UniProtKB - P63007 (LHX1_RAT)
Protein
LIM/homeobox protein Lhx1
Gene
Lhx1
Organism
Rattus norvegicus (Rat)
Status
Functioni
Potential transcription factor. May play a role in early mesoderm formation and later in lateral mesoderm differentiation and neurogenesis (By similarity).By similarity
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 180 – 239 | HomeoboxPROSITE-ProRule annotationAdd BLAST | 60 |
GO - Molecular functioni
- cis-regulatory region sequence-specific DNA binding Source: Ensembl
- DNA-binding transcription factor activity Source: UniProtKB
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- metal ion binding Source: UniProtKB-KW
- RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: GO_Central
- sequence-specific double-stranded DNA binding Source: RGD
GO - Biological processi
- anatomical structure formation involved in morphogenesis Source: UniProtKB
- anatomical structure morphogenesis Source: UniProtKB
- anterior/posterior axis specification Source: UniProtKB
- anterior/posterior pattern specification Source: UniProtKB
- branching involved in ureteric bud morphogenesis Source: RGD
- cell-cell signaling Source: UniProtKB
- cellular response to fibroblast growth factor stimulus Source: UniProtKB
- cerebellar Purkinje cell differentiation Source: UniProtKB
- cerebellar Purkinje cell-granule cell precursor cell signaling involved in regulation of granule cell precursor cell proliferation Source: UniProtKB
- cerebellum development Source: UniProtKB
- cervix development Source: UniProtKB
- comma-shaped body morphogenesis Source: UniProtKB
- dorsal/ventral pattern formation Source: UniProtKB
- ectoderm formation Source: UniProtKB
- embryonic pattern specification Source: UniProtKB
- embryonic retina morphogenesis in camera-type eye Source: UniProtKB
- embryonic viscerocranium morphogenesis Source: UniProtKB
- endoderm formation Source: UniProtKB
- epithelium development Source: UniProtKB
- forebrain regionalization Source: UniProtKB
- gastrulation with mouth forming second Source: UniProtKB
- head development Source: UniProtKB
- horizontal cell localization Source: RGD
- kidney development Source: UniProtKB
- lateral motor column neuron migration Source: UniProtKB
- mesendoderm development Source: Ensembl
- mesonephric duct development Source: UniProtKB
- mesonephric tubule development Source: UniProtKB
- mesonephros development Source: RGD
- metanephric comma-shaped body morphogenesis Source: UniProtKB
- metanephric glomerulus development Source: UniProtKB
- metanephric part of ureteric bud development Source: UniProtKB
- metanephric renal vesicle morphogenesis Source: RGD
- metanephric S-shaped body morphogenesis Source: UniProtKB
- metanephros development Source: RGD
- motor neuron axon guidance Source: UniProtKB
- negative regulation of transcription, DNA-templated Source: UniProtKB
- nephric duct elongation Source: RGD
- nephric duct morphogenesis Source: UniProtKB
- neuron differentiation Source: GO_Central
- oviduct development Source: UniProtKB
- oviduct epithelium development Source: UniProtKB
- paramesonephric duct development Source: UniProtKB
- pattern specification process Source: UniProtKB
- positive regulation of anterior head development Source: UniProtKB
- positive regulation of branching involved in ureteric bud morphogenesis Source: UniProtKB
- positive regulation of embryonic development Source: UniProtKB
- positive regulation of gastrulation Source: UniProtKB
- positive regulation of nephron tubule epithelial cell differentiation Source: UniProtKB
- positive regulation of transcription, DNA-templated Source: UniProtKB
- post-embryonic development Source: UniProtKB
- primitive streak formation Source: UniProtKB
- pronephros development Source: RGD
- regulation of gene expression Source: UniProtKB
- regulation of transcription by RNA polymerase II Source: GO_Central
- renal vesicle morphogenesis Source: UniProtKB
- retina development in camera-type eye Source: RGD
- retina layer formation Source: UniProtKB
- somite rostral/caudal axis specification Source: RGD
- spinal cord association neuron differentiation Source: UniProtKB
- spinal cord development Source: RGD
- S-shaped body morphogenesis Source: UniProtKB
- telencephalon development Source: RGD
- transcription by RNA polymerase II Source: UniProtKB
- ureteric bud development Source: UniProtKB
- ureter morphogenesis Source: RGD
- urogenital system development Source: UniProtKB
- uterine epithelium development Source: UniProtKB
- uterus development Source: UniProtKB
- vagina development Source: UniProtKB
- ventral spinal cord development Source: RGD
Keywordsi
Molecular function | Developmental protein, DNA-binding |
Biological process | Differentiation, Neurogenesis, Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Recommended name: LIM/homeobox protein Lhx1Short name: LIM homeobox protein 1 Alternative name(s): Homeobox protein Lim-1 Short name: Rlim |
Gene namesi | Name:Lhx1 Synonyms:Lim-1, Lim1 |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 71074, Lhx1 |
Subcellular locationi
Nucleus
- Nucleus PROSITE-ProRule annotation2 Publications
Nucleus
- nucleus Source: UniProtKB
Other locations
- protein-containing complex Source: UniProtKB
- transcription regulator complex Source: Ensembl
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000075773 | 1 – 406 | LIM/homeobox protein Lhx1Add BLAST | 406 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 162 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
PaxDbi | P63007 |
PRIDEi | P63007 |
PTM databases
iPTMneti | P63007 |
PhosphoSitePlusi | P63007 |
Expressioni
Tissue specificityi
Expressed in epithelial structures of the embryonic metanephric kidneys including the ureteric bud and its derivatives, and coma-shaped and S-shaped bodies differentiating from the metanephric mesenchyme. In the adult brain, expressed in the adrenal medulla, Purkinje cells of the cerebellum, hypothalamus, midbrain and pons. Also expressed in the adult testis.2 Publications
Gene expression databases
Bgeei | ENSRNOG00000002812, Expressed in kidney and 7 other tissues |
Genevisiblei | P63007, RN |
Interactioni
Subunit structurei
Interacts with LDB1 via the tandem LIM domains.
By similarityProtein-protein interaction databases
STRINGi | 10116.ENSRNOP00000003799 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 4 – 54 | LIM zinc-binding 1PROSITE-ProRule annotationAdd BLAST | 51 | |
Domaini | 63 – 117 | LIM zinc-binding 2PROSITE-ProRule annotationAdd BLAST | 55 |
Domaini
The LIM domains exert a negative regulatory function and disruption of the LIM domains produces an activated form. In addition, two activation domains and a negative regulatory domain exist C-terminally to the homeobox (By similarity).By similarity
Keywords - Domaini
Homeobox, LIM domain, RepeatPhylogenomic databases
eggNOGi | KOG0490, Eukaryota |
GeneTreei | ENSGT00940000160834 |
HOGENOMi | CLU_027802_3_1_1 |
InParanoidi | P63007 |
OMAi | CKEDYLT |
OrthoDBi | 1070389at2759 |
PhylomeDBi | P63007 |
TreeFami | TF315442 |
Family and domain databases
CDDi | cd00086, homeodomain, 1 hit |
InterProi | View protein in InterPro IPR009057, Homeobox-like_sf IPR017970, Homeobox_CS IPR001356, Homeobox_dom IPR001781, Znf_LIM |
Pfami | View protein in Pfam PF00046, Homeodomain, 1 hit PF00412, LIM, 2 hits |
SMARTi | View protein in SMART SM00389, HOX, 1 hit SM00132, LIM, 2 hits |
SUPFAMi | SSF46689, SSF46689, 1 hit |
PROSITEi | View protein in PROSITE PS00027, HOMEOBOX_1, 1 hit PS50071, HOMEOBOX_2, 1 hit PS00478, LIM_DOMAIN_1, 2 hits PS50023, LIM_DOMAIN_2, 2 hits |
i Sequence
Sequence statusi: Complete.
P63007-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MVHCAGCKRP ILDRFLLNVL DRAWHVKCVQ CCECKCNLTE KCFSREGKLY
60 70 80 90 100
CKNDFFRCFG TKCAGCAQGI SPSDLVRRAR SKVFHLNCFT CMMCNKQLST
110 120 130 140 150
GEELYIIDEN KFVCKEDYLS NSSVAKENSL HSATTGSDPS LSPDSQDPSQ
160 170 180 190 200
DDAKDSESAN VSDKEGGSNE NDDQNLGAKR RGPRTTIKAK QLETLKAAFA
210 220 230 240 250
ATPKPTRHIR EQLAQETGLN MRVIQVWFQN RRSKERRMKQ LSALGARRHA
260 270 280 290 300
FFRSPRRMRP LVDRLEPGEL IPNGPFSFYG DYQSEYYGPG GNYDFFPQGP
310 320 330 340 350
PSSQAQTPVD LPFVPSSGPS GTPLGGLDHP LPGHHPSSEA QRFTDILAHP
360 370 380 390 400
PGDSPSPEPS LPGPLHSMSA EVFGPSPPFS SLSVNGGASY GNHLSHPPEM
NEAAVW
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | S71523 mRNA Translation: AAC60696.1 |
RefSeqi | NP_665887.3, NM_145880.3 |
Genome annotation databases
Ensembli | ENSRNOT00000003799; ENSRNOP00000003799; ENSRNOG00000002812 |
GeneIDi | 257634 |
KEGGi | rno:257634 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | S71523 mRNA Translation: AAC60696.1 |
RefSeqi | NP_665887.3, NM_145880.3 |
3D structure databases
SMRi | P63007 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000003799 |
PTM databases
iPTMneti | P63007 |
PhosphoSitePlusi | P63007 |
Proteomic databases
PaxDbi | P63007 |
PRIDEi | P63007 |
Genome annotation databases
Ensembli | ENSRNOT00000003799; ENSRNOP00000003799; ENSRNOG00000002812 |
GeneIDi | 257634 |
KEGGi | rno:257634 |
Organism-specific databases
CTDi | 3975 |
RGDi | 71074, Lhx1 |
Phylogenomic databases
eggNOGi | KOG0490, Eukaryota |
GeneTreei | ENSGT00940000160834 |
HOGENOMi | CLU_027802_3_1_1 |
InParanoidi | P63007 |
OMAi | CKEDYLT |
OrthoDBi | 1070389at2759 |
PhylomeDBi | P63007 |
TreeFami | TF315442 |
Miscellaneous databases
PROi | PR:P63007 |
Gene expression databases
Bgeei | ENSRNOG00000002812, Expressed in kidney and 7 other tissues |
Genevisiblei | P63007, RN |
Family and domain databases
CDDi | cd00086, homeodomain, 1 hit |
InterProi | View protein in InterPro IPR009057, Homeobox-like_sf IPR017970, Homeobox_CS IPR001356, Homeobox_dom IPR001781, Znf_LIM |
Pfami | View protein in Pfam PF00046, Homeodomain, 1 hit PF00412, LIM, 2 hits |
SMARTi | View protein in SMART SM00389, HOX, 1 hit SM00132, LIM, 2 hits |
SUPFAMi | SSF46689, SSF46689, 1 hit |
PROSITEi | View protein in PROSITE PS00027, HOMEOBOX_1, 1 hit PS50071, HOMEOBOX_2, 1 hit PS00478, LIM_DOMAIN_1, 2 hits PS50023, LIM_DOMAIN_2, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | LHX1_RAT | |
Accessioni | P63007Primary (citable) accession number: P63007 Secondary accession number(s): P36199 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 31, 2004 |
Last sequence update: | August 31, 2004 | |
Last modified: | February 10, 2021 | |
This is version 127 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |