UniProtKB - P63058 (THA_MOUSE)
Thyroid hormone receptor alpha
Thra
Functioni
Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine. Isoform Alpha-deltaE6 does not bind DNA, inhibits the activity of isoform Alpha-1, and stimulates myoblast differentiation.
1 PublicationSites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 53 | Zinc 1By similarity | 1 | |
Metal bindingi | 56 | Zinc 1By similarity | 1 | |
Metal bindingi | 70 | Zinc 1By similarity | 1 | |
Metal bindingi | 73 | Zinc 1By similarity | 1 | |
Metal bindingi | 91 | Zinc 2By similarity | 1 | |
Metal bindingi | 97 | Zinc 2By similarity | 1 | |
Metal bindingi | 107 | Zinc 2By similarity | 1 | |
Metal bindingi | 110 | Zinc 2By similarity | 1 | |
Binding sitei | 228 | 3,3',5-triiodo-L-thyronineBy similarity | 1 | |
Binding sitei | 277 | 3,3',5-triiodo-L-thyronine; via amide nitrogenBy similarity | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 53 – 127 | Nuclear receptorPROSITE-ProRule annotationAdd BLAST | 75 | |
Zinc fingeri | 53 – 73 | NR C4-typePROSITE-ProRule annotationAdd BLAST | 21 | |
Zinc fingeri | 91 – 115 | NR C4-typePROSITE-ProRule annotationAdd BLAST | 25 |
GO - Molecular functioni
- chromatin DNA binding Source: MGI
- DNA-binding transcription factor activity Source: MGI
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: MGI
- intronic transcription regulatory region sequence-specific DNA binding Source: MGI
- nuclear receptor activity Source: MGI
- protein-containing complex binding Source: MGI
- protein domain specific binding Source: MGI
- protein homodimerization activity Source: MGI
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
- sequence-specific DNA binding Source: MGI
- single-stranded RNA binding Source: MGI
- TBP-class protein binding Source: MGI
- thyroid hormone binding Source: UniProtKB
- transcription cis-regulatory region binding Source: ParkinsonsUK-UCL
- zinc ion binding Source: InterPro
GO - Biological processi
- animal organ morphogenesis Source: MGI
- cartilage condensation Source: MGI
- cell differentiation Source: GO_Central
- erythrocyte differentiation Source: MGI
- female courtship behavior Source: MGI
- hormone-mediated signaling pathway Source: MGI
- learning or memory Source: MGI
- mRNA transcription by RNA polymerase II Source: ComplexPortal
- negative regulation of DNA-binding transcription factor activity Source: MGI
- negative regulation of DNA-templated transcription, initiation Source: MGI
- negative regulation of RNA polymerase II transcription preinitiation complex assembly Source: MGI
- negative regulation of transcription, DNA-templated Source: MGI
- negative regulation of transcription by RNA polymerase II Source: GO_Central
- ossification Source: MGI
- positive regulation of canonical Wnt signaling pathway Source: ParkinsonsUK-UCL
- positive regulation of cold-induced thermogenesis Source: YuBioLab
- positive regulation of female receptivity Source: MGI
- positive regulation of thyroid hormone mediated signaling pathway Source: ComplexPortal
- positive regulation of transcription by RNA polymerase II Source: ComplexPortal
- regulation of heart contraction Source: MGI
- regulation of lipid catabolic process Source: MGI
- regulation of myeloid cell apoptotic process Source: MGI
- regulation of thyroid hormone mediated signaling pathway Source: MGI
- regulation of transcription by RNA polymerase II Source: MGI
- response to cold Source: MGI
- thyroid gland development Source: MGI
- thyroid hormone mediated signaling pathway Source: GO_Central
- transcription by RNA polymerase II Source: MGI
- type I pneumocyte differentiation Source: MGI
Keywordsi
Molecular function | DNA-binding, Receptor |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
Reactomei | R-MMU-383280, Nuclear Receptor transcription pathway R-MMU-4090294, SUMOylation of intracellular receptors |
Names & Taxonomyi
Protein namesi | Recommended name: Thyroid hormone receptor alphaAlternative name(s): Nuclear receptor subfamily 1 group A member 1 c-erbA-1 c-erbA-alpha |
Gene namesi | Name:Thra Synonyms:C-erba-alpha, Nr1a1 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:98742, Thra |
VEuPathDBi | HostDB:ENSMUSG00000058756 |
Subcellular locationi
Nucleus
Cytosol
- cytosol Source: MGI
Mitochondrion
- mitochondrion Source: MGI
Nucleus
- nucleus Source: MGI
- RNA polymerase II transcription regulator complex Source: ComplexPortal
Other locations
- cytoplasm Source: MGI
Keywords - Cellular componenti
Cytoplasm, NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000053425 | 1 – 492 | Thyroid hormone receptor alphaAdd BLAST | 492 |
Proteomic databases
MaxQBi | P63058 |
PaxDbi | P63058 |
PRIDEi | P63058 |
ProteomicsDBi | 262770 262771 [P63058-2] 262772 [P63058-3] 262773 [P63058-4] |
PTM databases
iPTMneti | P63058 |
PhosphoSitePlusi | P63058 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSMUSG00000058756, Expressed in dentate gyrus of hippocampal formation granule cell and 319 other tissues |
ExpressionAtlasi | P63058, baseline and differential |
Genevisiblei | P63058, MM |
Interactioni
Subunit structurei
Binds DNA as a dimer; homodimer and heterodimer with RXRB.
Interacts with NCOA3 and NCOA6 coactivators, leading to a strong increase of transcription of target genes. Probably interacts with SFPQ.
Interacts with AKAP13.
Interacts with C1D.
Interacts with TP53INP2.
Interacts with PER2. Isoform alpha-2 and isoform alpha-1 interact with TACC1, but the interaction with alpha-1 is much weaker. The interaction with isoform alpha-1, but not alpha-2, is decreased in the presence of thyroid hormone T3 (PubMed:20078863).
4 PublicationsBinary interactionsi
P63058
With | #Exp. | IntAct |
---|---|---|
Cacnb4 [D4A055] from Rattus norvegicus. | 2 | EBI-6935292,EBI-8028403 |
GO - Molecular functioni
- protein domain specific binding Source: MGI
- protein homodimerization activity Source: MGI
- TBP-class protein binding Source: MGI
Protein-protein interaction databases
BioGRIDi | 204183, 9 interactors |
ComplexPortali | CPX-713, RXRalpha-TRalpha nuclear hormone receptor complex [P63058-2] |
DIPi | DIP-43752N |
IntActi | P63058, 5 interactors |
MINTi | P63058 |
STRINGi | 10090.ENSMUSP00000099428 |
Miscellaneous databases
RNActi | P63058, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 163 – 407 | NR LBDPROSITE-ProRule annotationAdd BLAST | 245 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 52 | ModulatingAdd BLAST | 52 | |
Regioni | 1 – 33 | DisorderedSequence analysisAdd BLAST | 33 | |
Regioni | 457 – 492 | DisorderedSequence analysisAdd BLAST | 36 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1 – 30 | Basic and acidic residuesSequence analysisAdd BLAST | 30 | |
Compositional biasi | 462 – 476 | Polar residuesSequence analysisAdd BLAST | 15 |
Domaini
Sequence similaritiesi
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 53 – 73 | NR C4-typePROSITE-ProRule annotationAdd BLAST | 21 | |
Zinc fingeri | 91 – 115 | NR C4-typePROSITE-ProRule annotationAdd BLAST | 25 |
Keywords - Domaini
Zinc-fingerPhylogenomic databases
eggNOGi | KOG3575, Eukaryota |
GeneTreei | ENSGT00940000157917 |
HOGENOMi | CLU_007368_18_0_1 |
InParanoidi | P63058 |
OMAi | VAEWDLI |
OrthoDBi | 1112927at2759 |
PhylomeDBi | P63058 |
TreeFami | TF328382 |
Family and domain databases
Gene3Di | 1.10.565.10, 1 hit 3.30.50.10, 1 hit |
InterProi | View protein in InterPro IPR035500, NHR-like_dom_sf IPR000536, Nucl_hrmn_rcpt_lig-bd IPR001723, Nuclear_hrmn_rcpt IPR001728, ThyrH_rcpt IPR001628, Znf_hrmn_rcpt IPR013088, Znf_NHR/GATA |
Pfami | View protein in Pfam PF00104, Hormone_recep, 1 hit PF00105, zf-C4, 1 hit |
PRINTSi | PR00398, STRDHORMONER PR00047, STROIDFINGER PR00546, THYROIDHORMR |
SMARTi | View protein in SMART SM00430, HOLI, 1 hit SM00399, ZnF_C4, 1 hit |
SUPFAMi | SSF48508, SSF48508, 1 hit |
PROSITEi | View protein in PROSITE PS51843, NR_LBD, 1 hit PS00031, NUCLEAR_REC_DBD_1, 1 hit PS51030, NUCLEAR_REC_DBD_2, 1 hit |
s (4+)i Sequence
Sequence statusi: Complete.
This entry describes 4 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 4 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MEQKPSKVEC GSDPEENSAR SPDGKRKRKN GQCPLKSSMS GYIPSYLDKD
60 70 80 90 100
EQCVVCGDKA TGYHYRCITC EGCKGFFRRT IQKNLHPTYS CKYDSCCVID
110 120 130 140 150
KITRNQCQLC RFKKCIAVGM AMDLVLDDSK RVAKRKLIEQ NRERRRKEEM
160 170 180 190 200
IRSLQQRPEP TPEEWDLIHV ATEAHRSTNA QGSHWKQRRK FLPDDIGQSP
210 220 230 240 250
IVSMPDGDKV DLEAFSEFTK IITPAITRVV DFAKKLPMFS ELPCEDQIIL
260 270 280 290 300
LKGCCMEIMS LRAAVRYDPE SDTLTLSGEM AVKREQLKNG GLGVVSDAIF
310 320 330 340 350
ELGKSLSAFN LDDTEVALLQ AVLLMSTDRS GLLCVDKIEK SQEAYLLAFE
360 370 380 390 400
HYVNHRKHNI PHFWPKLLMK EREVQSSILY KGAAAEGRPG GSLGVHPEGQ
410 420 430 440 450
QLLGMHVVQG PQVRQLEQQL GEAGSLRGPV LQHQSPKSPQ QRLLELLHRS
460 470 480 490
GILHSRAVCG EDDSSEASSL SSSSDTEDTE VCEDQAGKAA SP
The sequence of this isoform differs from the canonical sequence as follows:
371-492: EREVQSSILY...EDQAGKAASP → VTDLRMIGAC...FLEVFEDQEV
The sequence of this isoform differs from the canonical sequence as follows:
371-409: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
121-197: AMDLVLDDSK...RRKFLPDDIG → GTSP
371-492: EREVQSSILY...EDQAGKAASP → VTDLRMIGAC...FLEVFEDQEV
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A0R4J1R8 | A0A0R4J1R8_MOUSE | Thyroid hormone receptor alpha | Thra | 413 | Annotation score: | ||
A3KFN7 | A3KFN7_MOUSE | Thyroid hormone receptor alpha | Thra | 64 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 106 | Q → H in CAA36241 (PubMed:2349106).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_038640 | 121 – 197 | AMDLV…PDDIG → GTSP in isoform Alpha-deltaE6. CuratedAdd BLAST | 77 | |
Alternative sequenceiVSP_003624 | 371 – 492 | EREVQ…KAASP → VTDLRMIGACHASRFLHMKV ECPTELFPPLFLEVFEDQEV in isoform Alpha-1 and isoform Alpha-deltaE6. 3 PublicationsAdd BLAST | 122 | |
Alternative sequenceiVSP_003625 | 371 – 409 | Missing in isoform Alpha-3. 1 PublicationAdd BLAST | 39 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X07750 mRNA Translation: CAA30575.1 X07751 mRNA Translation: CAA30576.1 X07752 mRNA Translation: CAA30577.1 X51983 mRNA Translation: CAA36241.1 AK078233 mRNA Translation: BAC37186.1 AL590963 Genomic DNA Translation: CAM46188.1 Sequence problems. AL590963 Genomic DNA Translation: CAM46189.1 AL590963 Genomic DNA Translation: CAM46190.1 CH466556 Genomic DNA Translation: EDL16164.1 CH466556 Genomic DNA Translation: EDL16165.1 BC046795 mRNA Translation: AAH46795.1 |
CCDSi | CCDS25362.1 [P63058-2] CCDS83893.1 |
PIRi | S14416 S14417 S14418 S14690, QRMSA1 |
RefSeqi | NP_001300912.1, NM_001313983.1 [P63058-1] NP_835161.1, NM_178060.4 [P63058-2] |
Genome annotation databases
Ensembli | ENSMUST00000064187; ENSMUSP00000068281; ENSMUSG00000058756 [P63058-1] ENSMUST00000103139; ENSMUSP00000099428; ENSMUSG00000058756 [P63058-2] |
GeneIDi | 21833 |
KEGGi | mmu:21833 |
UCSCi | uc007lhe.1, mouse [P63058-2] uc007lhf.1, mouse uc007lhg.1, mouse [P63058-3] |
Keywords - Coding sequence diversityi
Alternative splicing, RNA editingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X07750 mRNA Translation: CAA30575.1 X07751 mRNA Translation: CAA30576.1 X07752 mRNA Translation: CAA30577.1 X51983 mRNA Translation: CAA36241.1 AK078233 mRNA Translation: BAC37186.1 AL590963 Genomic DNA Translation: CAM46188.1 Sequence problems. AL590963 Genomic DNA Translation: CAM46189.1 AL590963 Genomic DNA Translation: CAM46190.1 CH466556 Genomic DNA Translation: EDL16164.1 CH466556 Genomic DNA Translation: EDL16165.1 BC046795 mRNA Translation: AAH46795.1 |
CCDSi | CCDS25362.1 [P63058-2] CCDS83893.1 |
PIRi | S14416 S14417 S14418 S14690, QRMSA1 |
RefSeqi | NP_001300912.1, NM_001313983.1 [P63058-1] NP_835161.1, NM_178060.4 [P63058-2] |
3D structure databases
SMRi | P63058 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 204183, 9 interactors |
ComplexPortali | CPX-713, RXRalpha-TRalpha nuclear hormone receptor complex [P63058-2] |
DIPi | DIP-43752N |
IntActi | P63058, 5 interactors |
MINTi | P63058 |
STRINGi | 10090.ENSMUSP00000099428 |
PTM databases
iPTMneti | P63058 |
PhosphoSitePlusi | P63058 |
Proteomic databases
MaxQBi | P63058 |
PaxDbi | P63058 |
PRIDEi | P63058 |
ProteomicsDBi | 262770 262771 [P63058-2] 262772 [P63058-3] 262773 [P63058-4] |
Protocols and materials databases
ABCDi | P63058, 1 sequenced antibody |
Antibodypediai | 1300, 643 antibodies from 44 providers |
DNASUi | 21833 |
Genome annotation databases
Ensembli | ENSMUST00000064187; ENSMUSP00000068281; ENSMUSG00000058756 [P63058-1] ENSMUST00000103139; ENSMUSP00000099428; ENSMUSG00000058756 [P63058-2] |
GeneIDi | 21833 |
KEGGi | mmu:21833 |
UCSCi | uc007lhe.1, mouse [P63058-2] uc007lhf.1, mouse uc007lhg.1, mouse [P63058-3] |
Organism-specific databases
CTDi | 7067 |
MGIi | MGI:98742, Thra |
VEuPathDBi | HostDB:ENSMUSG00000058756 |
Phylogenomic databases
eggNOGi | KOG3575, Eukaryota |
GeneTreei | ENSGT00940000157917 |
HOGENOMi | CLU_007368_18_0_1 |
InParanoidi | P63058 |
OMAi | VAEWDLI |
OrthoDBi | 1112927at2759 |
PhylomeDBi | P63058 |
TreeFami | TF328382 |
Enzyme and pathway databases
Reactomei | R-MMU-383280, Nuclear Receptor transcription pathway R-MMU-4090294, SUMOylation of intracellular receptors |
Miscellaneous databases
BioGRID-ORCSi | 21833, 2 hits in 65 CRISPR screens |
PROi | PR:P63058 |
RNActi | P63058, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000058756, Expressed in dentate gyrus of hippocampal formation granule cell and 319 other tissues |
ExpressionAtlasi | P63058, baseline and differential |
Genevisiblei | P63058, MM |
Family and domain databases
Gene3Di | 1.10.565.10, 1 hit 3.30.50.10, 1 hit |
InterProi | View protein in InterPro IPR035500, NHR-like_dom_sf IPR000536, Nucl_hrmn_rcpt_lig-bd IPR001723, Nuclear_hrmn_rcpt IPR001728, ThyrH_rcpt IPR001628, Znf_hrmn_rcpt IPR013088, Znf_NHR/GATA |
Pfami | View protein in Pfam PF00104, Hormone_recep, 1 hit PF00105, zf-C4, 1 hit |
PRINTSi | PR00398, STRDHORMONER PR00047, STROIDFINGER PR00546, THYROIDHORMR |
SMARTi | View protein in SMART SM00430, HOLI, 1 hit SM00399, ZnF_C4, 1 hit |
SUPFAMi | SSF48508, SSF48508, 1 hit |
PROSITEi | View protein in PROSITE PS51843, NR_LBD, 1 hit PS00031, NUCLEAR_REC_DBD_1, 1 hit PS51030, NUCLEAR_REC_DBD_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | THA_MOUSE | |
Accessioni | P63058Primary (citable) accession number: P63058 Secondary accession number(s): A3KFN4 Q99146 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 13, 2004 |
Last sequence update: | January 19, 2010 | |
Last modified: | February 23, 2022 | |
This is version 167 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families