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Protein

Vesicle-associated membrane protein 3

Gene

Vamp3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei53 – 54(Microbial infection) Cleavage; by C.botulinum neurotoxin type X (BoNT/X)1 Publication2

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processProtein transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-1236974 ER-Phagosome pathway
R-MMU-6811440 Retrograde transport at the Trans-Golgi-Network
R-MMU-8856825 Cargo recognition for clathrin-mediated endocytosis
R-MMU-8856828 Clathrin-mediated endocytosis

Names & Taxonomyi

Protein namesi
Recommended name:
Vesicle-associated membrane protein 3
Short name:
VAMP-3
Alternative name(s):
Cellubrevin
Short name:
CEB
Synaptobrevin-3
Gene namesi
Name:Vamp3
Synonyms:Syb3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1321389 Vamp3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 81CytoplasmicSequence analysisAdd BLAST81
Transmembranei82 – 102Helical; Anchor for type IV membrane proteinSequence analysisAdd BLAST21
Topological domaini103VesicularSequence analysis1

Keywords - Cellular componenti

Cell junction, Membrane, Synapse, Synaptosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002067291 – 103Vesicle-associated membrane protein 3Add BLAST103

Post-translational modificationi

(Microbial infection) Targeted and hydrolyzed by C.botulinum neurotoxin type X (BoNT/X) which hydrolyzes the 53-Arg-|-Ala-54 bond and probably inhibits neurotransmitter release (PubMed:28770820). It remains unknown whether BoNT/X is ever produced, or what organisms it targets.1 Publication

Proteomic databases

EPDiP63024
MaxQBiP63024
PaxDbiP63024
PeptideAtlasiP63024
PRIDEiP63024

PTM databases

iPTMnetiP63024
PhosphoSitePlusiP63024
SwissPalmiP63024

Expressioni

Gene expression databases

BgeeiENSMUSG00000028955 Expressed in 285 organ(s), highest expression level in cornea
CleanExiMM_VAMP3
GenevisibleiP63024 MM

Interactioni

Subunit structurei

Interacts with BVES (via the C-terminus cytoplasmic tail). Interacts with BCAP31; involved in VAMP3 export from the endoplasmic reticulum. Interacts with BAIAP3; this interaction is increased in the presence of calcium (By similarity).By similarity2 Publications

GO - Molecular functioni

Protein-protein interaction databases

BioGridi204496, 4 interactors
CORUMiP63024
IntActiP63024, 4 interactors
MINTiP63024
STRINGi10090.ENSMUSP00000030797

Structurei

3D structure databases

ProteinModelPortaliP63024
SMRiP63024
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini18 – 78v-SNARE coiled-coil homologyPROSITE-ProRule annotationAdd BLAST61

Sequence similaritiesi

Belongs to the synaptobrevin family.Curated

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0860 Eukaryota
COG5143 LUCA
GeneTreeiENSGT00550000074449
HOGENOMiHOG000042711
HOVERGENiHBG006675
InParanoidiP63024
KOiK13505
OMAiIIIWACS
OrthoDBiEOG091G0MPE
PhylomeDBiP63024
TreeFamiTF313666

Family and domain databases

InterProiView protein in InterPro
IPR001388 Synaptobrevin
IPR016444 Synaptobrevin/VAMP
PfamiView protein in Pfam
PF00957 Synaptobrevin, 1 hit
PIRSFiPIRSF005409 Synaptobrevin_euk, 1 hit
PRINTSiPR00219 SYNAPTOBREVN
PROSITEiView protein in PROSITE
PS00417 SYNAPTOBREVIN, 1 hit
PS50892 V_SNARE, 1 hit

Sequencei

Sequence statusi: Complete.

P63024-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSTGVPSGSS AATGSNRRLQ QTQNQVDEVV DIMRVNVDKV LERDQKLSEL
60 70 80 90 100
DDRADALQAG ASQFETSAAK LKRKYWWKNC KMWAIGISVL VIIVIIIIVW

CVS
Length:103
Mass (Da):11,480
Last modified:August 31, 2004 - v1
Checksum:iEB502BBE5D0F5981
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U60961 mRNA Translation: AAB03490.1
AF308434, AF308433 Genomic DNA Translation: AAG42468.1
AK051272 mRNA Translation: BAC34586.1
AK051691 mRNA Translation: BAC34723.1
AK165947 mRNA Translation: BAE38479.1
AK168413 mRNA Translation: BAE40328.1
AK169056 mRNA Translation: BAE40844.1
AK169087 mRNA Translation: BAE40871.1
BC060045 mRNA Translation: AAH60045.1
CCDSiCCDS18979.1
RefSeqiNP_033524.1, NM_009498.4
UniGeneiMm.273930

Genome annotation databases

EnsembliENSMUST00000030797; ENSMUSP00000030797; ENSMUSG00000028955
GeneIDi22319
KEGGimmu:22319
UCSCiuc008vyj.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U60961 mRNA Translation: AAB03490.1
AF308434, AF308433 Genomic DNA Translation: AAG42468.1
AK051272 mRNA Translation: BAC34586.1
AK051691 mRNA Translation: BAC34723.1
AK165947 mRNA Translation: BAE38479.1
AK168413 mRNA Translation: BAE40328.1
AK169056 mRNA Translation: BAE40844.1
AK169087 mRNA Translation: BAE40871.1
BC060045 mRNA Translation: AAH60045.1
CCDSiCCDS18979.1
RefSeqiNP_033524.1, NM_009498.4
UniGeneiMm.273930

3D structure databases

ProteinModelPortaliP63024
SMRiP63024
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi204496, 4 interactors
CORUMiP63024
IntActiP63024, 4 interactors
MINTiP63024
STRINGi10090.ENSMUSP00000030797

PTM databases

iPTMnetiP63024
PhosphoSitePlusiP63024
SwissPalmiP63024

Proteomic databases

EPDiP63024
MaxQBiP63024
PaxDbiP63024
PeptideAtlasiP63024
PRIDEiP63024

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000030797; ENSMUSP00000030797; ENSMUSG00000028955
GeneIDi22319
KEGGimmu:22319
UCSCiuc008vyj.1 mouse

Organism-specific databases

CTDi9341
MGIiMGI:1321389 Vamp3

Phylogenomic databases

eggNOGiKOG0860 Eukaryota
COG5143 LUCA
GeneTreeiENSGT00550000074449
HOGENOMiHOG000042711
HOVERGENiHBG006675
InParanoidiP63024
KOiK13505
OMAiIIIWACS
OrthoDBiEOG091G0MPE
PhylomeDBiP63024
TreeFamiTF313666

Enzyme and pathway databases

ReactomeiR-MMU-1236974 ER-Phagosome pathway
R-MMU-6811440 Retrograde transport at the Trans-Golgi-Network
R-MMU-8856825 Cargo recognition for clathrin-mediated endocytosis
R-MMU-8856828 Clathrin-mediated endocytosis

Miscellaneous databases

ChiTaRSiVamp3 mouse
PROiPR:P63024
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000028955 Expressed in 285 organ(s), highest expression level in cornea
CleanExiMM_VAMP3
GenevisibleiP63024 MM

Family and domain databases

InterProiView protein in InterPro
IPR001388 Synaptobrevin
IPR016444 Synaptobrevin/VAMP
PfamiView protein in Pfam
PF00957 Synaptobrevin, 1 hit
PIRSFiPIRSF005409 Synaptobrevin_euk, 1 hit
PRINTSiPR00219 SYNAPTOBREVN
PROSITEiView protein in PROSITE
PS00417 SYNAPTOBREVIN, 1 hit
PS50892 V_SNARE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiVAMP3_MOUSE
AccessioniPrimary (citable) accession number: P63024
Secondary accession number(s): Q3TH70, Q64271
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: August 31, 2004
Last modified: September 12, 2018
This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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