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Protein

Ubiquitin-60S ribosomal protein L40

Gene

UBA52

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Ubiquitin: exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in lysosomal degradation; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling (By similarity).By similarity
60S ribosomal protein L40: component of the 60S subunit of the ribosome.By similarity

Miscellaneous

Ubiquitin is encoded by 4 different genes. Uba52 and Rps27a genes code for a single copy of ubiquitin fused to the ribosomal proteins L40 and S27a, respectively. UBB and UBC genes code for a polyubiquitin precursor with exact head to tail repeats, the number of repeats differ between species and strains.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei9Essential for function1
Binding sitei13Activating enzyme1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-GGA-1227882 TRAF mediated activation of IRF
R-GGA-1227888 Negative Regulation of MDA5 signaling
R-GGA-1227892 TRAF6 mediated NF-kB activation
R-GGA-351465 Fanconi Anemia Pathway in DNA repair
R-GGA-353299 RAD18 and ubiquitinated PCNA-mediated recruitment of translesion polymerases
R-GGA-353303 Nucleotide Excision Repair
R-GGA-433822 NFkB and MAPK activation mediated by TRAF6
R-GGA-433871 TRAF6 mediated induction of proinflammatory cytokines
R-GGA-434001 TAK1 activates NFkB by phosphorylation and activation of IKKs complex
R-GGA-434131 NFkB activation mediated by RIP1 complexed with activated TLR3
R-GGA-437980 Activated TAK1 mediates p38 MAP kinase phosphorylation
R-GGA-437986 Activated TAK1 mediates Jun kinases (JNK) phosphorylation and activation
R-GGA-573298 NFkB and MAPK activation mediated by TRAF6 upon TLR7 or TLR21 stimulation

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin-60S ribosomal protein L40
Alternative name(s):
Ubiquitin A-52 residue ribosomal protein fusion product 1
Cleaved into the following 2 chains:
Alternative name(s):
CEP52
Gene namesi
Name:UBA52
Synonyms:UBCEP2
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000396441‹1 – 17UbiquitinAdd BLAST›17
ChainiPRO_000013875518 – 6960S ribosomal protein L40Add BLAST52

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki4Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Cross-linki17Glycyl lysine isopeptide (Gly-Lys) (interchain with K-? in acceptor proteins)By similarity
Modified residuei39N6,N6,N6-trimethyllysineBy similarity1

Keywords - PTMi

Isopeptide bond, Methylation, Ubl conjugation

Proteomic databases

PRIDEiP62985

Interactioni

Subunit structurei

Ribosomal protein L40 is part of the 60S ribosomal subunit.By similarity

Structurei

3D structure databases

ProteinModelPortaliP62985
SMRiP62985
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini‹1 – 17Ubiquitin-likeAdd BLAST›17

Sequence similaritiesi

In the N-terminal section; belongs to the ubiquitin family.Curated
In the C-terminal section; belongs to the eukaryotic ribosomal protein eL40 family.Curated

Phylogenomic databases

HOVERGENiHBG079132
InParanoidiP62985
PhylomeDBiP62985

Family and domain databases

Gene3Di2.20.28.70, 1 hit
InterProiView protein in InterPro
IPR038587 L40e_sf
IPR001975 Ribosomal_L40e
IPR011332 Ribosomal_zn-bd
PfamiView protein in Pfam
PF01020 Ribosomal_L40e, 1 hit
SMARTiView protein in SMART
SM01377 Ribosomal_L40e, 1 hit
SUPFAMiSSF57829 SSF57829, 1 hit

Sequence (1+)i

Sequence statusi: Fragment.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.iShow all

P62985-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
NIQKESTLHL VLRLRGGIIE PSLRQLAQKY NCDKMICRKC YARLHPRAVN
60
CRKKKCGHTN NLRPKKKVK
Length:69
Mass (Da):8,098
Last modified:August 10, 2010 - v2
Checksum:i7ABF8DDDE660A429
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
O42388O42388_CHICK
Ubiquitin-60S ribosomal protein L40
UBA52
128Annotation score:
A0A1L1RTM7A0A1L1RTM7_CHICK
Ubiquitin-60S ribosomal protein L40
UBA52
71Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X13493 mRNA Translation: CAA31848.1
UniGeneiGga.569

Similar proteinsi

Entry informationi

Entry nameiRL40_CHICK
AccessioniPrimary (citable) accession number: P62985
Secondary accession number(s): P02248
, P02249, P02250, P14793, P62973, Q29120, Q91887, Q91888
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: August 10, 2010
Last modified: May 23, 2018
This is version 71 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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