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Entry version 204 (07 Oct 2020)
Sequence version 1 (31 Aug 2004)
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Protein

Growth factor receptor-bound protein 2

Gene

GRB2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway.
Isoform 2 does not bind to phosphorylated epidermal growth factor receptor (EGFR) but inhibits EGF-induced transactivation of a RAS-responsive element. Isoform 2 acts as a dominant negative protein over GRB2 and by suppressing proliferative signals, may trigger active programmed cell death.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processHost-virus interaction

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

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PathwayCommonsi
P62993

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-109704, PI3K Cascade [P62993-1]
R-HSA-112412, SOS-mediated signalling [P62993-1]
R-HSA-1236382, Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants [P62993-1]
R-HSA-1250196, SHC1 events in ERBB2 signaling [P62993-1]
R-HSA-1250347, SHC1 events in ERBB4 signaling [P62993-1]
R-HSA-1257604, PIP3 activates AKT signaling [P62993-1]
R-HSA-1295596, Spry regulation of FGF signaling [P62993-1]
R-HSA-1433557, Signaling by SCF-KIT [P62993-1]
R-HSA-1433559, Regulation of KIT signaling [P62993-1]
R-HSA-167044, Signalling to RAS [P62993-1]
R-HSA-179812, GRB2 events in EGFR signaling [P62993-1]
R-HSA-180292, GAB1 signalosome [P62993-1]
R-HSA-180336, SHC1 events in EGFR signaling [P62993-1]
R-HSA-182971, EGFR downregulation [P62993-1]
R-HSA-1839117, Signaling by cytosolic FGFR1 fusion mutants [P62993-1]
R-HSA-186763, Downstream signal transduction [P62993-1]
R-HSA-1963640, GRB2 events in ERBB2 signaling [P62993-1]
R-HSA-1963642, PI3K events in ERBB2 signaling [P62993-1]
R-HSA-2029482, Regulation of actin dynamics for phagocytic cup formation [P62993-1]
R-HSA-210993, Tie2 Signaling [P62993-1]
R-HSA-2179392, EGFR Transactivation by Gastrin [P62993-1]
R-HSA-2219530, Constitutive Signaling by Aberrant PI3K in Cancer [P62993-1]
R-HSA-2424491, DAP12 signaling [P62993-1]
R-HSA-2428933, SHC-related events triggered by IGF1R [P62993-1]
R-HSA-2730905, Role of LAT2/NTAL/LAB on calcium mobilization [P62993-1]
R-HSA-2871796, FCERI mediated MAPK activation [P62993-1]
R-HSA-2871809, FCERI mediated Ca+2 mobilization [P62993-1]
R-HSA-354194, GRB2:SOS provides linkage to MAPK signaling for Integrins [P62993-1]
R-HSA-375165, NCAM signaling for neurite out-growth [P62993-1]
R-HSA-388841, Costimulation by the CD28 family [P62993-1]
R-HSA-389359, CD28 dependent Vav1 pathway [P62993-1]
R-HSA-391160, Signal regulatory protein family interactions [P62993-1]
R-HSA-512988, Interleukin-3, Interleukin-5 and GM-CSF signaling [P62993-1]
R-HSA-5637810, Constitutive Signaling by EGFRvIII [P62993-1]
R-HSA-5654688, SHC-mediated cascade:FGFR1 [P62993-1]
R-HSA-5654689, PI-3K cascade:FGFR1 [P62993-1]
R-HSA-5654693, FRS-mediated FGFR1 signaling [P62993-1]
R-HSA-5654695, PI-3K cascade:FGFR2 [P62993-1]
R-HSA-5654699, SHC-mediated cascade:FGFR2 [P62993-1]
R-HSA-5654700, FRS-mediated FGFR2 signaling [P62993-1]
R-HSA-5654704, SHC-mediated cascade:FGFR3 [P62993-1]
R-HSA-5654706, FRS-mediated FGFR3 signaling [P62993-1]
R-HSA-5654710, PI-3K cascade:FGFR3 [P62993-1]
R-HSA-5654712, FRS-mediated FGFR4 signaling [P62993-1]
R-HSA-5654719, SHC-mediated cascade:FGFR4 [P62993-1]
R-HSA-5654720, PI-3K cascade:FGFR4 [P62993-1]
R-HSA-5654726, Negative regulation of FGFR1 signaling [P62993-1]
R-HSA-5654727, Negative regulation of FGFR2 signaling [P62993-1]
R-HSA-5654732, Negative regulation of FGFR3 signaling [P62993-1]
R-HSA-5654733, Negative regulation of FGFR4 signaling [P62993-1]
R-HSA-5655253, Signaling by FGFR2 in disease [P62993-1]
R-HSA-5655291, Signaling by FGFR4 in disease [P62993-1]
R-HSA-5655302, Signaling by FGFR1 in disease [P62993-1]
R-HSA-5663213, RHO GTPases Activate WASPs and WAVEs [P62993-1]
R-HSA-5673001, RAF/MAP kinase cascade [P62993-1]
R-HSA-6807004, Negative regulation of MET activity [P62993-1]
R-HSA-6811558, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling [P62993-1]
R-HSA-74749, Signal attenuation [P62993-1]
R-HSA-74751, Insulin receptor signalling cascade [P62993-1]
R-HSA-8851805, MET activates RAS signaling [P62993-1]
R-HSA-8851907, MET activates PI3K/AKT signaling [P62993-1]
R-HSA-8853334, Signaling by FGFR3 fusions in cancer [P62993-1]
R-HSA-8853338, Signaling by FGFR3 point mutants in cancer [P62993-1]
R-HSA-8853659, RET signaling [P62993-1]
R-HSA-8856825, Cargo recognition for clathrin-mediated endocytosis [P62993-1]
R-HSA-8856828, Clathrin-mediated endocytosis [P62993-1]
R-HSA-8865999, MET activates PTPN11 [P62993-1]
R-HSA-8875360, InlB-mediated entry of Listeria monocytogenes into host cell [P62993-1]
R-HSA-8875555, MET activates RAP1 and RAC1 [P62993-1]
R-HSA-8875656, MET receptor recycling [P62993-1]
R-HSA-8983432, Interleukin-15 signaling
R-HSA-9026519, Activated NTRK2 signals through RAS [P62993-1]
R-HSA-9027284, Erythropoietin activates RAS [P62993-1]
R-HSA-9028335, Activated NTRK2 signals through PI3K [P62993-1]
R-HSA-9028731, Activated NTRK2 signals through FRS2 and FRS3 [P62993-1]
R-HSA-9034864, Activated NTRK3 signals through RAS [P62993-1]
R-HSA-912526, Interleukin receptor SHC signaling [P62993-1]
R-HSA-912631, Regulation of signaling by CBL [P62993-1]
R-HSA-9607240, FLT3 Signaling [P62993-1]
R-HSA-9634285, Constitutive Signaling by Overexpressed ERBB2 [P62993-1]
R-HSA-9645135, STAT5 Activation [P62993-1]
R-HSA-9664422, FCGR3A-mediated phagocytosis [P62993-1]
R-HSA-9664565, Signaling by ERBB2 KD Mutants [P62993-1]
R-HSA-9665348, Signaling by ERBB2 ECD mutants [P62993-1]
R-HSA-9665686, Signaling by ERBB2 TMD/JMD mutants [P62993-1]
R-HSA-9670439, Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants [P62993-1]
R-HSA-9673767, Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants [P62993-1]
R-HSA-9673770, Signaling by PDGFRA extracellular domain mutants [P62993-1]
R-HSA-983695, Antigen activates B Cell Receptor (BCR) leading to generation of second messengers [P62993-1]

SignaLink: a signaling pathway resource with multi-layered regulatory networks

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SignaLinki
P62993

SIGNOR Signaling Network Open Resource

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SIGNORi
P62993

Protein family/group databases

MoonDB Database of extreme multifunctional and moonlighting proteins

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MoonDBi
P62993, Predicted

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Growth factor receptor-bound protein 2
Alternative name(s):
Adapter protein GRB2
Protein Ash
SH2/SH3 adapter GRB2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:GRB2
Synonyms:ASH
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000177885.13

Human Gene Nomenclature Database

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HGNCi
HGNC:4566, GRB2

Online Mendelian Inheritance in Man (OMIM)

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MIMi
108355, gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_P62993

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Endosome, Golgi apparatus, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi49P → L: Ineffective in DNA synthesis. Abolishes interaction with SHB; when associated with L-206. Abolishes interaction with SOS1. 3 Publications1
Mutagenesisi89E → K: No effect on the interaction with SOS1. 1 Publication1
Mutagenesisi90S → N: No effect on the interaction with SOS1. 1 Publication1
Mutagenesisi203G → R: Ineffective in DNA synthesis. Abolishes interaction with SOS1. 2 Publications1
Mutagenesisi206P → L: Abolishes interaction with SHB; when associated with L-49. 1 Publication1

Organism-specific databases

DisGeNET

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DisGeNETi
2885

Open Targets

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OpenTargetsi
ENSG00000177885

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA28962

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

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Pharosi
P62993, Tchem

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

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ChEMBLi
CHEMBL3663

Drug and drug target database

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DrugBanki
DB03276, 4-[(10s,14s,18s)-18-(2-Amino-2-Oxoethyl)-14-(1-Naphthylmethyl)-8,17,20-Trioxo-7,16,19-Triazaspiro[5.14]Icos-11-En-10-Yl]Benzylphosphonic Acid
DB00061, Pegademase

DrugCentral

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DrugCentrali
P62993

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
GRB2

Domain mapping of disease mutations (DMDM)

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DMDMi
51702266

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000881981 – 217Growth factor receptor-bound protein 2Add BLAST217

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineCombined sources1
Modified residuei6N6-acetyllysineCombined sources1
Modified residuei50N6-acetyllysineCombined sources1
Modified residuei109N6-acetyllysineCombined sources1
Modified residuei211PhosphothreonineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

The CPTAC Assay portal

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CPTACi
CPTAC-1421
CPTAC-1422
CPTAC-1423
CPTAC-1424
CPTAC-1425
CPTAC-1609
CPTAC-699

Encyclopedia of Proteome Dynamics

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EPDi
P62993

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
P62993

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
P62993

MaxQB - The MaxQuant DataBase

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MaxQBi
P62993

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P62993

PeptideAtlas

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PeptideAtlasi
P62993

PRoteomics IDEntifications database

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PRIDEi
P62993

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
57462
57463 [P62993-2]

Consortium for Top Down Proteomics

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TopDownProteomicsi
P62993-1 [P62993-1]
P62993-2 [P62993-2]

2D gel databases

USC-OGP 2-DE database

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OGPi
P62993

Two-dimensional polyacrylamide gel electrophoresis database from the Geneva University Hospital

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SWISS-2DPAGEi
P62993

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P62993

MetOSite database of methionine sulfoxide sites

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MetOSitei
P62993

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P62993

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000177885, Expressed in frontal cortex and 242 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P62993, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P62993, HS

Organism-specific databases

Human Protein Atlas

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HPAi
ENSG00000177885, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Associates (via SH2 domain) with activated EGF and PDGF receptors (tyrosine phosphorylated) (PubMed:10026169, PubMed:19836242).

Interacts with PDGFRA (tyrosine phosphorylated); the interaction may be indirect (By similarity). Also associates to other cellular Tyr-phosphorylated proteins such as SIT1, IRS1, IRS4, SHC and LNK; probably via the concerted action of both its SH2 and SH3 domains (PubMed:8388384, PubMed:8491186, PubMed:9553137, PubMed:11433379). It also seems to interact with RAS in the signaling pathway leading to DNA synthesis.

Interacts with SOS1 (PubMed:8493579, PubMed:7664271).

Forms a complex with MUC1 and SOS1, through interaction of the SH3 domains with SOS1 and the SH2 domain with phosphorylated MUC1 (PubMed:7664271).

Interacts with phosphorylated MET (PubMed:11063574, PubMed:11827484).

Interacts with phosphorylated TOM1L1 (By similarity).

Interacts with the phosphorylated C-terminus of SH2B2 (PubMed:9233773).

Interacts with phosphorylated SIT1, LAX1, LAT, LAT2 and LIME1 upon TCR and/or BCR activation (By similarity) (PubMed:9489702, PubMed:12359715, PubMed:12486104, PubMed:12514734).

Interacts with NISCH, PTPNS1 and REPS2 (PubMed:9062191, PubMed:9422736, PubMed:11912194).

Interacts with syntrophin SNTA1 (By similarity).

Interacts (via SH3 domains) with REPS1 (By similarity).

Interacts (via SH3 domains) with PIK3C2B (PubMed:11533253).

Interacts with CBL and CBLB (PubMed:10022120, PubMed:10086340).

Interacts with AJUBA and CLNK (By similarity).

Interacts (via SH2 domain) with TEK/TIE2 (tyrosine phosphorylated) (By similarity).

Interacts with SHB, INPP5D/SHIP1, SKAP1 and SKAP2 (PubMed:8723348, PubMed:9108392, PubMed:9484780, PubMed:10942756, PubMed:12171928).

Interacts with PTPN11 (By similarity).

Interacts with PRNP (By similarity).

Interacts with RALGPS1 (PubMed:10747847).

Interacts with HCST (PubMed:16582911).

Interacts with KDR (By similarity).

Interacts with FLT1 (tyrosine-phosphorylated) (By similarity).

Interacts with GAPT and PTPRE (PubMed:10980613, PubMed:18559951).

Interacts (via SH2 domain) with KIF26A (PubMed:19914172).

Interacts (via SH3 2) with GAB2 (PubMed:19523899).

Interacts with ADAM15 (PubMed:18296648).

Interacts with THEMIS2 (By similarity).

Interacts (via SH2 domain) with AXL (phosphorylated) (PubMed:9178760, PubMed:19815557).

Interacts (via SH2 domain) with KIT (phosphorylated) (PubMed:15526160, PubMed:16129412).

Interacts with PTPRJ and BCR (PubMed:12475979, PubMed:15302586).

Interacts with PTPN23 (PubMed:21179510).

Interacts with FLT4 (tyrosine phosphorylated) (PubMed:15102829).

Interacts with EPHB1 and SHC1; activates the MAPK/ERK cascade to regulate cell migration (PubMed:8798570, PubMed:12925710).

Part of a complex including TNK2, GRB2, LTK and one receptor tyrosine kinase (RTK) such as AXL and PDGFRL, in which GRB2 promotes RTK recruitment by TNK2 (PubMed:9178760, PubMed:19815557).

Interacts (via SH2 domain) with CSF1R (tyrosine phosphorylated) (PubMed:8262059).

Interacts with ERBB4 (PubMed:10867024).

Interacts with NTRK1 (phosphorylated upon ligand-binding) (PubMed:15488758).

Interacts with PTK2/FAK1 (tyrosine phosphorylated) (PubMed:9148935).

Interacts with PTK2B/PYK2 (tyrosine phosphorylated) (PubMed:20521079). Isoform 1:

Interacts (via SH2-domain) with SCIMP; this interaction is dependent on phosphorylation of SCIMP 'Tyr-69' (PubMed:21930792).

Interacts (via SH3 domains) with GAREM1 isoform 1 (via proline-rich domain and tyrosine phosphorylated); the interaction occurs upon EGF stimulation (PubMed:19509291).

Interacts with DAB2 (By similarity).

Interacts with TESPA1 (PubMed:22561606).

Interacts with PLCG1, LAT and THEMIS upon TCR activation in thymocytes; the association is weaker in the absence of TESPA1 (By similarity).

Interacts with CD28 (PubMed:24098653).

Interacts with RAB13; may recruit RAB13 to the leading edge of migrating endothelial cells where it can activate RHOA (By similarity).

Interacts with ASAP3 (phosphorylated form) (PubMed:22027826).

Interacts (via SH2 domain) with PTPRH (phosphorylated form) (By similarity).

Interacts with PTPRO (phosphorylated form) (By similarity).

Interacts with PTPRB (phosphorylated form) (By similarity).

Interacts (via SH3 domain 2) with PRR14 (via proline-rich region) (PubMed:27041574).

Interacts with FCRL6 (tyrosine phosphorylated form) (PubMed:20933011).

Interacts with RHEX (via tyrosine-phosphorylated form) (PubMed:25092874).

Interacts with DENND2B (PubMed:29030480).

Interacts (via SH3 domain) with ZDHHC19 (via SH3-binding motif); leading to recruit STAT3 (PubMed:31462771).

By similarity59 Publications

(Microbial infection) Interacts (via SH3 domain) with hepatitis E virus/HEV ORF3 protein.

1 Publication

(Microbial infection) Interacts with hepatitis C virus/HCV protein NS5A via its SH3 domains.

1 Publication

(Microbial infection) Interacts with herpes simplex virus 1 protein UL46.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

P62993
With#Exp.IntAct
ABI3 [Q9P2A4]3EBI-401755,EBI-742038
ABL2 [P42684]2EBI-401755,EBI-1102694
ACAP1 [Q15027]3EBI-401755,EBI-751746
ADAM10 [O14672]5EBI-401755,EBI-1536151
ADAM15 [Q13444]4EBI-401755,EBI-77818
AGER [Q15109]2EBI-401755,EBI-1646426
AGR2 [O95994]5EBI-401755,EBI-712648
ANK2 [Q01484]2EBI-401755,EBI-941975
ANKRD23 [Q86SG2]3EBI-401755,EBI-5661893
ARHGAP9 [Q9BRR9]3EBI-401755,EBI-750254
ARHGEF5 [Q12774]7EBI-401755,EBI-602199
ARID5A [Q03989]3EBI-401755,EBI-948603
ARL6IP4 - isoform 4 [Q66PJ3-4]2EBI-401755,EBI-5280499
ASAP1 [Q9ULH1]10EBI-401755,EBI-346622
ASAP2 [O43150]3EBI-401755,EBI-310968
AXL [P30530]3EBI-401755,EBI-2850927
BCR [P11274]9EBI-401755,EBI-712838
BLNK [Q8WV28]4EBI-401755,EBI-2623522
BRD4 [O60885]2EBI-401755,EBI-723869
BTG1 [P62324]3EBI-401755,EBI-742279
C1orf94 [Q6P1W5]3EBI-401755,EBI-946029
CBL [P22681]13EBI-401755,EBI-518228
CBLB [Q13191]25EBI-401755,EBI-744027
CCDC28B - isoform 2 [Q9BUN5-3]3EBI-401755,EBI-12920646
CD2AP [Q9Y5K6]3EBI-401755,EBI-298152
CPSF7 - isoform 3 [Q8N684-3]3EBI-401755,EBI-11523759
DAB2 [P98082]2EBI-401755,EBI-1171238
DARS1 [P14868]2EBI-401755,EBI-358730
DBN1 [Q16643]4EBI-401755,EBI-351394
DDIT4L [Q96D03]3EBI-401755,EBI-742054
DDX17 [Q92841]3EBI-401755,EBI-746012
DLGAP1 [O14490]3EBI-401755,EBI-1753207
DLGAP2 [Q9P1A6]2EBI-401755,EBI-1753397
DLGAP4 [Q9Y2H0]2EBI-401755,EBI-722139
DNM1 [Q05193]5EBI-401755,EBI-713135
DNM2 [P50570]8EBI-401755,EBI-346547
DOCK1 [Q14185]5EBI-401755,EBI-446740
DOCK4 [Q8N1I0]4EBI-401755,EBI-1059186
DPPA4 [Q7L190]3EBI-401755,EBI-710457
DTX3 [Q8N9I9]3EBI-401755,EBI-2340258
EFHC2 [Q5JST6]3EBI-401755,EBI-2349927
EGFR [P00533]45EBI-401755,EBI-297353
EPHB1 [P54762]2EBI-401755,EBI-80252
EPS8 [Q12929]3EBI-401755,EBI-375576
ERBB2 [P04626]5EBI-401755,EBI-641062
ERBB3 [P21860]3EBI-401755,EBI-720706
ERRFI1 [Q9UJM3]16EBI-401755,EBI-2941912
FAM22F [B7ZLH0]6EBI-401755,EBI-10220102
FANCA [O15360]2EBI-401755,EBI-81570
FGFR2 [P21802]5EBI-401755,EBI-1028658
FLNA [P21333]2EBI-401755,EBI-350432
FLNB [O75369]2EBI-401755,EBI-352089
FLNC [Q14315]2EBI-401755,EBI-489954
GAB1 [Q13480]8EBI-401755,EBI-517684
GAB2 [Q9UQC2]14EBI-401755,EBI-975200
GAREM1 [Q9H706]11EBI-401755,EBI-3440103
GGN [Q86UU5]3EBI-401755,EBI-10259069
GIT1 [Q9Y2X7]4EBI-401755,EBI-466061
itself5EBI-401755,EBI-401755
HNRNPK [P61978]10EBI-401755,EBI-304185
HOMEZ - isoform 2 [Q8IX15-3]3EBI-401755,EBI-10172004
HSPA5 [P11021]4EBI-401755,EBI-354921
IKZF3 [Q9UKT9]8EBI-401755,EBI-747204
INCA1 [Q0VD86]4EBI-401755,EBI-6509505
KHDRBS1 [Q07666]8EBI-401755,EBI-1364
KIAA0408 [Q6ZU52]3EBI-401755,EBI-739493
KIT [P10721]6EBI-401755,EBI-1379503
KRT8 [P05787]3EBI-401755,EBI-297852
LAT [O43561]7EBI-401755,EBI-1222766
LCP2 [Q13094]18EBI-401755,EBI-346946
LEPR [P48357]3EBI-401755,EBI-518596
LMO2 [P25791]3EBI-401755,EBI-739696
LMX1A [Q8TE12]3EBI-401755,EBI-10692065
LNX1 [Q8TBB1]4EBI-401755,EBI-739832
LY6G6F [Q5SQ64]3EBI-401755,EBI-6963742
LZTS2 [Q9BRK4]3EBI-401755,EBI-741037
MAP2K5 [Q13163]2EBI-401755,EBI-307294
MAP4K1 [Q92918]8EBI-401755,EBI-881
MAP4K3 [Q8IVH8]2EBI-401755,EBI-1758170
MAP4K5 [Q9Y4K4]5EBI-401755,EBI-1279
MED19 - isoform 2 [A0JLT2-2]3EBI-401755,EBI-13288755
MED28 [Q9H204]3EBI-401755,EBI-514199
MEI4 [A8MW99]3EBI-401755,EBI-19944212
MYG1 [Q9HB07]3EBI-401755,EBI-709754
MYH9 [P35579]3EBI-401755,EBI-350338
NELFB [Q8WX92]2EBI-401755,EBI-347721
NIF3L1 [Q9GZT8]3EBI-401755,EBI-740897
PAK2 [Q13177]2EBI-401755,EBI-1045887
PARD6A - isoform 2 [Q9NPB6-2]3EBI-401755,EBI-10693102
PHETA1 - isoform 4 [Q8N4B1-4]3EBI-401755,EBI-14131832
PIK3AP1 [Q6ZUJ8]5EBI-401755,EBI-2654168
PIK3C2B [O00750]5EBI-401755,EBI-641107
PIK3R1 [P27986]4EBI-401755,EBI-79464
PIK3R2 [O00459]4EBI-401755,EBI-346930
PIK3R3 [Q92569]4EBI-401755,EBI-79893
PLCG1 [P19174]2EBI-401755,EBI-79387
PLD2 [O14939]4EBI-401755,EBI-1053996
PLEKHA7 - isoform 2 [Q6IQ23-2]3EBI-401755,EBI-12069346
PLEKHS1 [Q5SXH7]3EBI-401755,EBI-10691507
PNMA5 [Q96PV4]3EBI-401755,EBI-10171633
PPARA [Q07869]3EBI-401755,EBI-78615
PPP3CA [Q08209]3EBI-401755,EBI-352922
PRKAB1 [Q9Y478]2EBI-401755,EBI-719769
PRR5-ARHGAP8 [B1AHC3]3EBI-401755,EBI-17437404
PTK2 [Q05397]4EBI-401755,EBI-702142
PTPN1 [P18031]4EBI-401755,EBI-968788
PTPN11 [Q06124]10EBI-401755,EBI-297779
PTPN22 [Q9Y2R2]2EBI-401755,EBI-1211241
PTPN23 [Q9H3S7]7EBI-401755,EBI-724478
PTPN6 [P29350]3EBI-401755,EBI-78260
PTPRA [P18433]13EBI-401755,EBI-2609645
PTPRT [O14522]2EBI-401755,EBI-728180
RB1 [P06400]4EBI-401755,EBI-491274
REL [Q04864]3EBI-401755,EBI-307352
REPS2 - isoform 2 [Q8NFH8-2]8EBI-401755,EBI-8029141
RNF208 [Q9H0X6]3EBI-401755,EBI-751555
SF3A2 [Q15428]3EBI-401755,EBI-2462271
SF3B4 [Q15427]2EBI-401755,EBI-348469
SH2B1 - isoform 2 [Q9NRF2-2]3EBI-401755,EBI-10691662
SH2D4A [Q9H788]4EBI-401755,EBI-747035
SHANK2 [Q9UPX8]2EBI-401755,EBI-1570571
SHANK3 [Q9BYB0]2EBI-401755,EBI-1752330
SHC1 [P29353]27EBI-401755,EBI-78835
SHC1 - isoform p66Shc [P29353-1]3EBI-401755,EBI-8160716
SOCS4 [Q8WXH5]3EBI-401755,EBI-3942425
SOCS7 [O14512]3EBI-401755,EBI-1539606
SOS1 [Q07889]26EBI-401755,EBI-297487
SOS2 [Q07890]11EBI-401755,EBI-298181
SPATA2L [Q8IUW3]4EBI-401755,EBI-2510414
SPRY2 [O43597]3EBI-401755,EBI-742487
SRGAP3 [O43295]2EBI-401755,EBI-368166
STAMBP [O95630]9EBI-401755,EBI-396676
SYNJ2 [O15056]2EBI-401755,EBI-310513
TBC1D3G [Q6DHY5]3EBI-401755,EBI-13092532
THEMIS [Q8N1K5]10EBI-401755,EBI-2873538
THEMIS - isoform 1 [Q8N1K5-1]10EBI-401755,EBI-15102259
TLE5 [Q08117]3EBI-401755,EBI-717810
TMEM128 - isoform 2 [Q5BJH2-2]3EBI-401755,EBI-10694905
TNPO1 [Q92973]2EBI-401755,EBI-286693
TOM1L1 [O75674]2EBI-401755,EBI-712991
TP53BP2 - isoform 3 [Q13625-3]3EBI-401755,EBI-10175039
TPX2 [Q9ULW0]2EBI-401755,EBI-1037322
TRIB3 [Q96RU7]3EBI-401755,EBI-492476
TRIM27 [P14373]3EBI-401755,EBI-719493
TSPAN2 [O60636]6EBI-401755,EBI-3914288
TXK [P42681]3EBI-401755,EBI-7877438
TYRO3 [Q06418]3EBI-401755,EBI-3951628
UGP2 [Q16851]2EBI-401755,EBI-743729
VAV1 [P15498]3EBI-401755,EBI-625518
VAV3 [Q9UKW4]8EBI-401755,EBI-297568
VCP [P55072]3EBI-401755,EBI-355164
VPS37C [A5D8V6]3EBI-401755,EBI-2559305
WASF1 [Q92558]3EBI-401755,EBI-1548747
WASL [O00401]11EBI-401755,EBI-957615
WBP11 [Q9Y2W2]4EBI-401755,EBI-714455
WIPF1 [O43516]4EBI-401755,EBI-346356
WIPF2 [Q8TF74]6EBI-401755,EBI-2850112
ZBTB12 [Q9Y330]5EBI-401755,EBI-12377219
ZBTB7B [O15156]3EBI-401755,EBI-740434
ZNF341 [Q9BYN7]3EBI-401755,EBI-9089622
ZNF474 [Q6S9Z5]3EBI-401755,EBI-17269964
ZNF620 [Q6ZNG0]3EBI-401755,EBI-4395669
Q7Z7833EBI-401755,EBI-9088990
Dab2 [P98078] from Mus musculus.4EBI-401755,EBI-1391846
Irs1 [P35570] from Rattus norvegicus.5EBI-401755,EBI-520230
Ptk2 [P34152] from Mus musculus.3EBI-401755,EBI-77070
Ptpn11 [P35235] from Mus musculus.7EBI-401755,EBI-397236
Sos1 [Q62245] from Mus musculus.4EBI-401755,EBI-1693
Zdhhc19 [Q810M5] from Mus musculus.2EBI-401755,EBI-22225085
O92972 from Hepatitis C virus genotype 1b (strain HC-J4).2EBI-401755,EBI-710506
Non-structural protein 5A (PRO_0000037647) from Hepatitis C virus genotype 1b (isolate Japanese).3EBI-401755,EBI-9099462
P27958 from Hepatitis C virus genotype 1a (isolate H77).3EBI-401755,EBI-706378
Isoform 1 [P62993-1]
With#Exp.IntAct
GAB2 - isoform 1 [Q9UQC2-1]3EBI-15787932,EBI-15787947
LAT - isoform 2 [O43561-2]3EBI-15787932,EBI-8070286
Sos1 [Q62245] from Mus musculus.2EBI-15787932,EBI-1693

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
109142, 609 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
P62993

Database of interacting proteins

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DIPi
DIP-29229N

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

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ELMi
P62993

Protein interaction database and analysis system

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IntActi
P62993, 840 interactors

Molecular INTeraction database

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MINTi
P62993

STRING: functional protein association networks

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STRINGi
9606.ENSP00000376345

Chemistry databases

BindingDB database of measured binding affinities

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BindingDBi
P62993

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

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RNActi
P62993, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1217
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Biological Magnetic Resonance Data Bank

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BMRBi
P62993

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P62993

Database of comparative protein structure models

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ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

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PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

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EvolutionaryTracei
P62993

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1 – 58SH3 1PROSITE-ProRule annotationAdd BLAST58
Domaini60 – 152SH2PROSITE-ProRule annotationAdd BLAST93
Domaini156 – 215SH3 2PROSITE-ProRule annotationAdd BLAST60

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The SH3 domains mediate interaction with RALGPS1 and SHB.

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the GRB2/sem-5/DRK family.Curated

Keywords - Domaini

Repeat, SH2 domain, SH3 domain

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG3601, Eukaryota

Ensembl GeneTree

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GeneTreei
ENSGT00940000155738

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
CLU_073617_1_0_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P62993

KEGG Orthology (KO)

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KOi
K04364

Identification of Orthologs from Complete Genome Data

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OMAi
PATYVCP

Database for complete collections of gene phylogenies

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PhylomeDBi
P62993

TreeFam database of animal gene trees

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TreeFami
TF354288

Family and domain databases

Conserved Domains Database

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CDDi
cd11949, SH3_GRB2_C, 1 hit
cd11946, SH3_GRB2_N, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.30.505.10, 1 hit

Intrinsically Disordered proteins with Extensive Annotations and Literature

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IDEALi
IID00459

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR030219, Grb2
IPR043539, Grb2-like
IPR035643, GRB2_C_SH3
IPR035641, GRB2_N_SH3
IPR000980, SH2
IPR036860, SH2_dom_sf
IPR036028, SH3-like_dom_sf
IPR001452, SH3_domain

The PANTHER Classification System

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PANTHERi
PTHR46037, PTHR46037, 1 hit
PTHR46037:SF4, PTHR46037:SF4, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF00017, SH2, 1 hit
PF00018, SH3_1, 2 hits

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR00401, SH2DOMAIN
PR00452, SH3DOMAIN

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00252, SH2, 1 hit
SM00326, SH3, 2 hits

Superfamily database of structural and functional annotation

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SUPFAMi
SSF50044, SSF50044, 2 hits
SSF55550, SSF55550, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS50001, SH2, 1 hit
PS50002, SH3, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: Additional isoforms seem to exist.

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P62993-1) [UniParc]FASTAAdd to basket
Also known as: Ash-L

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEAIAKYDFK ATADDELSFK RGDILKVLNE ECDQNWYKAE LNGKDGFIPK
60 70 80 90 100
NYIEMKPHPW FFGKIPRAKA EEMLSKQRHD GAFLIRESES APGDFSLSVK
110 120 130 140 150
FGNDVQHFKV LRDGAGKYFL WVVKFNSLNE LVDYHRSTSV SRNQQIFLRD
160 170 180 190 200
IEQVPQQPTY VQALFDFDPQ EDGELGFRRG DFIHVMDNSD PNWWKGACHG
210
QTGMFPRNYV TPVNRNV
Length:217
Mass (Da):25,206
Last modified:August 31, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i83A4B0BA1B248DC4
GO
Isoform 2 (identifier: P62993-2) [UniParc] [UniParc]FASTAAdd to basket
Also known as: GRB3-3

The sequence of this isoform differs from the canonical sequence as follows:
     60-100: Missing.

Show »
Length:176
Mass (Da):20,557
Checksum:i70622BED0FE940DE
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3KT38J3KT38_HUMAN
Growth factor receptor-bound protei...
GRB2
110Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QRL5J3QRL5_HUMAN
Growth factor receptor-bound protei...
GRB2
156Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QLF6J3QLF6_HUMAN
Growth factor receptor-bound protei...
GRB2
42Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_00183960 – 100Missing in isoform 2. 1 PublicationAdd BLAST41

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
M96995 mRNA Translation: AAA58448.1
X62852 mRNA Translation: CAA44664.1
L29511 mRNA Translation: AAC37549.1
AF063618 AF063617 Genomic DNA Translation: AAC72075.1
AF498925 mRNA Translation: AAM21073.1
CR541942 mRNA Translation: CAG46740.1
AC011933 Genomic DNA No translation available.
BC000631 mRNA Translation: AAH00631.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS11721.1
CCDS11722.1 [P62993-2]

Protein sequence database of the Protein Information Resource

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PIRi
A43321

NCBI Reference Sequences

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RefSeqi
NP_002077.1, NM_002086.4 [P62993-1]
NP_987102.1, NM_203506.2 [P62993-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000316615; ENSP00000317360; ENSG00000177885 [P62993-2]
ENST00000316804; ENSP00000339007; ENSG00000177885 [P62993-1]
ENST00000392562; ENSP00000376345; ENSG00000177885 [P62993-1]
ENST00000392563; ENSP00000376346; ENSG00000177885 [P62993-2]
ENST00000392564; ENSP00000376347; ENSG00000177885 [P62993-1]
ENST00000648046; ENSP00000496913; ENSG00000177885 [P62993-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
2885

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:2885

UCSC genome browser

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UCSCi
uc002jnx.5, human

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M96995 mRNA Translation: AAA58448.1
X62852 mRNA Translation: CAA44664.1
L29511 mRNA Translation: AAC37549.1
AF063618 AF063617 Genomic DNA Translation: AAC72075.1
AF498925 mRNA Translation: AAM21073.1
CR541942 mRNA Translation: CAG46740.1
AC011933 Genomic DNA No translation available.
BC000631 mRNA Translation: AAH00631.1
CCDSiCCDS11721.1
CCDS11722.1 [P62993-2]
PIRiA43321
RefSeqiNP_002077.1, NM_002086.4 [P62993-1]
NP_987102.1, NM_203506.2 [P62993-2]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1AZENMR-A1-56[»]
1BM2X-ray2.10A49-163[»]
1BMBX-ray1.80A49-168[»]
1CJ1X-ray3.00A/B/C/D/E/F/G/H/I/J/K/L57-152[»]
1FHSNMR-A53-163[»]
1FYRX-ray2.40A/B/C/D50-161[»]
1GCQX-ray1.68A/B159-217[»]
1GFCNMR-A159-215[»]
1GFDNMR-A159-215[»]
1GHUNMR-A60-158[»]
1GRIX-ray3.10A/B1-217[»]
1IO6NMR-A159-215[»]
1JYQX-ray2.00A/B60-151[»]
1JYRX-ray1.55A60-151[»]
1JYUX-ray2.75A60-151[»]
1QG1NMR-E58-159[»]
1TZEX-ray2.10E55-152[»]
1X0NNMR-A58-159[»]
1ZFPX-ray1.80E56-153[»]
2AOAX-ray1.99A/B55-153[»]
2AOBX-ray1.80A/B/C/D55-153[»]
2H46X-ray1.90E53-162[»]
2H5KX-ray3.25A/B53-162[»]
2HUWX-ray1.90A/B53-162[»]
2VVKX-ray1.60A161-214[»]
2VWFX-ray1.58A159-214[»]
2W0ZX-ray1.70A159-214[»]
3C7IX-ray1.70A53-162[»]
3IMDX-ray2.00A/B53-163[»]
3IMJX-ray2.02A/B53-163[»]
3IN7X-ray2.00A/C53-163[»]
3IN8X-ray1.70A53-163[»]
3KFJX-ray2.02A53-163[»]
3MXCX-ray2.00A55-152[»]
3MXYX-ray2.30A55-152[»]
3N7YX-ray2.02A/B/C55-152[»]
3N84X-ray2.00A/B/C/D/E/F53-163[»]
3N8MX-ray2.00A53-163[»]
3OV1X-ray1.60A53-163[»]
3OVEX-ray1.82A53-163[»]
3S8LX-ray1.71A53-163[»]
3S8NX-ray1.71A53-163[»]
3S8OX-ray1.85A53-163[»]
3WA4X-ray1.35A60-152[»]
4P9VX-ray1.64A53-163[»]
4P9ZX-ray1.80A53-163[»]
5CDWX-ray2.60A/B/C/E/G/H/K/L/O/P/U/V/Y/Z/c/d54-153[»]
6ICGX-ray1.15A/B60-152[»]
6ICHX-ray2.00A60-152[»]
6SDFX-ray2.50A/B2-59[»]
BMRBiP62993
SMRiP62993
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi109142, 609 interactors
CORUMiP62993
DIPiDIP-29229N
ELMiP62993
IntActiP62993, 840 interactors
MINTiP62993
STRINGi9606.ENSP00000376345

Chemistry databases

BindingDBiP62993
ChEMBLiCHEMBL3663
DrugBankiDB03276, 4-[(10s,14s,18s)-18-(2-Amino-2-Oxoethyl)-14-(1-Naphthylmethyl)-8,17,20-Trioxo-7,16,19-Triazaspiro[5.14]Icos-11-En-10-Yl]Benzylphosphonic Acid
DB00061, Pegademase
DrugCentraliP62993

Protein family/group databases

MoonDBiP62993, Predicted

PTM databases

iPTMnetiP62993
MetOSiteiP62993
PhosphoSitePlusiP62993

Polymorphism and mutation databases

BioMutaiGRB2
DMDMi51702266

2D gel databases

OGPiP62993
SWISS-2DPAGEiP62993

Proteomic databases

CPTACiCPTAC-1421
CPTAC-1422
CPTAC-1423
CPTAC-1424
CPTAC-1425
CPTAC-1609
CPTAC-699
EPDiP62993
jPOSTiP62993
MassIVEiP62993
MaxQBiP62993
PaxDbiP62993
PeptideAtlasiP62993
PRIDEiP62993
ProteomicsDBi57462
57463 [P62993-2]
TopDownProteomicsiP62993-1 [P62993-1]
P62993-2 [P62993-2]

Protocols and materials databases

ABCD curated depository of sequenced antibodies

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ABCDi
P62993, 8 sequenced antibodies

Antibodypedia a portal for validated antibodies

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Antibodypediai
3408, 658 antibodies

The CPTC Antibody Portal

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CPTCi
P62993, 1 antibody

The DNASU plasmid repository

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DNASUi
2885

Genome annotation databases

EnsembliENST00000316615; ENSP00000317360; ENSG00000177885 [P62993-2]
ENST00000316804; ENSP00000339007; ENSG00000177885 [P62993-1]
ENST00000392562; ENSP00000376345; ENSG00000177885 [P62993-1]
ENST00000392563; ENSP00000376346; ENSG00000177885 [P62993-2]
ENST00000392564; ENSP00000376347; ENSG00000177885 [P62993-1]
ENST00000648046; ENSP00000496913; ENSG00000177885 [P62993-1]
GeneIDi2885
KEGGihsa:2885
UCSCiuc002jnx.5, human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
2885
DisGeNETi2885
EuPathDBiHostDB:ENSG00000177885.13

GeneCards: human genes, protein and diseases

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GeneCardsi
GRB2
HGNCiHGNC:4566, GRB2
HPAiENSG00000177885, Low tissue specificity
MIMi108355, gene
neXtProtiNX_P62993
OpenTargetsiENSG00000177885
PharmGKBiPA28962

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3601, Eukaryota
GeneTreeiENSGT00940000155738
HOGENOMiCLU_073617_1_0_1
InParanoidiP62993
KOiK04364
OMAiPATYVCP
PhylomeDBiP62993
TreeFamiTF354288

Enzyme and pathway databases

PathwayCommonsiP62993
ReactomeiR-HSA-109704, PI3K Cascade [P62993-1]
R-HSA-112412, SOS-mediated signalling [P62993-1]
R-HSA-1236382, Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants [P62993-1]
R-HSA-1250196, SHC1 events in ERBB2 signaling [P62993-1]
R-HSA-1250347, SHC1 events in ERBB4 signaling [P62993-1]
R-HSA-1257604, PIP3 activates AKT signaling [P62993-1]
R-HSA-1295596, Spry regulation of FGF signaling [P62993-1]
R-HSA-1433557, Signaling by SCF-KIT [P62993-1]
R-HSA-1433559, Regulation of KIT signaling [P62993-1]
R-HSA-167044, Signalling to RAS [P62993-1]
R-HSA-179812, GRB2 events in EGFR signaling [P62993-1]
R-HSA-180292, GAB1 signalosome [P62993-1]
R-HSA-180336, SHC1 events in EGFR signaling [P62993-1]
R-HSA-182971, EGFR downregulation [P62993-1]
R-HSA-1839117, Signaling by cytosolic FGFR1 fusion mutants [P62993-1]
R-HSA-186763, Downstream signal transduction [P62993-1]
R-HSA-1963640, GRB2 events in ERBB2 signaling [P62993-1]
R-HSA-1963642, PI3K events in ERBB2 signaling [P62993-1]
R-HSA-2029482, Regulation of actin dynamics for phagocytic cup formation [P62993-1]
R-HSA-210993, Tie2 Signaling [P62993-1]
R-HSA-2179392, EGFR Transactivation by Gastrin [P62993-1]
R-HSA-2219530, Constitutive Signaling by Aberrant PI3K in Cancer [P62993-1]
R-HSA-2424491, DAP12 signaling [P62993-1]
R-HSA-2428933, SHC-related events triggered by IGF1R [P62993-1]
R-HSA-2730905, Role of LAT2/NTAL/LAB on calcium mobilization [P62993-1]
R-HSA-2871796, FCERI mediated MAPK activation [P62993-1]
R-HSA-2871809, FCERI mediated Ca+2 mobilization [P62993-1]
R-HSA-354194, GRB2:SOS provides linkage to MAPK signaling for Integrins [P62993-1]
R-HSA-375165, NCAM signaling for neurite out-growth [P62993-1]
R-HSA-388841, Costimulation by the CD28 family [P62993-1]
R-HSA-389359, CD28 dependent Vav1 pathway [P62993-1]
R-HSA-391160, Signal regulatory protein family interactions [P62993-1]
R-HSA-512988, Interleukin-3, Interleukin-5 and GM-CSF signaling [P62993-1]
R-HSA-5637810, Constitutive Signaling by EGFRvIII [P62993-1]
R-HSA-5654688, SHC-mediated cascade:FGFR1 [P62993-1]
R-HSA-5654689, PI-3K cascade:FGFR1 [P62993-1]
R-HSA-5654693, FRS-mediated FGFR1 signaling [P62993-1]
R-HSA-5654695, PI-3K cascade:FGFR2 [P62993-1]
R-HSA-5654699, SHC-mediated cascade:FGFR2 [P62993-1]
R-HSA-5654700, FRS-mediated FGFR2 signaling [P62993-1]
R-HSA-5654704, SHC-mediated cascade:FGFR3 [P62993-1]
R-HSA-5654706, FRS-mediated FGFR3 signaling [P62993-1]
R-HSA-5654710, PI-3K cascade:FGFR3 [P62993-1]
R-HSA-5654712, FRS-mediated FGFR4 signaling [P62993-1]
R-HSA-5654719, SHC-mediated cascade:FGFR4 [P62993-1]
R-HSA-5654720, PI-3K cascade:FGFR4 [P62993-1]
R-HSA-5654726, Negative regulation of FGFR1 signaling [P62993-1]
R-HSA-5654727, Negative regulation of FGFR2 signaling [P62993-1]
R-HSA-5654732, Negative regulation of FGFR3 signaling [P62993-1]
R-HSA-5654733, Negative regulation of FGFR4 signaling [P62993-1]
R-HSA-5655253, Signaling by FGFR2 in disease [P62993-1]
R-HSA-5655291, Signaling by FGFR4 in disease [P62993-1]
R-HSA-5655302, Signaling by FGFR1 in disease [P62993-1]
R-HSA-5663213, RHO GTPases Activate WASPs and WAVEs [P62993-1]
R-HSA-5673001, RAF/MAP kinase cascade [P62993-1]
R-HSA-6807004, Negative regulation of MET activity [P62993-1]
R-HSA-6811558, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling [P62993-1]
R-HSA-74749, Signal attenuation [P62993-1]
R-HSA-74751, Insulin receptor signalling cascade [P62993-1]
R-HSA-8851805, MET activates RAS signaling [P62993-1]
R-HSA-8851907, MET activates PI3K/AKT signaling [P62993-1]
R-HSA-8853334, Signaling by FGFR3 fusions in cancer [P62993-1]
R-HSA-8853338, Signaling by FGFR3 point mutants in cancer [P62993-1]
R-HSA-8853659, RET signaling [P62993-1]
R-HSA-8856825, Cargo recognition for clathrin-mediated endocytosis [P62993-1]
R-HSA-8856828, Clathrin-mediated endocytosis [P62993-1]
R-HSA-8865999, MET activates PTPN11 [P62993-1]
R-HSA-8875360, InlB-mediated entry of Listeria monocytogenes into host cell [P62993-1]
R-HSA-8875555, MET activates RAP1 and RAC1 [P62993-1]
R-HSA-8875656, MET receptor recycling [P62993-1]
R-HSA-8983432, Interleukin-15 signaling
R-HSA-9026519, Activated NTRK2 signals through RAS [P62993-1]
R-HSA-9027284, Erythropoietin activates RAS [P62993-1]
R-HSA-9028335, Activated NTRK2 signals through PI3K [P62993-1]
R-HSA-9028731, Activated NTRK2 signals through FRS2 and FRS3 [P62993-1]
R-HSA-9034864, Activated NTRK3 signals through RAS [P62993-1]
R-HSA-912526, Interleukin receptor SHC signaling [P62993-1]
R-HSA-912631, Regulation of signaling by CBL [P62993-1]
R-HSA-9607240, FLT3 Signaling [P62993-1]
R-HSA-9634285, Constitutive Signaling by Overexpressed ERBB2 [P62993-1]
R-HSA-9645135, STAT5 Activation [P62993-1]
R-HSA-9664422, FCGR3A-mediated phagocytosis [P62993-1]
R-HSA-9664565, Signaling by ERBB2 KD Mutants [P62993-1]
R-HSA-9665348, Signaling by ERBB2 ECD mutants [P62993-1]
R-HSA-9665686, Signaling by ERBB2 TMD/JMD mutants [P62993-1]
R-HSA-9670439, Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants [P62993-1]
R-HSA-9673767, Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants [P62993-1]
R-HSA-9673770, Signaling by PDGFRA extracellular domain mutants [P62993-1]
R-HSA-983695, Antigen activates B Cell Receptor (BCR) leading to generation of second messengers [P62993-1]
SignaLinkiP62993
SIGNORiP62993

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
2885, 524 hits in 884 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
GRB2, human
EvolutionaryTraceiP62993

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
GRB2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
2885
PharosiP62993, Tchem

Protein Ontology

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PROi
PR:P62993
RNActiP62993, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000177885, Expressed in frontal cortex and 242 other tissues
ExpressionAtlasiP62993, baseline and differential
GenevisibleiP62993, HS

Family and domain databases

CDDicd11949, SH3_GRB2_C, 1 hit
cd11946, SH3_GRB2_N, 1 hit
Gene3Di3.30.505.10, 1 hit
IDEALiIID00459
InterProiView protein in InterPro
IPR030219, Grb2
IPR043539, Grb2-like
IPR035643, GRB2_C_SH3
IPR035641, GRB2_N_SH3
IPR000980, SH2
IPR036860, SH2_dom_sf
IPR036028, SH3-like_dom_sf
IPR001452, SH3_domain
PANTHERiPTHR46037, PTHR46037, 1 hit
PTHR46037:SF4, PTHR46037:SF4, 1 hit
PfamiView protein in Pfam
PF00017, SH2, 1 hit
PF00018, SH3_1, 2 hits
PRINTSiPR00401, SH2DOMAIN
PR00452, SH3DOMAIN
SMARTiView protein in SMART
SM00252, SH2, 1 hit
SM00326, SH3, 2 hits
SUPFAMiSSF50044, SSF50044, 2 hits
SSF55550, SSF55550, 1 hit
PROSITEiView protein in PROSITE
PS50001, SH2, 1 hit
PS50002, SH3, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGRB2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P62993
Secondary accession number(s): P29354
, Q14450, Q63057, Q63059
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: August 31, 2004
Last modified: October 7, 2020
This is version 204 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families
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