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Protein

Stathmin-4

Gene

Stmn4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Exhibits microtubule-destabilizing activity.By similarity

GO - Molecular functioni

  • tubulin binding Source: GO_Central

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Stathmin-4
Alternative name(s):
Stathmin-like protein B3
Short name:
RB3
Gene namesi
Name:Stmn4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:1931224 Stmn4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Golgi apparatus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001824071 – 189Stathmin-4Add BLAST189

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi20S-palmitoyl cysteineBy similarity1
Lipidationi22S-palmitoyl cysteineBy similarity1
Modified residuei90PhosphoserineBy similarity1

Keywords - PTMi

Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

MaxQBiP63042
PaxDbiP63042
PRIDEiP63042

PTM databases

iPTMnetiP63042
PhosphoSitePlusiP63042

Expressioni

Gene expression databases

BgeeiENSMUSG00000022044 Expressed in 180 organ(s), highest expression level in brain
CleanExiMM_STMN4
ExpressionAtlasiP63042 baseline and differential
GenevisibleiP63042 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000074113

Structurei

3D structure databases

ProteinModelPortaliP63042
SMRiP63042
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini48 – 189SLDPROSITE-ProRule annotationAdd BLAST142

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili90 – 189Sequence analysisAdd BLAST100

Sequence similaritiesi

Belongs to the stathmin family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IJEC Eukaryota
ENOG410ZIRZ LUCA
GeneTreeiENSGT00390000003691
HOGENOMiHOG000013197
HOVERGENiHBG054037
InParanoidiP63042
OMAiTVDLTWC
PhylomeDBiP63042
TreeFamiTF326935

Family and domain databases

InterProiView protein in InterPro
IPR028834 Stathmin-4
IPR030514 Stathmin_CS
IPR000956 Stathmin_fam
IPR036002 Stathmin_sf
PANTHERiPTHR10104 PTHR10104, 2 hits
PTHR10104:SF6 PTHR10104:SF6, 2 hits
PfamiView protein in Pfam
PF00836 Stathmin, 1 hit
PIRSFiPIRSF002285 Stathmin, 1 hit
PRINTSiPR00345 STATHMIN
SUPFAMiSSF101494 SSF101494, 1 hit
PROSITEiView protein in PROSITE
PS00563 STATHMIN_1, 1 hit
PS01041 STATHMIN_2, 1 hit
PS51663 STATHMIN_3, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

P63042-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTLAAYKEKM KELPLVSLFC SCFLSDPLNK SSYKYEADTV DLNWCVISDM
60 70 80 90 100
EVIELNKCTS GQSFEVILKP PSFDGVPEFN ASLPRRRDPS LEEIQKKLEA
110 120 130 140 150
AEERRKYQEA ELLKHLAEKR EHEREVIQKA IEENNNFIKM AKEKLAQKME
160 170 180
SNKENREAHL AAMLERLQEK DKHAEEVRKN KELKEEASR
Length:189
Mass (Da):22,087
Last modified:August 31, 2004 - v1
Checksum:i4D61AAE5E8131551
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q05DI3Q05DI3_MOUSE
Stathmin
Stmn4
176Annotation score:
D3Z4C2D3Z4C2_MOUSE
Stathmin-4
Stmn4
203Annotation score:
G3X9Z6G3X9Z6_MOUSE
Stathmin-4
Stmn4 mCG_2505
216Annotation score:
D3Z6P6D3Z6P6_MOUSE
Stathmin-4
Stmn4
52Annotation score:
D3YUL4D3YUL4_MOUSE
Stathmin-4
Stmn4
81Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF105222 mRNA Translation: AAC96328.1
BC046752 mRNA Translation: AAH46752.1
CCDSiCCDS27222.1
RefSeqiNP_001297451.1, NM_001310522.1
NP_001297452.1, NM_001310523.1
NP_062649.1, NM_019675.3
UniGeneiMm.35474

Genome annotation databases

EnsembliENSMUST00000074523; ENSMUSP00000074113; ENSMUSG00000022044
GeneIDi56471
KEGGimmu:56471
UCSCiuc007ukf.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF105222 mRNA Translation: AAC96328.1
BC046752 mRNA Translation: AAH46752.1
CCDSiCCDS27222.1
RefSeqiNP_001297451.1, NM_001310522.1
NP_001297452.1, NM_001310523.1
NP_062649.1, NM_019675.3
UniGeneiMm.35474

3D structure databases

ProteinModelPortaliP63042
SMRiP63042
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000074113

PTM databases

iPTMnetiP63042
PhosphoSitePlusiP63042

Proteomic databases

MaxQBiP63042
PaxDbiP63042
PRIDEiP63042

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000074523; ENSMUSP00000074113; ENSMUSG00000022044
GeneIDi56471
KEGGimmu:56471
UCSCiuc007ukf.1 mouse

Organism-specific databases

CTDi81551
MGIiMGI:1931224 Stmn4

Phylogenomic databases

eggNOGiENOG410IJEC Eukaryota
ENOG410ZIRZ LUCA
GeneTreeiENSGT00390000003691
HOGENOMiHOG000013197
HOVERGENiHBG054037
InParanoidiP63042
OMAiTVDLTWC
PhylomeDBiP63042
TreeFamiTF326935

Miscellaneous databases

PROiPR:P63042
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000022044 Expressed in 180 organ(s), highest expression level in brain
CleanExiMM_STMN4
ExpressionAtlasiP63042 baseline and differential
GenevisibleiP63042 MM

Family and domain databases

InterProiView protein in InterPro
IPR028834 Stathmin-4
IPR030514 Stathmin_CS
IPR000956 Stathmin_fam
IPR036002 Stathmin_sf
PANTHERiPTHR10104 PTHR10104, 2 hits
PTHR10104:SF6 PTHR10104:SF6, 2 hits
PfamiView protein in Pfam
PF00836 Stathmin, 1 hit
PIRSFiPIRSF002285 Stathmin, 1 hit
PRINTSiPR00345 STATHMIN
SUPFAMiSSF101494 SSF101494, 1 hit
PROSITEiView protein in PROSITE
PS00563 STATHMIN_1, 1 hit
PS01041 STATHMIN_2, 1 hit
PS51663 STATHMIN_3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSTMN4_MOUSE
AccessioniPrimary (citable) accession number: P63042
Secondary accession number(s): O35414, O35415, O35416
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: August 31, 2004
Last modified: November 7, 2018
This is version 96 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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