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Protein

Complexin-1

Gene

Cplx1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Positively regulates a late step in exocytosis of various cytoplasmic vesicles, such as synaptic vesicles and other secretory vesicles. Organizes the SNAREs into a cross-linked zigzag topology that, when interposed between the vesicle and plasma membranes, is incompatible with fusion, thereby preventing SNAREs from releasing neurotransmitters until an action potential arrives at the synapse. Also involved in glucose-induced secretion of insulin by pancreatic beta-cells. Essential for motor behavior.By similarity

GO - Molecular functioni

  • neurotransmitter transporter activity Source: Ensembl
  • SNARE binding Source: RGD
  • syntaxin-1 binding Source: MGI

GO - Biological processi

  • insulin secretion Source: Ensembl
  • synaptic vesicle exocytosis Source: RGD

Keywordsi

Biological processExocytosis, Neurotransmitter transport, Transport

Enzyme and pathway databases

ReactomeiR-RNO-181429 Serotonin Neurotransmitter Release Cycle
R-RNO-181430 Norepinephrine Neurotransmitter Release Cycle
R-RNO-210500 Glutamate Neurotransmitter Release Cycle
R-RNO-212676 Dopamine Neurotransmitter Release Cycle
R-RNO-264642 Acetylcholine Neurotransmitter Release Cycle
R-RNO-888590 GABA synthesis, release, reuptake and degradation

Names & Taxonomyi

Protein namesi
Recommended name:
Complexin-1
Alternative name(s):
Complexin I
Short name:
CPX I
Synaphin-2
Gene namesi
Name:Cplx1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 14

Organism-specific databases

RGDi70944 Cplx1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001448721 – 134Complexin-1Add BLAST134

Proteomic databases

PaxDbiP63041
PRIDEiP63041

PTM databases

iPTMnetiP63041
PhosphoSitePlusiP63041

Expressioni

Tissue specificityi

Nervous system. Strongly expressed in brain, where it is predominant in neurons from cerebral cortex and thalamus (at protein level).4 Publications

Gene expression databases

BgeeiENSRNOG00000000060
GenevisibleiP63041 RN

Interactioni

Subunit structurei

Binds to the SNARE core complex containing SNAP25, VAMP2 and STX1A.5 Publications

GO - Molecular functioni

  • SNARE binding Source: RGD
  • syntaxin-1 binding Source: MGI

Protein-protein interaction databases

CORUMiP63041
DIPiDIP-35502N
IntActiP63041, 5 interactors
STRINGi10116.ENSRNOP00000058432

Structurei

Secondary structure

1134
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi52 – 70Combined sources19

3D structure databases

ProteinModelPortaliP63041
SMRiP63041
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP63041

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni48 – 70Interaction with the SNARE complexAdd BLAST23

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili29 – 64Sequence analysisAdd BLAST36

Sequence similaritiesi

Belongs to the complexin/synaphin family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IWGS Eukaryota
ENOG4111MX0 LUCA
GeneTreeiENSGT00490000043416
HOGENOMiHOG000017716
HOVERGENiHBG062792
InParanoidiP63041
KOiK15294
OMAiTVMKFIP
PhylomeDBiP63041
TreeFamiTF315172

Family and domain databases

InterProiView protein in InterPro
IPR008849 Synaphin
PANTHERiPTHR16705 PTHR16705, 1 hit
PfamiView protein in Pfam
PF05835 Synaphin, 1 hit

Sequencei

Sequence statusi: Complete.

P63041-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEFVMKQALG GATKDMGKML GGDEEKDPDA AKKEEERQEA LRQAEEERKA
60 70 80 90 100
KYAKMEAERE VMRQGIRDKY GIKKKEEREA EAQAAMEANS EGSLTRPKKA
110 120 130
IPPGCGDEPE EEDESILDTV IKYLPGPLQD MFKK
Length:134
Mass (Da):15,122
Last modified:August 31, 2004 - v1
Checksum:iBA1B6F074923A3A4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U35098 mRNA Translation: AAC52270.1
D70817 mRNA Translation: BAA11097.1
BC093605 mRNA Translation: AAH93605.1
PIRiA57233
RefSeqiNP_074055.1, NM_022864.3
XP_006250633.1, XM_006250571.3
UniGeneiRn.10133

Genome annotation databases

EnsembliENSRNOT00000061720; ENSRNOP00000058432; ENSRNOG00000000060
GeneIDi64832
KEGGirno:64832
UCSCiRGD:70944 rat

Similar proteinsi

Entry informationi

Entry nameiCPLX1_RAT
AccessioniPrimary (citable) accession number: P63041
Secondary accession number(s): O09057
, O09142, Q566D7, Q64276
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: August 31, 2004
Last modified: May 23, 2018
This is version 106 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

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