |
Genevisiblei | P63075, MM |
Interactioni
Subunit structurei
Interacts with FGFR3 and FGFR4.
By similarityGO - Molecular functioni
- fibroblast growth factor receptor binding Source: GO_Central
- growth factor activity Source: GO_Central
- type 1 fibroblast growth factor receptor binding Source: MGI
- type 2 fibroblast growth factor receptor binding Source: MGI
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000022697 |
Miscellaneous databases
RNActi | P63075, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the heparin-binding growth factors family.Curated
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | KOG3885, Eukaryota |
GeneTreei | ENSGT00940000161965 |
HOGENOMi | CLU_090682_0_0_1 |
InParanoidi | P63075 |
OrthoDBi | 1190450at2759 |
PhylomeDBi | P63075 |
TreeFami | TF331233 |
Family and domain databases
CDDi | cd00058, FGF, 1 hit |
InterProi | View protein in InterPro IPR028287, FGF17 IPR002209, Fibroblast_GF_fam IPR008996, IL1/FGF |
PANTHERi | PTHR11486, PTHR11486, 1 hit PTHR11486:SF71, PTHR11486:SF71, 1 hit |
Pfami | View protein in Pfam PF00167, FGF, 1 hit |
SMARTi | View protein in SMART SM00442, FGF, 1 hit |
SUPFAMi | SSF50353, SSF50353, 1 hit |
PROSITEi | View protein in PROSITE PS00247, HBGF_FGF, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
P63075-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGAARLLPNL TLCLQLLILC CQTQGENHPS PNFNQYVRDQ GAMTDQLSRR
60 70 80 90 100
QIREYQLYSR TSGKHVQVTG RRISATAEDG NKFAKLIVET DTFGSRVRIK
110 120 130 140 150
GAESEKYICM NKRGKLIGKP SGKSKDCVFT EIVLENNYTA FQNARHEGWF
160 170 180 190 200
MAFTRQGRPR QASRSRQNQR EAHFIKRLYQ GQLPFPNHAE RQKQFEFVGS
210
APTRRTKRTR RPQSQT
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketB7ZMS7 | B7ZMS7_MOUSE | Fibroblast growth factor | Fgf17 | 205 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB009250 mRNA Translation: BAA25430.1 AK077555 mRNA Translation: BAC36859.1 |
CCDSi | CCDS27260.1 |
RefSeqi | NP_032030.1, NM_008004.4 XP_006518614.1, XM_006518551.3 XP_011243255.1, XM_011244953.2 |
Genome annotation databases
Ensembli | ENSMUST00000022697; ENSMUSP00000022697; ENSMUSG00000022101 |
GeneIDi | 14171 |
KEGGi | mmu:14171 |
UCSCi | uc007uos.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB009250 mRNA Translation: BAA25430.1 AK077555 mRNA Translation: BAC36859.1 |
CCDSi | CCDS27260.1 |
RefSeqi | NP_032030.1, NM_008004.4 XP_006518614.1, XM_006518551.3 XP_011243255.1, XM_011244953.2 |
3D structure databases
SMRi | P63075 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000022697 |
PTM databases
GlyGeni | P63075, 1 site |
PhosphoSitePlusi | P63075 |
Proteomic databases
PaxDbi | P63075 |
PRIDEi | P63075 |
Protocols and materials databases
Antibodypediai | 22456, 306 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000022697; ENSMUSP00000022697; ENSMUSG00000022101 |
GeneIDi | 14171 |
KEGGi | mmu:14171 |
UCSCi | uc007uos.1, mouse |
Organism-specific databases
CTDi | 8822 |
MGIi | MGI:1202401, Fgf17 |
Phylogenomic databases
eggNOGi | KOG3885, Eukaryota |
GeneTreei | ENSGT00940000161965 |
HOGENOMi | CLU_090682_0_0_1 |
InParanoidi | P63075 |
OrthoDBi | 1190450at2759 |
PhylomeDBi | P63075 |
TreeFami | TF331233 |
Enzyme and pathway databases
Reactomei | R-MMU-109704, PI3K Cascade R-MMU-1257604, PIP3 activates AKT signaling R-MMU-190322, FGFR4 ligand binding and activation R-MMU-190371, FGFR3b ligand binding and activation R-MMU-190372, FGFR3c ligand binding and activation R-MMU-190373, FGFR1c ligand binding and activation R-MMU-190375, FGFR2c ligand binding and activation R-MMU-5654219, Phospholipase C-mediated cascade: FGFR1 R-MMU-5654221, Phospholipase C-mediated cascade, FGFR2 R-MMU-5654227, Phospholipase C-mediated cascade, FGFR3 R-MMU-5654228, Phospholipase C-mediated cascade, FGFR4 R-MMU-5654687, Downstream signaling of activated FGFR1 R-MMU-5654688, SHC-mediated cascade:FGFR1 R-MMU-5654689, PI-3K cascade:FGFR1 R-MMU-5654693, FRS-mediated FGFR1 signaling R-MMU-5654695, PI-3K cascade:FGFR2 R-MMU-5654699, SHC-mediated cascade:FGFR2 R-MMU-5654700, FRS-mediated FGFR2 signaling R-MMU-5654704, SHC-mediated cascade:FGFR3 R-MMU-5654706, FRS-mediated FGFR3 signaling R-MMU-5654710, PI-3K cascade:FGFR3 R-MMU-5654712, FRS-mediated FGFR4 signaling R-MMU-5654719, SHC-mediated cascade:FGFR4 R-MMU-5654720, PI-3K cascade:FGFR4 R-MMU-5654726, Negative regulation of FGFR1 signaling R-MMU-5654727, Negative regulation of FGFR2 signaling R-MMU-5654732, Negative regulation of FGFR3 signaling R-MMU-5654733, Negative regulation of FGFR4 signaling R-MMU-5658623, FGFRL1 modulation of FGFR1 signaling R-MMU-5673001, RAF/MAP kinase cascade R-MMU-6811558, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling |
Miscellaneous databases
BioGRID-ORCSi | 14171, 0 hits in 17 CRISPR screens |
PROi | PR:P63075 |
RNActi | P63075, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000022101, Expressed in embryonic post-anal tail and 93 other tissues |
ExpressionAtlasi | P63075, baseline and differential |
Genevisiblei | P63075, MM |
Family and domain databases
CDDi | cd00058, FGF, 1 hit |
InterProi | View protein in InterPro IPR028287, FGF17 IPR002209, Fibroblast_GF_fam IPR008996, IL1/FGF |
PANTHERi | PTHR11486, PTHR11486, 1 hit PTHR11486:SF71, PTHR11486:SF71, 1 hit |
Pfami | View protein in Pfam PF00167, FGF, 1 hit |
SMARTi | View protein in SMART SM00442, FGF, 1 hit |
SUPFAMi | SSF50353, SSF50353, 1 hit |
PROSITEi | View protein in PROSITE PS00247, HBGF_FGF, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | FGF17_MOUSE | |
Accessioni | P63075Primary (citable) accession number: P63075 Secondary accession number(s): O70627 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 13, 2004 |
Last sequence update: | September 13, 2004 | |
Last modified: | December 2, 2020 | |
This is version 123 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families