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Protein

AP-2 complex subunit beta

Gene

AP2B1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules. AP-2 may also play a role in maintaining normal post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway. The AP-2 beta subunit acts via its C-terminal appendage domain as a scaffolding platform for endocytic accessory proteins; at least some clathrin-associated sorting proteins (CLASPs) are recognized by their [DE]-X(1,2)-F-X-X-[FL]-X-X-X-R motif. The AP-2 beta subunit binds to clathrin heavy chain, promoting clathrin lattice assembly; clathrin displaces at least some CLASPs from AP2B1 which probably then can be positioned for further coat assembly.4 Publications

GO - Molecular functioni

  • cargo receptor activity Source: Ensembl
  • clathrin binding Source: UniProtKB
  • protein-containing complex binding Source: Ensembl
  • signal sequence binding Source: BHF-UCL

GO - Biological processi

Keywordsi

Biological processEndocytosis, Protein transport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-167590 Nef Mediated CD4 Down-regulation
R-HSA-177504 Retrograde neurotrophin signalling
R-HSA-182218 Nef Mediated CD8 Down-regulation
R-HSA-2132295 MHC class II antigen presentation
R-HSA-3928665 EPH-ephrin mediated repulsion of cells
R-HSA-416993 Trafficking of GluR2-containing AMPA receptors
R-HSA-437239 Recycling pathway of L1
R-HSA-5099900 WNT5A-dependent internalization of FZD4
R-HSA-5140745 WNT5A-dependent internalization of FZD2, FZD5 and ROR2
R-HSA-8856825 Cargo recognition for clathrin-mediated endocytosis
R-HSA-8856828 Clathrin-mediated endocytosis
R-HSA-8866427 VLDLR internalisation and degradation
R-HSA-8964038 LDL clearance
SignaLinkiP63010
SIGNORiP63010

Names & Taxonomyi

Protein namesi
Recommended name:
AP-2 complex subunit beta
Alternative name(s):
AP105B
Adaptor protein complex AP-2 subunit beta
Adaptor-related protein complex 2 subunit beta
Beta-2-adaptin
Beta-adaptin
Clathrin assembly protein complex 2 beta large chain
Plasma membrane adaptor HA2/AP2 adaptin beta subunit
Gene namesi
Name:AP2B1
Synonyms:ADTB2, CLAPB1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000006125.16
HGNCiHGNC:563 AP2B1
MIMi601025 gene
neXtProtiNX_P63010

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Coated pit, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi815Y → A: Strongly reduces interaction with SNAP91, EPS15, AMPH and BIN1 and clathrin heavy chain. 2 Publications1
Mutagenesisi841W → A: Abolishes interaction with LDLRAP1 and ARRB1. Greatly reduces DENND1B-binding. 4 Publications1
Mutagenesisi842K → E: Strongly reduces interaction with ARRB1. 1 Publication1
Mutagenesisi849E → A: Strongly reduces interaction with LDLRAP1, ARRB1 and EPN1. No effect on DENND1B-binding. 3 Publications1
Mutagenesisi851Q → A: Strongly reduces interaction with ARRB1. 1 Publication1
Mutagenesisi879R → A: No effect on interaction with ARRB1. 2 Publications1
Mutagenesisi879R → E: Strongly reduces interaction with EPN1. Reduces interaction with SNAP91 and clathrin. No effect on EPS15 binding. 2 Publications1
Mutagenesisi888Y → V: Strongly reduces interaction with SNAP91, EPN1 and clathrin. No effect on EPS15 binding. Abolishes interaction with ARRB1 and with DENND1B. 5 Publications1
Mutagenesisi902E → A: Strongly reduces interaction with LDLRAP1 and ARRB1. No effect on DENND1B-binding. 3 Publications1
Mutagenesisi917K → Q: Strongly reduces interaction with LDLRAP1. SNAP91 and clathrin. Reduces interaction with EPN1. No effect on EPS15 binding. 1 Publication1

Organism-specific databases

DisGeNETi163
OpenTargetsiENSG00000006125
PharmGKBiPA24854

Polymorphism and mutation databases

BioMutaiAP2B1
DMDMi51702211

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00001937422 – 937AP-2 complex subunit betaAdd BLAST936

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylthreonineCombined sources1
Modified residuei4PhosphoserineCombined sources1
Modified residuei265N6-acetyllysineCombined sources1
Modified residuei737Phosphotyrosine; by SRC2 Publications1
Modified residuei928PhosphotyrosineBy similarity1

Post-translational modificationi

Phosphorylation at Tyr-737 by SRC occurs at the plasma membrane in clathrin-coated vesicles (CCVs).2 Publications

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP63010
MaxQBiP63010
PaxDbiP63010
PeptideAtlasiP63010
PRIDEiP63010
ProteomicsDBi57469
57470 [P63010-2]

PTM databases

iPTMnetiP63010
PhosphoSitePlusiP63010
SwissPalmiP63010

Expressioni

Gene expression databases

BgeeiENSG00000006125 Expressed in 228 organ(s), highest expression level in testis
CleanExiHS_AP2B1
ExpressionAtlasiP63010 baseline and differential
GenevisibleiP63010 HS

Organism-specific databases

HPAiCAB017631
HPA056733
HPA067983

Interactioni

Subunit structurei

Adaptor protein complex 2 (AP-2) is a heterotetramer composed of two large adaptins (alpha-type subunit AP2A1 or AP2A2 and beta-type subunit AP2B1), a medium adaptin (mu-type subunit AP2M1) and a small adaptin (sigma-type subunit AP2S1) (PubMed:12086608, PubMed:19140243). Interacts with EPN1 (PubMed:10944104, PubMed:16516836). Interacts with EPS15; clathrin competes with EPS15 (PubMed:10944104, PubMed:16903783). Interacts with SNAP91; clathrin competes with SNAP91 (PubMed:10944104, PubMed:16516836, PubMed:16903783). Interacts with CLTC; clathrin competes with EPS15, SNAP91 and PIP5K1C (PubMed:10944104). Interacts with LDLRAP1 (PubMed:15728179, PubMed:16516836, PubMed:16903783). Interacts with AMPH and BIN1 (PubMed:16516836, PubMed:16903783). Interacts with ARF6 (GDP-bound) (PubMed:17719203). Interacts (dephosphorylated at Tyr-737) with ARRB1; phosphorylation of AP2B1 at Tyr-737 disrupts the interaction (PubMed:11777907, PubMed:16516836, PubMed:17456551, PubMed:16903783). Interacts with SLC2A8 (PubMed:16723738). Interacts with SCYL1 and SCYL2 (PubMed:16903783). Interacts with TGFBR1 and TGFBR2 (PubMed:12429842). Interacts with PIP5K1C; clathrin competes with PIP5K1C (By similarity). Interacts with DENND1B, but not with DENND1A, nor DENND1C (PubMed:20154091). Interacts with FCHO1 (PubMed:22484487). Interacts with RFTN1 (PubMed:27022195). Interacts with KIAA1107 (PubMed:29262337).By similarity15 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi106672, 131 interactors
CORUMiP63010
DIPiDIP-33098N
IntActiP63010, 98 interactors
MINTiP63010
STRINGi9606.ENSP00000314414

Structurei

Secondary structure

1937
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP63010
SMRiP63010
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP63010

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni841 – 937Interaction with ARRB1Add BLAST97

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi576 – 716Pro-rich (stalk region)Add BLAST141

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1061 Eukaryota
COG5096 LUCA
GeneTreeiENSGT00530000063138
HOGENOMiHOG000163270
HOVERGENiHBG050515
InParanoidiP63010
KOiK11825
OMAiARASMVW
OrthoDBiEOG091G019U
PhylomeDBiP63010
TreeFamiTF300318

Family and domain databases

Gene3Di1.25.10.10, 1 hit
2.60.40.1150, 1 hit
3.30.310.10, 1 hit
InterProiView protein in InterPro
IPR026739 AP_beta
IPR016342 AP_complex_bsu_1_2_4
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR000225 Armadillo
IPR015151 B-adaptin_app_sub_C
IPR002553 Clathrin/coatomer_adapt-like_N
IPR008152 Clathrin_a/b/g-adaptin_app_Ig
IPR013041 Clathrin_app_Ig-like_sf
IPR013037 Clathrin_b-adaptin_app_Ig-like
IPR009028 Coatomer/calthrin_app_sub_C
IPR012295 TBP_dom_sf
PANTHERiPTHR11134 PTHR11134, 1 hit
PfamiView protein in Pfam
PF01602 Adaptin_N, 1 hit
PF02883 Alpha_adaptinC2, 1 hit
PF09066 B2-adapt-app_C, 1 hit
PIRSFiPIRSF002291 AP_complex_beta, 1 hit
SMARTiView protein in SMART
SM00809 Alpha_adaptinC2, 1 hit
SM00185 ARM, 2 hits
SM01020 B2-adapt-app_C, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit
SSF49348 SSF49348, 1 hit
SSF55711 SSF55711, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 11 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P63010-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTDSKYFTTN KKGEIFELKA ELNNEKKEKR KEAVKKVIAA MTVGKDVSSL
60 70 80 90 100
FPDVVNCMQT DNLELKKLVY LYLMNYAKSQ PDMAIMAVNS FVKDCEDPNP
110 120 130 140 150
LIRALAVRTM GCIRVDKITE YLCEPLRKCL KDEDPYVRKT AAVCVAKLHD
160 170 180 190 200
INAQMVEDQG FLDSLRDLIA DSNPMVVANA VAALSEISES HPNSNLLDLN
210 220 230 240 250
PQNINKLLTA LNECTEWGQI FILDCLSNYN PKDDREAQSI CERVTPRLSH
260 270 280 290 300
ANSAVVLSAV KVLMKFLELL PKDSDYYNML LKKLAPPLVT LLSGEPEVQY
310 320 330 340 350
VALRNINLIV QKRPEILKQE IKVFFVKYND PIYVKLEKLD IMIRLASQAN
360 370 380 390 400
IAQVLAELKE YATEVDVDFV RKAVRAIGRC AIKVEQSAER CVSTLLDLIQ
410 420 430 440 450
TKVNYVVQEA IVVIRDIFRK YPNKYESIIA TLCENLDSLD EPDARAAMIW
460 470 480 490 500
IVGEYAERID NADELLESFL EGFHDESTQV QLTLLTAIVK LFLKKPSETQ
510 520 530 540 550
ELVQQVLSLA TQDSDNPDLR DRGYIYWRLL STDPVTAKEV VLSEKPLISE
560 570 580 590 600
ETDLIEPTLL DELICHIGSL ASVYHKPPNA FVEGSHGIHR KHLPIHHGST
610 620 630 640 650
DAGDSPVGTT TATNLEQPQV IPSQGDLLGD LLNLDLGPPV NVPQVSSMQM
660 670 680 690 700
GAVDLLGGGL DSLVGQSFIP SSVPATFAPS PTPAVVSSGL NDLFELSTGI
710 720 730 740 750
GMAPGGYVAP KAVWLPAVKA KGLEISGTFT HRQGHIYMEM NFTNKALQHM
760 770 780 790 800
TDFAIQFNKN SFGVIPSTPL AIHTPLMPNQ SIDVSLPLNT LGPVMKMEPL
810 820 830 840 850
NNLQVAVKNN IDVFYFSCLI PLNVLFVEDG KMERQVFLAT WKDIPNENEL
860 870 880 890 900
QFQIKECHLN ADTVSSKLQN NNVYTIAKRN VEGQDMLYQS LKLTNGIWIL
910 920 930
AELRIQPGNP NYTLSLKCRA PEVSQYIYQV YDSILKN
Length:937
Mass (Da):104,553
Last modified:August 31, 2004 - v1
Checksum:iB472EE5B2AE176DF
GO
Isoform 2 (identifier: P63010-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     663-663: L → LLGSDLGGGIGGSPA

Show »
Length:951
Mass (Da):105,692
Checksum:i3199C9F8C7F027F2
GO
Isoform 3 (identifier: P63010-3) [UniParc]FASTAAdd to basket
Also known as: Ap2beta-NY

The sequence of this isoform differs from the canonical sequence as follows:
     1-57: Missing.

Note: Highly expressed in the testis, spleen, thymus, prostate, ovary, blood leukocyte and brain, but not in the heart, placenta, lung, liver, skeletal muscle, kidney and pancreas. Testis expression is restricted to germ cells and is about 3-fold higher in adults than in embryos.
Show »
Length:880
Mass (Da):98,118
Checksum:i468D8B39AD35C7E4
GO

Computationally mapped potential isoform sequencesi

There are 11 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087X253A0A087X253_HUMAN
AP complex subunit beta
AP2B1
913Annotation score:
A0A087WZQ6A0A087WZQ6_HUMAN
AP-2 complex subunit beta
AP2B1
677Annotation score:
A0A087WYD1A0A087WYD1_HUMAN
AP-2 complex subunit beta
AP2B1
639Annotation score:
A0A087WU93A0A087WU93_HUMAN
AP-2 complex subunit beta
AP2B1
663Annotation score:
K7EJ01K7EJ01_HUMAN
AP-2 complex subunit beta
AP2B1
164Annotation score:
K7EN71K7EN71_HUMAN
AP-2 complex subunit beta
AP2B1
132Annotation score:
K7EJX1K7EJX1_HUMAN
AP-2 complex subunit beta
AP2B1
80Annotation score:
K7ERB2K7ERB2_HUMAN
AP-2 complex subunit beta
AP2B1
151Annotation score:
K7EMN7K7EMN7_HUMAN
AP-2 complex subunit beta
AP2B1
181Annotation score:
A0A087WXS3A0A087WXS3_HUMAN
AP-2 complex subunit beta
AP2B1
49Annotation score:
There is more potential isoformShow all

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0478051 – 57Missing in isoform 3. 1 PublicationAdd BLAST57
Alternative sequenceiVSP_011490663L → LLGSDLGGGIGGSPA in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M34175 mRNA Translation: AAA35583.1
AY341427 mRNA Translation: AAQ20044.1
AC004134 Genomic DNA No translation available.
AC006237 Genomic DNA No translation available.
AC015911 Genomic DNA No translation available.
CH471147 Genomic DNA Translation: EAW80133.1
CH471147 Genomic DNA Translation: EAW80139.1
BC006201 mRNA Translation: AAH06201.1
CCDSiCCDS32621.1 [P63010-2]
CCDS32622.1 [P63010-1]
PIRiA35553
RefSeqiNP_001025177.1, NM_001030006.1 [P63010-2]
NP_001273.1, NM_001282.2 [P63010-1]
XP_005257994.1, XM_005257937.3 [P63010-2]
XP_005257995.1, XM_005257938.2 [P63010-2]
XP_011522757.1, XM_011524455.2 [P63010-3]
XP_016879773.1, XM_017024284.1 [P63010-1]
XP_016879775.1, XM_017024286.1 [P63010-3]
UniGeneiHs.514819

Genome annotation databases

EnsembliENST00000610402; ENSP00000483185; ENSG00000006125 [P63010-2]
ENST00000618940; ENSP00000482835; ENSG00000006125 [P63010-2]
ENST00000621914; ENSP00000482315; ENSG00000006125 [P63010-1]
GeneIDi163
KEGGihsa:163
UCSCiuc002hjq.4 human [P63010-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M34175 mRNA Translation: AAA35583.1
AY341427 mRNA Translation: AAQ20044.1
AC004134 Genomic DNA No translation available.
AC006237 Genomic DNA No translation available.
AC015911 Genomic DNA No translation available.
CH471147 Genomic DNA Translation: EAW80133.1
CH471147 Genomic DNA Translation: EAW80139.1
BC006201 mRNA Translation: AAH06201.1
CCDSiCCDS32621.1 [P63010-2]
CCDS32622.1 [P63010-1]
PIRiA35553
RefSeqiNP_001025177.1, NM_001030006.1 [P63010-2]
NP_001273.1, NM_001282.2 [P63010-1]
XP_005257994.1, XM_005257937.3 [P63010-2]
XP_005257995.1, XM_005257938.2 [P63010-2]
XP_011522757.1, XM_011524455.2 [P63010-3]
XP_016879773.1, XM_017024284.1 [P63010-1]
XP_016879775.1, XM_017024286.1 [P63010-3]
UniGeneiHs.514819

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1E42X-ray1.70A/B701-937[»]
2G30X-ray1.60A701-937[»]
2IV8X-ray2.80A700-937[»]
2IV9X-ray1.90A/B700-937[»]
2JKRX-ray2.98B/E1-591[»]
2JKTX-ray3.40B/E1-591[»]
2VGLX-ray2.59B1-591[»]
2XA7X-ray3.10B1-592[»]
4UQIX-ray2.79B1-651[»]
5M5RX-ray1.76C/D628-637[»]
ProteinModelPortaliP63010
SMRiP63010
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi106672, 131 interactors
CORUMiP63010
DIPiDIP-33098N
IntActiP63010, 98 interactors
MINTiP63010
STRINGi9606.ENSP00000314414

PTM databases

iPTMnetiP63010
PhosphoSitePlusiP63010
SwissPalmiP63010

Polymorphism and mutation databases

BioMutaiAP2B1
DMDMi51702211

Proteomic databases

EPDiP63010
MaxQBiP63010
PaxDbiP63010
PeptideAtlasiP63010
PRIDEiP63010
ProteomicsDBi57469
57470 [P63010-2]

Protocols and materials databases

DNASUi163
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000610402; ENSP00000483185; ENSG00000006125 [P63010-2]
ENST00000618940; ENSP00000482835; ENSG00000006125 [P63010-2]
ENST00000621914; ENSP00000482315; ENSG00000006125 [P63010-1]
GeneIDi163
KEGGihsa:163
UCSCiuc002hjq.4 human [P63010-1]

Organism-specific databases

CTDi163
DisGeNETi163
EuPathDBiHostDB:ENSG00000006125.16
GeneCardsiAP2B1
HGNCiHGNC:563 AP2B1
HPAiCAB017631
HPA056733
HPA067983
MIMi601025 gene
neXtProtiNX_P63010
OpenTargetsiENSG00000006125
PharmGKBiPA24854
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1061 Eukaryota
COG5096 LUCA
GeneTreeiENSGT00530000063138
HOGENOMiHOG000163270
HOVERGENiHBG050515
InParanoidiP63010
KOiK11825
OMAiARASMVW
OrthoDBiEOG091G019U
PhylomeDBiP63010
TreeFamiTF300318

Enzyme and pathway databases

ReactomeiR-HSA-167590 Nef Mediated CD4 Down-regulation
R-HSA-177504 Retrograde neurotrophin signalling
R-HSA-182218 Nef Mediated CD8 Down-regulation
R-HSA-2132295 MHC class II antigen presentation
R-HSA-3928665 EPH-ephrin mediated repulsion of cells
R-HSA-416993 Trafficking of GluR2-containing AMPA receptors
R-HSA-437239 Recycling pathway of L1
R-HSA-5099900 WNT5A-dependent internalization of FZD4
R-HSA-5140745 WNT5A-dependent internalization of FZD2, FZD5 and ROR2
R-HSA-8856825 Cargo recognition for clathrin-mediated endocytosis
R-HSA-8856828 Clathrin-mediated endocytosis
R-HSA-8866427 VLDLR internalisation and degradation
R-HSA-8964038 LDL clearance
SignaLinkiP63010
SIGNORiP63010

Miscellaneous databases

ChiTaRSiAP2B1 human
EvolutionaryTraceiP63010
GeneWikiiAP2B1
GenomeRNAii163
PROiPR:P63010
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000006125 Expressed in 228 organ(s), highest expression level in testis
CleanExiHS_AP2B1
ExpressionAtlasiP63010 baseline and differential
GenevisibleiP63010 HS

Family and domain databases

Gene3Di1.25.10.10, 1 hit
2.60.40.1150, 1 hit
3.30.310.10, 1 hit
InterProiView protein in InterPro
IPR026739 AP_beta
IPR016342 AP_complex_bsu_1_2_4
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR000225 Armadillo
IPR015151 B-adaptin_app_sub_C
IPR002553 Clathrin/coatomer_adapt-like_N
IPR008152 Clathrin_a/b/g-adaptin_app_Ig
IPR013041 Clathrin_app_Ig-like_sf
IPR013037 Clathrin_b-adaptin_app_Ig-like
IPR009028 Coatomer/calthrin_app_sub_C
IPR012295 TBP_dom_sf
PANTHERiPTHR11134 PTHR11134, 1 hit
PfamiView protein in Pfam
PF01602 Adaptin_N, 1 hit
PF02883 Alpha_adaptinC2, 1 hit
PF09066 B2-adapt-app_C, 1 hit
PIRSFiPIRSF002291 AP_complex_beta, 1 hit
SMARTiView protein in SMART
SM00809 Alpha_adaptinC2, 1 hit
SM00185 ARM, 2 hits
SM01020 B2-adapt-app_C, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit
SSF49348 SSF49348, 1 hit
SSF55711 SSF55711, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiAP2B1_HUMAN
AccessioniPrimary (citable) accession number: P63010
Secondary accession number(s): A6NJP3
, P21851, Q7Z451, Q96J19
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: August 31, 2004
Last modified: October 10, 2018
This is version 163 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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