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Protein

Thyroid hormone receptor alpha

Gene

Thra

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei228Thyroid hormoneBy similarity1
Binding sitei277Thyroid hormone; via amide nitrogenBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi53 – 127Nuclear receptorPROSITE-ProRule annotationAdd BLAST75
Zinc fingeri53 – 73NR C4-typePROSITE-ProRule annotationAdd BLAST21
Zinc fingeri91 – 115NR C4-typePROSITE-ProRule annotationAdd BLAST25

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Receptor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-RNO-383280 Nuclear Receptor transcription pathway
R-RNO-4090294 SUMOylation of intracellular receptors

Names & Taxonomyi

Protein namesi
Recommended name:
Thyroid hormone receptor alpha
Alternative name(s):
Nuclear receptor subfamily 1 group A member 1
c-erbA-1
c-erbA-alpha
Gene namesi
Name:Thra
Synonyms:C-erba-alpha, Nr1a1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi3857 Thra

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000534271 – 492Thyroid hormone receptor alphaAdd BLAST492

Proteomic databases

PaxDbiP63059
PRIDEiP63059

PTM databases

iPTMnetiP63059
PhosphoSitePlusiP63059

Expressioni

Gene expression databases

BgeeiENSRNOG00000009066 Expressed in 10 organ(s), highest expression level in brain
ExpressionAtlasiP63059 baseline and differential

Interactioni

Subunit structurei

Binds DNA as a dimer; homodimer and heterodimer with RXRB. Interacts with NCOA3 and NCOA6 coactivators, leading to a strong increase of transcription of target genes. Probably interacts with SFPQ. Interacts with C1D. Interacts with AKAP13. Interacts with TP53INP2. Interacts with PER2 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi249670, 3 interactors
STRINGi10116.ENSRNOP00000012340

Chemistry databases

BindingDBiP63059

Structurei

3D structure databases

ProteinModelPortaliP63059
SMRiP63059
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini163 – 407NR LBDPROSITE-ProRule annotationAdd BLAST245

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 52ModulatingAdd BLAST52

Domaini

Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri53 – 73NR C4-typePROSITE-ProRule annotationAdd BLAST21
Zinc fingeri91 – 115NR C4-typePROSITE-ProRule annotationAdd BLAST25

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG3575 Eukaryota
ENOG410XRZC LUCA
GeneTreeiENSGT00870000136372
HOVERGENiHBG005606
InParanoidiP63059
KOiK05547
PhylomeDBiP63059

Family and domain databases

Gene3Di3.30.50.10, 1 hit
InterProiView protein in InterPro
IPR035500 NHR_like_dom_sf
IPR000536 Nucl_hrmn_rcpt_lig-bd
IPR001723 Nuclear_hrmn_rcpt
IPR001728 ThyrH_rcpt
IPR001628 Znf_hrmn_rcpt
IPR013088 Znf_NHR/GATA
PfamiView protein in Pfam
PF00104 Hormone_recep, 1 hit
PF00105 zf-C4, 1 hit
PRINTSiPR00398 STRDHORMONER
PR00047 STROIDFINGER
PR00546 THYROIDHORMR
SMARTiView protein in SMART
SM00430 HOLI, 1 hit
SM00399 ZnF_C4, 1 hit
SUPFAMiSSF48508 SSF48508, 1 hit
PROSITEiView protein in PROSITE
PS51843 NR_LBD, 1 hit
PS00031 NUCLEAR_REC_DBD_1, 1 hit
PS51030 NUCLEAR_REC_DBD_2, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform Alpha-2 (identifier: P63059-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEQKPSKVEC GSDPEENSAR SPDGKRKRKN GQCPLKSSMS GYIPSYLDKD
60 70 80 90 100
EQCVVCGDKA TGYHYRCITC EGCKGFFRRT IQKNLHPTYS CKYDSCCVID
110 120 130 140 150
KITRNQCQLC RFKKCIAVGM AMDLVLDDSK RVAKRKLIEQ NRERRRKEEM
160 170 180 190 200
IRSLQQRPEP TPEEWDLIHV ATEAHRSTNA QGSHWKQRRK FLPDDIGQSP
210 220 230 240 250
IVSMPDGDKV DLEAFSEFTK IITPAITRVV DFAKKLPMFS ELPCEDQIIL
260 270 280 290 300
LKGCCMEIMS LRAAVRYDPE SDTLTLSGEM AVKREQLKNG GLGVVSDAIF
310 320 330 340 350
ELGKSLSAFN LDDTEVALLQ AVLLMSTDRS GLLCVDKIEK SQEAYLLAFE
360 370 380 390 400
HYVNHRKHNI PHFWPKLLMK EREVQSSILY KGAAAEGRPG GSLGVHPEGQ
410 420 430 440 450
QLLGMHVVQG PQVRQLEQQF GEAGSLRGPV LQHQSPKSPQ QRLLELLHRS
460 470 480 490
GILHSRAVCG EDDSSEASSL SSSSSDEDTE VFEDLAGKAA SP
Length:492
Mass (Da):55,072
Last modified:September 13, 2004 - v1
Checksum:i0B0411F51F614A01
GO
Isoform Alpha-1 (identifier: P63059-2) [UniParc] [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     371-492: EREVQSSILY...EDLAGKAASP → VTDLRMIGAC...FLEVFEDQEV

Show »
Length:410
Mass (Da):46,795
Checksum:iEC0240EF1ECF4111
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3V764G3V764_RAT
Thyroid hormone receptor alpha
Thra rCG_33846
492Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti72G → C in AAA41121 (PubMed:2903438).Curated1
Sequence conflicti281A → T in AAA42238 (PubMed:3629259).Curated1
Sequence conflicti285E → K (PubMed:2841611).Curated1
Sequence conflicti285E → K in AAA42238 (PubMed:3629259).Curated1
Sequence conflicti482F → C in AAA41121 (PubMed:2903438).Curated1
Sequence conflicti482F → C in AAA41122 (PubMed:2903438).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_011550371 – 492EREVQ…KAASP → VTDLRMIGACHASRFLHMKV ECPTELFPPLFLEVFEDQEV in isoform Alpha-1. 3 PublicationsAdd BLAST122

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M31174 mRNA Translation: AAA41121.1
M31177 mRNA Translation: AAA41122.1
M18028 mRNA Translation: AAA42238.1
X12744 mRNA Translation: CAA31237.1
PIRiA36752 TVRTAR
I57696
I67429
S06410
S06907
S09178
RefSeqiNP_001017960.1, NM_001017960.1 [P63059-2]
NP_112396.2, NM_031134.2
UniGeneiRn.11307

Genome annotation databases

EnsembliENSRNOT00000087346; ENSRNOP00000072739; ENSRNOG00000009066 [P63059-2]
GeneIDi81812
KEGGirno:81812

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M31174 mRNA Translation: AAA41121.1
M31177 mRNA Translation: AAA41122.1
M18028 mRNA Translation: AAA42238.1
X12744 mRNA Translation: CAA31237.1
PIRiA36752 TVRTAR
I57696
I67429
S06410
S06907
S09178
RefSeqiNP_001017960.1, NM_001017960.1 [P63059-2]
NP_112396.2, NM_031134.2
UniGeneiRn.11307

3D structure databases

ProteinModelPortaliP63059
SMRiP63059
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi249670, 3 interactors
STRINGi10116.ENSRNOP00000012340

Chemistry databases

BindingDBiP63059

PTM databases

iPTMnetiP63059
PhosphoSitePlusiP63059

Proteomic databases

PaxDbiP63059
PRIDEiP63059

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000087346; ENSRNOP00000072739; ENSRNOG00000009066 [P63059-2]
GeneIDi81812
KEGGirno:81812

Organism-specific databases

CTDi7067
RGDi3857 Thra

Phylogenomic databases

eggNOGiKOG3575 Eukaryota
ENOG410XRZC LUCA
GeneTreeiENSGT00870000136372
HOVERGENiHBG005606
InParanoidiP63059
KOiK05547
PhylomeDBiP63059

Enzyme and pathway databases

ReactomeiR-RNO-383280 Nuclear Receptor transcription pathway
R-RNO-4090294 SUMOylation of intracellular receptors

Miscellaneous databases

PROiPR:P63059

Gene expression databases

BgeeiENSRNOG00000009066 Expressed in 10 organ(s), highest expression level in brain
ExpressionAtlasiP63059 baseline and differential

Family and domain databases

Gene3Di3.30.50.10, 1 hit
InterProiView protein in InterPro
IPR035500 NHR_like_dom_sf
IPR000536 Nucl_hrmn_rcpt_lig-bd
IPR001723 Nuclear_hrmn_rcpt
IPR001728 ThyrH_rcpt
IPR001628 Znf_hrmn_rcpt
IPR013088 Znf_NHR/GATA
PfamiView protein in Pfam
PF00104 Hormone_recep, 1 hit
PF00105 zf-C4, 1 hit
PRINTSiPR00398 STRDHORMONER
PR00047 STROIDFINGER
PR00546 THYROIDHORMR
SMARTiView protein in SMART
SM00430 HOLI, 1 hit
SM00399 ZnF_C4, 1 hit
SUPFAMiSSF48508 SSF48508, 1 hit
PROSITEiView protein in PROSITE
PS51843 NR_LBD, 1 hit
PS00031 NUCLEAR_REC_DBD_1, 1 hit
PS51030 NUCLEAR_REC_DBD_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTHA_RAT
AccessioniPrimary (citable) accession number: P63059
Secondary accession number(s): P10685
, P15827, P16416, P37241, Q63107, Q63195, Q63196, Q99146
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 13, 2004
Last sequence update: September 13, 2004
Last modified: November 7, 2018
This is version 136 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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