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Entry version 153 (16 Oct 2019)
Sequence version 3 (09 Feb 2010)
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Protein

Vesicle-associated membrane protein 2

Gene

VAMP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in the targeting and/or fusion of transport vesicles to their target membrane. Modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1.By similarity

Caution

A structure of a fragment of this protein in complex with the catalytic domain of C.botulinum neurotoxin type B (BoNT/B, botB) was reported; because of the lack of clear and continuous electron density for the VAMP2 peptide in the complex structure, the paper was retracted (PubMed:10932255, PubMed:19578378). However this protein is a substrate for BoNT/B (PubMed:7803399, PubMed:22289120).1 Publication3 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei58 – 59(Microbial infection) Cleavage; by C.botulinum neurotoxin type F (BoNT/F, botF)1 Publication2
Sitei76 – 77(Microbial infection) Cleavage; by C.botulinum neurotoxin type D (BoNT/D, botD)1 Publication2
Sitei76 – 77(Microbial infection) Cleavage; by C.tetani toxin (tetX)1 Publication2

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-1445148 Translocation of SLC2A4 (GLUT4) to the plasma membrane
R-HSA-181429 Serotonin Neurotransmitter Release Cycle
R-HSA-181430 Norepinephrine Neurotransmitter Release Cycle
R-HSA-199992 trans-Golgi Network Vesicle Budding
R-HSA-210500 Glutamate Neurotransmitter Release Cycle
R-HSA-212676 Dopamine Neurotransmitter Release Cycle
R-HSA-264642 Acetylcholine Neurotransmitter Release Cycle
R-HSA-264876 Insulin processing
R-HSA-422356 Regulation of insulin secretion
R-HSA-432720 Lysosome Vesicle Biogenesis
R-HSA-432722 Golgi Associated Vesicle Biogenesis
R-HSA-449836 Other interleukin signaling
R-HSA-5250955 Toxicity of botulinum toxin type D (BoNT/D)
R-HSA-5250958 Toxicity of botulinum toxin type B (BoNT/B)
R-HSA-5250981 Toxicity of botulinum toxin type F (BoNT/F)
R-HSA-5250982 Toxicity of tetanus toxin (TeNT)
R-HSA-5250989 Toxicity of botulinum toxin type G (BoNT/G)
R-HSA-8856825 Cargo recognition for clathrin-mediated endocytosis
R-HSA-8856828 Clathrin-mediated endocytosis
R-HSA-888590 GABA synthesis, release, reuptake and degradation
R-HSA-9609523 Insertion of tail-anchored proteins into the endoplasmic reticulum membrane

Protein family/group databases

Transport Classification Database

More...
TCDBi
1.F.1.1.1 the synaptosomal vesicle fusion pore (svf-pore) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Vesicle-associated membrane protein 2
Short name:
VAMP-2
Alternative name(s):
Synaptobrevin-2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:VAMP2
Synonyms:SYB2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:12643 VAMP2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
185881 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P63027

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini2 – 94CytoplasmicSequence analysisAdd BLAST93
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei95 – 114Helical; Anchor for type IV membrane proteinSequence analysisAdd BLAST20
Topological domaini115 – 116VesicularSequence analysis2

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell junction, Cell membrane, Cytoplasmic vesicle, Membrane, Synapse, Synaptosome

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi28S → A: Significant loss of phosphorylation; when associated with A-61, A-75 and A-80. 1 Publication1
Mutagenesisi41E → A: 70% reduction in cleavage by C.botulinum neurotoxin type F (BoNT/F, botF). 1 Publication1
Mutagenesisi50V → D: 65% reduction in cleavage by BoNT/F. 1 Publication1
Mutagenesisi53 – 54VL → DD: 98% reduction in cleavage by BoNT/F. 1 Publication2
Mutagenesisi53V → A: Wild-type cleavage by BoNT/F. 1 Publication1
Mutagenesisi53V → D: 90% reduction in cleavage by BoNT/F. 1 Publication1
Mutagenesisi61S → A: Significant loss of phosphorylation; when associated with A-28, A-75 and A-80. 1 Publication1
Mutagenesisi75S → A: Significant loss of phosphorylation; when associated with A-28, A-61 and A-80. 1 Publication1
Mutagenesisi80S → A: Significant loss of phosphorylation; when associated with A-28, A-61 and A-75. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
6844

Open Targets

More...
OpenTargetsi
ENSG00000220205

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA37267

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
P63027

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL2364160

Drug and drug target database

More...
DrugBanki
DB00042 Botulinum Toxin Type B

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
VAMP2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
288558837

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedBy similarity
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002067232 – 116Vesicle-associated membrane protein 2Add BLAST115

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated by PRKCZ in vitro and this phosphorylation is increased in the presence of WDFY2.1 Publication
(Microbial infection) Targeted and hydrolyzed by C.botulinum neurotoxin type B (BoNT/B, botB) which hydrolyzes the 76-Gln-|-Phe-77 bond and probably inhibits neurotransmitter release (PubMed:7803399).1 Publication1 Publication
(Microbial infection) Targeted and hydrolyzed by C.botulinum neurotoxin type D (BoNT/D, botD) which probably hydrolyzes the 59-Lys-|-Leu-60 bond and inhibits neurotransmitter release (PubMed:22289120). Note that humans are not known to be infected by C.botulinum type D.Curated1 Publication
(Microbial infection) Targeted and hydrolyzed by C.botulinum neurotoxin type F (BoNT/F, botF) which hydrolyzes the 58-Gln-|-Lys-59 bond and probably inhibits neurotransmitter release (PubMed:19543288).2 Publications
(Microbial infection) Targeted and hydrolyzed by C.tetani tetanus toxin (tetX) which hydrolyzes the 76-Gln-|-Phe-77 bond and probably inhibits neurotransmitter release (PubMed:7803399).1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P63027

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P63027

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
P63027

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P63027

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P63027

PeptideAtlas

More...
PeptideAtlasi
P63027

PRoteomics IDEntifications database

More...
PRIDEi
P63027

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
57471

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
P63027

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P63027

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P63027

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P63027

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Nervous system and skeletal muscle.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000220205 Expressed in 230 organ(s), highest expression level in right frontal lobe

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P63027 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P63027 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB078785

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts (via N-terminus) with KCNB1 (via N-terminus and C-terminus); stimulates the channel inactivation rate of KCNB1 (By similarity). Part of the SNARE core complex containing SNAP25, VAMP2 and STX1A. This complex binds to CPLX1.

Interacts with BVES and STX4 (By similarity).

Interacts with VAPA and VAPB.

Interacts with WDFY2, PRKCZ and PRKCI (PubMed:17313651).

Forms a complex with WDFY2 and PRKCZ (PubMed:17313651).

Interacts with SEPT8; the interaction inhibits interaction of VAMP2 with SYP.

Interacts with SYP; the interaction is inhibited by interaction with SEPT8 (By similarity).

Interacts with PICALM (PubMed:22118466).

Interacts with alpha-synuclein/SNCA (PubMed:20798282).

Interacts with STX3 (By similarity).

By similarity4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
112711, 86 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
P63027

Database of interacting proteins

More...
DIPi
DIP-39072N

Protein interaction database and analysis system

More...
IntActi
P63027, 42 interactors

Molecular INTeraction database

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MINTi
P63027

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000314214

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1116
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P63027

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P63027

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini31 – 91v-SNARE coiled-coil homologyPROSITE-ProRule annotationAdd BLAST61

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni92 – 116Required for interaction with SEPT8By similarityAdd BLAST25

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the synaptobrevin family.Curated

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0860 Eukaryota
COG5143 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158370

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000042711

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P63027

KEGG Orthology (KO)

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KOi
K13504

Database of Orthologous Groups

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OrthoDBi
1606985at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P63027

TreeFam database of animal gene trees

More...
TreeFami
TF313666

Family and domain databases

Database of protein disorder

More...
DisProti
DP00069

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001388 Synaptobrevin
IPR016444 Synaptobrevin/VAMP
IPR042855 V_SNARE_CC
IPR028717 VAMP2

The PANTHER Classification System

More...
PANTHERi
PTHR45701 PTHR45701, 1 hit
PTHR45701:SF15 PTHR45701:SF15, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF00957 Synaptobrevin, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF005409 Synaptobrevin_euk, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00219 SYNAPTOBREVN

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00417 SYNAPTOBREVIN, 1 hit
PS50892 V_SNARE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

P63027-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSATAATAPP AAPAGEGGPP APPPNLTSNR RLQQTQAQVD EVVDIMRVNV
60 70 80 90 100
DKVLERDQKL SELDDRADAL QAGASQFETS AAKLKRKYWW KNLKMMIILG
110
VICAIILIII IVYFST
Length:116
Mass (Da):12,663
Last modified:February 9, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9CD679C4F6F1B5A8
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8WCA0F8WCA0_HUMAN
Vesicle-associated membrane protein...
VAMP2
118Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QRU4J3QRU4_HUMAN
Vesicle-associated membrane protein...
VAMP2
113Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7ENK9K7ENK9_HUMAN
Vesicle-associated membrane protein...
VAMP2
68Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti116T → S in AAA60604 (PubMed:1976629).Curated1
Sequence conflicti116T → S in CAA12385 (Ref. 2) Curated1
Sequence conflicti116T → S in AAF15551 (Ref. 3) Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
M36205
, M36201, M36202, M36203, M36204 Genomic DNA Translation: AAA60604.1
AJ225044 mRNA Translation: CAA12385.1
AF135372 Genomic DNA Translation: AAF15551.1
AK289555 mRNA Translation: BAF82244.1
CH471108 Genomic DNA Translation: EAW90087.1
BC002737 mRNA Translation: AAH02737.3
BC019608 mRNA Translation: AAH19608.1
BC033870 mRNA Translation: AAH33870.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS32561.1

Protein sequence database of the Protein Information Resource

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PIRi
B38315

NCBI Reference Sequences

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RefSeqi
NP_055047.2, NM_014232.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000316509; ENSP00000314214; ENSG00000220205

Database of genes from NCBI RefSeq genomes

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GeneIDi
6844

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:6844

UCSC genome browser

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UCSCi
uc010cnt.2 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M36205
, M36201, M36202, M36203, M36204 Genomic DNA Translation: AAA60604.1
AJ225044 mRNA Translation: CAA12385.1
AF135372 Genomic DNA Translation: AAF15551.1
AK289555 mRNA Translation: BAF82244.1
CH471108 Genomic DNA Translation: EAW90087.1
BC002737 mRNA Translation: AAH02737.3
BC019608 mRNA Translation: AAH19608.1
BC033870 mRNA Translation: AAH33870.1
CCDSiCCDS32561.1
PIRiB38315
RefSeqiNP_055047.2, NM_014232.2

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3FIEX-ray2.10C/D25-57[»]
3FIIX-ray2.17B32-57[»]
3RK2X-ray2.20A/E28-60[»]
3RK3X-ray3.50A28-60[»]
3RL0X-ray3.80A/E/I/M/Q/U/Y/c28-60[»]
SMRiP63027
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi112711, 86 interactors
CORUMiP63027
DIPiDIP-39072N
IntActiP63027, 42 interactors
MINTiP63027
STRINGi9606.ENSP00000314214

Chemistry databases

ChEMBLiCHEMBL2364160
DrugBankiDB00042 Botulinum Toxin Type B

Protein family/group databases

TCDBi1.F.1.1.1 the synaptosomal vesicle fusion pore (svf-pore) family

PTM databases

iPTMnetiP63027
PhosphoSitePlusiP63027
SwissPalmiP63027

Polymorphism and mutation databases

BioMutaiVAMP2
DMDMi288558837

Proteomic databases

EPDiP63027
jPOSTiP63027
MassIVEiP63027
MaxQBiP63027
PaxDbiP63027
PeptideAtlasiP63027
PRIDEiP63027
ProteomicsDBi57471
TopDownProteomicsiP63027

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
6844

Genome annotation databases

EnsembliENST00000316509; ENSP00000314214; ENSG00000220205
GeneIDi6844
KEGGihsa:6844
UCSCiuc010cnt.2 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
6844
DisGeNETi6844

GeneCards: human genes, protein and diseases

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GeneCardsi
VAMP2
HGNCiHGNC:12643 VAMP2
HPAiCAB078785
MIMi185881 gene
neXtProtiNX_P63027
OpenTargetsiENSG00000220205
PharmGKBiPA37267

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0860 Eukaryota
COG5143 LUCA
GeneTreeiENSGT00940000158370
HOGENOMiHOG000042711
InParanoidiP63027
KOiK13504
OrthoDBi1606985at2759
PhylomeDBiP63027
TreeFamiTF313666

Enzyme and pathway databases

ReactomeiR-HSA-1445148 Translocation of SLC2A4 (GLUT4) to the plasma membrane
R-HSA-181429 Serotonin Neurotransmitter Release Cycle
R-HSA-181430 Norepinephrine Neurotransmitter Release Cycle
R-HSA-199992 trans-Golgi Network Vesicle Budding
R-HSA-210500 Glutamate Neurotransmitter Release Cycle
R-HSA-212676 Dopamine Neurotransmitter Release Cycle
R-HSA-264642 Acetylcholine Neurotransmitter Release Cycle
R-HSA-264876 Insulin processing
R-HSA-422356 Regulation of insulin secretion
R-HSA-432720 Lysosome Vesicle Biogenesis
R-HSA-432722 Golgi Associated Vesicle Biogenesis
R-HSA-449836 Other interleukin signaling
R-HSA-5250955 Toxicity of botulinum toxin type D (BoNT/D)
R-HSA-5250958 Toxicity of botulinum toxin type B (BoNT/B)
R-HSA-5250981 Toxicity of botulinum toxin type F (BoNT/F)
R-HSA-5250982 Toxicity of tetanus toxin (TeNT)
R-HSA-5250989 Toxicity of botulinum toxin type G (BoNT/G)
R-HSA-8856825 Cargo recognition for clathrin-mediated endocytosis
R-HSA-8856828 Clathrin-mediated endocytosis
R-HSA-888590 GABA synthesis, release, reuptake and degradation
R-HSA-9609523 Insertion of tail-anchored proteins into the endoplasmic reticulum membrane

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
VAMP2 human
EvolutionaryTraceiP63027

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
VAMP2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
6844
PharosiP63027

Protein Ontology

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PROi
PR:P63027

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000220205 Expressed in 230 organ(s), highest expression level in right frontal lobe
ExpressionAtlasiP63027 baseline and differential
GenevisibleiP63027 HS

Family and domain databases

DisProtiDP00069
InterProiView protein in InterPro
IPR001388 Synaptobrevin
IPR016444 Synaptobrevin/VAMP
IPR042855 V_SNARE_CC
IPR028717 VAMP2
PANTHERiPTHR45701 PTHR45701, 1 hit
PTHR45701:SF15 PTHR45701:SF15, 1 hit
PfamiView protein in Pfam
PF00957 Synaptobrevin, 1 hit
PIRSFiPIRSF005409 Synaptobrevin_euk, 1 hit
PRINTSiPR00219 SYNAPTOBREVN
PROSITEiView protein in PROSITE
PS00417 SYNAPTOBREVIN, 1 hit
PS50892 V_SNARE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiVAMP2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P63027
Secondary accession number(s): P19065, Q9BUC2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: February 9, 2010
Last modified: October 16, 2019
This is version 153 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
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