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Protein

Paired box protein Pax-6

Gene

Pax6

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Transcription factor with important functions in the development of the eye, nose, central nervous system and pancreas. Required for the differentiation of pancreatic islet alpha cells. Competes with PAX4 in binding to a common element in the glucagon, insulin and somatostatin promoters (By similarity). Regulates specification of the ventral neuron subtypes by establishing the correct progenitor domains.By similarity1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi210 – 269HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processDifferentiation, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Paired box protein Pax-6
Alternative name(s):
Oculorhombin
Gene namesi
Name:Pax6
Synonyms:Pax-6, Sey
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 3

Organism-specific databases

RGDi3258 Pax6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Involvement in diseasei

Defects in Pax6 are the cause of a condition known as small eye (Sey) which results in the complete lack of eyes and nasal primordia.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000501871 – 422Paired box protein Pax-6Add BLAST422

Post-translational modificationi

Ubiquitinated by TRIM11, leading to ubiquitination and proteasomal degradation.By similarity

Keywords - PTMi

Ubl conjugation

Proteomic databases

PaxDbiP63016

PTM databases

PhosphoSitePlusiP63016

Expressioni

Tissue specificityi

Isoform 1 and isoform 5a are hardly expressed in mesenchymal stem cells or in the developed neurons.1 Publication

Developmental stagei

Isoform 1 and isoform 5a are expressed in the E10 embryonic headfolds and to a lesser extent in the trunk of neurula.1 Publication

Inductioni

Up-regulated in response to transient cerebral ischemia in cerebral cortex, striatum and subcortical white matter fibers in the ischemic region starting from 24 hours after initiating the ischemia.1 Publication

Gene expression databases

BgeeiENSRNOG00000004410 Expressed in 5 organ(s), highest expression level in brain
ExpressionAtlasiP63016 baseline and differential
GenevisibleiP63016 RN

Interactioni

Subunit structurei

Interacts with MAF and MAFB. Interacts with TRIM11; this interaction leads to ubiquitination and proteasomal degradation, as well as inhibition of transactivation, possibly in part by preventing PAX6 binding to consensus DNA sequences.By similarity

Protein-protein interaction databases

BioGridi247541, 1 interactor
STRINGi10116.ENSRNOP00000006302

Structurei

3D structure databases

ProteinModelPortaliP63016
SMRiP63016
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 130PairedPROSITE-ProRule annotationAdd BLAST127

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi131 – 209Gln/Gly-richAdd BLAST79
Compositional biasi279 – 422Pro/Ser/Thr-richAdd BLAST144

Sequence similaritiesi

Belongs to the paired homeobox family.Curated

Keywords - Domaini

Homeobox, Paired box

Phylogenomic databases

eggNOGiKOG0849 Eukaryota
ENOG410XS01 LUCA
GeneTreeiENSGT00680000099553
HOVERGENiHBG009115
InParanoidiP63016
KOiK08031
PhylomeDBiP63016
TreeFamiTF320146

Family and domain databases

CDDicd00086 homeodomain, 1 hit
cd00131 PAX, 1 hit
Gene3Di1.10.10.10, 2 hits
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR001523 Paired_dom
IPR036388 WH-like_DNA-bd_sf
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PF00292 PAX, 1 hit
PRINTSiPR00027 PAIREDBOX
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SM00351 PAX, 1 hit
SUPFAMiSSF46689 SSF46689, 2 hits
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit
PS00034 PAIRED_1, 1 hit
PS51057 PAIRED_2, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: P63016-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MQNSHSGVNQ LGGVFVNGRP LPDSTRQKIV ELAHSGARPC DISRILQVSN
60 70 80 90 100
GCVSKILGRY YETGSIRPRA IGGSKPRVAT PEVVSKIAQY KRECPSIFAW
110 120 130 140 150
EIRDRLLSEG VCTNDNIPSV SSINRVLRNL ASEKQQMGAD GMYDKLRMLN
160 170 180 190 200
GQTGSWGTRP GWYPGTSVPG QPTQDGCQQQ EGQGENTNSI SSNGEDSDEA
210 220 230 240 250
QMRLQLKRKL QRNRTSFTQE QIEALEKEFE RTHYPDVFAR ERLAAKIDLP
260 270 280 290 300
EARIQVWFSN RRAKWRREEK LRNQRRQASN TPSHIPISSS FSTSVYQPIP
310 320 330 340 350
QPTTPVSSFT SGSMLGRTDT ALTNTYSALP PMPSFTMANN LPMQPPVPSQ
360 370 380 390 400
TSSYSCMLPT SPSVNGRSYD TYTPPHMQTH MNSQPMGTSG TTSTGLISPG
410 420
VSVPVQVPGS EPDMSQYWPR LQ
Length:422
Mass (Da):46,754
Last modified:August 31, 2004 - v1
Checksum:iB0B2E5C176A518FE
GO
Isoform 5a (identifier: P63016-2) [UniParc]FASTAAdd to basket
Also known as: Pax6-5a1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     47-47: Q → QTHADAKVQVLDSEN

Show »
Length:436
Mass (Da):48,263
Checksum:iA6719A36AC8FDE53
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0G2JZE2A0A0G2JZE2_RAT
Paired box protein Pax-6
Pax6
433Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti159R → C in CAF29075 (Ref. 2) Curated1
Sequence conflicti183Q → G in AAB32671 (PubMed:7981749).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_01153147Q → QTHADAKVQVLDSEN in isoform 5a. 1 Publication1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U69644 mRNA Translation: AAB09042.1
AJ627631 mRNA Translation: CAF29075.1
AY540905 mRNA Translation: AAS48919.1
AY540906 mRNA Translation: AAS48920.1
BC128741 mRNA Translation: AAI28742.1
S74393 mRNA Translation: AAB32671.1 Different termination.
PIRiS36166
RefSeqiNP_037133.1, NM_013001.2 [P63016-1]
XP_006234695.1, XM_006234633.3 [P63016-2]
XP_006234696.1, XM_006234634.3 [P63016-2]
XP_006234697.1, XM_006234635.3 [P63016-2]
XP_006234698.1, XM_006234636.3 [P63016-2]
XP_017446983.1, XM_017591494.1 [P63016-2]
XP_017446984.1, XM_017591495.1 [P63016-1]
UniGeneiRn.89724

Genome annotation databases

EnsembliENSRNOT00000005882; ENSRNOP00000005882; ENSRNOG00000004410 [P63016-1]
ENSRNOT00000006302; ENSRNOP00000006302; ENSRNOG00000004410 [P63016-1]
GeneIDi25509
KEGGirno:25509
UCSCiRGD:3258 rat [P63016-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U69644 mRNA Translation: AAB09042.1
AJ627631 mRNA Translation: CAF29075.1
AY540905 mRNA Translation: AAS48919.1
AY540906 mRNA Translation: AAS48920.1
BC128741 mRNA Translation: AAI28742.1
S74393 mRNA Translation: AAB32671.1 Different termination.
PIRiS36166
RefSeqiNP_037133.1, NM_013001.2 [P63016-1]
XP_006234695.1, XM_006234633.3 [P63016-2]
XP_006234696.1, XM_006234634.3 [P63016-2]
XP_006234697.1, XM_006234635.3 [P63016-2]
XP_006234698.1, XM_006234636.3 [P63016-2]
XP_017446983.1, XM_017591494.1 [P63016-2]
XP_017446984.1, XM_017591495.1 [P63016-1]
UniGeneiRn.89724

3D structure databases

ProteinModelPortaliP63016
SMRiP63016
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi247541, 1 interactor
STRINGi10116.ENSRNOP00000006302

PTM databases

PhosphoSitePlusiP63016

Proteomic databases

PaxDbiP63016

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000005882; ENSRNOP00000005882; ENSRNOG00000004410 [P63016-1]
ENSRNOT00000006302; ENSRNOP00000006302; ENSRNOG00000004410 [P63016-1]
GeneIDi25509
KEGGirno:25509
UCSCiRGD:3258 rat [P63016-1]

Organism-specific databases

CTDi5080
RGDi3258 Pax6

Phylogenomic databases

eggNOGiKOG0849 Eukaryota
ENOG410XS01 LUCA
GeneTreeiENSGT00680000099553
HOVERGENiHBG009115
InParanoidiP63016
KOiK08031
PhylomeDBiP63016
TreeFamiTF320146

Miscellaneous databases

PROiPR:P63016

Gene expression databases

BgeeiENSRNOG00000004410 Expressed in 5 organ(s), highest expression level in brain
ExpressionAtlasiP63016 baseline and differential
GenevisibleiP63016 RN

Family and domain databases

CDDicd00086 homeodomain, 1 hit
cd00131 PAX, 1 hit
Gene3Di1.10.10.10, 2 hits
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR001523 Paired_dom
IPR036388 WH-like_DNA-bd_sf
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PF00292 PAX, 1 hit
PRINTSiPR00027 PAIREDBOX
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SM00351 PAX, 1 hit
SUPFAMiSSF46689 SSF46689, 2 hits
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit
PS00034 PAIRED_1, 1 hit
PS51057 PAIRED_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPAX6_RAT
AccessioniPrimary (citable) accession number: P63016
Secondary accession number(s): A1A5N7
, P32117, P70601, Q62222, Q64037, Q6QHS5, Q701Q8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: August 31, 2004
Last modified: September 12, 2018
This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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