Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

GTP-binding protein Rhes

Gene

Rasd2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GTPase signaling protein that binds to and hydrolyzes GTP. Regulates signaling pathways involving G-proteins-coupled receptor and heterotrimeric proteins such as GNB1, GNB2 and GNB3. May be involved in selected striatal competencies, mainly locomotor activity and motor coordination.2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi26 – 33GTPBy similarity8
Nucleotide bindingi73 – 77GTPBy similarity5
Nucleotide bindingi140 – 143GTPBy similarity4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processBehavior
LigandGTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
GTP-binding protein Rhes
Alternative name(s):
Ras homolog enriched in striatum
Gene namesi
Name:Rasd2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1922391 Rasd2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

Shows behavioral abnormalities, displaying a gender-dependent increase in anxiety levels and a clear motor coordination deficit and a mild hyperactive phenotype. Mice are more sensitive to D2 receptor stimulation and have decreased body weight.3 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000827211 – 263GTP-binding protein RhesAdd BLAST263
PropeptideiPRO_0000281376264 – 266Removed in mature formBy similarity3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei263Cysteine methyl esterBy similarity1
Lipidationi263S-farnesyl cysteineBy similarity1

Post-translational modificationi

Farnesylated. Farnesylation is required for membrane targeting (By similarity).By similarity

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Proteomic databases

PaxDbiP63032
PRIDEiP63032

PTM databases

iPTMnetiP63032
PhosphoSitePlusiP63032

Expressioni

Tissue specificityi

Highly expressed in brain; prominently in the striatum and weakly in kidney, thyroid, lung, heart and testis. Not expressed in liver. Expressed in pancreatic cell lines and in a embryonic stem cell line.2 Publications

Developmental stagei

Expressed in the brain from E13.5.1 Publication

Inductioni

Down-regulated in hypothyroid conditions and up-regulated by glibenclamide.2 Publications

Gene expression databases

BgeeiENSMUSG00000034472 Expressed in 151 organ(s), highest expression level in dorsal striatum
CleanExiMM_RASD2
GenevisibleiP63032 MM

Interactioni

Subunit structurei

Monomer (Potential). Interacts with PIK3CA and UBE2I. Interacts with GNB1, GNB2 and GNB3 (By similarity).By similarityCurated

GO - Molecular functioni

Protein-protein interaction databases

BioGridi217250, 8 interactors
STRINGi10090.ENSMUSP00000118070

Structurei

3D structure databases

ProteinModelPortaliP63032
SMRiP63032
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni189 – 235Interaction with GNB1, GNB2 and GNB3By similarityAdd BLAST47

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi48 – 56Effector region9

Sequence similaritiesi

Belongs to the small GTPase superfamily. RasD family.Curated

Phylogenomic databases

eggNOGiKOG0395 Eukaryota
COG1100 LUCA
GeneTreeiENSGT00860000133678
HOVERGENiHBG009351
InParanoidiP63032
KOiK07844
OMAiDMDAYGM
OrthoDBiEOG091G0U2W
TreeFamiTF316238

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
IPR020849 Small_GTPase_Ras-type
PANTHERiPTHR24070 PTHR24070, 1 hit
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51421 RAS, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P63032-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MMKTLSSGNC TLNVPAKNSY RMVVLGASRV GKSSIVSRFL NGRFEDQYTP
60 70 80 90 100
TIEDFHRKVY NIHGDMYQLD ILDTSGNHPF PAMRRLSILT GDVFILVFSL
110 120 130 140 150
DSRESFDEVK RLQKQILEVK SCLKNKTKEA AELPMVICGN KNDHSELCRQ
160 170 180 190 200
VPAMEAELLV SGDENCAYFE VSAKKNTNVN EMFYVLFSMA KLPHEMSPAL
210 220 230 240 250
HHKISVQYGD AFHPRPFCMR RTKVAGAYGM VSPFARRPSV NSDLKYIKAK
260
VLREGQARER DKCSIQ
Length:266
Mass (Da):30,197
Last modified:August 31, 2004 - v1
Checksum:i21B00C11CADD40B0
GO

Sequence cautioni

The sequence AAH26377 differs from that shown. Contaminating sequence.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK015898 mRNA Translation: BAB30023.1
BC026377 mRNA Translation: AAH26377.1 Sequence problems.
CCDSiCCDS52602.1
RefSeqiNP_083458.1, NM_029182.1
UniGeneiMm.179267

Genome annotation databases

EnsembliENSMUST00000132133; ENSMUSP00000120717; ENSMUSG00000034472
ENSMUST00000139848; ENSMUSP00000118070; ENSMUSG00000034472
GeneIDi75141
KEGGimmu:75141
UCSCiuc009mhg.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK015898 mRNA Translation: BAB30023.1
BC026377 mRNA Translation: AAH26377.1 Sequence problems.
CCDSiCCDS52602.1
RefSeqiNP_083458.1, NM_029182.1
UniGeneiMm.179267

3D structure databases

ProteinModelPortaliP63032
SMRiP63032
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi217250, 8 interactors
STRINGi10090.ENSMUSP00000118070

PTM databases

iPTMnetiP63032
PhosphoSitePlusiP63032

Proteomic databases

PaxDbiP63032
PRIDEiP63032

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000132133; ENSMUSP00000120717; ENSMUSG00000034472
ENSMUST00000139848; ENSMUSP00000118070; ENSMUSG00000034472
GeneIDi75141
KEGGimmu:75141
UCSCiuc009mhg.2 mouse

Organism-specific databases

CTDi23551
MGIiMGI:1922391 Rasd2

Phylogenomic databases

eggNOGiKOG0395 Eukaryota
COG1100 LUCA
GeneTreeiENSGT00860000133678
HOVERGENiHBG009351
InParanoidiP63032
KOiK07844
OMAiDMDAYGM
OrthoDBiEOG091G0U2W
TreeFamiTF316238

Miscellaneous databases

PROiPR:P63032
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000034472 Expressed in 151 organ(s), highest expression level in dorsal striatum
CleanExiMM_RASD2
GenevisibleiP63032 MM

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
IPR020849 Small_GTPase_Ras-type
PANTHERiPTHR24070 PTHR24070, 1 hit
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51421 RAS, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRHES_MOUSE
AccessioniPrimary (citable) accession number: P63032
Secondary accession number(s): Q9WVD3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: August 31, 2004
Last modified: September 12, 2018
This is version 111 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again