UniProtKB - P63030 (MPC1_MOUSE)
Protein
Mitochondrial pyruvate carrier 1
Gene
Mpc1
Organism
Mus musculus (Mouse)
Status
Functioni
Mediates the uptake of pyruvate into mitochondria.1 Publication
GO - Biological processi
- cellular response to leukemia inhibitory factor Source: MGI
- mitochondrial acetyl-CoA biosynthetic process from pyruvate Source: MGI
- mitochondrial pyruvate transmembrane transport Source: MGI
Keywordsi
Biological process | Transport |
Names & Taxonomyi
Protein namesi | Recommended name: Mitochondrial pyruvate carrier 1Alternative name(s): Brain protein 44-like protein |
Gene namesi | Name:Mpc1 Synonyms:Brp44l |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1915240, Mpc1 |
Subcellular locationi
Mitochondrion
- Mitochondrion inner membrane 1 Publication; Multi-pass membrane protein 1 Publication
Mitochondrion
- integral component of mitochondrial inner membrane Source: GO_Central
- mitochondrial inner membrane Source: MGI
- mitochondrion Source: MGI
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 21 – 41 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 53 – 71 | HelicalSequence analysisAdd BLAST | 19 |
Keywords - Cellular componenti
Membrane, Mitochondrion, Mitochondrion inner membranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedBy similarity | |||
ChainiPRO_0000212798 | 2 – 109 | Mitochondrial pyruvate carrier 1Add BLAST | 108 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylalanineBy similarity | 1 | |
Modified residuei | 72 | N6-acetyllysineCombined sources | 1 |
Keywords - PTMi
AcetylationProteomic databases
jPOSTi | P63030 |
PaxDbi | P63030 |
PeptideAtlasi | P63030 |
PRIDEi | P63030 |
PTM databases
iPTMneti | P63030 |
PhosphoSitePlusi | P63030 |
SwissPalmi | P63030 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000023861, Expressed in heart and 77 other tissues |
ExpressionAtlasi | P63030, baseline and differential |
Genevisiblei | P63030, MM |
Interactioni
Subunit structurei
The functional 150 kDa pyruvate import complex is a heteromer of MPC1 and MPC2.
1 PublicationProtein-protein interaction databases
BioGRIDi | 207746, 1 interactor |
STRINGi | 10090.ENSMUSP00000119443 |
Miscellaneous databases
RNActi | P63030, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family. [View classification]Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG1590, Eukaryota |
GeneTreei | ENSGT00510000046988 |
InParanoidi | P63030 |
OMAi | YTDYFCS |
OrthoDBi | 1584711at2759 |
PhylomeDBi | P63030 |
TreeFami | TF314444 |
Family and domain databases
InterProi | View protein in InterPro IPR005336, MPC |
Pfami | View protein in Pfam PF03650, MPC, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All
P63030-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAGALVRKAA DYVRSKDFRD YLMSTHFWGP VANWGLPIAA INDMKKSPEI
60 70 80 90 100
ISGRMTFALC CYSLTFMRFA YKVQPRNWLL FACHVTNEVA QLIQGGRLIN
YEMSKRPSA
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketD3Z786 | D3Z786_MOUSE | Mitochondrial pyruvate carrier | Mpc1 Brp44l | 78 | Annotation score: | ||
D3Z5S0 | D3Z5S0_MOUSE | Mitochondrial pyruvate carrier | Mpc1 Brp44l | 86 | Annotation score: | ||
D3YWY6 | D3YWY6_MOUSE | Mitochondrial pyruvate carrier | Mpc1 Brp44l | 85 | Annotation score: | ||
E9Q0V4 | E9Q0V4_MOUSE | Mitochondrial pyruvate carrier | Mpc1 Brp44l | 167 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 64 | L → Q in BAB29340 (PubMed:16141072).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF181116 mRNA Translation: AAF25816.1 AK002241 mRNA Translation: BAB21958.1 AK002266 mRNA Translation: BAB21976.1 AK004013 mRNA Translation: BAB23124.1 AK013391 mRNA Translation: BAB28826.1 AK014421 mRNA Translation: BAB29340.1 BC024365 mRNA Translation: AAH24365.1 |
CCDSi | CCDS49944.1 |
RefSeqi | NP_061289.1, NM_018819.4 |
Genome annotation databases
Ensembli | ENSMUST00000046754; ENSMUSP00000045654; ENSMUSG00000023861 ENSMUST00000155364; ENSMUSP00000119443; ENSMUSG00000023861 |
GeneIDi | 55951 |
KEGGi | mmu:55951 |
UCSCi | uc033hao.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF181116 mRNA Translation: AAF25816.1 AK002241 mRNA Translation: BAB21958.1 AK002266 mRNA Translation: BAB21976.1 AK004013 mRNA Translation: BAB23124.1 AK013391 mRNA Translation: BAB28826.1 AK014421 mRNA Translation: BAB29340.1 BC024365 mRNA Translation: AAH24365.1 |
CCDSi | CCDS49944.1 |
RefSeqi | NP_061289.1, NM_018819.4 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 207746, 1 interactor |
STRINGi | 10090.ENSMUSP00000119443 |
PTM databases
iPTMneti | P63030 |
PhosphoSitePlusi | P63030 |
SwissPalmi | P63030 |
Proteomic databases
jPOSTi | P63030 |
PaxDbi | P63030 |
PeptideAtlasi | P63030 |
PRIDEi | P63030 |
Protocols and materials databases
Antibodypediai | 49022, 138 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000046754; ENSMUSP00000045654; ENSMUSG00000023861 ENSMUST00000155364; ENSMUSP00000119443; ENSMUSG00000023861 |
GeneIDi | 55951 |
KEGGi | mmu:55951 |
UCSCi | uc033hao.1, mouse |
Organism-specific databases
CTDi | 51660 |
MGIi | MGI:1915240, Mpc1 |
Phylogenomic databases
eggNOGi | KOG1590, Eukaryota |
GeneTreei | ENSGT00510000046988 |
InParanoidi | P63030 |
OMAi | YTDYFCS |
OrthoDBi | 1584711at2759 |
PhylomeDBi | P63030 |
TreeFami | TF314444 |
Miscellaneous databases
BioGRID-ORCSi | 55951, 2 hits in 17 CRISPR screens |
ChiTaRSi | Mpc1, mouse |
PROi | PR:P63030 |
RNActi | P63030, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000023861, Expressed in heart and 77 other tissues |
ExpressionAtlasi | P63030, baseline and differential |
Genevisiblei | P63030, MM |
Family and domain databases
InterProi | View protein in InterPro IPR005336, MPC |
Pfami | View protein in Pfam PF03650, MPC, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | MPC1_MOUSE | |
Accessioni | P63030Primary (citable) accession number: P63030 Secondary accession number(s): Q9D6C0, Q9JLG5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 31, 2004 |
Last sequence update: | August 31, 2004 | |
Last modified: | December 2, 2020 | |
This is version 114 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- Uncharacterized protein families (UPF)
List of uncharacterized protein family (UPF) entries - MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families