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Protein

Growth factor receptor-bound protein 2

Gene

GRB2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway.
Isoform 2 does not bind to phosphorylated epidermal growth factor receptor (EGFR) but inhibits EGF-induced transactivation of a RAS-responsive element. Isoform 2 acts as a dominant negative protein over GRB2 and by suppressing proliferative signals, may trigger active programmed cell death.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processHost-virus interaction

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-109704 PI3K Cascade
R-HSA-112412 SOS-mediated signalling
R-HSA-1236382 Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
R-HSA-1250196 SHC1 events in ERBB2 signaling
R-HSA-1250347 SHC1 events in ERBB4 signaling
R-HSA-1257604 PIP3 activates AKT signaling
R-HSA-1295596 Spry regulation of FGF signaling
R-HSA-1433557 Signaling by SCF-KIT
R-HSA-1433559 Regulation of KIT signaling
R-HSA-167044 Signalling to RAS
R-HSA-179812 GRB2 events in EGFR signaling
R-HSA-180292 GAB1 signalosome
R-HSA-180336 SHC1 events in EGFR signaling
R-HSA-182971 EGFR downregulation
R-HSA-1839117 Signaling by cytosolic FGFR1 fusion mutants
R-HSA-186763 Downstream signal transduction
R-HSA-1963640 GRB2 events in ERBB2 signaling
R-HSA-1963642 PI3K events in ERBB2 signaling
R-HSA-2029482 Regulation of actin dynamics for phagocytic cup formation
R-HSA-210993 Tie2 Signaling
R-HSA-2179392 EGFR Transactivation by Gastrin
R-HSA-2219530 Constitutive Signaling by Aberrant PI3K in Cancer
R-HSA-2424491 DAP12 signaling
R-HSA-2428933 SHC-related events triggered by IGF1R
R-HSA-2730905 Role of LAT2/NTAL/LAB on calcium mobilization
R-HSA-2871796 FCERI mediated MAPK activation
R-HSA-2871809 FCERI mediated Ca+2 mobilization
R-HSA-354194 GRB2:SOS provides linkage to MAPK signaling for Integrins
R-HSA-375165 NCAM signaling for neurite out-growth
R-HSA-388841 Costimulation by the CD28 family
R-HSA-389359 CD28 dependent Vav1 pathway
R-HSA-391160 Signal regulatory protein family interactions
R-HSA-512988 Interleukin-3, Interleukin-5 and GM-CSF signaling
R-HSA-5637810 Constitutive Signaling by EGFRvIII
R-HSA-5654688 SHC-mediated cascade:FGFR1
R-HSA-5654689 PI-3K cascade:FGFR1
R-HSA-5654693 FRS-mediated FGFR1 signaling
R-HSA-5654695 PI-3K cascade:FGFR2
R-HSA-5654699 SHC-mediated cascade:FGFR2
R-HSA-5654700 FRS-mediated FGFR2 signaling
R-HSA-5654704 SHC-mediated cascade:FGFR3
R-HSA-5654706 FRS-mediated FGFR3 signaling
R-HSA-5654710 PI-3K cascade:FGFR3
R-HSA-5654712 FRS-mediated FGFR4 signaling
R-HSA-5654719 SHC-mediated cascade:FGFR4
R-HSA-5654720 PI-3K cascade:FGFR4
R-HSA-5654726 Negative regulation of FGFR1 signaling
R-HSA-5654727 Negative regulation of FGFR2 signaling
R-HSA-5654732 Negative regulation of FGFR3 signaling
R-HSA-5654733 Negative regulation of FGFR4 signaling
R-HSA-5655253 Signaling by FGFR2 in disease
R-HSA-5655291 Signaling by FGFR4 in disease
R-HSA-5655302 Signaling by FGFR1 in disease
R-HSA-5663213 RHO GTPases Activate WASPs and WAVEs
R-HSA-5673001 RAF/MAP kinase cascade
R-HSA-6807004 Negative regulation of MET activity
R-HSA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-HSA-74749 Signal attenuation
R-HSA-74751 Insulin receptor signalling cascade
R-HSA-8851805 MET activates RAS signaling
R-HSA-8851907 MET activates PI3K/AKT signaling
R-HSA-8853334 Signaling by FGFR3 fusions in cancer
R-HSA-8853338 Signaling by FGFR3 point mutants in cancer
R-HSA-8853659 RET signaling
R-HSA-8856825 Cargo recognition for clathrin-mediated endocytosis
R-HSA-8856828 Clathrin-mediated endocytosis
R-HSA-8865999 MET activates PTPN11
R-HSA-8875360 InlB-mediated entry of Listeria monocytogenes into host cell
R-HSA-8875555 MET activates RAP1 and RAC1
R-HSA-8875656 MET receptor recycling
R-HSA-8983432 Interleukin-15 signaling
R-HSA-9026519 Activated NTRK2 signals through RAS
R-HSA-9027284 Erythropoietin activates RAS
R-HSA-9028335 Activated NTRK2 signals through PI3K
R-HSA-9028731 Activated NTRK2 signals through FRS2 and FRS3
R-HSA-9034864 Activated NTRK3 signals through RAS
R-HSA-912526 Interleukin receptor SHC signaling
R-HSA-912631 Regulation of signaling by CBL
R-HSA-983695 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers

SignaLink: a signaling pathway resource with multi-layered regulatory networks

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SignaLinki
P62993

SIGNOR Signaling Network Open Resource

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SIGNORi
P62993

Protein family/group databases

MoonDB Database of extreme multifunctional and moonlighting proteins

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MoonDBi
P62993 Predicted

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Growth factor receptor-bound protein 2
Alternative name(s):
Adapter protein GRB2
Protein Ash
SH2/SH3 adapter GRB2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:GRB2
Synonyms:ASH
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000177885.13

Human Gene Nomenclature Database

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HGNCi
HGNC:4566 GRB2

Online Mendelian Inheritance in Man (OMIM)

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MIMi
108355 gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_P62993

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Endosome, Golgi apparatus, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi49P → L: Ineffective in DNA synthesis. Abolishes interaction with SHB; when associated with L-206. Abolishes interaction with SOS1. 3 Publications1
Mutagenesisi89E → K: No effect on the interaction with SOS1. 1 Publication1
Mutagenesisi90S → N: No effect on the interaction with SOS1. 1 Publication1
Mutagenesisi203G → R: Ineffective in DNA synthesis. Abolishes interaction with SOS1. 2 Publications1
Mutagenesisi206P → L: Abolishes interaction with SHB; when associated with L-49. 1 Publication1

Organism-specific databases

DisGeNET

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DisGeNETi
2885

Open Targets

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OpenTargetsi
ENSG00000177885

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA28962

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

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ChEMBLi
CHEMBL3663

Drug and drug target database

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DrugBanki
DB00061 Pegademase bovine

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
GRB2

Domain mapping of disease mutations (DMDM)

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DMDMi
51702266

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000881981 – 217Growth factor receptor-bound protein 2Add BLAST217

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineCombined sources1
Modified residuei6N6-acetyllysineCombined sources1
Modified residuei50N6-acetyllysineCombined sources1
Modified residuei109N6-acetyllysineCombined sources1
Modified residuei211PhosphothreonineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
P62993

MaxQB - The MaxQuant DataBase

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MaxQBi
P62993

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P62993

PeptideAtlas

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PeptideAtlasi
P62993

PRoteomics IDEntifications database

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PRIDEi
P62993

ProteomicsDB human proteome resource

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ProteomicsDBi
57462
57463 [P62993-2]

Consortium for Top Down Proteomics

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TopDownProteomicsi
P62993-1 [P62993-1]
P62993-2 [P62993-2]

2D gel databases

USC-OGP 2-DE database

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OGPi
P62993

Two-dimensional polyacrylamide gel electrophoresis database from the Geneva University Hospital

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SWISS-2DPAGEi
P62993

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P62993

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P62993

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000177885 Expressed in 226 organ(s), highest expression level in blood

CleanEx database of gene expression profiles

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CleanExi
HS_GRB2

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P62993 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P62993 HS

Organism-specific databases

Human Protein Atlas

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HPAi
CAB002589
HPA030749
HPA030750

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Associates (via SH2 domain) with activated EGF and PDGF receptors (tyrosine phosphorylated) (PubMed:10026169, PubMed:19836242). Interacts with PDGFRA (tyrosine phosphorylated); the interaction may be indirect (By similarity). Also associates to other cellular Tyr-phosphorylated proteins such as SIT1, IRS1, IRS4, SHC and LNK; probably via the concerted action of both its SH2 and SH3 domains (PubMed:8388384, PubMed:8491186, PubMed:9553137, PubMed:11433379). It also seems to interact with RAS in the signaling pathway leading to DNA synthesis. Interacts with SOS1 (PubMed:8493579, PubMed:7664271). Forms a complex with MUC1 and SOS1, through interaction of the SH3 domains with SOS1 and the SH2 domain with phosphorylated MUC1 (PubMed:7664271). Interacts with phosphorylated MET (PubMed:11063574, PubMed:11827484). Interacts with phosphorylated TOM1L1 (By similarity). Interacts with the phosphorylated C-terminus of SH2B2 (PubMed:9233773). Interacts with phosphorylated SIT1, LAX1, LAT, LAT2 and LIME1 upon TCR and/or BCR activation (By similarity) (PubMed:9489702, PubMed:12359715, PubMed:12486104, PubMed:12514734). Interacts with NISCH, PTPNS1 and REPS2 (PubMed:9062191, PubMed:9422736, PubMed:11912194). Interacts with syntrophin SNTA1 (By similarity). Interacts (via SH3 domains) with REPS1 (By similarity). Interacts (via SH3 domains) with PIK3C2B (PubMed:11533253). Interacts with CBL and CBLB (PubMed:10022120, PubMed:10086340). Interacts with AJUBA and CLNK (By similarity). Interacts (via SH2 domain) with TEK/TIE2 (tyrosine phosphorylated) (By similarity). Interacts with SHB, INPP5D/SHIP1, SKAP1 and SKAP2 (PubMed:8723348, PubMed:9108392, PubMed:9484780, PubMed:10942756, PubMed:12171928). Interacts with PTPN11 (By similarity). Interacts with PRNP (By similarity). Interacts with RALGPS1 (PubMed:10747847). Interacts with HCST (PubMed:16582911). Interacts with KDR (By similarity). Interacts with FLT1 (tyrosine-phosphorylated) (By similarity). Interacts with GAPT and PTPRE (PubMed:10980613, PubMed:18559951). Interacts (via SH2 domain) with KIF26A (PubMed:19914172). Interacts (via SH3 2) with GAB2 (PubMed:19523899). Interacts with ADAM15 (PubMed:18296648). Interacts with THEMIS2 (By similarity). Interacts (via SH2 domain) with AXL (phosphorylated) (PubMed:9178760, PubMed:19815557). Interacts (via SH2 domain) with KIT (phosphorylated) (PubMed:15526160, PubMed:16129412). Interacts with PTPRJ and BCR (PubMed:12475979, PubMed:15302586). Interacts with PTPN23 (PubMed:21179510). Interacts with FLT4 (tyrosine phosphorylated) (PubMed:15102829). Interacts with EPHB1 and SHC1; activates the MAPK/ERK cascade to regulate cell migration (PubMed:8798570, PubMed:12925710). Part of a complex including TNK2, GRB2, LTK and one receptor tyrosine kinase (RTK) such as AXL and PDGFRL, in which GRB2 promotes RTK recruitment by TNK2 (PubMed:9178760, PubMed:19815557). Interacts (via SH2 domain) with CSF1R (tyrosine phosphorylated) (PubMed:8262059). Interacts with ERBB4 (PubMed:10867024). Interacts with NTRK1 (phosphorylated upon ligand-binding) (PubMed:15488758). Interacts with PTK2/FAK1 (tyrosine phosphorylated) (PubMed:9148935). Interacts with PTK2B/PYK2 (tyrosine phosphorylated) (PubMed:20521079). Isoform 1 interacts with SCIMP (PubMed:21930792). Interacts (via SH3 domains) with GAREM1 isoform 1 (via proline-rich domain and tyrosine phosphorylated); the interaction occurs upon EGF stimulation (PubMed:19509291). Interacts with DAB2 (By similarity). Interacts with TESPA1 (PubMed:22561606). Interacts with PLCG1, LAT and THEMIS upon TCR activation in thymocytes; the association is weaker in the absence of TESPA1 (By similarity). Interacts with CD28 (PubMed:24098653). Interacts with RAB13; may recruit RAB13 to the leading edge of migrating endothelial cells where it can activate RHOA (By similarity). Interacts with ASAP3 (phosphorylated form) (PubMed:22027826). Interacts (via SH2 domain) with PTPRH (phosphorylated form) (By similarity). Interacts with PTPRO (phosphorylated form) (By similarity). Interacts with PTPRB (phosphorylated form) (By similarity). Interacts (via SH3 domain 2) with PRR14 (via proline-rich region) (PubMed:27041574). Interacts with FCRL6 (tyrosine phosphorylated form) (PubMed:20933011). Interacts with RHEX (via tyrosine-phosphorylated form) (PubMed:25092874).By similarity57 Publications
(Microbial infection) Interacts (via SH3 domain) with hepatitis E virus/HEV ORF3 protein.1 Publication
(Microbial infection) Interacts with hepatitis C virus/HCV protein NS5A via its SH3 domains.1 Publication
(Microbial infection) Interacts with herpes simplex virus 1 protein UL46.1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
itself5EBI-401755,EBI-401755
O929722EBI-401755,EBI-710506From Hepatitis C virus genotype 1b (strain HC-J4).
P266623EBI-401755,EBI-9099462From Hepatitis C virus genotype 1b (isolate Japanese).
P279583EBI-401755,EBI-706378From Hepatitis C virus genotype 1a (isolate H).
ABI3Q9P2A43EBI-401755,EBI-742038
ABL2P426842EBI-401755,EBI-1102694
ACAP1Q150273EBI-401755,EBI-751746
ADAM15Q134443EBI-401755,EBI-77818
AESQ081173EBI-401755,EBI-717810
AGERQ151092EBI-401755,EBI-1646426
ANK2Q014842EBI-401755,EBI-941975
ARHGAP9Q9BRR93EBI-401755,EBI-750254
ARHGEF5Q127744EBI-401755,EBI-602199
ARL6IP4Q66PJ3-42EBI-401755,EBI-5280499
ASAP1Q9ULH17EBI-401755,EBI-346622
ASAP2O431503EBI-401755,EBI-310968
AXLP305303EBI-401755,EBI-2850927
BCRP112748EBI-401755,EBI-712838
BLNKQ8WV284EBI-401755,EBI-2623522
BRD4O608852EBI-401755,EBI-723869
C1orf94Q6P1W53EBI-401755,EBI-946029
CBLP2268110EBI-401755,EBI-518228
CBLBQ1319112EBI-401755,EBI-744027
CD2APQ9Y5K63EBI-401755,EBI-298152
DAB2P980822EBI-401755,EBI-1171238
Dab2P980784EBI-401755,EBI-1391846From Mus musculus.
DARSP148682EBI-401755,EBI-358730
DBN1Q166434EBI-401755,EBI-351394
DDX17Q928413EBI-401755,EBI-746012
DLGAP1O144903EBI-401755,EBI-1753207
DLGAP2Q9P1A62EBI-401755,EBI-1753397
DLGAP4Q9Y2H02EBI-401755,EBI-722139
DNM1Q051933EBI-401755,EBI-713135
DNM2P505706EBI-401755,EBI-346547
DOCK1Q141852EBI-401755,EBI-446740
DPPA4Q7L1903EBI-401755,EBI-710457
EGFRP0053336EBI-401755,EBI-297353
EPHB1P547622EBI-401755,EBI-80252
EPS8Q129293EBI-401755,EBI-375576
ERBB2P046264EBI-401755,EBI-641062
ERBB3P218603EBI-401755,EBI-720706
ERRFI1Q9UJM312EBI-401755,EBI-2941912
FAM22FB7ZLH05EBI-401755,EBI-10220102
FANCAO153602EBI-401755,EBI-81570
FGFR2P218025EBI-401755,EBI-1028658
FLNAP213332EBI-401755,EBI-350432
FLNBO753692EBI-401755,EBI-352089
FLNCQ143152EBI-401755,EBI-489954
GAB1Q134805EBI-401755,EBI-517684
GAB2Q9UQC210EBI-401755,EBI-975200
GAB2Q9UQC2-13EBI-15787932,EBI-15787947
GAREM1Q9H7068EBI-401755,EBI-3440103
HNRNPKP619789EBI-401755,EBI-304185
HOMEZQ8IX15-33EBI-401755,EBI-10172004
IKZF3Q9UKT97EBI-401755,EBI-747204
INCA1Q0VD863EBI-401755,EBI-6509505
Irs1P355705EBI-401755,EBI-520230From Rattus norvegicus.
KHDRBS1Q076668EBI-401755,EBI-1364
KITP107216EBI-401755,EBI-1379503
KRT8P057873EBI-401755,EBI-297852
LATO435617EBI-401755,EBI-1222766
LATO43561-23EBI-15787932,EBI-8070286
LCP2Q1309414EBI-401755,EBI-346946
LEPRP483573EBI-401755,EBI-518596
LMO2P257913EBI-401755,EBI-739696
LMX1AQ8TE123EBI-401755,EBI-10692065
LNX1Q8TBB13EBI-401755,EBI-739832
LZTS2Q9BRK43EBI-401755,EBI-741037
MAP2K5Q131632EBI-401755,EBI-307294
MAP4K1Q929188EBI-401755,EBI-881
MAP4K3Q8IVH82EBI-401755,EBI-1758170
MAP4K5Q9Y4K44EBI-401755,EBI-1279
MED28Q9H2043EBI-401755,EBI-514199
MYH9P355793EBI-401755,EBI-350338
NELFBQ8WX922EBI-401755,EBI-347721
NIF3L1Q9GZT83EBI-401755,EBI-740897
PAK2Q131772EBI-401755,EBI-1045887
PARD6AQ9NPB6-23EBI-401755,EBI-10693102
PIK3C2BO007502EBI-401755,EBI-641107
PIK3R1P279864EBI-401755,EBI-79464
PIK3R2O004594EBI-401755,EBI-346930
PLCG1P191742EBI-401755,EBI-79387
PLD2O149394EBI-401755,EBI-1053996
PLEKHS1Q5SXH73EBI-401755,EBI-10691507
PNMA5Q96PV43EBI-401755,EBI-10171633
PPARAQ078693EBI-401755,EBI-78615
PPP3CAQ082093EBI-401755,EBI-352922
PRKAB1Q9Y4782EBI-401755,EBI-719769
Ptk2P341523EBI-401755,EBI-77070From Mus musculus.
PTPN1P180312EBI-401755,EBI-968788
PTPN11Q061246EBI-401755,EBI-297779
Ptpn11P352357EBI-401755,EBI-397236From Mus musculus.
PTPN22Q9Y2R22EBI-401755,EBI-1211241
PTPN23Q9H3S76EBI-401755,EBI-724478
PTPN6P293503EBI-401755,EBI-78260
PTPRAP184339EBI-401755,EBI-2609645
PTPRTO145222EBI-401755,EBI-728180
RB1P064004EBI-401755,EBI-491274
RELQ048643EBI-401755,EBI-307352
REPS2Q8NFH8-28EBI-401755,EBI-8029141
SF3B4Q154272EBI-401755,EBI-348469
SH2D4AQ9H7883EBI-401755,EBI-747035
SHANK2Q9UPX82EBI-401755,EBI-1570571
SHANK3Q9BYB02EBI-401755,EBI-1752330
SHC1P2935323EBI-401755,EBI-78835
SHC1P29353-13EBI-401755,EBI-8160716
SOCS4Q8WXH53EBI-401755,EBI-3942425
SOS1Q0788922EBI-401755,EBI-297487
Sos1Q622454EBI-401755,EBI-1693From Mus musculus.
SOS2Q078908EBI-401755,EBI-298181
SPRY2O435973EBI-401755,EBI-742487
SRGAP3O432952EBI-401755,EBI-368166
STAMBPO956307EBI-401755,EBI-396676
SYNJ2O150562EBI-401755,EBI-310513
THEMISQ8N1K510EBI-401755,EBI-2873538
THEMISQ8N1K5-110EBI-401755,EBI-15102259
TMEM128Q5BJH2-23EBI-401755,EBI-10694905
TNPO1Q929732EBI-401755,EBI-286693
TOM1L1O756742EBI-401755,EBI-712991
TP53BP2Q13625-33EBI-401755,EBI-10175039
TPX2Q9ULW02EBI-401755,EBI-1037322
TRIM27P143733EBI-401755,EBI-719493
TSPAN2O606366EBI-401755,EBI-3914288
UGP2Q168512EBI-401755,EBI-743729
VAV1P154983EBI-401755,EBI-625518
VAV3Q9UKW47EBI-401755,EBI-297568
VCPP550723EBI-401755,EBI-355164
WASLO004018EBI-401755,EBI-957615
WBP11Q9Y2W24EBI-401755,EBI-714455
WIPF1O435163EBI-401755,EBI-346356
WIPF2Q8TF743EBI-401755,EBI-2850112
ZBTB7BO151563EBI-401755,EBI-740434

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
109142, 545 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
P62993

Database of interacting proteins

More...
DIPi
DIP-29229N

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...
ELMi
P62993

Protein interaction database and analysis system

More...
IntActi
P62993, 780 interactors

Molecular INTeraction database

More...
MINTi
P62993

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000339007

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
P62993

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1217
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Database of protein disorder

More...
DisProti
DP00210

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P62993

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P62993

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P62993

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1 – 58SH3 1PROSITE-ProRule annotationAdd BLAST58
Domaini60 – 152SH2PROSITE-ProRule annotationAdd BLAST93
Domaini156 – 215SH3 2PROSITE-ProRule annotationAdd BLAST60

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The SH3 domains mediate interaction with RALGPS1 and SHB.

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the GRB2/sem-5/DRK family.Curated

Keywords - Domaini

Repeat, SH2 domain, SH3 domain

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3601 Eukaryota
ENOG410XR1G LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155738

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000251625

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG005404

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P62993

KEGG Orthology (KO)

More...
KOi
K04364

Identification of Orthologs from Complete Genome Data

More...
OMAi
HWWHGEI

Database of Orthologous Groups

More...
OrthoDBi
EOG091G0HWS

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P62993

TreeFam database of animal gene trees

More...
TreeFami
TF354288

Family and domain databases

Conserved Domains Database

More...
CDDi
cd11949 SH3_GRB2_C, 1 hit
cd11946 SH3_GRB2_N, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.505.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR030219 Grb2
IPR035643 GRB2_C_SH3
IPR035641 GRB2_N_SH3
IPR000980 SH2
IPR036860 SH2_dom_sf
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain

The PANTHER Classification System

More...
PANTHERi
PTHR24418:SF290 PTHR24418:SF290, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00017 SH2, 1 hit
PF00018 SH3_1, 2 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00401 SH2DOMAIN
PR00452 SH3DOMAIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00252 SH2, 1 hit
SM00326 SH3, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50044 SSF50044, 2 hits
SSF55550 SSF55550, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50001 SH2, 1 hit
PS50002 SH3, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: Additional isoforms seem to exist.

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P62993-1) [UniParc]FASTAAdd to basket
Also known as: Ash-L

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEAIAKYDFK ATADDELSFK RGDILKVLNE ECDQNWYKAE LNGKDGFIPK
60 70 80 90 100
NYIEMKPHPW FFGKIPRAKA EEMLSKQRHD GAFLIRESES APGDFSLSVK
110 120 130 140 150
FGNDVQHFKV LRDGAGKYFL WVVKFNSLNE LVDYHRSTSV SRNQQIFLRD
160 170 180 190 200
IEQVPQQPTY VQALFDFDPQ EDGELGFRRG DFIHVMDNSD PNWWKGACHG
210
QTGMFPRNYV TPVNRNV
Length:217
Mass (Da):25,206
Last modified:August 31, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i83A4B0BA1B248DC4
GO
Isoform 2 (identifier: P62993-2) [UniParc] [UniParc]FASTAAdd to basket
Also known as: GRB3-3

The sequence of this isoform differs from the canonical sequence as follows:
     60-100: Missing.

Show »
Length:176
Mass (Da):20,557
Checksum:i70622BED0FE940DE
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3QRL5J3QRL5_HUMAN
Growth factor receptor-bound protei...
GRB2
156Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KT38J3KT38_HUMAN
Growth factor receptor-bound protei...
GRB2
110Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QLF6J3QLF6_HUMAN
Growth factor receptor-bound protei...
GRB2
42Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_00183960 – 100Missing in isoform 2. 1 PublicationAdd BLAST41

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M96995 mRNA Translation: AAA58448.1
X62852 mRNA Translation: CAA44664.1
L29511 mRNA Translation: AAC37549.1
AF063618
, AF063614, AF063615, AF063616, AF063617 Genomic DNA Translation: AAC72075.1
AF498925 mRNA Translation: AAM21073.1
CR541942 mRNA Translation: CAG46740.1
AC011933 Genomic DNA No translation available.
BC000631 mRNA Translation: AAH00631.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS11721.1
CCDS11722.1 [P62993-2]

Protein sequence database of the Protein Information Resource

More...
PIRi
A43321

NCBI Reference Sequences

More...
RefSeqi
NP_002077.1, NM_002086.4 [P62993-1]
NP_987102.1, NM_203506.2 [P62993-2]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.444356

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000316615; ENSP00000317360; ENSG00000177885 [P62993-2]
ENST00000316804; ENSP00000339007; ENSG00000177885 [P62993-1]
ENST00000392562; ENSP00000376345; ENSG00000177885 [P62993-1]
ENST00000392563; ENSP00000376346; ENSG00000177885 [P62993-2]
ENST00000392564; ENSP00000376347; ENSG00000177885 [P62993-1]
ENST00000648046; ENSP00000496913; ENSG00000177885 [P62993-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
2885

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:2885

UCSC genome browser

More...
UCSCi
uc002jnx.5 human

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M96995 mRNA Translation: AAA58448.1
X62852 mRNA Translation: CAA44664.1
L29511 mRNA Translation: AAC37549.1
AF063618
, AF063614, AF063615, AF063616, AF063617 Genomic DNA Translation: AAC72075.1
AF498925 mRNA Translation: AAM21073.1
CR541942 mRNA Translation: CAG46740.1
AC011933 Genomic DNA No translation available.
BC000631 mRNA Translation: AAH00631.1
CCDSiCCDS11721.1
CCDS11722.1 [P62993-2]
PIRiA43321
RefSeqiNP_002077.1, NM_002086.4 [P62993-1]
NP_987102.1, NM_203506.2 [P62993-2]
UniGeneiHs.444356

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1AZENMR-A1-56[»]
1BM2X-ray2.10A49-163[»]
1BMBX-ray1.80A49-168[»]
1CJ1X-ray3.00A/B/C/D/E/F/G/H/I/J/K/L57-152[»]
1FHSNMR-A53-163[»]
1FYRX-ray2.40A/B/C/D50-161[»]
1GCQX-ray1.68A/B159-217[»]
1GFCNMR-A159-215[»]
1GFDNMR-A159-215[»]
1GHUNMR-A60-158[»]
1GRIX-ray3.10A/B1-217[»]
1IO6NMR-A159-215[»]
1JYQX-ray2.00A/B60-151[»]
1JYRX-ray1.55A60-151[»]
1JYUX-ray2.75A60-151[»]
1QG1NMR-E58-159[»]
1TZEX-ray2.10E55-152[»]
1X0NNMR-A58-159[»]
1ZFPX-ray1.80E56-153[»]
2AOAX-ray1.99A/B55-153[»]
2AOBX-ray1.80A/B/C/D55-153[»]
2H46X-ray1.90E53-162[»]
2H5KX-ray3.25A/B53-162[»]
2HUWX-ray1.90A/B53-162[»]
2VVKX-ray1.60A161-214[»]
2VWFX-ray1.58A159-214[»]
2W0ZX-ray1.70A159-214[»]
3C7IX-ray1.70A53-162[»]
3IMDX-ray2.00A/B53-163[»]
3IMJX-ray2.02A/B53-163[»]
3IN7X-ray2.00A/C53-163[»]
3IN8X-ray1.70A53-163[»]
3KFJX-ray2.02A53-163[»]
3MXCX-ray2.00A55-152[»]
3MXYX-ray2.30A55-152[»]
3N7YX-ray2.02A/B/C55-152[»]
3N84X-ray2.00A/B/C/D/E/F53-163[»]
3N8MX-ray2.00A53-163[»]
3OV1X-ray1.60A53-163[»]
3OVEX-ray1.82A53-163[»]
3S8LX-ray1.71A53-163[»]
3S8NX-ray1.71A53-163[»]
3S8OX-ray1.85A53-163[»]
3WA4X-ray1.35A60-152[»]
4P9VX-ray1.64A53-163[»]
4P9ZX-ray1.80A53-163[»]
5CDWX-ray2.60A/B/C/E/G/H/K/L/O/P/U/V/Y/Z/c/d54-153[»]
DisProtiDP00210
ProteinModelPortaliP62993
SMRiP62993
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109142, 545 interactors
CORUMiP62993
DIPiDIP-29229N
ELMiP62993
IntActiP62993, 780 interactors
MINTiP62993
STRINGi9606.ENSP00000339007

Chemistry databases

BindingDBiP62993
ChEMBLiCHEMBL3663
DrugBankiDB00061 Pegademase bovine

Protein family/group databases

MoonDBiP62993 Predicted

PTM databases

iPTMnetiP62993
PhosphoSitePlusiP62993

Polymorphism and mutation databases

BioMutaiGRB2
DMDMi51702266

2D gel databases

OGPiP62993
SWISS-2DPAGEiP62993

Proteomic databases

EPDiP62993
MaxQBiP62993
PaxDbiP62993
PeptideAtlasiP62993
PRIDEiP62993
ProteomicsDBi57462
57463 [P62993-2]
TopDownProteomicsiP62993-1 [P62993-1]
P62993-2 [P62993-2]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
2885
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000316615; ENSP00000317360; ENSG00000177885 [P62993-2]
ENST00000316804; ENSP00000339007; ENSG00000177885 [P62993-1]
ENST00000392562; ENSP00000376345; ENSG00000177885 [P62993-1]
ENST00000392563; ENSP00000376346; ENSG00000177885 [P62993-2]
ENST00000392564; ENSP00000376347; ENSG00000177885 [P62993-1]
ENST00000648046; ENSP00000496913; ENSG00000177885 [P62993-1]
GeneIDi2885
KEGGihsa:2885
UCSCiuc002jnx.5 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
2885
DisGeNETi2885
EuPathDBiHostDB:ENSG00000177885.13

GeneCards: human genes, protein and diseases

More...
GeneCardsi
GRB2
HGNCiHGNC:4566 GRB2
HPAiCAB002589
HPA030749
HPA030750
MIMi108355 gene
neXtProtiNX_P62993
OpenTargetsiENSG00000177885
PharmGKBiPA28962

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3601 Eukaryota
ENOG410XR1G LUCA
GeneTreeiENSGT00940000155738
HOGENOMiHOG000251625
HOVERGENiHBG005404
InParanoidiP62993
KOiK04364
OMAiHWWHGEI
OrthoDBiEOG091G0HWS
PhylomeDBiP62993
TreeFamiTF354288

Enzyme and pathway databases

ReactomeiR-HSA-109704 PI3K Cascade
R-HSA-112412 SOS-mediated signalling
R-HSA-1236382 Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
R-HSA-1250196 SHC1 events in ERBB2 signaling
R-HSA-1250347 SHC1 events in ERBB4 signaling
R-HSA-1257604 PIP3 activates AKT signaling
R-HSA-1295596 Spry regulation of FGF signaling
R-HSA-1433557 Signaling by SCF-KIT
R-HSA-1433559 Regulation of KIT signaling
R-HSA-167044 Signalling to RAS
R-HSA-179812 GRB2 events in EGFR signaling
R-HSA-180292 GAB1 signalosome
R-HSA-180336 SHC1 events in EGFR signaling
R-HSA-182971 EGFR downregulation
R-HSA-1839117 Signaling by cytosolic FGFR1 fusion mutants
R-HSA-186763 Downstream signal transduction
R-HSA-1963640 GRB2 events in ERBB2 signaling
R-HSA-1963642 PI3K events in ERBB2 signaling
R-HSA-2029482 Regulation of actin dynamics for phagocytic cup formation
R-HSA-210993 Tie2 Signaling
R-HSA-2179392 EGFR Transactivation by Gastrin
R-HSA-2219530 Constitutive Signaling by Aberrant PI3K in Cancer
R-HSA-2424491 DAP12 signaling
R-HSA-2428933 SHC-related events triggered by IGF1R
R-HSA-2730905 Role of LAT2/NTAL/LAB on calcium mobilization
R-HSA-2871796 FCERI mediated MAPK activation
R-HSA-2871809 FCERI mediated Ca+2 mobilization
R-HSA-354194 GRB2:SOS provides linkage to MAPK signaling for Integrins
R-HSA-375165 NCAM signaling for neurite out-growth
R-HSA-388841 Costimulation by the CD28 family
R-HSA-389359 CD28 dependent Vav1 pathway
R-HSA-391160 Signal regulatory protein family interactions
R-HSA-512988 Interleukin-3, Interleukin-5 and GM-CSF signaling
R-HSA-5637810 Constitutive Signaling by EGFRvIII
R-HSA-5654688 SHC-mediated cascade:FGFR1
R-HSA-5654689 PI-3K cascade:FGFR1
R-HSA-5654693 FRS-mediated FGFR1 signaling
R-HSA-5654695 PI-3K cascade:FGFR2
R-HSA-5654699 SHC-mediated cascade:FGFR2
R-HSA-5654700 FRS-mediated FGFR2 signaling
R-HSA-5654704 SHC-mediated cascade:FGFR3
R-HSA-5654706 FRS-mediated FGFR3 signaling
R-HSA-5654710 PI-3K cascade:FGFR3
R-HSA-5654712 FRS-mediated FGFR4 signaling
R-HSA-5654719 SHC-mediated cascade:FGFR4
R-HSA-5654720 PI-3K cascade:FGFR4
R-HSA-5654726 Negative regulation of FGFR1 signaling
R-HSA-5654727 Negative regulation of FGFR2 signaling
R-HSA-5654732 Negative regulation of FGFR3 signaling
R-HSA-5654733 Negative regulation of FGFR4 signaling
R-HSA-5655253 Signaling by FGFR2 in disease
R-HSA-5655291 Signaling by FGFR4 in disease
R-HSA-5655302 Signaling by FGFR1 in disease
R-HSA-5663213 RHO GTPases Activate WASPs and WAVEs
R-HSA-5673001 RAF/MAP kinase cascade
R-HSA-6807004 Negative regulation of MET activity
R-HSA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-HSA-74749 Signal attenuation
R-HSA-74751 Insulin receptor signalling cascade
R-HSA-8851805 MET activates RAS signaling
R-HSA-8851907 MET activates PI3K/AKT signaling
R-HSA-8853334 Signaling by FGFR3 fusions in cancer
R-HSA-8853338 Signaling by FGFR3 point mutants in cancer
R-HSA-8853659 RET signaling
R-HSA-8856825 Cargo recognition for clathrin-mediated endocytosis
R-HSA-8856828 Clathrin-mediated endocytosis
R-HSA-8865999 MET activates PTPN11
R-HSA-8875360 InlB-mediated entry of Listeria monocytogenes into host cell
R-HSA-8875555 MET activates RAP1 and RAC1
R-HSA-8875656 MET receptor recycling
R-HSA-8983432 Interleukin-15 signaling
R-HSA-9026519 Activated NTRK2 signals through RAS
R-HSA-9027284 Erythropoietin activates RAS
R-HSA-9028335 Activated NTRK2 signals through PI3K
R-HSA-9028731 Activated NTRK2 signals through FRS2 and FRS3
R-HSA-9034864 Activated NTRK3 signals through RAS
R-HSA-912526 Interleukin receptor SHC signaling
R-HSA-912631 Regulation of signaling by CBL
R-HSA-983695 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
SignaLinkiP62993
SIGNORiP62993

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
GRB2 human
EvolutionaryTraceiP62993

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
GRB2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
2885

Protein Ontology

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PROi
PR:P62993

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000177885 Expressed in 226 organ(s), highest expression level in blood
CleanExiHS_GRB2
ExpressionAtlasiP62993 baseline and differential
GenevisibleiP62993 HS

Family and domain databases

CDDicd11949 SH3_GRB2_C, 1 hit
cd11946 SH3_GRB2_N, 1 hit
Gene3Di3.30.505.10, 1 hit
InterProiView protein in InterPro
IPR030219 Grb2
IPR035643 GRB2_C_SH3
IPR035641 GRB2_N_SH3
IPR000980 SH2
IPR036860 SH2_dom_sf
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
PANTHERiPTHR24418:SF290 PTHR24418:SF290, 1 hit
PfamiView protein in Pfam
PF00017 SH2, 1 hit
PF00018 SH3_1, 2 hits
PRINTSiPR00401 SH2DOMAIN
PR00452 SH3DOMAIN
SMARTiView protein in SMART
SM00252 SH2, 1 hit
SM00326 SH3, 2 hits
SUPFAMiSSF50044 SSF50044, 2 hits
SSF55550 SSF55550, 1 hit
PROSITEiView protein in PROSITE
PS50001 SH2, 1 hit
PS50002 SH3, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGRB2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P62993
Secondary accession number(s): P29354
, Q14450, Q63057, Q63059
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: August 31, 2004
Last modified: December 5, 2018
This is version 188 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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