Fgf17

Functionⁱ

Plays an important role in the regulation of embryonic development and as signaling molecule in the induction and patterning of the embryonic brain. Required for normal brain development.

GO - Molecular functionⁱ

growth factor activity Source: UniProtKB-KW
type 1 fibroblast growth factor receptor binding Source: MGI
type 2 fibroblast growth factor receptor binding Source: MGI

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

fibroblast growth factor receptor signaling pathway
Source: MGI
Inferred from direct assayⁱ
- 10381577
multicellular organism development Source: UniProtKB-KW
positive regulation of cell proliferation
Source: MGI
Inferred from direct assayⁱ
- 10381577

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Developmental protein, Growth factor

Molecular function

Developmental protein, Growth factor

Enzyme and pathway databases

Reactomeⁱ	R-MMU-109704 PI3K Cascade R-MMU-1257604 PIP3 activates AKT signaling R-MMU-190322 FGFR4 ligand binding and activation R-MMU-190371 FGFR3b ligand binding and activation R-MMU-190372 FGFR3c ligand binding and activation R-MMU-190373 FGFR1c ligand binding and activation R-MMU-190375 FGFR2c ligand binding and activation R-MMU-5654219 Phospholipase C-mediated cascade: FGFR1 R-MMU-5654221 Phospholipase C-mediated cascade, FGFR2 R-MMU-5654227 Phospholipase C-mediated cascade, FGFR3 R-MMU-5654228 Phospholipase C-mediated cascade, FGFR4 R-MMU-5654687 Downstream signaling of activated FGFR1 R-MMU-5654688 SHC-mediated cascade:FGFR1 R-MMU-5654689 PI-3K cascade:FGFR1 R-MMU-5654693 FRS-mediated FGFR1 signaling R-MMU-5654695 PI-3K cascade:FGFR2 R-MMU-5654699 SHC-mediated cascade:FGFR2 R-MMU-5654700 FRS-mediated FGFR2 signaling R-MMU-5654704 SHC-mediated cascade:FGFR3 R-MMU-5654706 FRS-mediated FGFR3 signaling R-MMU-5654710 PI-3K cascade:FGFR3 R-MMU-5654712 FRS-mediated FGFR4 signaling R-MMU-5654719 SHC-mediated cascade:FGFR4 R-MMU-5654720 PI-3K cascade:FGFR4 R-MMU-5654726 Negative regulation of FGFR1 signaling R-MMU-5654727 Negative regulation of FGFR2 signaling R-MMU-5654732 Negative regulation of FGFR3 signaling R-MMU-5654733 Negative regulation of FGFR4 signaling R-MMU-5658623 FGFRL1 modulation of FGFR1 signaling R-MMU-5673001 RAF/MAP kinase cascade R-MMU-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling

Reactomeⁱ

R-MMU-109704 PI3K Cascade
R-MMU-1257604 PIP3 activates AKT signaling
R-MMU-190322 FGFR4 ligand binding and activation
R-MMU-190371 FGFR3b ligand binding and activation
R-MMU-190372 FGFR3c ligand binding and activation
R-MMU-190373 FGFR1c ligand binding and activation
R-MMU-190375 FGFR2c ligand binding and activation
R-MMU-5654219 Phospholipase C-mediated cascade: FGFR1
R-MMU-5654221 Phospholipase C-mediated cascade, FGFR2
R-MMU-5654227 Phospholipase C-mediated cascade, FGFR3
R-MMU-5654228 Phospholipase C-mediated cascade, FGFR4
R-MMU-5654687 Downstream signaling of activated FGFR1
R-MMU-5654688 SHC-mediated cascade:FGFR1
R-MMU-5654689 PI-3K cascade:FGFR1
R-MMU-5654693 FRS-mediated FGFR1 signaling
R-MMU-5654695 PI-3K cascade:FGFR2
R-MMU-5654699 SHC-mediated cascade:FGFR2
R-MMU-5654700 FRS-mediated FGFR2 signaling
R-MMU-5654704 SHC-mediated cascade:FGFR3
R-MMU-5654706 FRS-mediated FGFR3 signaling
R-MMU-5654710 PI-3K cascade:FGFR3
R-MMU-5654712 FRS-mediated FGFR4 signaling
R-MMU-5654719 SHC-mediated cascade:FGFR4
R-MMU-5654720 PI-3K cascade:FGFR4
R-MMU-5654726 Negative regulation of FGFR1 signaling
R-MMU-5654727 Negative regulation of FGFR2 signaling
R-MMU-5654732 Negative regulation of FGFR3 signaling
R-MMU-5654733 Negative regulation of FGFR4 signaling
R-MMU-5658623 FGFRL1 modulation of FGFR1 signaling
R-MMU-5673001 RAF/MAP kinase cascade
R-MMU-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Fibroblast growth factor 17 Short name: FGF-17
Gene namesⁱ	Name:Fgf17
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 14

Organism-specific databases

MGIⁱ	MGI:1202401 Fgf17

Keywords - Cellular componentⁱ

Secreted

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 22	Sequence analysisAdd BLAST		22
ChainⁱPRO_0000008986	23 – 216	Fibroblast growth factor 17Add BLAST		194

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Glycosylationⁱ	137	N-linked (GlcNAc...) asparagineSequence analysis		1

Keywords - PTMⁱ

Glycoprotein

Proteomic databases

PaxDbⁱ	P63075
PRIDEⁱ	P63075

PTM databases

PhosphoSitePlusⁱ	P63075

PhosphoSitePlusⁱ

P63075

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000022101 Expressed in 70 organ(s), highest expression level in midbrain
CleanExⁱ	MM_FGF17
ExpressionAtlasⁱ	P63075 baseline and differential
Genevisibleⁱ	P63075 MM

Interactionⁱ

Subunit structureⁱ

Interacts with FGFR3 and FGFR4.By similarity

GO - Molecular functionⁱ

growth factor activity Source: UniProtKB-KW
type 1 fibroblast growth factor receptor binding Source: MGI
type 2 fibroblast growth factor receptor binding Source: MGI

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000022697

STRINGⁱ

10090.ENSMUSP00000022697

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P63075
SMRⁱ	P63075
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the heparin-binding growth factors family.Curated

Keywords - Domainⁱ

Signal

Phylogenomic databases

eggNOGⁱ	KOG3885 Eukaryota ENOG4111IPH LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00730000110785
HOGENOMⁱ	HOG000115986
HOVERGENⁱ	HBG005659
InParanoidⁱ	P63075
KEGG Orthology (KO) More...KOⁱ	K04358
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0NQH
PhylomeDBⁱ	P63075
TreeFamⁱ	TF331233

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00058 FGF, 1 hit
InterProⁱ	View protein in InterPro IPR028287 FGF17 IPR002209 Fibroblast_GF_fam IPR008996 IL1/FGF
PANTHERⁱ	PTHR11486 PTHR11486, 1 hit PTHR11486:SF71 PTHR11486:SF71, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00167 FGF, 1 hit
SMARTⁱ	View protein in SMART SM00442 FGF, 1 hit
SUPFAMⁱ	SSF50353 SSF50353, 1 hit
PROSITEⁱ	View protein in PROSITE PS00247 HBGF_FGF, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show all Align All

P63075-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MGAARLLPNL TLCLQLLILC CQTQGENHPS PNFNQYVRDQ GAMTDQLSRR 
        60         70         80         90        100
QIREYQLYSR TSGKHVQVTG RRISATAEDG NKFAKLIVET DTFGSRVRIK 
       110        120        130        140        150
GAESEKYICM NKRGKLIGKP SGKSKDCVFT EIVLENNYTA FQNARHEGWF 
       160        170        180        190        200
MAFTRQGRPR QASRSRQNQR EAHFIKRLYQ GQLPFPNHAE RQKQFEFVGS 
       210 
APTRRTKRTR RPQSQT

Length:216

Mass (Da):24,924

Last modified:September 13, 2004 - v1

Checksum:ⁱ2EE94BDF75220F4C

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	B7ZMS7	B7ZMS7_MOUSE		Fibroblast growth factor Fibroblast growth factor, FGF	Fgf17	205	Annotation score:

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB009250 mRNA Translation: BAA25430.1 AK077555 mRNA Translation: BAC36859.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS27260.1
NCBI Reference Sequences More...RefSeqⁱ	NP_032030.1, NM_008004.4 XP_006518614.1, XM_006518551.3 XP_011243255.1, XM_011244953.2
UniGeneⁱ	Mm.12814

Genome annotation databases

Ensemblⁱ	ENSMUST00000022697; ENSMUSP00000022697; ENSMUSG00000022101
GeneIDⁱ	14171
KEGGⁱ	mmu:14171
UCSC genome browser More...UCSCⁱ	uc007uos.1 mouse

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P63075	Fibroblast growth factor 17		RAT		216	UniRef100_P63075
Fibroblast growth factor		MOUSE		216

Protein	Similar proteins		Species	Score	Length	Source
P63075	Fibroblast growth factor 17		HUMAN		216	UniRef90_O60258
Fibroblast growth factor 17		RAT		216
Fibroblast growth factor		PANTR		216
Fibroblast growth factor		PONAB		216
Fibroblast growth factor		MACMU		216
+63

Protein	Similar proteins		Species	Score	Length	Source
P63075	Fibroblast growth factor 8		DANRE		210	UniRef50_O57341
Fibroblast growth factor 17		RAT		216
Fibroblast growth factor 17		HUMAN		216
Fibroblast growth factor 8		CHICK		214
Fibroblast growth factor (Fragment)		Clarias magur		210
+481

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB009250 mRNA Translation: BAA25430.1 AK077555 mRNA Translation: BAC36859.1
CCDSⁱ	CCDS27260.1
RefSeqⁱ	NP_032030.1, NM_008004.4 XP_006518614.1, XM_006518551.3 XP_011243255.1, XM_011244953.2
UniGeneⁱ	Mm.12814

3D structure databases

ProteinModelPortalⁱ	P63075
SMRⁱ	P63075
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000022697

STRINGⁱ

10090.ENSMUSP00000022697

PTM databases

PhosphoSitePlusⁱ	P63075

PhosphoSitePlusⁱ

P63075

Proteomic databases

PaxDbⁱ	P63075
PRIDEⁱ	P63075

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000022697; ENSMUSP00000022697; ENSMUSG00000022101
GeneIDⁱ	14171
KEGGⁱ	mmu:14171
UCSCⁱ	uc007uos.1 mouse

Organism-specific databases

CTDⁱ	8822
MGIⁱ	MGI:1202401 Fgf17

Phylogenomic databases

eggNOGⁱ	KOG3885 Eukaryota ENOG4111IPH LUCA
GeneTreeⁱ	ENSGT00730000110785
HOGENOMⁱ	HOG000115986
HOVERGENⁱ	HBG005659
InParanoidⁱ	P63075
KOⁱ	K04358
OrthoDBⁱ	EOG091G0NQH
PhylomeDBⁱ	P63075
TreeFamⁱ	TF331233

Enzyme and pathway databases

Reactomeⁱ	R-MMU-109704 PI3K Cascade R-MMU-1257604 PIP3 activates AKT signaling R-MMU-190322 FGFR4 ligand binding and activation R-MMU-190371 FGFR3b ligand binding and activation R-MMU-190372 FGFR3c ligand binding and activation R-MMU-190373 FGFR1c ligand binding and activation R-MMU-190375 FGFR2c ligand binding and activation R-MMU-5654219 Phospholipase C-mediated cascade: FGFR1 R-MMU-5654221 Phospholipase C-mediated cascade, FGFR2 R-MMU-5654227 Phospholipase C-mediated cascade, FGFR3 R-MMU-5654228 Phospholipase C-mediated cascade, FGFR4 R-MMU-5654687 Downstream signaling of activated FGFR1 R-MMU-5654688 SHC-mediated cascade:FGFR1 R-MMU-5654689 PI-3K cascade:FGFR1 R-MMU-5654693 FRS-mediated FGFR1 signaling R-MMU-5654695 PI-3K cascade:FGFR2 R-MMU-5654699 SHC-mediated cascade:FGFR2 R-MMU-5654700 FRS-mediated FGFR2 signaling R-MMU-5654704 SHC-mediated cascade:FGFR3 R-MMU-5654706 FRS-mediated FGFR3 signaling R-MMU-5654710 PI-3K cascade:FGFR3 R-MMU-5654712 FRS-mediated FGFR4 signaling R-MMU-5654719 SHC-mediated cascade:FGFR4 R-MMU-5654720 PI-3K cascade:FGFR4 R-MMU-5654726 Negative regulation of FGFR1 signaling R-MMU-5654727 Negative regulation of FGFR2 signaling R-MMU-5654732 Negative regulation of FGFR3 signaling R-MMU-5654733 Negative regulation of FGFR4 signaling R-MMU-5658623 FGFRL1 modulation of FGFR1 signaling R-MMU-5673001 RAF/MAP kinase cascade R-MMU-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling

Reactomeⁱ

R-MMU-109704 PI3K Cascade
R-MMU-1257604 PIP3 activates AKT signaling
R-MMU-190322 FGFR4 ligand binding and activation
R-MMU-190371 FGFR3b ligand binding and activation
R-MMU-190372 FGFR3c ligand binding and activation
R-MMU-190373 FGFR1c ligand binding and activation
R-MMU-190375 FGFR2c ligand binding and activation
R-MMU-5654219 Phospholipase C-mediated cascade: FGFR1
R-MMU-5654221 Phospholipase C-mediated cascade, FGFR2
R-MMU-5654227 Phospholipase C-mediated cascade, FGFR3
R-MMU-5654228 Phospholipase C-mediated cascade, FGFR4
R-MMU-5654687 Downstream signaling of activated FGFR1
R-MMU-5654688 SHC-mediated cascade:FGFR1
R-MMU-5654689 PI-3K cascade:FGFR1
R-MMU-5654693 FRS-mediated FGFR1 signaling
R-MMU-5654695 PI-3K cascade:FGFR2
R-MMU-5654699 SHC-mediated cascade:FGFR2
R-MMU-5654700 FRS-mediated FGFR2 signaling
R-MMU-5654704 SHC-mediated cascade:FGFR3
R-MMU-5654706 FRS-mediated FGFR3 signaling
R-MMU-5654710 PI-3K cascade:FGFR3
R-MMU-5654712 FRS-mediated FGFR4 signaling
R-MMU-5654719 SHC-mediated cascade:FGFR4
R-MMU-5654720 PI-3K cascade:FGFR4
R-MMU-5654726 Negative regulation of FGFR1 signaling
R-MMU-5654727 Negative regulation of FGFR2 signaling
R-MMU-5654732 Negative regulation of FGFR3 signaling
R-MMU-5654733 Negative regulation of FGFR4 signaling
R-MMU-5658623 FGFRL1 modulation of FGFR1 signaling
R-MMU-5673001 RAF/MAP kinase cascade
R-MMU-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:P63075
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000022101 Expressed in 70 organ(s), highest expression level in midbrain
CleanExⁱ	MM_FGF17
ExpressionAtlasⁱ	P63075 baseline and differential
Genevisibleⁱ	P63075 MM

Family and domain databases

CDDⁱ	cd00058 FGF, 1 hit
InterProⁱ	View protein in InterPro IPR028287 FGF17 IPR002209 Fibroblast_GF_fam IPR008996 IL1/FGF
PANTHERⁱ	PTHR11486 PTHR11486, 1 hit PTHR11486:SF71 PTHR11486:SF71, 1 hit
Pfamⁱ	View protein in Pfam PF00167 FGF, 1 hit
SMARTⁱ	View protein in SMART SM00442 FGF, 1 hit
SUPFAMⁱ	SSF50353 SSF50353, 1 hit
PROSITEⁱ	View protein in PROSITE PS00247 HBGF_FGF, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	FGF17_MOUSE
Accessionⁱ	P63075Primary (citable) accession number: P63075 Secondary accession number(s): O70627
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	September 13, 2004
	Last sequence update:	September 13, 2004
	Last modified:	November 7, 2018
	This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P63075 (FGF17_MOUSE)

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Fibroblast growth factor 17

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted

Extracellular region or secreted

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ