UniProtKB - P62983 (RS27A_MOUSE)
Protein
Ubiquitin-40S ribosomal protein S27a
Gene
Rps27a
Organism
Mus musculus (Mouse)
Status
Functioni
Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in lysosomal degradation; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling.1 Publication
Component of the 40S subunit of the ribosome.1 Publication
Miscellaneous
Ubiquitin is encoded by 4 different genes. Uba52 and Rps27a genes code for a single copy of ubiquitin fused to the ribosomal proteins L40 and S27a, respectively. UBB and UBC genes code for a polyubiquitin precursor with exact head to tail repeats, the number of repeats differ between species and strains.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 54 | Activating enzyme | 1 | |
Sitei | 68 | Essential for function | 1 | |
Binding sitei | 72 | Activating enzyme | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 121 – 144 | C4-typeAdd BLAST | 24 |
GO - Molecular functioni
- metal ion binding Source: UniProtKB-KW
- protein tag Source: GO_Central
- structural constituent of ribosome Source: InterPro
- ubiquitin protein ligase binding Source: GO_Central
GO - Biological processi
- modification-dependent protein catabolic process Source: GO_Central
- protein ubiquitination Source: GO_Central
- translation Source: InterPro
Keywordsi
Molecular function | Ribonucleoprotein, Ribosomal protein |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
Reactomei | R-MMU-110312, Translesion synthesis by REV1 R-MMU-110314, Recognition of DNA damage by PCNA-containing replication complex R-MMU-110320, Translesion Synthesis by POLH R-MMU-1169091, Activation of NF-kappaB in B cells R-MMU-1234176, Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-MMU-1253288, Downregulation of ERBB4 signaling R-MMU-1295596, Spry regulation of FGF signaling R-MMU-1358803, Downregulation of ERBB2:ERBB3 signaling R-MMU-156827, L13a-mediated translational silencing of Ceruloplasmin expression R-MMU-168638, NOD1/2 Signaling Pathway R-MMU-174048, APC/C:Cdc20 mediated degradation of Cyclin B R-MMU-174084, Autodegradation of Cdh1 by Cdh1:APC/C R-MMU-174154, APC/C:Cdc20 mediated degradation of Securin R-MMU-174178, APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-MMU-174184, Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-MMU-179409, APC-Cdc20 mediated degradation of Nek2A R-MMU-1799339, SRP-dependent cotranslational protein targeting to membrane R-MMU-182971, EGFR downregulation R-MMU-187577, SCF(Skp2)-mediated degradation of p27/p21 R-MMU-195253, Degradation of beta-catenin by the destruction complex R-MMU-201681, TCF dependent signaling in response to WNT R-MMU-202424, Downstream TCR signaling R-MMU-205043, NRIF signals cell death from the nucleus R-MMU-209543, p75NTR recruits signalling complexes R-MMU-209560, NF-kB is activated and signals survival R-MMU-2122948, Activated NOTCH1 Transmits Signal to the Nucleus R-MMU-2173788, Downregulation of TGF-beta receptor signaling R-MMU-2173791, TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-MMU-2173795, Downregulation of SMAD2/3:SMAD4 transcriptional activity R-MMU-2173796, SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-MMU-2467813, Separation of Sister Chromatids R-MMU-2559580, Oxidative Stress Induced Senescence R-MMU-2559582, Senescence-Associated Secretory Phenotype (SASP) R-MMU-2559585, Oncogene Induced Senescence R-MMU-2565942, Regulation of PLK1 Activity at G2/M Transition R-MMU-2672351, Stimuli-sensing channels R-MMU-2871837, FCERI mediated NF-kB activation R-MMU-3134975, Regulation of innate immune responses to cytosolic DNA R-MMU-349425, Autodegradation of the E3 ubiquitin ligase COP1 R-MMU-3769402, Deactivation of the beta-catenin transactivating complex R-MMU-382556, ABC-family proteins mediated transport R-MMU-445989, TAK1 activates NFkB by phosphorylation and activation of IKKs complex R-MMU-450302, activated TAK1 mediates p38 MAPK activation R-MMU-450321, JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-MMU-450408, AUF1 (hnRNP D0) binds and destabilizes mRNA R-MMU-4608870, Asymmetric localization of PCP proteins R-MMU-4641257, Degradation of AXIN R-MMU-4641258, Degradation of DVL R-MMU-4641263, Regulation of FZD by ubiquitination R-MMU-5205685, PINK1-PRKN Mediated Mitophagy R-MMU-532668, N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-MMU-5357905, Regulation of TNFR1 signaling R-MMU-5357956, TNFR1-induced NFkappaB signaling pathway R-MMU-5358346, Hedgehog ligand biogenesis R-MMU-5607761, Dectin-1 mediated noncanonical NF-kB signaling R-MMU-5607764, CLEC7A (Dectin-1) signaling R-MMU-5610780, Degradation of GLI1 by the proteasome R-MMU-5610785, GLI3 is processed to GLI3R by the proteasome R-MMU-5632684, Hedgehog 'on' state R-MMU-5654726, Negative regulation of FGFR1 signaling R-MMU-5654727, Negative regulation of FGFR2 signaling R-MMU-5654732, Negative regulation of FGFR3 signaling R-MMU-5654733, Negative regulation of FGFR4 signaling R-MMU-5655862, Translesion synthesis by POLK R-MMU-5656121, Translesion synthesis by POLI R-MMU-5656169, Termination of translesion DNA synthesis R-MMU-5658442, Regulation of RAS by GAPs R-MMU-5668541, TNFR2 non-canonical NF-kB pathway R-MMU-5675221, Negative regulation of MAPK pathway R-MMU-5675482, Regulation of necroptotic cell death R-MMU-5676590, NIK-->noncanonical NF-kB signaling R-MMU-5684264, MAP3K8 (TPL2)-dependent MAPK1/3 activation R-MMU-5685942, HDR through Homologous Recombination (HRR) R-MMU-5687128, MAPK6/MAPK4 signaling R-MMU-5689603, UCH proteinases R-MMU-5689877, Josephin domain DUBs R-MMU-5689880, Ub-specific processing proteases R-MMU-5689896, Ovarian tumor domain proteases R-MMU-5689901, Metalloprotease DUBs R-MMU-5693565, Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-MMU-5696394, DNA Damage Recognition in GG-NER R-MMU-5696395, Formation of Incision Complex in GG-NER R-MMU-5696397, Gap-filling DNA repair synthesis and ligation in GG-NER R-MMU-5696400, Dual Incision in GG-NER R-MMU-6781823, Formation of TC-NER Pre-Incision Complex R-MMU-6782135, Dual incision in TC-NER R-MMU-6782210, Gap-filling DNA repair synthesis and ligation in TC-NER R-MMU-6783310, Fanconi Anemia Pathway R-MMU-6791226, Major pathway of rRNA processing in the nucleolus and cytosol R-MMU-6804756, Regulation of TP53 Activity through Phosphorylation R-MMU-6804757, Regulation of TP53 Degradation R-MMU-6804760, Regulation of TP53 Activity through Methylation R-MMU-6807004, Negative regulation of MET activity R-MMU-68827, CDT1 association with the CDC6:ORC:origin complex R-MMU-68949, Orc1 removal from chromatin R-MMU-69017, CDK-mediated phosphorylation and removal of Cdc6 R-MMU-69231, Cyclin D associated events in G1 R-MMU-69481, G2/M Checkpoints R-MMU-69541, Stabilization of p53 R-MMU-69601, Ubiquitin Mediated Degradation of Phosphorylated Cdc25A R-MMU-72649, Translation initiation complex formation R-MMU-72689, Formation of a pool of free 40S subunits R-MMU-72695, Formation of the ternary complex, and subsequently, the 43S complex R-MMU-72702, Ribosomal scanning and start codon recognition R-MMU-72706, GTP hydrolysis and joining of the 60S ribosomal subunit R-MMU-75815, Ubiquitin-dependent degradation of Cyclin D R-MMU-8849469, PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-MMU-8852276, The role of GTSE1 in G2/M progression after G2 checkpoint R-MMU-8854050, FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-MMU-8856825, Cargo recognition for clathrin-mediated endocytosis R-MMU-8856828, Clathrin-mediated endocytosis R-MMU-8863795, Downregulation of ERBB2 signaling R-MMU-8866652, Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-MMU-8866654, E3 ubiquitin ligases ubiquitinate target proteins R-MMU-8939236, RUNX1 regulates transcription of genes involved in differentiation of HSCs R-MMU-8939902, Regulation of RUNX2 expression and activity R-MMU-8941858, Regulation of RUNX3 expression and activity R-MMU-8948747, Regulation of PTEN localization R-MMU-8948751, Regulation of PTEN stability and activity R-MMU-8951664, Neddylation R-MMU-901032, ER Quality Control Compartment (ERQC) R-MMU-9010553, Regulation of expression of SLITs and ROBOs R-MMU-9013507, NOTCH3 Activation and Transmission of Signal to the Nucleus R-MMU-9020702, Interleukin-1 signaling R-MMU-9033241, Peroxisomal protein import R-MMU-912631, Regulation of signaling by CBL R-MMU-917729, Endosomal Sorting Complex Required For Transport (ESCRT) R-MMU-917937, Iron uptake and transport R-MMU-936440, Negative regulators of DDX58/IFIH1 signaling R-MMU-936964, Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon R-MMU-937039, IRAK1 recruits IKK complex R-MMU-937041, IKK complex recruitment mediated by RIP1 R-MMU-937042, IRAK2 mediated activation of TAK1 complex R-MMU-937072, TRAF6-mediated induction of TAK1 complex within TLR4 complex R-MMU-9645460, Alpha-protein kinase 1 signaling pathway R-MMU-9646399, Aggrephagy R-MMU-9648002, RAS processing R-MMU-9664873, Pexophagy R-MMU-975144, IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation R-MMU-975163, IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-MMU-975956, Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-MMU-975957, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-MMU-983168, Antigen processing: Ubiquitination & Proteasome degradation |
Names & Taxonomyi
Protein namesi | Recommended name: Ubiquitin-40S ribosomal protein S27aAlternative name(s): Ubiquitin carboxyl extension protein 80 Cleaved into the following 2 chains: |
Gene namesi | Name:Rps27a Synonyms:Uba80, Ubcep1 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1925544, Rps27a |
Subcellular locationi
Cytosol
- cytosol Source: Reactome
- cytosolic small ribosomal subunit Source: MGI
Nucleus
- nucleoplasm Source: Reactome
- nucleus Source: GO_Central
Other locations
- cytoplasm Source: GO_Central
- myelin sheath Source: UniProtKB
- small ribosomal subunit Source: GO_Central
Keywords - Cellular componenti
Cytoplasm, NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000396479 | 1 – 76 | UbiquitinAdd BLAST | 76 | |
ChainiPRO_0000137663 | 77 – 156 | 40S ribosomal protein S27aAdd BLAST | 80 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Cross-linki | 6 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity | ||
Cross-linki | 11 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity | ||
Cross-linki | 27 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity | ||
Cross-linki | 29 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity | ||
Cross-linki | 48 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity | ||
Cross-linki | 63 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity | ||
Modified residuei | 65 | Phosphoserine; by PINK1By similarity | 1 | |
Modified residuei | 76 | ADP-ribosylglycineBy similarity | 1 | |
Cross-linki | 76 | Glycyl lysine isopeptide (Gly-Lys) (interchain with K-? in acceptor proteins)PROSITE-ProRule annotation | ||
Modified residuei | 104 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 113 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 152 | N6-acetyllysineCombined sources | 1 |
Post-translational modificationi
Phosphorylated at Ser-65 by PINK1 during mitophagy. Phosphorylated ubiquitin specifically binds and activates parkin (PRKN), triggering mitophagy. Phosphorylation does not affect E1-mediated E2 charging of ubiquitin but affects discharging of E2 enzymes to form polyubiquitin chains. It also affects deubiquitination by deubiquitinase enzymes such as USP30.By similarity
Mono-ADP-ribosylated at the C-terminus by PARP9, a component of the PPAR9-DTX3L complex. ADP-ribosylation requires processing by E1 and E2 enzymes and prevents ubiquitin conjugation to substrates such as histones.By similarity
Keywords - PTMi
Acetylation, ADP-ribosylation, Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | P62983 |
jPOSTi | P62983 |
PaxDbi | P62983 |
PeptideAtlasi | P62983 |
PRIDEi | P62983 |
TopDownProteomicsi | P62983 |
2D gel databases
REPRODUCTION-2DPAGEi | P62991 |
PTM databases
iPTMneti | P62983 |
PhosphoSitePlusi | P62983 |
SwissPalmi | P62983 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000020460, Expressed in ectoplacental cone and 53 other tissues |
ExpressionAtlasi | P62983, baseline and differential |
Genevisiblei | P62983, MM |
Interactioni
Subunit structurei
Ribosomal protein S27a is part of the 40S ribosomal subunit.
By similarityGO - Molecular functioni
- ubiquitin protein ligase binding Source: GO_Central
Protein-protein interaction databases
BioGRIDi | 219309, 93 interactors |
ComplexPortali | CPX-5261, 40S cytosolic small ribosomal subunit |
IntActi | P62983, 5 interactors |
STRINGi | 10090.ENSMUSP00000099909 |
Miscellaneous databases
RNActi | P62983, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P62983 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1 – 76 | Ubiquitin-likePROSITE-ProRule annotationAdd BLAST | 76 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 77 – 99 | Lys-rich (highly basic)Add BLAST | 23 | |
Compositional biasi | 78 – 107 | Lys-richAdd BLAST | 30 |
Sequence similaritiesi
In the N-terminal section; belongs to the ubiquitin family.Curated
In the C-terminal section; belongs to the eukaryotic ribosomal protein eS31 family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 121 – 144 | C4-typeAdd BLAST | 24 |
Keywords - Domaini
Zinc-fingerPhylogenomic databases
eggNOGi | KOG0004, Eukaryota |
GeneTreei | ENSGT00910000144152 |
HOGENOMi | CLU_010412_2_0_1 |
InParanoidi | P62983 |
OMAi | FMAQHAN |
OrthoDBi | 1536766at2759 |
PhylomeDBi | P62983 |
TreeFami | TF300036 |
Family and domain databases
Gene3Di | 2.20.25.660, 1 hit |
InterProi | View protein in InterPro IPR002906, Ribosomal_S27a IPR011332, Ribosomal_zn-bd IPR038582, S27a-like_sf IPR000626, Ubiquitin-like_dom IPR029071, Ubiquitin-like_domsf IPR019954, Ubiquitin_CS IPR019956, Ubiquitin_dom |
Pfami | View protein in Pfam PF01599, Ribosomal_S27, 1 hit PF00240, ubiquitin, 1 hit |
PRINTSi | PR00348, UBIQUITIN |
SMARTi | View protein in SMART SM01402, Ribosomal_S27, 1 hit SM00213, UBQ, 1 hit |
SUPFAMi | SSF54236, SSF54236, 1 hit SSF57829, SSF57829, 1 hit |
PROSITEi | View protein in PROSITE PS00299, UBIQUITIN_1, 1 hit PS50053, UBIQUITIN_2, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P62983-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MQIFVKTLTG KTITLEVEPS DTIENVKAKI QDKEGIPPDQ QRLIFAGKQL
60 70 80 90 100
EDGRTLSDYN IQKESTLHLV LRLRGGAKKR KKKSYTTPKK NKHKRKKVKL
110 120 130 140 150
AVLKYYKVDE NGKISRLRRE CPSDECGAGV FMGSHFDRHY CGKCCLTYCF
NKPEDK
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK018706 mRNA Translation: BAB31357.1 BC002108 mRNA Translation: AAH02108.1 |
CCDSi | CCDS24497.1 |
RefSeqi | NP_001029037.1, NM_001033865.1 NP_077239.1, NM_024277.2 |
Genome annotation databases
Ensembli | ENSMUST00000102844; ENSMUSP00000099908; ENSMUSG00000020460 ENSMUST00000102845; ENSMUSP00000099909; ENSMUSG00000020460 |
GeneIDi | 78294 |
KEGGi | mmu:78294 |
UCSCi | uc007ihg.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK018706 mRNA Translation: BAB31357.1 BC002108 mRNA Translation: AAH02108.1 |
CCDSi | CCDS24497.1 |
RefSeqi | NP_001029037.1, NM_001033865.1 NP_077239.1, NM_024277.2 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
5GVI | X-ray | 1.87 | B | 1-76 | [»] | |
C | 1-72 | [»] | ||||
5XIS | X-ray | 1.78 | B/C/E/F | 1-76 | [»] | |
5XIT | X-ray | 2.25 | B/D/F/H | 1-76 | [»] | |
5XIU | X-ray | 1.80 | B | 1-76 | [»] | |
SMRi | P62983 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 219309, 93 interactors |
ComplexPortali | CPX-5261, 40S cytosolic small ribosomal subunit |
IntActi | P62983, 5 interactors |
STRINGi | 10090.ENSMUSP00000099909 |
PTM databases
iPTMneti | P62983 |
PhosphoSitePlusi | P62983 |
SwissPalmi | P62983 |
2D gel databases
REPRODUCTION-2DPAGEi | P62991 |
Proteomic databases
EPDi | P62983 |
jPOSTi | P62983 |
PaxDbi | P62983 |
PeptideAtlasi | P62983 |
PRIDEi | P62983 |
TopDownProteomicsi | P62983 |
Protocols and materials databases
Antibodypediai | 30320, 228 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000102844; ENSMUSP00000099908; ENSMUSG00000020460 ENSMUST00000102845; ENSMUSP00000099909; ENSMUSG00000020460 |
GeneIDi | 78294 |
KEGGi | mmu:78294 |
UCSCi | uc007ihg.1, mouse |
Organism-specific databases
CTDi | 6233 |
MGIi | MGI:1925544, Rps27a |
Phylogenomic databases
eggNOGi | KOG0004, Eukaryota |
GeneTreei | ENSGT00910000144152 |
HOGENOMi | CLU_010412_2_0_1 |
InParanoidi | P62983 |
OMAi | FMAQHAN |
OrthoDBi | 1536766at2759 |
PhylomeDBi | P62983 |
TreeFami | TF300036 |
Enzyme and pathway databases
Reactomei | R-MMU-110312, Translesion synthesis by REV1 R-MMU-110314, Recognition of DNA damage by PCNA-containing replication complex R-MMU-110320, Translesion Synthesis by POLH R-MMU-1169091, Activation of NF-kappaB in B cells R-MMU-1234176, Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-MMU-1253288, Downregulation of ERBB4 signaling R-MMU-1295596, Spry regulation of FGF signaling R-MMU-1358803, Downregulation of ERBB2:ERBB3 signaling R-MMU-156827, L13a-mediated translational silencing of Ceruloplasmin expression R-MMU-168638, NOD1/2 Signaling Pathway R-MMU-174048, APC/C:Cdc20 mediated degradation of Cyclin B R-MMU-174084, Autodegradation of Cdh1 by Cdh1:APC/C R-MMU-174154, APC/C:Cdc20 mediated degradation of Securin R-MMU-174178, APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-MMU-174184, Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-MMU-179409, APC-Cdc20 mediated degradation of Nek2A R-MMU-1799339, SRP-dependent cotranslational protein targeting to membrane R-MMU-182971, EGFR downregulation R-MMU-187577, SCF(Skp2)-mediated degradation of p27/p21 R-MMU-195253, Degradation of beta-catenin by the destruction complex R-MMU-201681, TCF dependent signaling in response to WNT R-MMU-202424, Downstream TCR signaling R-MMU-205043, NRIF signals cell death from the nucleus R-MMU-209543, p75NTR recruits signalling complexes R-MMU-209560, NF-kB is activated and signals survival R-MMU-2122948, Activated NOTCH1 Transmits Signal to the Nucleus R-MMU-2173788, Downregulation of TGF-beta receptor signaling R-MMU-2173791, TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-MMU-2173795, Downregulation of SMAD2/3:SMAD4 transcriptional activity R-MMU-2173796, SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-MMU-2467813, Separation of Sister Chromatids R-MMU-2559580, Oxidative Stress Induced Senescence R-MMU-2559582, Senescence-Associated Secretory Phenotype (SASP) R-MMU-2559585, Oncogene Induced Senescence R-MMU-2565942, Regulation of PLK1 Activity at G2/M Transition R-MMU-2672351, Stimuli-sensing channels R-MMU-2871837, FCERI mediated NF-kB activation R-MMU-3134975, Regulation of innate immune responses to cytosolic DNA R-MMU-349425, Autodegradation of the E3 ubiquitin ligase COP1 R-MMU-3769402, Deactivation of the beta-catenin transactivating complex R-MMU-382556, ABC-family proteins mediated transport R-MMU-445989, TAK1 activates NFkB by phosphorylation and activation of IKKs complex R-MMU-450302, activated TAK1 mediates p38 MAPK activation R-MMU-450321, JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-MMU-450408, AUF1 (hnRNP D0) binds and destabilizes mRNA R-MMU-4608870, Asymmetric localization of PCP proteins R-MMU-4641257, Degradation of AXIN R-MMU-4641258, Degradation of DVL R-MMU-4641263, Regulation of FZD by ubiquitination R-MMU-5205685, PINK1-PRKN Mediated Mitophagy R-MMU-532668, N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-MMU-5357905, Regulation of TNFR1 signaling R-MMU-5357956, TNFR1-induced NFkappaB signaling pathway R-MMU-5358346, Hedgehog ligand biogenesis R-MMU-5607761, Dectin-1 mediated noncanonical NF-kB signaling R-MMU-5607764, CLEC7A (Dectin-1) signaling R-MMU-5610780, Degradation of GLI1 by the proteasome R-MMU-5610785, GLI3 is processed to GLI3R by the proteasome R-MMU-5632684, Hedgehog 'on' state R-MMU-5654726, Negative regulation of FGFR1 signaling R-MMU-5654727, Negative regulation of FGFR2 signaling R-MMU-5654732, Negative regulation of FGFR3 signaling R-MMU-5654733, Negative regulation of FGFR4 signaling R-MMU-5655862, Translesion synthesis by POLK R-MMU-5656121, Translesion synthesis by POLI R-MMU-5656169, Termination of translesion DNA synthesis R-MMU-5658442, Regulation of RAS by GAPs R-MMU-5668541, TNFR2 non-canonical NF-kB pathway R-MMU-5675221, Negative regulation of MAPK pathway R-MMU-5675482, Regulation of necroptotic cell death R-MMU-5676590, NIK-->noncanonical NF-kB signaling R-MMU-5684264, MAP3K8 (TPL2)-dependent MAPK1/3 activation R-MMU-5685942, HDR through Homologous Recombination (HRR) R-MMU-5687128, MAPK6/MAPK4 signaling R-MMU-5689603, UCH proteinases R-MMU-5689877, Josephin domain DUBs R-MMU-5689880, Ub-specific processing proteases R-MMU-5689896, Ovarian tumor domain proteases R-MMU-5689901, Metalloprotease DUBs R-MMU-5693565, Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-MMU-5696394, DNA Damage Recognition in GG-NER R-MMU-5696395, Formation of Incision Complex in GG-NER R-MMU-5696397, Gap-filling DNA repair synthesis and ligation in GG-NER R-MMU-5696400, Dual Incision in GG-NER R-MMU-6781823, Formation of TC-NER Pre-Incision Complex R-MMU-6782135, Dual incision in TC-NER R-MMU-6782210, Gap-filling DNA repair synthesis and ligation in TC-NER R-MMU-6783310, Fanconi Anemia Pathway R-MMU-6791226, Major pathway of rRNA processing in the nucleolus and cytosol R-MMU-6804756, Regulation of TP53 Activity through Phosphorylation R-MMU-6804757, Regulation of TP53 Degradation R-MMU-6804760, Regulation of TP53 Activity through Methylation R-MMU-6807004, Negative regulation of MET activity R-MMU-68827, CDT1 association with the CDC6:ORC:origin complex R-MMU-68949, Orc1 removal from chromatin R-MMU-69017, CDK-mediated phosphorylation and removal of Cdc6 R-MMU-69231, Cyclin D associated events in G1 R-MMU-69481, G2/M Checkpoints R-MMU-69541, Stabilization of p53 R-MMU-69601, Ubiquitin Mediated Degradation of Phosphorylated Cdc25A R-MMU-72649, Translation initiation complex formation R-MMU-72689, Formation of a pool of free 40S subunits R-MMU-72695, Formation of the ternary complex, and subsequently, the 43S complex R-MMU-72702, Ribosomal scanning and start codon recognition R-MMU-72706, GTP hydrolysis and joining of the 60S ribosomal subunit R-MMU-75815, Ubiquitin-dependent degradation of Cyclin D R-MMU-8849469, PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-MMU-8852276, The role of GTSE1 in G2/M progression after G2 checkpoint R-MMU-8854050, FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-MMU-8856825, Cargo recognition for clathrin-mediated endocytosis R-MMU-8856828, Clathrin-mediated endocytosis R-MMU-8863795, Downregulation of ERBB2 signaling R-MMU-8866652, Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-MMU-8866654, E3 ubiquitin ligases ubiquitinate target proteins R-MMU-8939236, RUNX1 regulates transcription of genes involved in differentiation of HSCs R-MMU-8939902, Regulation of RUNX2 expression and activity R-MMU-8941858, Regulation of RUNX3 expression and activity R-MMU-8948747, Regulation of PTEN localization R-MMU-8948751, Regulation of PTEN stability and activity R-MMU-8951664, Neddylation R-MMU-901032, ER Quality Control Compartment (ERQC) R-MMU-9010553, Regulation of expression of SLITs and ROBOs R-MMU-9013507, NOTCH3 Activation and Transmission of Signal to the Nucleus R-MMU-9020702, Interleukin-1 signaling R-MMU-9033241, Peroxisomal protein import R-MMU-912631, Regulation of signaling by CBL R-MMU-917729, Endosomal Sorting Complex Required For Transport (ESCRT) R-MMU-917937, Iron uptake and transport R-MMU-936440, Negative regulators of DDX58/IFIH1 signaling R-MMU-936964, Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon R-MMU-937039, IRAK1 recruits IKK complex R-MMU-937041, IKK complex recruitment mediated by RIP1 R-MMU-937042, IRAK2 mediated activation of TAK1 complex R-MMU-937072, TRAF6-mediated induction of TAK1 complex within TLR4 complex R-MMU-9645460, Alpha-protein kinase 1 signaling pathway R-MMU-9646399, Aggrephagy R-MMU-9648002, RAS processing R-MMU-9664873, Pexophagy R-MMU-975144, IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation R-MMU-975163, IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-MMU-975956, Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-MMU-975957, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-MMU-983168, Antigen processing: Ubiquitination & Proteasome degradation |
Miscellaneous databases
BioGRID-ORCSi | 78294, 8 hits in 14 CRISPR screens |
ChiTaRSi | Rps27a, mouse |
PROi | PR:P62983 |
RNActi | P62983, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000020460, Expressed in ectoplacental cone and 53 other tissues |
ExpressionAtlasi | P62983, baseline and differential |
Genevisiblei | P62983, MM |
Family and domain databases
Gene3Di | 2.20.25.660, 1 hit |
InterProi | View protein in InterPro IPR002906, Ribosomal_S27a IPR011332, Ribosomal_zn-bd IPR038582, S27a-like_sf IPR000626, Ubiquitin-like_dom IPR029071, Ubiquitin-like_domsf IPR019954, Ubiquitin_CS IPR019956, Ubiquitin_dom |
Pfami | View protein in Pfam PF01599, Ribosomal_S27, 1 hit PF00240, ubiquitin, 1 hit |
PRINTSi | PR00348, UBIQUITIN |
SMARTi | View protein in SMART SM01402, Ribosomal_S27, 1 hit SM00213, UBQ, 1 hit |
SUPFAMi | SSF54236, SSF54236, 1 hit SSF57829, SSF57829, 1 hit |
PROSITEi | View protein in PROSITE PS00299, UBIQUITIN_1, 1 hit PS50053, UBIQUITIN_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | RS27A_MOUSE | |
Accessioni | P62983Primary (citable) accession number: P62983 Secondary accession number(s): P02248 Q9Z0H9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 31, 2004 |
Last sequence update: | August 10, 2010 | |
Last modified: | December 2, 2020 | |
This is version 151 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Ribosomal proteins
Ribosomal proteins families and list of entries