Thyroid hormone receptor alpha

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

Sites

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• chromatin DNA binding Source: MGI <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • 17952069
• DNA-binding transcription factor activity Source: MGI
• DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • 21873635
• intronic transcription regulatory region DNA binding Source: MGI
• nuclear receptor activity Source: MGIInferred from direct assayⁱ
  • 15322135
• nuclear receptor transcription coactivator activity Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635
• protein-containing complex binding Source: MGIInferred from direct assayⁱ
  • 15340084
• protein dimerization activity Source: MGI
• protein domain specific binding Source: MGI
• protein heterodimerization activity Source: MGI
• protein homodimerization activity Source: MGI
• RNA polymerase II regulatory region sequence-specific DNA binding Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635
• sequence-specific DNA binding Source: MGI
• signaling receptor activity Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635
• single-stranded RNA binding Source: MGIInferred from direct assayⁱ
  • 15180993
• steroid hormone receptor activity Source: InterPro
• steroid receptor RNA activator RNA binding Source: MGIInferred from direct assayⁱ
  • 15180993
• TBP-class protein binding Source: MGI
• thyroid hormone binding Source: UniProtKB
• thyroid hormone receptor activity Source: UniProtKB
• transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding Source: MGI
• transcription factor binding Source: MGI
• transcription regulatory region DNA binding Source: MGI
• transcription regulatory region sequence-specific DNA binding Source: ParkinsonsUK-UCLInferred from direct assayⁱ
  • 19001373
• zinc ion binding Source: InterPro

GO - Biological processⁱ

• animal organ morphogenesis Source: MGI <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • 9927422
• brain development Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635
• cartilage condensation Source: MGIInferred from mutant phenotypeⁱ
  • 9250685
• cell differentiation Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635
• cytoplasmic sequestering of transcription factor Source: MGIInferred from direct assayⁱ
  • 16322094
• erythrocyte differentiation Source: MGIInferred from mutant phenotypeⁱ
  • 18203951
• female courtship behavior Source: MGIInferred from mutant phenotypeⁱ
  • 10769387
• hormone-mediated signaling pathway Source: MGI
• learning or memory Source: MGIInferred from mutant phenotypeⁱ
  • 17129617
• multicellular organism development Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635
• negative regulation of DNA-binding transcription factor activity Source: MGI
• negative regulation of DNA-templated transcription, initiation Source: MGI
• negative regulation of RNA polymerase II transcriptional preinitiation complex assembly Source: MGI
• negative regulation of transcription, DNA-templated Source: MGIInferred from direct assayⁱ
  • 11641275
  • 15062575
  • 15322135
• negative regulation of transcription by RNA polymerase II Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635
• ossification Source: MGIInferred from mutant phenotypeⁱ
  • 9250685
  • 9927422
• positive regulation of canonical Wnt signaling pathway Source: ParkinsonsUK-UCL <p>Inferred by Curator</p> <p>Used for cases where an annotation is not supported by any evidence but can be reasonably inferred by a curator from other GO annotations for which evidence <br />is available.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ic">GO evidence code guide</a></p> Inferred by curatorⁱ
  • 19001373
• positive regulation of cold-induced thermogenesis Source: YuBioLabInferred from mutant phenotypeⁱ
  • 21652727
• positive regulation of female receptivity Source: MGIInferred from mutant phenotypeⁱ
  • 10769387
• positive regulation of myotube differentiation Source: MGIInferred from direct assayⁱ
  • 16322094
• positive regulation of transcription by RNA polymerase II Source: MGIInferred from direct assayⁱ
  • 15340084
• regulation of heart contraction Source: MGIInferred from mutant phenotypeⁱ
  • 15240882
  • 9430637
• regulation of lipid catabolic process Source: MGIInferred from mutant phenotypeⁱ
  • 12869545
• regulation of myeloid cell apoptotic process Source: MGIInferred from mutant phenotypeⁱ
  • 18203951
• regulation of thyroid hormone mediated signaling pathway Source: MGIInferred from mutant phenotypeⁱ
  • 12869545
• regulation of transcription by RNA polymerase II Source: MGI
• response to cold Source: MGIInferred from mutant phenotypeⁱ
  • 12869545
• response to lipid Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635
• thyroid gland development Source: MGI <p>Inferred from Genetic Interaction</p> <p>Used to describe “traditional” genetic interactions such as suppressors and synthetic lethals as well as other techniques such as functional complementation, rescue experiments, or inferences about a gene drawn from the phenotype of a mutation in a different gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#igi">GO evidence code guide</a></p> Inferred from genetic interactionⁱ
  • 11773436
• transcription by RNA polymerase II Source: MGI
• type I pneumocyte differentiation Source: MGIInferred from genetic interactionⁱ
  • 22001906

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Keywords - Cellular componentⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsⁱ

GO - Molecular functionⁱ

• protein dimerization activity Source: MGI
• protein domain specific binding Source: MGI
• protein heterodimerization activity Source: MGI
• protein homodimerization activity Source: MGI
• TBP-class protein binding Source: MGI
• transcription factor binding Source: MGI

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Region

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domainⁱ

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Zinc finger

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

This entry has 4 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

        10         20         30         40         50
MEQKPSKVEC GSDPEENSAR SPDGKRKRKN GQCPLKSSMS GYIPSYLDKD 
        60         70         80         90        100
EQCVVCGDKA TGYHYRCITC EGCKGFFRRT IQKNLHPTYS CKYDSCCVID 
       110        120        130        140        150
KITRNQCQLC RFKKCIAVGM AMDLVLDDSK RVAKRKLIEQ NRERRRKEEM 
       160        170        180        190        200
IRSLQQRPEP TPEEWDLIHV ATEAHRSTNA QGSHWKQRRK FLPDDIGQSP 
       210        220        230        240        250
IVSMPDGDKV DLEAFSEFTK IITPAITRVV DFAKKLPMFS ELPCEDQIIL 
       260        270        280        290        300
LKGCCMEIMS LRAAVRYDPE SDTLTLSGEM AVKREQLKNG GLGVVSDAIF 
       310        320        330        340        350
ELGKSLSAFN LDDTEVALLQ AVLLMSTDRS GLLCVDKIEK SQEAYLLAFE 
       360        370        380        390        400
HYVNHRKHNI PHFWPKLLMK EREVQSSILY KGAAAEGRPG GSLGVHPEGQ 
       410        420        430        440        450
QLLGMHVVQG PQVRQLEQQL GEAGSLRGPV LQHQSPKSPQ QRLLELLHRS 
       460        470        480        490 
GILHSRAVCG EDDSSEASSL SSSSDTEDTE VCEDQAGKAA SP         

        10         20         30         40         50
MEQKPSKVEC GSDPEENSAR SPDGKRKRKN GQCPLKSSMS GYIPSYLDKD 
        60         70         80         90        100
EQCVVCGDKA TGYHYRCITC EGCKGFFRRT IQKNLHPTYS CKYDSCCVID 
       110        120        130        140        150
KITRNQCQLC RFKKCIAVGM AMDLVLDDSK RVAKRKLIEQ NRERRRKEEM 
       160        170        180        190        200
IRSLQQRPEP TPEEWDLIHV ATEAHRSTNA QGSHWKQRRK FLPDDIGQSP 
       210        220        230        240        250
IVSMPDGDKV DLEAFSEFTK IITPAITRVV DFAKKLPMFS ELPCEDQIIL 
       260        270        280        290        300
LKGCCMEIMS LRAAVRYDPE SDTLTLSGEM AVKREQLKNG GLGVVSDAIF 
       310        320        330        340        350
ELGKSLSAFN LDDTEVALLQ AVLLMSTDRS GLLCVDKIEK SQEAYLLAFE 
       360        370        380        390        400
HYVNHRKHNI PHFWPKLLMK VTDLRMIGAC HASRFLHMKV ECPTELFPPL 
       410
FLEVFEDQEV                                             

        10         20         30         40         50
MEQKPSKVEC GSDPEENSAR SPDGKRKRKN GQCPLKSSMS GYIPSYLDKD 
        60         70         80         90        100
EQCVVCGDKA TGYHYRCITC EGCKGFFRRT IQKNLHPTYS CKYDSCCVID 
       110        120        130        140        150
KITRNQCQLC RFKKCIAVGM AMDLVLDDSK RVAKRKLIEQ NRERRRKEEM 
       160        170        180        190        200
IRSLQQRPEP TPEEWDLIHV ATEAHRSTNA QGSHWKQRRK FLPDDIGQSP 
       210        220        230        240        250
IVSMPDGDKV DLEAFSEFTK IITPAITRVV DFAKKLPMFS ELPCEDQIIL 
       260        270        280        290        300
LKGCCMEIMS LRAAVRYDPE SDTLTLSGEM AVKREQLKNG GLGVVSDAIF 
       310        320        330        340        350
ELGKSLSAFN LDDTEVALLQ AVLLMSTDRS GLLCVDKIEK SQEAYLLAFE 
       360        370        380        390        400
HYVNHRKHNI PHFWPKLLMK GPQVRQLEQQ LGEAGSLRGP VLQHQSPKSP 
       410        420        430        440        450
QQRLLELLHR SGILHSRAVC GEDDSSEASS LSSSSDTEDT EVCEDQAGKA 

ASP                                                    

        10         20         30         40         50
MEQKPSKVEC GSDPEENSAR SPDGKRKRKN GQCPLKSSMS GYIPSYLDKD 
        60         70         80         90        100
EQCVVCGDKA TGYHYRCITC EGCKGFFRRT IQKNLHPTYS CKYDSCCVID 
       110        120        130        140        150
KITRNQCQLC RFKKCIAVGM GTSPQSPIVS MPDGDKVDLE AFSEFTKIIT 
       160        170        180        190        200
PAITRVVDFA KKLPMFSELP CEDQIILLKG CCMEIMSLRA AVRYDPESDT 
       210        220        230        240        250
LTLSGEMAVK REQLKNGGLG VVSDAIFELG KSLSAFNLDD TEVALLQAVL 
       260        270        280        290        300
LMSTDRSGLL CVDKIEKSQE AYLLAFEHYV NHRKHNIPHF WPKLLMKVTD 
       310        320        330 
LRMIGACHAS RFLHMKVECP TELFPPLFLE VFEDQEV               

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautionⁱ

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityⁱ

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. SIMILARITY comments
   Index of protein domains and families
2. MGD cross-references
   Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot