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Protein

Thyroid hormone receptor alpha

Gene

Thra

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine. Isoform Alpha-deltaE6 does not bind DNA, inhibits the activity of isoform Alpha-1, and stimulates myoblast differentiation.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei228Thyroid hormoneBy similarity1
Binding sitei277Thyroid hormone; via amide nitrogenBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi53 – 127Nuclear receptorPROSITE-ProRule annotationAdd BLAST75
Zinc fingeri53 – 73NR C4-typePROSITE-ProRule annotationAdd BLAST21
Zinc fingeri91 – 115NR C4-typePROSITE-ProRule annotationAdd BLAST25

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Receptor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-MMU-383280 Nuclear Receptor transcription pathway
R-MMU-4090294 SUMOylation of intracellular receptors

Names & Taxonomyi

Protein namesi
Recommended name:
Thyroid hormone receptor alpha
Alternative name(s):
Nuclear receptor subfamily 1 group A member 1
c-erbA-1
c-erbA-alpha
Gene namesi
Name:Thra
Synonyms:C-erba-alpha, Nr1a1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:98742 Thra

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000534251 – 492Thyroid hormone receptor alphaAdd BLAST492

Proteomic databases

MaxQBiP63058
PaxDbiP63058
PRIDEiP63058

PTM databases

iPTMnetiP63058
PhosphoSitePlusiP63058

Expressioni

Tissue specificityi

Ubiquitous (Isoform Alpha-deltaE6).1 Publication

Gene expression databases

BgeeiENSMUSG00000058756 Expressed in 301 organ(s), highest expression level in Ammon's horn
CleanExiMM_THRA
ExpressionAtlasiP63058 baseline and differential
GenevisibleiP63058 MM

Interactioni

Subunit structurei

Binds DNA as a dimer; homodimer and heterodimer with RXRB. Interacts with NCOA3 and NCOA6 coactivators, leading to a strong increase of transcription of target genes. Probably interacts with SFPQ. Interacts with AKAP13. Interacts with C1D. Interacts with TP53INP2. Interacts with PER2.3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
Cacnb4D4A0552EBI-6935292,EBI-8028403From Rattus norvegicus.

GO - Molecular functioni

Protein-protein interaction databases

BioGridi204183, 5 interactors
ComplexPortaliCPX-713 RXRalpha-TRalpha nuclear hormone receptor complex [P63058-2]
DIPiDIP-43752N
IntActiP63058, 4 interactors
MINTiP63058
STRINGi10090.ENSMUSP00000099428

Structurei

3D structure databases

ProteinModelPortaliP63058
SMRiP63058
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini163 – 407NR LBDPROSITE-ProRule annotationAdd BLAST245

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 52ModulatingAdd BLAST52

Domaini

Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain. Isoform Alpha-deltaE6 lacks the hinge region that connects the modulating domain and the DNA binding domain.

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri53 – 73NR C4-typePROSITE-ProRule annotationAdd BLAST21
Zinc fingeri91 – 115NR C4-typePROSITE-ProRule annotationAdd BLAST25

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG3575 Eukaryota
ENOG410XRZC LUCA
GeneTreeiENSGT00870000136372
HOVERGENiHBG005606
InParanoidiP63058
KOiK05547
OMAiAQGAQWK
OrthoDBiEOG091G0GC1
PhylomeDBiP63058
TreeFamiTF328382

Family and domain databases

Gene3Di3.30.50.10, 1 hit
InterProiView protein in InterPro
IPR035500 NHR_like_dom_sf
IPR000536 Nucl_hrmn_rcpt_lig-bd
IPR001723 Nuclear_hrmn_rcpt
IPR001728 ThyrH_rcpt
IPR001628 Znf_hrmn_rcpt
IPR013088 Znf_NHR/GATA
PfamiView protein in Pfam
PF00104 Hormone_recep, 1 hit
PF00105 zf-C4, 1 hit
PRINTSiPR00398 STRDHORMONER
PR00047 STROIDFINGER
PR00546 THYROIDHORMR
SMARTiView protein in SMART
SM00430 HOLI, 1 hit
SM00399 ZnF_C4, 1 hit
SUPFAMiSSF48508 SSF48508, 1 hit
PROSITEiView protein in PROSITE
PS51843 NR_LBD, 1 hit
PS00031 NUCLEAR_REC_DBD_1, 1 hit
PS51030 NUCLEAR_REC_DBD_2, 1 hit

Sequences (4+)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform Alpha-2 (identifier: P63058-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEQKPSKVEC GSDPEENSAR SPDGKRKRKN GQCPLKSSMS GYIPSYLDKD
60 70 80 90 100
EQCVVCGDKA TGYHYRCITC EGCKGFFRRT IQKNLHPTYS CKYDSCCVID
110 120 130 140 150
KITRNQCQLC RFKKCIAVGM AMDLVLDDSK RVAKRKLIEQ NRERRRKEEM
160 170 180 190 200
IRSLQQRPEP TPEEWDLIHV ATEAHRSTNA QGSHWKQRRK FLPDDIGQSP
210 220 230 240 250
IVSMPDGDKV DLEAFSEFTK IITPAITRVV DFAKKLPMFS ELPCEDQIIL
260 270 280 290 300
LKGCCMEIMS LRAAVRYDPE SDTLTLSGEM AVKREQLKNG GLGVVSDAIF
310 320 330 340 350
ELGKSLSAFN LDDTEVALLQ AVLLMSTDRS GLLCVDKIEK SQEAYLLAFE
360 370 380 390 400
HYVNHRKHNI PHFWPKLLMK EREVQSSILY KGAAAEGRPG GSLGVHPEGQ
410 420 430 440 450
QLLGMHVVQG PQVRQLEQQL GEAGSLRGPV LQHQSPKSPQ QRLLELLHRS
460 470 480 490
GILHSRAVCG EDDSSEASSL SSSSDTEDTE VCEDQAGKAA SP
Length:492
Mass (Da):55,023
Last modified:January 19, 2010 - v2
Checksum:i870100FCB5C34A10
GO
Isoform Alpha-1 (identifier: P63058-2) [UniParc] [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     371-492: EREVQSSILY...EDQAGKAASP → VTDLRMIGAC...FLEVFEDQEV

Show »
Length:410
Mass (Da):46,795
Checksum:iEC0240EF1ECF4111
GO
Isoform Alpha-3 (identifier: P63058-3) [UniParc] [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     371-409: Missing.

Show »
Length:453
Mass (Da):50,954
Checksum:i6DE1FECA97686CAF
GO
Isoform Alpha-deltaE6 (identifier: P63058-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     121-197: AMDLVLDDSK...RRKFLPDDIG → GTSP
     371-492: EREVQSSILY...EDQAGKAASP → VTDLRMIGAC...FLEVFEDQEV

Note: Due to mismatches with the underlying genomic sequence that lie within a microexon, this isoform has been proposed to undergo RNA editing involving both base insertion and deletion.
Show »
Length:337
Mass (Da):37,926
Checksum:i27137623BED67783
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0R4J1R8A0A0R4J1R8_MOUSE
Thyroid hormone receptor alpha
Thra
413Annotation score:
A3KFN7A3KFN7_MOUSE
Thyroid hormone receptor alpha
Thra
64Annotation score:

Sequence cautioni

The sequence CAM46188 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti106Q → H in CAA36241 (PubMed:2349106).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_038640121 – 197AMDLV…PDDIG → GTSP in isoform Alpha-deltaE6. CuratedAdd BLAST77
Alternative sequenceiVSP_003624371 – 492EREVQ…KAASP → VTDLRMIGACHASRFLHMKV ECPTELFPPLFLEVFEDQEV in isoform Alpha-1 and isoform Alpha-deltaE6. 3 PublicationsAdd BLAST122
Alternative sequenceiVSP_003625371 – 409Missing in isoform Alpha-3. 1 PublicationAdd BLAST39

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X07750 mRNA Translation: CAA30575.1
X07751 mRNA Translation: CAA30576.1
X07752 mRNA Translation: CAA30577.1
X51983 mRNA Translation: CAA36241.1
AK078233 mRNA Translation: BAC37186.1
AL590963 Genomic DNA Translation: CAM46188.1 Sequence problems.
AL590963 Genomic DNA Translation: CAM46189.1
AL590963 Genomic DNA Translation: CAM46190.1
CH466556 Genomic DNA Translation: EDL16164.1
CH466556 Genomic DNA Translation: EDL16165.1
BC046795 mRNA Translation: AAH46795.1
CCDSiCCDS25362.1 [P63058-2]
CCDS83893.1
PIRiS14416
S14417
S14418
S14690 QRMSA1
RefSeqiNP_001300912.1, NM_001313983.1 [P63058-1]
NP_835161.1, NM_178060.4 [P63058-2]
UniGeneiMm.265917
Mm.442648

Genome annotation databases

EnsembliENSMUST00000064187; ENSMUSP00000068281; ENSMUSG00000058756 [P63058-1]
ENSMUST00000103139; ENSMUSP00000099428; ENSMUSG00000058756 [P63058-2]
GeneIDi21833
KEGGimmu:21833
UCSCiuc007lhe.1 mouse [P63058-2]
uc007lhf.1 mouse
uc007lhg.1 mouse [P63058-3]

Keywords - Coding sequence diversityi

Alternative splicing, RNA editing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X07750 mRNA Translation: CAA30575.1
X07751 mRNA Translation: CAA30576.1
X07752 mRNA Translation: CAA30577.1
X51983 mRNA Translation: CAA36241.1
AK078233 mRNA Translation: BAC37186.1
AL590963 Genomic DNA Translation: CAM46188.1 Sequence problems.
AL590963 Genomic DNA Translation: CAM46189.1
AL590963 Genomic DNA Translation: CAM46190.1
CH466556 Genomic DNA Translation: EDL16164.1
CH466556 Genomic DNA Translation: EDL16165.1
BC046795 mRNA Translation: AAH46795.1
CCDSiCCDS25362.1 [P63058-2]
CCDS83893.1
PIRiS14416
S14417
S14418
S14690 QRMSA1
RefSeqiNP_001300912.1, NM_001313983.1 [P63058-1]
NP_835161.1, NM_178060.4 [P63058-2]
UniGeneiMm.265917
Mm.442648

3D structure databases

ProteinModelPortaliP63058
SMRiP63058
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi204183, 5 interactors
ComplexPortaliCPX-713 RXRalpha-TRalpha nuclear hormone receptor complex [P63058-2]
DIPiDIP-43752N
IntActiP63058, 4 interactors
MINTiP63058
STRINGi10090.ENSMUSP00000099428

PTM databases

iPTMnetiP63058
PhosphoSitePlusiP63058

Proteomic databases

MaxQBiP63058
PaxDbiP63058
PRIDEiP63058

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000064187; ENSMUSP00000068281; ENSMUSG00000058756 [P63058-1]
ENSMUST00000103139; ENSMUSP00000099428; ENSMUSG00000058756 [P63058-2]
GeneIDi21833
KEGGimmu:21833
UCSCiuc007lhe.1 mouse [P63058-2]
uc007lhf.1 mouse
uc007lhg.1 mouse [P63058-3]

Organism-specific databases

CTDi7067
MGIiMGI:98742 Thra

Phylogenomic databases

eggNOGiKOG3575 Eukaryota
ENOG410XRZC LUCA
GeneTreeiENSGT00870000136372
HOVERGENiHBG005606
InParanoidiP63058
KOiK05547
OMAiAQGAQWK
OrthoDBiEOG091G0GC1
PhylomeDBiP63058
TreeFamiTF328382

Enzyme and pathway databases

ReactomeiR-MMU-383280 Nuclear Receptor transcription pathway
R-MMU-4090294 SUMOylation of intracellular receptors

Miscellaneous databases

PROiPR:P63058
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000058756 Expressed in 301 organ(s), highest expression level in Ammon's horn
CleanExiMM_THRA
ExpressionAtlasiP63058 baseline and differential
GenevisibleiP63058 MM

Family and domain databases

Gene3Di3.30.50.10, 1 hit
InterProiView protein in InterPro
IPR035500 NHR_like_dom_sf
IPR000536 Nucl_hrmn_rcpt_lig-bd
IPR001723 Nuclear_hrmn_rcpt
IPR001728 ThyrH_rcpt
IPR001628 Znf_hrmn_rcpt
IPR013088 Znf_NHR/GATA
PfamiView protein in Pfam
PF00104 Hormone_recep, 1 hit
PF00105 zf-C4, 1 hit
PRINTSiPR00398 STRDHORMONER
PR00047 STROIDFINGER
PR00546 THYROIDHORMR
SMARTiView protein in SMART
SM00430 HOLI, 1 hit
SM00399 ZnF_C4, 1 hit
SUPFAMiSSF48508 SSF48508, 1 hit
PROSITEiView protein in PROSITE
PS51843 NR_LBD, 1 hit
PS00031 NUCLEAR_REC_DBD_1, 1 hit
PS51030 NUCLEAR_REC_DBD_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTHA_MOUSE
AccessioniPrimary (citable) accession number: P63058
Secondary accession number(s): A3KFN4
, P10685, P15827, P16416, P37241, Q542U8, Q63107, Q63195, Q63196, Q80Y90, Q99146
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 13, 2004
Last sequence update: January 19, 2010
Last modified: November 7, 2018
This is version 149 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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