UniProtKB - P62995 (TRA2B_HUMAN)
Transformer-2 protein homolog beta
TRA2B
Functioni
GO - Molecular functioni
- identical protein binding Source: UniProtKB
- mRNA binding Source: UniProtKB
- pre-mRNA binding Source: CAFA
- protein domain specific binding Source: UniProtKB
- RNA binding Source: UniProtKB
GO - Biological processi
- cellular response to glucose stimulus Source: CAFA
- cerebral cortex regionalization Source: Ensembl
- embryonic brain development Source: Ensembl
- mRNA splicing, via spliceosome Source: UniProtKB
- positive regulation of mRNA splicing, via spliceosome Source: UniProtKB
- regulation of alternative mRNA splicing, via spliceosome Source: UniProtKB
- regulation of RNA splicing Source: UniProtKB
- response to reactive oxygen species Source: Ensembl
- RNA splicing, via transesterification reactions Source: UniProtKB
Keywordsi
Molecular function | Activator, Repressor, RNA-binding |
Biological process | mRNA processing, mRNA splicing |
Enzyme and pathway databases
PathwayCommonsi | P62995 |
Reactomei | R-HSA-72163, mRNA Splicing - Major Pathway |
SIGNORi | P62995 |
Names & Taxonomyi
Protein namesi | Recommended name: Transformer-2 protein homolog betaShort name: TRA-2 beta Short name: TRA2-beta Short name: hTRA2-beta Alternative name(s): Splicing factor, arginine/serine-rich 10 Transformer-2 protein homolog B |
Gene namesi | Name:TRA2B Synonyms:SFRS10 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:10781, TRA2B |
MIMi | 602719, gene |
neXtProti | NX_P62995 |
VEuPathDBi | HostDB:ENSG00000136527.17 |
Subcellular locationi
Nucleus
- Nucleus 2 Publications
Nucleus
- nuclear inner membrane Source: Ensembl
- nucleoplasm Source: HPA
- nucleus Source: UniProtKB
- spliceosomal complex Source: CAFA
Other locations
- perinuclear region of cytoplasm Source: Ensembl
- protein-containing complex Source: UniProtKB
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 6434 |
OpenTargetsi | ENSG00000136527 |
PharmGKBi | PA35697 |
Miscellaneous databases
Pharosi | P62995, Tbio |
Genetic variation databases
BioMutai | TRA2B |
DMDMi | 51703330 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources | |||
ChainiPRO_0000081983 | 2 – 288 | Transformer-2 protein homolog betaAdd BLAST | 287 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylserineCombined sources | 1 | |
Modified residuei | 2 | PhosphoserineCombined sources | 1 | |
Modified residuei | 4 | PhosphoserineCombined sources | 1 | |
Modified residuei | 14 | PhosphoserineCombined sources | 1 | |
Modified residuei | 29 | PhosphoserineBy similarity | 1 | |
Modified residuei | 33 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 83 | PhosphoserineCombined sources | 1 | |
Modified residuei | 85 | PhosphoserineCombined sources | 1 | |
Modified residuei | 87 | PhosphoserineCombined sources | 1 | |
Modified residuei | 95 | PhosphoserineCombined sources | 1 | |
Modified residuei | 97 | PhosphoserineCombined sources | 1 | |
Modified residuei | 99 | PhosphoserineCombined sources | 1 | |
Modified residuei | 103 | PhosphothreonineCombined sources | 1 | |
Cross-linki | 197 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 201 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 203 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 215 | PhosphoserineCombined sources | 1 | |
Modified residuei | 237 | PhosphoserineCombined sources | 1 | |
Modified residuei | 241 | Asymmetric dimethylarginine; alternateCombined sources | 1 | |
Modified residuei | 241 | Dimethylated arginine; alternateCombined sources1 Publication | 1 | |
Modified residuei | 241 | Omega-N-methylarginine; alternateCombined sources | 1 |
Post-translational modificationi
Keywords - PTMi
Acetylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | P62995 |
jPOSTi | P62995 |
MassIVEi | P62995 |
MaxQBi | P62995 |
PaxDbi | P62995 |
PeptideAtlasi | P62995 |
PRIDEi | P62995 |
ProteomicsDBi | 57464 57465 [P62995-2] 57466 [P62995-3] |
PTM databases
iPTMneti | P62995 |
PhosphoSitePlusi | P62995 |
SwissPalmi | P62995 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000136527, Expressed in endometrium and 252 other tissues |
ExpressionAtlasi | P62995, baseline and differential |
Genevisiblei | P62995, HS |
Organism-specific databases
HPAi | ENSG00000136527, Low tissue specificity |
Interactioni
Subunit structurei
Interacts with SAFB/SAFB1 (By similarity).
Found in a pre-mRNA exonic splicing enhancer (ESE) complex with TRA2B/SFRS10, SNRNP70, SNRPA1 and SRRM1. Binds to A3 enhancer proteins SFRS4, SFRS5, SFRS6 and SFRS9.
Interacts with CPSF6, RBMY1A1, RBMX, RNPS1 and phosphorylated SFRS13A.
By similarity7 PublicationsBinary interactionsi
Hide detailsP62995
GO - Molecular functioni
- identical protein binding Source: UniProtKB
- protein domain specific binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 112332, 267 interactors |
CORUMi | P62995 |
DIPi | DIP-42278N |
IntActi | P62995, 64 interactors |
MINTi | P62995 |
STRINGi | 9606.ENSP00000416959 |
Miscellaneous databases
RNActi | P62995, protein |
Structurei
Secondary structure
3D structure databases
BMRBi | P62995 |
SMRi | P62995 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P62995 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 118 – 196 | RRMPROSITE-ProRule annotationAdd BLAST | 79 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 193 – 230 | LinkerAdd BLAST | 38 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 31 – 113 | Arg/Ser-rich (RS1 domain)Add BLAST | 83 | |
Compositional biasi | 231 – 287 | Arg/Ser-rich (RS2 domain)Add BLAST | 57 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG0118, Eukaryota |
GeneTreei | ENSGT00950000183009 |
HOGENOMi | CLU_050438_3_0_1 |
InParanoidi | P62995 |
OMAi | GRYSPEY |
OrthoDBi | 1524134at2759 |
PhylomeDBi | P62995 |
TreeFami | TF106265 |
Family and domain databases
Gene3Di | 3.30.70.330, 1 hit |
InterProi | View protein in InterPro IPR012677, Nucleotide-bd_a/b_plait_sf IPR035979, RBD_domain_sf IPR000504, RRM_dom |
Pfami | View protein in Pfam PF00076, RRM_1, 1 hit |
SMARTi | View protein in SMART SM00360, RRM, 1 hit |
SUPFAMi | SSF54928, SSF54928, 1 hit |
PROSITEi | View protein in PROSITE PS50102, RRM, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSDSGEQNYG ERESRSASRS GSAHGSGKSA RHTPARSRSK EDSRRSRSKS
60 70 80 90 100
RSRSESRSRS RRSSRRHYTR SRSRSRSHRR SRSRSYSRDY RRRHSHSHSP
110 120 130 140 150
MSTRRRHVGN RANPDPNCCL GVFGLSLYTT ERDLREVFSK YGPIADVSIV
160 170 180 190 200
YDQQSRRSRG FAFVYFENVD DAKEAKERAN GMELDGRRIR VDFSITKRPH
210 220 230 240 250
TPTPGIYMGR PTYGSSRRRD YYDRGYDRGY DDRDYYSRSY RGGGGGGGGW
260 270 280
RAAQDRDQIY RRRSPSPYYS RGGYRSRSRS RSYSPRRY
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH7C2L4 | H7C2L4_HUMAN | Transformer-2 protein homolog beta | TRA2B | 107 | Annotation score: | ||
H7BXF3 | H7BXF3_HUMAN | Transformer-2 protein homolog beta | TRA2B | 127 | Annotation score: |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_005896 | 1 – 100 | Missing in isoform 3. 1 PublicationAdd BLAST | 100 | |
Alternative sequenceiVSP_005898 | 13 – 38 | ESRSA…PARSR → VNVEEGKCGSRHLTSFINEY LKLRNK in isoform 2. 1 PublicationAdd BLAST | 26 | |
Alternative sequenceiVSP_005899 | 39 – 288 | Missing in isoform 2. 1 PublicationAdd BLAST | 250 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U61267 mRNA Translation: AAC28242.1 U87836 mRNA Translation: AAB69763.1 AF057159 Genomic DNA Translation: AAD19277.1 AF057159 Genomic DNA Translation: AAD19278.1 AF057159 Genomic DNA Translation: AAD19279.1 U68063 mRNA Translation: AAB08701.1 AK301118 mRNA Translation: BAG62714.1 CH471052 Genomic DNA Translation: EAW78204.1 CH471052 Genomic DNA Translation: EAW78205.1 CH471052 Genomic DNA Translation: EAW78208.1 BC000160 mRNA Translation: AAH00160.1 BC000451 mRNA Translation: AAH00451.1 BC005898 mRNA Translation: AAH05898.1 |
CCDSi | CCDS33905.1 CCDS58872.1 [P62995-3] |
RefSeqi | NP_001230808.1, NM_001243879.1 [P62995-3] NP_004584.1, NM_004593.2 [P62995-1] XP_005247760.1, XM_005247703.1 [P62995-3] XP_011511374.1, XM_011513072.2 XP_016862522.1, XM_017007033.1 |
Genome annotation databases
Ensembli | ENST00000342294; ENSP00000343857; ENSG00000136527 [P62995-2] ENST00000382191; ENSP00000371626; ENSG00000136527 [P62995-3] ENST00000453386; ENSP00000416959; ENSG00000136527 [P62995-1] ENST00000456380; ENSP00000416887; ENSG00000136527 [P62995-2] |
GeneIDi | 6434 |
KEGGi | hsa:6434 |
UCSCi | uc003fpv.4, human |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U61267 mRNA Translation: AAC28242.1 U87836 mRNA Translation: AAB69763.1 AF057159 Genomic DNA Translation: AAD19277.1 AF057159 Genomic DNA Translation: AAD19278.1 AF057159 Genomic DNA Translation: AAD19279.1 U68063 mRNA Translation: AAB08701.1 AK301118 mRNA Translation: BAG62714.1 CH471052 Genomic DNA Translation: EAW78204.1 CH471052 Genomic DNA Translation: EAW78205.1 CH471052 Genomic DNA Translation: EAW78208.1 BC000160 mRNA Translation: AAH00160.1 BC000451 mRNA Translation: AAH00451.1 BC005898 mRNA Translation: AAH05898.1 |
CCDSi | CCDS33905.1 CCDS58872.1 [P62995-3] |
RefSeqi | NP_001230808.1, NM_001243879.1 [P62995-3] NP_004584.1, NM_004593.2 [P62995-1] XP_005247760.1, XM_005247703.1 [P62995-3] XP_011511374.1, XM_011513072.2 XP_016862522.1, XM_017007033.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2CQC | NMR | - | A | 110-191 | [»] | |
2KXN | NMR | - | B | 106-200 | [»] | |
2RRA | NMR | - | A | 109-201 | [»] | |
2RRB | NMR | - | A | 111-201 | [»] | |
BMRBi | P62995 | |||||
SMRi | P62995 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 112332, 267 interactors |
CORUMi | P62995 |
DIPi | DIP-42278N |
IntActi | P62995, 64 interactors |
MINTi | P62995 |
STRINGi | 9606.ENSP00000416959 |
PTM databases
iPTMneti | P62995 |
PhosphoSitePlusi | P62995 |
SwissPalmi | P62995 |
Genetic variation databases
BioMutai | TRA2B |
DMDMi | 51703330 |
Proteomic databases
EPDi | P62995 |
jPOSTi | P62995 |
MassIVEi | P62995 |
MaxQBi | P62995 |
PaxDbi | P62995 |
PeptideAtlasi | P62995 |
PRIDEi | P62995 |
ProteomicsDBi | 57464 57465 [P62995-2] 57466 [P62995-3] |
Protocols and materials databases
Antibodypediai | 3190, 172 antibodies |
DNASUi | 6434 |
Genome annotation databases
Ensembli | ENST00000342294; ENSP00000343857; ENSG00000136527 [P62995-2] ENST00000382191; ENSP00000371626; ENSG00000136527 [P62995-3] ENST00000453386; ENSP00000416959; ENSG00000136527 [P62995-1] ENST00000456380; ENSP00000416887; ENSG00000136527 [P62995-2] |
GeneIDi | 6434 |
KEGGi | hsa:6434 |
UCSCi | uc003fpv.4, human |
Organism-specific databases
CTDi | 6434 |
DisGeNETi | 6434 |
GeneCardsi | TRA2B |
HGNCi | HGNC:10781, TRA2B |
HPAi | ENSG00000136527, Low tissue specificity |
MIMi | 602719, gene |
neXtProti | NX_P62995 |
OpenTargetsi | ENSG00000136527 |
PharmGKBi | PA35697 |
VEuPathDBi | HostDB:ENSG00000136527.17 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0118, Eukaryota |
GeneTreei | ENSGT00950000183009 |
HOGENOMi | CLU_050438_3_0_1 |
InParanoidi | P62995 |
OMAi | GRYSPEY |
OrthoDBi | 1524134at2759 |
PhylomeDBi | P62995 |
TreeFami | TF106265 |
Enzyme and pathway databases
PathwayCommonsi | P62995 |
Reactomei | R-HSA-72163, mRNA Splicing - Major Pathway |
SIGNORi | P62995 |
Miscellaneous databases
BioGRID-ORCSi | 6434, 404 hits in 1012 CRISPR screens |
ChiTaRSi | TRA2B, human |
EvolutionaryTracei | P62995 |
GeneWikii | TRA2B |
GenomeRNAii | 6434 |
Pharosi | P62995, Tbio |
PROi | PR:P62995 |
RNActi | P62995, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000136527, Expressed in endometrium and 252 other tissues |
ExpressionAtlasi | P62995, baseline and differential |
Genevisiblei | P62995, HS |
Family and domain databases
Gene3Di | 3.30.70.330, 1 hit |
InterProi | View protein in InterPro IPR012677, Nucleotide-bd_a/b_plait_sf IPR035979, RBD_domain_sf IPR000504, RRM_dom |
Pfami | View protein in Pfam PF00076, RRM_1, 1 hit |
SMARTi | View protein in SMART SM00360, RRM, 1 hit |
SUPFAMi | SSF54928, SSF54928, 1 hit |
PROSITEi | View protein in PROSITE PS50102, RRM, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | TRA2B_HUMAN | |
Accessioni | P62995Primary (citable) accession number: P62995 Secondary accession number(s): B4DVK2 Q64283 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 31, 2004 |
Last sequence update: | August 31, 2004 | |
Last modified: | April 7, 2021 | |
This is version 173 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 3
Human chromosome 3: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families