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Protein

Ras-related protein Rab-3A

Gene

Rab3a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in exocytosis by regulating a late step in synaptic vesicle fusion. Could play a role in neurotransmitter release by regulating membrane flow in the nerve terminal (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi29 – 37GTPBy similarity9
Nucleotide bindingi48 – 54GTPBy similarity7
Nucleotide bindingi77 – 81GTPBy similarity5
Nucleotide bindingi135 – 138GTPBy similarity4
Nucleotide bindingi165 – 167GTPBy similarity3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processExocytosis, Protein transport, Transport
LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-181429 Serotonin Neurotransmitter Release Cycle
R-MMU-181430 Norepinephrine Neurotransmitter Release Cycle
R-MMU-210500 Glutamate Neurotransmitter Release Cycle
R-MMU-212676 Dopamine Neurotransmitter Release Cycle
R-MMU-264642 Acetylcholine Neurotransmitter Release Cycle
R-MMU-6798695 Neutrophil degranulation
R-MMU-8873719 RAB geranylgeranylation
R-MMU-8876198 RAB GEFs exchange GTP for GDP on RABs
R-MMU-888590 GABA synthesis, release, reuptake and degradation

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rab-3A
Gene namesi
Name:Rab3a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:97843 Rab3a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001210781 – 220Ras-related protein Rab-3AAdd BLAST220

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei188PhosphoserineCombined sources1
Modified residuei190PhosphoserineCombined sources1
Lipidationi218S-geranylgeranyl cysteineBy similarity1
Modified residuei220Cysteine methyl esterBy similarity1
Lipidationi220S-geranylgeranyl cysteineBy similarity1

Keywords - PTMi

Lipoprotein, Methylation, Phosphoprotein, Prenylation

Proteomic databases

EPDiP63011
PaxDbiP63011
PeptideAtlasiP63011
PRIDEiP63011

PTM databases

iPTMnetiP63011
PhosphoSitePlusiP63011
SwissPalmiP63011

Expressioni

Gene expression databases

BgeeiENSMUSG00000031840 Expressed in 176 organ(s), highest expression level in hypothalamus
CleanExiMM_RAB3A
ExpressionAtlasiP63011 baseline and differential
GenevisibleiP63011 MM

Interactioni

Subunit structurei

Heterodimer with RIMS2. Part of a ternary complex involving PCLO and EPAC2. Interacts with RPH3A and RPH3AL. Interacts with the exocyst complex through SEC15. Binds SYTL4, RIMS1 and RIMS2. Interacts with RAB3IP. Interacts with SGSM1 and SGSM3.6 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi202544, 9 interactors
CORUMiP63011
DIPiDIP-31051N
IntActiP63011, 55 interactors
MINTiP63011
STRINGi10090.ENSMUSP00000034301

Structurei

3D structure databases

ProteinModelPortaliP63011
SMRiP63011
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi51 – 59Effector regionBy similarity9

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGiKOG0093 Eukaryota
ENOG410ZZXQ LUCA
GeneTreeiENSGT00890000139330
HOGENOMiHOG000233968
HOVERGENiHBG009351
InParanoidiP63011
KOiK07882
OMAiQLTEQPA
OrthoDBiEOG091G0J64
PhylomeDBiP63011
TreeFamiTF313199

Family and domain databases

CDDicd01865 Rab3, 1 hit
InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR037872 Rab3
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51419 RAB, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P63011-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASATDSRYG QKESSDQNFD YMFKILIIGN SSVGKTSFLF RYADDSFTPA
60 70 80 90 100
FVSTVGIDFK VKTIYRNDKR IKLQIWDTAG QERYRTITTA YYRGAMGFIL
110 120 130 140 150
MYDITNEESF NAVQDWSTQI KTYSWDNAQV LLVGNKCDME DERVVSSERG
160 170 180 190 200
RQLADHLGFE FFEASAKDNI NVKQTFERLV DVICEKMSES LDTADPAVTG
210 220
AKQGPQLTDQ QAPPHQDCAC
Length:220
Mass (Da):24,970
Last modified:August 31, 2004 - v1
Checksum:i1A3E9F8C9D09EB40
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3YZP5D3YZP5_MOUSE
Ras-related protein Rab-3A
Rab3a
62Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X72966 Genomic DNA Translation: CAA51470.1
AK005362 mRNA Translation: BAB23976.1
AK158727 mRNA Translation: BAE34630.1
AK161975 mRNA Translation: BAE36661.1
BC053519 mRNA Translation: AAH53519.1
CCDSiCCDS22379.1
PIRiS34070
RefSeqiNP_001159871.1, NM_001166399.2
NP_001314976.1, NM_001328047.1
NP_033027.1, NM_009001.6
XP_006509666.1, XM_006509603.3
UniGeneiMm.5083

Genome annotation databases

EnsembliENSMUST00000034301; ENSMUSP00000034301; ENSMUSG00000031840
ENSMUST00000110090; ENSMUSP00000105717; ENSMUSG00000031840
ENSMUST00000110092; ENSMUSP00000105719; ENSMUSG00000031840
ENSMUST00000110093; ENSMUSP00000105720; ENSMUSG00000031840
ENSMUST00000217185; ENSMUSP00000150125; ENSMUSG00000111277
ENSMUST00000229860; ENSMUSP00000155513; ENSMUSG00000111277
GeneIDi19339
KEGGimmu:19339
UCSCiuc009mbi.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X72966 Genomic DNA Translation: CAA51470.1
AK005362 mRNA Translation: BAB23976.1
AK158727 mRNA Translation: BAE34630.1
AK161975 mRNA Translation: BAE36661.1
BC053519 mRNA Translation: AAH53519.1
CCDSiCCDS22379.1
PIRiS34070
RefSeqiNP_001159871.1, NM_001166399.2
NP_001314976.1, NM_001328047.1
NP_033027.1, NM_009001.6
XP_006509666.1, XM_006509603.3
UniGeneiMm.5083

3D structure databases

ProteinModelPortaliP63011
SMRiP63011
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi202544, 9 interactors
CORUMiP63011
DIPiDIP-31051N
IntActiP63011, 55 interactors
MINTiP63011
STRINGi10090.ENSMUSP00000034301

PTM databases

iPTMnetiP63011
PhosphoSitePlusiP63011
SwissPalmiP63011

Proteomic databases

EPDiP63011
PaxDbiP63011
PeptideAtlasiP63011
PRIDEiP63011

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000034301; ENSMUSP00000034301; ENSMUSG00000031840
ENSMUST00000110090; ENSMUSP00000105717; ENSMUSG00000031840
ENSMUST00000110092; ENSMUSP00000105719; ENSMUSG00000031840
ENSMUST00000110093; ENSMUSP00000105720; ENSMUSG00000031840
ENSMUST00000217185; ENSMUSP00000150125; ENSMUSG00000111277
ENSMUST00000229860; ENSMUSP00000155513; ENSMUSG00000111277
GeneIDi19339
KEGGimmu:19339
UCSCiuc009mbi.2 mouse

Organism-specific databases

CTDi5864
MGIiMGI:97843 Rab3a

Phylogenomic databases

eggNOGiKOG0093 Eukaryota
ENOG410ZZXQ LUCA
GeneTreeiENSGT00890000139330
HOGENOMiHOG000233968
HOVERGENiHBG009351
InParanoidiP63011
KOiK07882
OMAiQLTEQPA
OrthoDBiEOG091G0J64
PhylomeDBiP63011
TreeFamiTF313199

Enzyme and pathway databases

ReactomeiR-MMU-181429 Serotonin Neurotransmitter Release Cycle
R-MMU-181430 Norepinephrine Neurotransmitter Release Cycle
R-MMU-210500 Glutamate Neurotransmitter Release Cycle
R-MMU-212676 Dopamine Neurotransmitter Release Cycle
R-MMU-264642 Acetylcholine Neurotransmitter Release Cycle
R-MMU-6798695 Neutrophil degranulation
R-MMU-8873719 RAB geranylgeranylation
R-MMU-8876198 RAB GEFs exchange GTP for GDP on RABs
R-MMU-888590 GABA synthesis, release, reuptake and degradation

Miscellaneous databases

ChiTaRSiRab3a mouse
PROiPR:P63011
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000031840 Expressed in 176 organ(s), highest expression level in hypothalamus
CleanExiMM_RAB3A
ExpressionAtlasiP63011 baseline and differential
GenevisibleiP63011 MM

Family and domain databases

CDDicd01865 Rab3, 1 hit
InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR037872 Rab3
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51419 RAB, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRAB3A_MOUSE
AccessioniPrimary (citable) accession number: P63011
Secondary accession number(s): P05713, Q3TSL4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: August 31, 2004
Last modified: November 7, 2018
This is version 151 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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