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Entry version 159 (07 Apr 2021)
Sequence version 1 (31 Aug 2004)
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Protein

Growth factor receptor-bound protein 2

Gene

Grb2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway.

1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-RNO-109704, PI3K Cascade
R-RNO-112412, SOS-mediated signalling
R-RNO-1250347, SHC1 events in ERBB4 signaling
R-RNO-1257604, PIP3 activates AKT signaling
R-RNO-1295596, Spry regulation of FGF signaling
R-RNO-1433557, Signaling by SCF-KIT
R-RNO-1433559, Regulation of KIT signaling
R-RNO-167044, Signalling to RAS
R-RNO-179812, GRB2 events in EGFR signaling
R-RNO-180292, GAB1 signalosome
R-RNO-180336, SHC1 events in EGFR signaling
R-RNO-182971, EGFR downregulation
R-RNO-186763, Downstream signal transduction
R-RNO-1963640, GRB2 events in ERBB2 signaling
R-RNO-1963642, PI3K events in ERBB2 signaling
R-RNO-2029482, Regulation of actin dynamics for phagocytic cup formation
R-RNO-210993, Tie2 Signaling
R-RNO-2179392, EGFR Transactivation by Gastrin
R-RNO-2424491, DAP12 signaling
R-RNO-2428933, SHC-related events triggered by IGF1R
R-RNO-2730905, Role of LAT2/NTAL/LAB on calcium mobilization
R-RNO-2871796, FCERI mediated MAPK activation
R-RNO-2871809, FCERI mediated Ca+2 mobilization
R-RNO-354194, GRB2:SOS provides linkage to MAPK signaling for Integrins
R-RNO-375165, NCAM signaling for neurite out-growth
R-RNO-388841, Costimulation by the CD28 family
R-RNO-389359, CD28 dependent Vav1 pathway
R-RNO-391160, Signal regulatory protein family interactions
R-RNO-5654688, SHC-mediated cascade:FGFR1
R-RNO-5654689, PI-3K cascade:FGFR1
R-RNO-5654693, FRS-mediated FGFR1 signaling
R-RNO-5654695, PI-3K cascade:FGFR2
R-RNO-5654699, SHC-mediated cascade:FGFR2
R-RNO-5654700, FRS-mediated FGFR2 signaling
R-RNO-5654704, SHC-mediated cascade:FGFR3
R-RNO-5654706, FRS-mediated FGFR3 signaling
R-RNO-5654710, PI-3K cascade:FGFR3
R-RNO-5654712, FRS-mediated FGFR4 signaling
R-RNO-5654719, SHC-mediated cascade:FGFR4
R-RNO-5654720, PI-3K cascade:FGFR4
R-RNO-5654726, Negative regulation of FGFR1 signaling
R-RNO-5654727, Negative regulation of FGFR2 signaling
R-RNO-5654732, Negative regulation of FGFR3 signaling
R-RNO-5654733, Negative regulation of FGFR4 signaling
R-RNO-5663213, RHO GTPases Activate WASPs and WAVEs
R-RNO-5673001, RAF/MAP kinase cascade
R-RNO-6807004, Negative regulation of MET activity
R-RNO-6811558, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-RNO-74749, Signal attenuation
R-RNO-74751, Insulin receptor signalling cascade
R-RNO-8851805, MET activates RAS signaling
R-RNO-8851907, MET activates PI3K/AKT signaling
R-RNO-8853659, RET signaling
R-RNO-8856825, Cargo recognition for clathrin-mediated endocytosis
R-RNO-8856828, Clathrin-mediated endocytosis
R-RNO-8865999, MET activates PTPN11
R-RNO-8875555, MET activates RAP1 and RAC1
R-RNO-8875656, MET receptor recycling
R-RNO-8983432, Interleukin-15 signaling
R-RNO-9027284, Erythropoietin activates RAS
R-RNO-9028731, Activated NTRK2 signals through FRS2 and FRS3
R-RNO-912526, Interleukin receptor SHC signaling
R-RNO-912631, Regulation of signaling by CBL
R-RNO-9607240, FLT3 Signaling
R-RNO-983695, Antigen activates B Cell Receptor (BCR) leading to generation of second messengers

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Growth factor receptor-bound protein 2
Alternative name(s):
Adapter protein GRB2
Protein Ash
SH2/SH3 adapter GRB2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Grb2
Synonyms:Ash
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Rat genome database

More...
RGDi
619758, Grb2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm, Endosome, Golgi apparatus, Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000882011 – 217Growth factor receptor-bound protein 2Add BLAST217

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineBy similarity1
Modified residuei6N6-acetyllysineBy similarity1
Modified residuei50N6-acetyllysineBy similarity1
Modified residuei109N6-acetyllysineBy similarity1
Modified residuei211PhosphothreonineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P62994

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P62994

PRoteomics IDEntifications database

More...
PRIDEi
P62994

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P62994

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P62994

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P62994

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Wide tissue distribution.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSRNOG00000003990, Expressed in frontal cortex and 21 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P62994, RN

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Associates (via SH2 domain) with activated EGF and PDGF receptors (tyrosine phosphorylated).

Interacts with PDGFRA (tyrosine phosphorylated); the interaction may be indirect.

Interacts with IRS4 (when Tyr-phosphorylated). Also associates to other cellular Tyr-phosphorylated proteins such as SIT1, SHC and LNK; probably via the concerted action of both its SH2 and SH3 domains. It also seems to interact with RAS in the signaling pathway leading to DNA synthesis.

Interacts with SOS1.

Forms a complex with MUC1 and SOS1, through interaction of the SH3 domains with SOS1 and the SH2 domain with phosphorylated MUC1.

Interacts with phosphorylated MET.

Interacts with phosphorylated TOM1L1.

Interacts with the phosphorylated C-terminus of SH2B2.

Interacts with phosphorylated SIT1, LAX1, LAT, LAT2 and LIME1 upon TCR and/or BCR activation.

Interacts with NISCH, PTPNS1 and REPS2.

Interacts with syntrophin SNTA1.

Interacts (via SH3 domains) with REPS1.

Interacts (via SH3 domains) with PIK3C2B.

Interacts with CBL and CBLB.

Interacts with AJUBA and CLNK.

Interacts (via SH2 domain) with TEK/TIE2 (tyrosine phosphorylated).

Interacts with SHB, INPP5D/SHIP1, SKAP1 and SKAP2.

Interacts with PTPN11.

Interacts with PRNP.

Interacts with RALGPS1.

Interacts also with HCST.

Interacts with KDR.

Interacts with FLT1 (tyrosine-phosphorylated).

Interacts with GAPT and PTPRE.

Interacts (via SH2 domain) with KIF26A.

Interacts (via SH3 2) with GAB2.

Interacts with ADAM15.

Interacts with THEMIS2.

Interacts (via SH2 domain) with AXL (phosphorylated).

Interacts (via SH2 domain) with KIT (phosphorylated).

Interacts with PTPRJ and BCR.

Interacts with PTPN23.

Interacts with FLT4 (tyrosine phosphorylated).

Interacts with EPHB1 and SHC1; activates the MAPK/ERK cascade to regulate cell migration.

Part of a complex including TNK2, GRB2 and one receptor tyrosine kinase (RTK) such as AXL and PDGFRL, in which GRB2 promotes RTK recruitment by TNK2.

Interacts with ERBB4.

Interacts with NTRK1 (phosphorylated upon ligand-binding).

Interacts with PTK2/FAK1 (tyrosine phosphorylated).

Interacts with PTK2B/PYK2 (tyrosine phosphorylated).

Interacts (via SH2-domain) with SCIMP; this interaction is dependent on phosphorylation on SCIMP 'Tyr-58' (By similarity).

Interacts (via SH3 domains) with GAREM1 (via proline-rich domain and tyrosine phosphorylated); the interaction occurs upon EGF stimulation.

Interacts with DAB2.

Interacts with TESPA1.

Interacts with THEMIS.

Interacts with PLCG1, LAT and THEMIS upon TCR activation in thymocytes; the association is weaker in the absence of TESPA1.

Interacts with CD28.

Interacts with RAB13; may recruit RAB13 to the leading edge of migrating endothelial cells where it can activate RHOA.

Interacts with ASAP3 (phosphorylated form) (By similarity).

Interacts (via SH2 domain) with CSF1R and IRS1 (tyrosine phosphorylated) (PubMed:8262059, PubMed:8388384).

Interacts (via SH2 domain) with PTPRH (phosphorylated form) (By similarity).

Interacts with PTPRO (phosphorylated form) (By similarity).

Interacts with PTPRB (phosphorylated form) (By similarity).

Interacts (via SH3 domain 2) with PRR14 (via proline-rich region) (By similarity).

Interacts with DENND2B (By similarity).

Interacts with SPRY2 (By similarity).

Interacts with LRRC8A (By similarity).

By similarity2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
249501, 13 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
P62994

Protein interaction database and analysis system

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IntActi
P62994, 27 interactors

Molecular INTeraction database

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MINTi
P62994

STRING: functional protein association networks

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STRINGi
10116.ENSRNOP00000005347

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Biological Magnetic Resonance Data Bank

More...
BMRBi
P62994

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P62994

Database of comparative protein structure models

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ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1 – 58SH3 1PROSITE-ProRule annotationAdd BLAST58
Domaini60 – 152SH2PROSITE-ProRule annotationAdd BLAST93
Domaini156 – 215SH3 2PROSITE-ProRule annotationAdd BLAST60

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The SH3 domains mediate interaction with RALGPS1 and SHB.By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the GRB2/sem-5/DRK family.Curated

Keywords - Domaini

Repeat, SH2 domain, SH3 domain

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG3601, Eukaryota

Ensembl GeneTree

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GeneTreei
ENSGT00940000155738

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
CLU_073617_1_0_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P62994

Identification of Orthologs from Complete Genome Data

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OMAi
PATYVCP

Database of Orthologous Groups

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OrthoDBi
1091250at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
P62994

TreeFam database of animal gene trees

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TreeFami
TF354288

Family and domain databases

Conserved Domains Database

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CDDi
cd11949, SH3_GRB2_C, 1 hit
cd11946, SH3_GRB2_N, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.30.505.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR035643, GRB2_C_SH3
IPR035641, GRB2_N_SH3
IPR000980, SH2
IPR036860, SH2_dom_sf
IPR036028, SH3-like_dom_sf
IPR001452, SH3_domain

Pfam protein domain database

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Pfami
View protein in Pfam
PF00017, SH2, 1 hit
PF00018, SH3_1, 2 hits

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR00401, SH2DOMAIN
PR00452, SH3DOMAIN

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00252, SH2, 1 hit
SM00326, SH3, 2 hits

Superfamily database of structural and functional annotation

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SUPFAMi
SSF50044, SSF50044, 2 hits
SSF55550, SSF55550, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS50001, SH2, 1 hit
PS50002, SH3, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: Additional isoforms seem to exist.
Isoform 1 (identifier: P62994-1) [UniParc]FASTAAdd to basket
Also known as: Ash-L

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEAIAKYDFK ATADDELSFK RGDILKVLNE ECDQNWYKAE LNGKDGFIPK
60 70 80 90 100
NYIEMKPHPW FFGKIPRAKA EEMLSKQRHD GAFLIRESES APGDFSLSVK
110 120 130 140 150
FGNDVQHFKV LRDGAGKYFL WVVKFNSLNE LVDYHRSTSV SRNQQIFLRD
160 170 180 190 200
IEQVPQQPTY VQALFDFDPQ EDGELGFRRG DFIHVMDNSD PNWWKGACHG
210
QTGMFPRNYV TPVNRNV
Length:217
Mass (Da):25,206
Last modified:August 31, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i83A4B0BA1B248DC4
GO
Isoform 2 (identifier: P62994-2) [UniParc] [UniParc]FASTAAdd to basket
Also known as: Ash-M

The sequence of this isoform differs from the canonical sequence as follows:
     157-170: Missing.

Show »
Length:203
Mass (Da):23,556
Checksum:i8FB4869BE35F6CF5
GO
Isoform 3 (identifier: P62994-3) [UniParc] [UniParc]FASTAAdd to basket
Also known as: Ash-S

The sequence of this isoform differs from the canonical sequence as follows:
     60-217: Missing.

Show »
Length:59
Mass (Da):6,880
Checksum:i61EC429649FEBFF0
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_00183860 – 217Missing in isoform 3. 1 PublicationAdd BLAST158
Alternative sequenceiVSP_001840157 – 170Missing in isoform 2. 1 PublicationAdd BLAST14

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
X62853 mRNA Translation: CAA44665.1
D49846 mRNA Translation: BAA08645.1
D49847 mRNA Translation: BAA08646.1
BC091144 mRNA Translation: AAH91144.1

Protein sequence database of the Protein Information Resource

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PIRi
S26050

NCBI Reference Sequences

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RefSeqi
NP_110473.2, NM_030846.2 [P62994-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSRNOT00000005347; ENSRNOP00000005347; ENSRNOG00000003990 [P62994-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
81504

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
rno:81504

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X62853 mRNA Translation: CAA44665.1
D49846 mRNA Translation: BAA08645.1
D49847 mRNA Translation: BAA08646.1
BC091144 mRNA Translation: AAH91144.1
PIRiS26050
RefSeqiNP_110473.2, NM_030846.2 [P62994-1]

3D structure databases

BMRBiP62994
SMRiP62994
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi249501, 13 interactors
CORUMiP62994
IntActiP62994, 27 interactors
MINTiP62994
STRINGi10116.ENSRNOP00000005347

PTM databases

iPTMnetiP62994
PhosphoSitePlusiP62994
SwissPalmiP62994

Proteomic databases

jPOSTiP62994
PaxDbiP62994
PRIDEiP62994

Genome annotation databases

EnsembliENSRNOT00000005347; ENSRNOP00000005347; ENSRNOG00000003990 [P62994-1]
GeneIDi81504
KEGGirno:81504

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
2885
RGDi619758, Grb2

Phylogenomic databases

eggNOGiKOG3601, Eukaryota
GeneTreeiENSGT00940000155738
HOGENOMiCLU_073617_1_0_1
InParanoidiP62994
OMAiPATYVCP
OrthoDBi1091250at2759
PhylomeDBiP62994
TreeFamiTF354288

Enzyme and pathway databases

ReactomeiR-RNO-109704, PI3K Cascade
R-RNO-112412, SOS-mediated signalling
R-RNO-1250347, SHC1 events in ERBB4 signaling
R-RNO-1257604, PIP3 activates AKT signaling
R-RNO-1295596, Spry regulation of FGF signaling
R-RNO-1433557, Signaling by SCF-KIT
R-RNO-1433559, Regulation of KIT signaling
R-RNO-167044, Signalling to RAS
R-RNO-179812, GRB2 events in EGFR signaling
R-RNO-180292, GAB1 signalosome
R-RNO-180336, SHC1 events in EGFR signaling
R-RNO-182971, EGFR downregulation
R-RNO-186763, Downstream signal transduction
R-RNO-1963640, GRB2 events in ERBB2 signaling
R-RNO-1963642, PI3K events in ERBB2 signaling
R-RNO-2029482, Regulation of actin dynamics for phagocytic cup formation
R-RNO-210993, Tie2 Signaling
R-RNO-2179392, EGFR Transactivation by Gastrin
R-RNO-2424491, DAP12 signaling
R-RNO-2428933, SHC-related events triggered by IGF1R
R-RNO-2730905, Role of LAT2/NTAL/LAB on calcium mobilization
R-RNO-2871796, FCERI mediated MAPK activation
R-RNO-2871809, FCERI mediated Ca+2 mobilization
R-RNO-354194, GRB2:SOS provides linkage to MAPK signaling for Integrins
R-RNO-375165, NCAM signaling for neurite out-growth
R-RNO-388841, Costimulation by the CD28 family
R-RNO-389359, CD28 dependent Vav1 pathway
R-RNO-391160, Signal regulatory protein family interactions
R-RNO-5654688, SHC-mediated cascade:FGFR1
R-RNO-5654689, PI-3K cascade:FGFR1
R-RNO-5654693, FRS-mediated FGFR1 signaling
R-RNO-5654695, PI-3K cascade:FGFR2
R-RNO-5654699, SHC-mediated cascade:FGFR2
R-RNO-5654700, FRS-mediated FGFR2 signaling
R-RNO-5654704, SHC-mediated cascade:FGFR3
R-RNO-5654706, FRS-mediated FGFR3 signaling
R-RNO-5654710, PI-3K cascade:FGFR3
R-RNO-5654712, FRS-mediated FGFR4 signaling
R-RNO-5654719, SHC-mediated cascade:FGFR4
R-RNO-5654720, PI-3K cascade:FGFR4
R-RNO-5654726, Negative regulation of FGFR1 signaling
R-RNO-5654727, Negative regulation of FGFR2 signaling
R-RNO-5654732, Negative regulation of FGFR3 signaling
R-RNO-5654733, Negative regulation of FGFR4 signaling
R-RNO-5663213, RHO GTPases Activate WASPs and WAVEs
R-RNO-5673001, RAF/MAP kinase cascade
R-RNO-6807004, Negative regulation of MET activity
R-RNO-6811558, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-RNO-74749, Signal attenuation
R-RNO-74751, Insulin receptor signalling cascade
R-RNO-8851805, MET activates RAS signaling
R-RNO-8851907, MET activates PI3K/AKT signaling
R-RNO-8853659, RET signaling
R-RNO-8856825, Cargo recognition for clathrin-mediated endocytosis
R-RNO-8856828, Clathrin-mediated endocytosis
R-RNO-8865999, MET activates PTPN11
R-RNO-8875555, MET activates RAP1 and RAC1
R-RNO-8875656, MET receptor recycling
R-RNO-8983432, Interleukin-15 signaling
R-RNO-9027284, Erythropoietin activates RAS
R-RNO-9028731, Activated NTRK2 signals through FRS2 and FRS3
R-RNO-912526, Interleukin receptor SHC signaling
R-RNO-912631, Regulation of signaling by CBL
R-RNO-9607240, FLT3 Signaling
R-RNO-983695, Antigen activates B Cell Receptor (BCR) leading to generation of second messengers

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P62994

Gene expression databases

BgeeiENSRNOG00000003990, Expressed in frontal cortex and 21 other tissues
GenevisibleiP62994, RN

Family and domain databases

CDDicd11949, SH3_GRB2_C, 1 hit
cd11946, SH3_GRB2_N, 1 hit
Gene3Di3.30.505.10, 1 hit
InterProiView protein in InterPro
IPR035643, GRB2_C_SH3
IPR035641, GRB2_N_SH3
IPR000980, SH2
IPR036860, SH2_dom_sf
IPR036028, SH3-like_dom_sf
IPR001452, SH3_domain
PfamiView protein in Pfam
PF00017, SH2, 1 hit
PF00018, SH3_1, 2 hits
PRINTSiPR00401, SH2DOMAIN
PR00452, SH3DOMAIN
SMARTiView protein in SMART
SM00252, SH2, 1 hit
SM00326, SH3, 2 hits
SUPFAMiSSF50044, SSF50044, 2 hits
SSF55550, SSF55550, 1 hit
PROSITEiView protein in PROSITE
PS50001, SH2, 1 hit
PS50002, SH3, 2 hits

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGRB2_RAT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P62994
Secondary accession number(s): P29354
, Q14450, Q5BKA7, Q63057, Q63059
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: August 31, 2004
Last modified: April 7, 2021
This is version 159 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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