UniProtKB - P63046 (ST4A1_MOUSE)
Protein
Sulfotransferase 4A1
Gene
Sult4a1
Organism
Mus musculus (Mouse)
Status
Functioni
Atypical sulfotransferase family member with very low affinity for 3'-phospho-5'-adenylyl sulfate (PAPS) and very low catalytic activity towards L-triiodothyronine, thyroxine, estrone, p-nitrophenol, 2-naphthylamine, and 2-beta-naphthol. May have a role in the metabolism of drugs and neurotransmitters in the CNS.1 Publication
GO - Molecular functioni
- identical protein binding Source: MGI
- sulfotransferase activity Source: MGI
GO - Biological processi
- steroid metabolic process Source: UniProtKB-KW
- sulfur compound metabolic process Source: MGI
Keywordsi
Molecular function | Transferase |
Biological process | Lipid metabolism, Steroid metabolism |
Enzyme and pathway databases
Reactomei | R-MMU-156584, Cytosolic sulfonation of small molecules |
Names & Taxonomyi
Protein namesi | Recommended name: Sulfotransferase 4A1 (EC:2.8.2.-)Short name: ST4A1 Alternative name(s): Brain sulfotransferase-like protein Short name: mBR-STL Nervous system sulfotransferase Short name: NST |
Gene namesi | Name:Sult4a1 Synonyms:Sultx3 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1888971, Sult4a1 |
Subcellular locationi
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000085168 | 1 – 284 | Sulfotransferase 4A1Add BLAST | 284 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 8 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 11 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 205 | PhosphothreonineBy similarity | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
MaxQBi | P63046 |
PaxDbi | P63046 |
PeptideAtlasi | P63046 |
PRIDEi | P63046 |
PTM databases
iPTMneti | P63046 |
PhosphoSitePlusi | P63046 |
Expressioni
Tissue specificityi
Expressed in brain, cerebellum and hypothalamus. Not detected in pancreas, liver, lung, intestine, kidney, uterus, adrenal gland, thymus, spleen, epididymis, testicle, and heart.1 Publication
Gene expression databases
Bgeei | ENSMUSG00000018865, Expressed in primary visual cortex and 159 other tissues |
Genevisiblei | P63046, MM |
Interactioni
GO - Molecular functioni
- identical protein binding Source: MGI
Protein-protein interaction databases
BioGRIDi | 205926, 3 interactors |
IntActi | P63046, 1 interactor |
MINTi | P63046 |
STRINGi | 10090.ENSMUSP00000080973 |
Miscellaneous databases
RNActi | P63046, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the sulfotransferase 1 family.Curated
Phylogenomic databases
eggNOGi | KOG1584, Eukaryota |
GeneTreei | ENSGT00940000158662 |
HOGENOMi | CLU_027239_1_1_1 |
InParanoidi | P63046 |
OMAi | MVESCHQ |
OrthoDBi | 780670at2759 |
PhylomeDBi | P63046 |
TreeFami | TF321745 |
Family and domain databases
InterProi | View protein in InterPro IPR027417, P-loop_NTPase IPR000863, Sulfotransferase_dom |
Pfami | View protein in Pfam PF00685, Sulfotransfer_1, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
s (2)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketIsoform 1 (identifier: P63046-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAESEAETPG TPGEFESKYF EFHGVRLPPF CRGKMEDIAD FPVRPSDVWI
60 70 80 90 100
VTYPKSGTSL LQEVVYLVSQ GADPDEIGLM NIDEQLPVLE YPQPGLDIIK
110 120 130 140 150
ELTSPRLIKS HLPYRFLPSD LHNGDSKVIY MARNPKDLVV SYYQFHRSLR
160 170 180 190 200
TMSYRGTFQE FCRRFMNDKL GYGSWFEHVQ EFWEHRMDAN VLFLKYEDMH
210 220 230 240 250
RDLVTMVEQL ARFLGVSCDK AQLESLIEHC HQLVDQCCNA EALPVGRGRV
260 270 280
GLWKDIFTVS MNEKFDLVYK QKMGKCDLTF DFYL
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 6 | A → R in BAB22522 (PubMed:16141072).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_006305 | 248 – 284 | GRVGL…FDFYL → AHCLFTQKIALRWRGCRGSG SRLHCLDLVHVTA in isoform 2. 1 PublicationAdd BLAST | 37 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF059257 mRNA Translation: AAC63999.1 AK003034 mRNA Translation: BAB22522.1 AK010293 mRNA Translation: BAB26829.1 AK159034 mRNA Translation: BAE34779.1 BC051132 mRNA Translation: AAH51132.1 BC054757 mRNA Translation: AAH54757.1 |
CCDSi | CCDS27708.1 CCDS88819.1 [P63046-2] |
RefSeqi | NP_038901.3, NM_013873.3 [P63046-1] XP_006521128.1, XM_006521065.3 |
Genome annotation databases
Ensembli | ENSMUST00000082365; ENSMUSP00000080973; ENSMUSG00000018865 [P63046-1] ENSMUST00000229826; ENSMUSP00000155695; ENSMUSG00000018865 [P63046-2] |
GeneIDi | 29859 |
KEGGi | mmu:29859 |
UCSCi | uc007xbs.1, mouse uc007xbt.1, mouse [P63046-2] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF059257 mRNA Translation: AAC63999.1 AK003034 mRNA Translation: BAB22522.1 AK010293 mRNA Translation: BAB26829.1 AK159034 mRNA Translation: BAE34779.1 BC051132 mRNA Translation: AAH51132.1 BC054757 mRNA Translation: AAH54757.1 |
CCDSi | CCDS27708.1 CCDS88819.1 [P63046-2] |
RefSeqi | NP_038901.3, NM_013873.3 [P63046-1] XP_006521128.1, XM_006521065.3 |
3D structure databases
SMRi | P63046 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 205926, 3 interactors |
IntActi | P63046, 1 interactor |
MINTi | P63046 |
STRINGi | 10090.ENSMUSP00000080973 |
PTM databases
iPTMneti | P63046 |
PhosphoSitePlusi | P63046 |
Proteomic databases
MaxQBi | P63046 |
PaxDbi | P63046 |
PeptideAtlasi | P63046 |
PRIDEi | P63046 |
Protocols and materials databases
Antibodypediai | 304, 163 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000082365; ENSMUSP00000080973; ENSMUSG00000018865 [P63046-1] ENSMUST00000229826; ENSMUSP00000155695; ENSMUSG00000018865 [P63046-2] |
GeneIDi | 29859 |
KEGGi | mmu:29859 |
UCSCi | uc007xbs.1, mouse uc007xbt.1, mouse [P63046-2] |
Organism-specific databases
CTDi | 25830 |
MGIi | MGI:1888971, Sult4a1 |
Phylogenomic databases
eggNOGi | KOG1584, Eukaryota |
GeneTreei | ENSGT00940000158662 |
HOGENOMi | CLU_027239_1_1_1 |
InParanoidi | P63046 |
OMAi | MVESCHQ |
OrthoDBi | 780670at2759 |
PhylomeDBi | P63046 |
TreeFami | TF321745 |
Enzyme and pathway databases
Reactomei | R-MMU-156584, Cytosolic sulfonation of small molecules |
Miscellaneous databases
BioGRID-ORCSi | 29859, 1 hit in 17 CRISPR screens |
ChiTaRSi | Sult4a1, mouse |
PROi | PR:P63046 |
RNActi | P63046, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000018865, Expressed in primary visual cortex and 159 other tissues |
Genevisiblei | P63046, MM |
Family and domain databases
InterProi | View protein in InterPro IPR027417, P-loop_NTPase IPR000863, Sulfotransferase_dom |
Pfami | View protein in Pfam PF00685, Sulfotransfer_1, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ST4A1_MOUSE | |
Accessioni | P63046Primary (citable) accession number: P63046 Secondary accession number(s): O88872 Q9DC97 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 31, 2004 |
Last sequence update: | August 31, 2004 | |
Last modified: | December 2, 2020 | |
This is version 124 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families