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Protein

Transformer-2 protein homolog beta

Gene

TRA2B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Sequence-specific RNA-binding protein which participates in the control of pre-mRNA splicing. Can either activate or suppress exon inclusion. Acts additively with RBMX to promote exon 7 inclusion of the survival motor neuron SMN2. Activates the splicing of MAPT/Tau exon 10. Alters pre-mRNA splicing patterns by antagonizing the effects of splicing regulators, like RBMX. Binds to the AG-rich SE2 domain in the SMN exon 7 RNA. Binds to pre-mRNA.4 Publications

GO - Molecular functioni

  • identical protein binding Source: UniProtKB
  • mRNA binding Source: UniProtKB
  • pre-mRNA binding Source: CAFA
  • protein domain specific binding Source: UniProtKB
  • RNA binding Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionActivator, Repressor, RNA-binding
Biological processmRNA processing, mRNA splicing

Enzyme and pathway databases

ReactomeiR-HSA-72163 mRNA Splicing - Major Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Transformer-2 protein homolog beta
Short name:
TRA-2 beta
Short name:
TRA2-beta
Short name:
hTRA2-beta
Alternative name(s):
Splicing factor, arginine/serine-rich 10
Transformer-2 protein homolog B
Gene namesi
Name:TRA2B
Synonyms:SFRS10
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000136527.17
HGNCiHGNC:10781 TRA2B
MIMi602719 gene
neXtProtiNX_P62995

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi6434
OpenTargetsiENSG00000136527
PharmGKBiPA35697

Polymorphism and mutation databases

BioMutaiTRA2B
DMDMi51703330

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00000819832 – 288Transformer-2 protein homolog betaAdd BLAST287

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1
Modified residuei2PhosphoserineCombined sources1
Modified residuei4PhosphoserineCombined sources1
Modified residuei14PhosphoserineCombined sources1
Modified residuei29PhosphoserineBy similarity1
Modified residuei33PhosphothreonineBy similarity1
Modified residuei83PhosphoserineCombined sources1
Modified residuei85PhosphoserineCombined sources1
Modified residuei87PhosphoserineCombined sources1
Modified residuei95PhosphoserineCombined sources1
Modified residuei97PhosphoserineCombined sources1
Modified residuei99PhosphoserineCombined sources1
Modified residuei103PhosphothreonineCombined sources1
Cross-linki197Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei201PhosphothreonineCombined sources1
Modified residuei203PhosphothreonineCombined sources1
Modified residuei215PhosphoserineCombined sources1
Modified residuei237PhosphoserineCombined sources1
Modified residuei241Asymmetric dimethylarginine; alternateCombined sources1
Modified residuei241Dimethylated arginine; alternateCombined sources1 Publication1
Modified residuei241Omega-N-methylarginine; alternateCombined sources1

Post-translational modificationi

Phosphorylated in the RS domains.1 Publication
Dimethylation at Arg-241 is probably asymmetric.

Keywords - PTMi

Acetylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP62995
MaxQBiP62995
PaxDbiP62995
PeptideAtlasiP62995
PRIDEiP62995
ProteomicsDBi57464
57465 [P62995-2]
57466 [P62995-3]

PTM databases

iPTMnetiP62995
PhosphoSitePlusiP62995
SwissPalmiP62995

Expressioni

Tissue specificityi

Highest expression in heart, skeletal muscle and pancreas. Less abundant in kidney, placenta and brain. Lowest expression in kidney and liver.1 Publication

Gene expression databases

BgeeiENSG00000136527 Expressed in 242 organ(s), highest expression level in endometrium
CleanExiHS_SFRS10
ExpressionAtlasiP62995 baseline and differential
GenevisibleiP62995 HS

Organism-specific databases

HPAiCAB011692
HPA063597
HPA064972

Interactioni

Subunit structurei

Interacts with SAFB/SAFB1 (By similarity). Found in a pre-mRNA exonic splicing enhancer (ESE) complex with TRA2B/SFRS10, SNRNP70, SNRPA1 and SRRM1. Binds to A3 enhancer proteins SFRS4, SFRS5, SFRS6 and SFRS9. Interacts with CPSF6, RBMY1A1, RBMX, RNPS1 and phosphorylated SFRS13A.By similarity7 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi112332, 190 interactors
CORUMiP62995
DIPiDIP-42278N
IntActiP62995, 38 interactors
MINTiP62995
STRINGi9606.ENSP00000416959

Structurei

Secondary structure

1288
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP62995
SMRiP62995
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP62995

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini118 – 196RRMPROSITE-ProRule annotationAdd BLAST79

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni193 – 230LinkerAdd BLAST38

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi31 – 113Arg/Ser-rich (RS1 domain)Add BLAST83
Compositional biasi231 – 287Arg/Ser-rich (RS2 domain)Add BLAST57

Sequence similaritiesi

Belongs to the splicing factor SR family.Curated

Phylogenomic databases

eggNOGiENOG410IQXD Eukaryota
ENOG4110CTH LUCA
GeneTreeiENSGT00710000106295
HOGENOMiHOG000276232
HOVERGENiHBG104971
InParanoidiP62995
KOiK12897
OMAiFGFVNMV
OrthoDBiEOG091G0Y02
PhylomeDBiP62995
TreeFamiTF106265

Family and domain databases

Gene3Di3.30.70.330, 1 hit
InterProiView protein in InterPro
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
PfamiView protein in Pfam
PF00076 RRM_1, 1 hit
SMARTiView protein in SMART
SM00360 RRM, 1 hit
SUPFAMiSSF54928 SSF54928, 1 hit
PROSITEiView protein in PROSITE
PS50102 RRM, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P62995-1) [UniParc]FASTAAdd to basket
Also known as: HTRA2-beta1

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSDSGEQNYG ERESRSASRS GSAHGSGKSA RHTPARSRSK EDSRRSRSKS
60 70 80 90 100
RSRSESRSRS RRSSRRHYTR SRSRSRSHRR SRSRSYSRDY RRRHSHSHSP
110 120 130 140 150
MSTRRRHVGN RANPDPNCCL GVFGLSLYTT ERDLREVFSK YGPIADVSIV
160 170 180 190 200
YDQQSRRSRG FAFVYFENVD DAKEAKERAN GMELDGRRIR VDFSITKRPH
210 220 230 240 250
TPTPGIYMGR PTYGSSRRRD YYDRGYDRGY DDRDYYSRSY RGGGGGGGGW
260 270 280
RAAQDRDQIY RRRSPSPYYS RGGYRSRSRS RSYSPRRY
Length:288
Mass (Da):33,666
Last modified:August 31, 2004 - v1
Checksum:i60B310C8BA443E28
GO
Isoform 2 (identifier: P62995-2) [UniParc] [UniParc]FASTAAdd to basket
Also known as: HTRA2-beta2

The sequence of this isoform differs from the canonical sequence as follows:
     13-38: ESRSASRSGSAHGSGKSARHTPARSR → VNVEEGKCGSRHLTSFINEYLKLRNK
     39-288: Missing.

Show »
Length:38
Mass (Da):4,390
Checksum:i9E1E02297010CF61
GO
Isoform 3 (identifier: P62995-3) [UniParc] [UniParc]FASTAAdd to basket
Also known as: HTRA2-beta3

The sequence of this isoform differs from the canonical sequence as follows:
     1-100: Missing.

Show »
Length:188
Mass (Da):21,935
Checksum:iAC9D4171E481BAF7
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7C2L4H7C2L4_HUMAN
Transformer-2 protein homolog beta
TRA2B
107Annotation score:
H7BXF3H7BXF3_HUMAN
Transformer-2 protein homolog beta
TRA2B
127Annotation score:

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0058961 – 100Missing in isoform 3. 1 PublicationAdd BLAST100
Alternative sequenceiVSP_00589813 – 38ESRSA…PARSR → VNVEEGKCGSRHLTSFINEY LKLRNK in isoform 2. 1 PublicationAdd BLAST26
Alternative sequenceiVSP_00589939 – 288Missing in isoform 2. 1 PublicationAdd BLAST250

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U61267 mRNA Translation: AAC28242.1
U87836 mRNA Translation: AAB69763.1
AF057159 Genomic DNA Translation: AAD19277.1
AF057159 Genomic DNA Translation: AAD19278.1
AF057159 Genomic DNA Translation: AAD19279.1
U68063 mRNA Translation: AAB08701.1
AK301118 mRNA Translation: BAG62714.1
CH471052 Genomic DNA Translation: EAW78204.1
CH471052 Genomic DNA Translation: EAW78205.1
CH471052 Genomic DNA Translation: EAW78208.1
BC000160 mRNA Translation: AAH00160.1
BC000451 mRNA Translation: AAH00451.1
BC005898 mRNA Translation: AAH05898.1
CCDSiCCDS33905.1
CCDS58872.1 [P62995-3]
RefSeqiNP_001230808.1, NM_001243879.1 [P62995-3]
NP_004584.1, NM_004593.2 [P62995-1]
XP_005247760.1, XM_005247703.1 [P62995-3]
XP_011511374.1, XM_011513072.2
XP_016862522.1, XM_017007033.1
UniGeneiHs.533122

Genome annotation databases

EnsembliENST00000342294; ENSP00000343857; ENSG00000136527 [P62995-2]
ENST00000382191; ENSP00000371626; ENSG00000136527 [P62995-3]
ENST00000453386; ENSP00000416959; ENSG00000136527 [P62995-1]
ENST00000456380; ENSP00000416887; ENSG00000136527 [P62995-2]
GeneIDi6434
KEGGihsa:6434
UCSCiuc003fpv.4 human

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U61267 mRNA Translation: AAC28242.1
U87836 mRNA Translation: AAB69763.1
AF057159 Genomic DNA Translation: AAD19277.1
AF057159 Genomic DNA Translation: AAD19278.1
AF057159 Genomic DNA Translation: AAD19279.1
U68063 mRNA Translation: AAB08701.1
AK301118 mRNA Translation: BAG62714.1
CH471052 Genomic DNA Translation: EAW78204.1
CH471052 Genomic DNA Translation: EAW78205.1
CH471052 Genomic DNA Translation: EAW78208.1
BC000160 mRNA Translation: AAH00160.1
BC000451 mRNA Translation: AAH00451.1
BC005898 mRNA Translation: AAH05898.1
CCDSiCCDS33905.1
CCDS58872.1 [P62995-3]
RefSeqiNP_001230808.1, NM_001243879.1 [P62995-3]
NP_004584.1, NM_004593.2 [P62995-1]
XP_005247760.1, XM_005247703.1 [P62995-3]
XP_011511374.1, XM_011513072.2
XP_016862522.1, XM_017007033.1
UniGeneiHs.533122

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2CQCNMR-A110-191[»]
2KXNNMR-B106-200[»]
2RRANMR-A109-201[»]
2RRBNMR-A111-201[»]
ProteinModelPortaliP62995
SMRiP62995
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112332, 190 interactors
CORUMiP62995
DIPiDIP-42278N
IntActiP62995, 38 interactors
MINTiP62995
STRINGi9606.ENSP00000416959

PTM databases

iPTMnetiP62995
PhosphoSitePlusiP62995
SwissPalmiP62995

Polymorphism and mutation databases

BioMutaiTRA2B
DMDMi51703330

Proteomic databases

EPDiP62995
MaxQBiP62995
PaxDbiP62995
PeptideAtlasiP62995
PRIDEiP62995
ProteomicsDBi57464
57465 [P62995-2]
57466 [P62995-3]

Protocols and materials databases

DNASUi6434
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000342294; ENSP00000343857; ENSG00000136527 [P62995-2]
ENST00000382191; ENSP00000371626; ENSG00000136527 [P62995-3]
ENST00000453386; ENSP00000416959; ENSG00000136527 [P62995-1]
ENST00000456380; ENSP00000416887; ENSG00000136527 [P62995-2]
GeneIDi6434
KEGGihsa:6434
UCSCiuc003fpv.4 human

Organism-specific databases

CTDi6434
DisGeNETi6434
EuPathDBiHostDB:ENSG00000136527.17
GeneCardsiTRA2B
H-InvDBiHIX0003928
HGNCiHGNC:10781 TRA2B
HPAiCAB011692
HPA063597
HPA064972
MIMi602719 gene
neXtProtiNX_P62995
OpenTargetsiENSG00000136527
PharmGKBiPA35697
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IQXD Eukaryota
ENOG4110CTH LUCA
GeneTreeiENSGT00710000106295
HOGENOMiHOG000276232
HOVERGENiHBG104971
InParanoidiP62995
KOiK12897
OMAiFGFVNMV
OrthoDBiEOG091G0Y02
PhylomeDBiP62995
TreeFamiTF106265

Enzyme and pathway databases

ReactomeiR-HSA-72163 mRNA Splicing - Major Pathway

Miscellaneous databases

ChiTaRSiTRA2B human
EvolutionaryTraceiP62995
GeneWikiiTRA2B
GenomeRNAii6434
PROiPR:P62995
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000136527 Expressed in 242 organ(s), highest expression level in endometrium
CleanExiHS_SFRS10
ExpressionAtlasiP62995 baseline and differential
GenevisibleiP62995 HS

Family and domain databases

Gene3Di3.30.70.330, 1 hit
InterProiView protein in InterPro
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
PfamiView protein in Pfam
PF00076 RRM_1, 1 hit
SMARTiView protein in SMART
SM00360 RRM, 1 hit
SUPFAMiSSF54928 SSF54928, 1 hit
PROSITEiView protein in PROSITE
PS50102 RRM, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTRA2B_HUMAN
AccessioniPrimary (citable) accession number: P62995
Secondary accession number(s): B4DVK2
, D3DNU3, O15449, Q15815, Q64283
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: August 31, 2004
Last modified: November 7, 2018
This is version 154 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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