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Protein

Bladder cancer-associated protein

Gene

BLCAP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May regulate cell proliferation and coordinate apoptosis and cell cycle progression via a novel mechanism independent of both p53/TP53 and NF-kappa-B.1 Publication

GO - Biological processi

  • apoptotic nuclear changes Source: UniProtKB
  • cell cycle Source: UniProtKB-KW

Keywordsi

Biological processApoptosis, Cell cycle

Names & Taxonomyi

Protein namesi
Recommended name:
Bladder cancer-associated protein
Alternative name(s):
Bladder cancer 10 kDa protein
Short name:
Bc10
Gene namesi
Name:BLCAP
Synonyms:BC10
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

EuPathDBiHostDB:ENSG00000166619.12
HGNCiHGNC:1055 BLCAP
MIMi613110 gene
neXtProtiNX_P62952

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei19 – 39HelicalSequence analysisAdd BLAST21
Transmembranei43 – 63HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi10904
OpenTargetsiENSG00000166619
PharmGKBiPA25367

Polymorphism and mutation databases

BioMutaiBLCAP
DMDMi51702217

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000648501 – 87Bladder cancer-associated proteinAdd BLAST87

Proteomic databases

PaxDbiP62952
PeptideAtlasiP62952
PRIDEiP62952
ProteomicsDBi57458

Expressioni

Tissue specificityi

Ubiquitous. Expressed in cervical tissues. Down-regulated in bladder invasive carcinoma, renal cell carcinoma and in primary cervical carcinoma.3 Publications

Gene expression databases

BgeeiENSG00000166619
CleanExiHS_BLCAP
ExpressionAtlasiP62952 baseline and differential
GenevisibleiP62952 HS

Organism-specific databases

HPAiHPA047390

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi116110, 4 interactors
IntActiP62952, 7 interactors
STRINGi9606.ENSP00000362637

Structurei

3D structure databases

ProteinModelPortaliP62952
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the BLCAP family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4489 Eukaryota
ENOG4111WJP LUCA
GeneTreeiENSGT00390000014105
HOVERGENiHBG105413
InParanoidiP62952
OMAiTHVMFMV
OrthoDBiEOG091G18IM
PhylomeDBiP62952
TreeFamiTF313306

Family and domain databases

InterProiView protein in InterPro
IPR009598 BC10
PANTHERiPTHR13259 PTHR13259, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD062192 BC10-like, 1 hit
SMARTiView protein in SMART
SM01396 BC10, 1 hit

Sequencei

Sequence statusi: Complete.

P62952-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYCLQWLLPV LLIPKPLNPA LWFSHSMFMG FYLLSFLLER KPCTICALVF
60 70 80
LAALFLICYS CWGNCFLYHC SDSPLPESAH DPGVVGT
Length:87
Mass (Da):9,876
Last modified:August 31, 2004 - v1
Checksum:i06A45C03E27D3E87
GO

RNA editingi

Edited at positions 2, 5 and 15.1 Publication
Partially edited. Decreased editing levels seen in astrocytomas, bladder cancer and colorectal cancer as compared to the related normal tissues.

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0689082Y → C in RNA edited version. Corresponds to variant dbSNP:rs11557677Ensembl.1
Natural variantiVAR_0689095Q → R in RNA edited version. 1
Natural variantiVAR_06891015K → R in RNA edited version. Corresponds to variant dbSNP:rs11557676Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF053470 mRNA Translation: AAC06370.1
AL109614 Genomic DNA No translation available.
BC047692 mRNA Translation: AAH47692.1
BC071704 mRNA Translation: AAH71704.1
CCDSiCCDS13295.1
RefSeqiNP_001161292.1, NM_001167820.1
NP_001161293.1, NM_001167821.1
NP_001161294.1, NM_001167822.2
NP_001161295.1, NM_001167823.1
NP_001304003.1, NM_001317074.1
NP_001304004.1, NM_001317075.1
NP_006689.1, NM_006698.3
XP_016883088.1, XM_017027599.1
UniGeneiHs.472651

Genome annotation databases

EnsembliENST00000373537; ENSP00000362637; ENSG00000166619
ENST00000397131; ENSP00000380320; ENSG00000166619
ENST00000397134; ENSP00000380323; ENSG00000166619
ENST00000397135; ENSP00000380324; ENSG00000166619
ENST00000397137; ENSP00000380326; ENSG00000166619
ENST00000414542; ENSP00000397172; ENSG00000166619
ENST00000432507; ENSP00000414973; ENSG00000166619
GeneIDi10904
KEGGihsa:10904
UCSCiuc002xha.4 human

Keywords - Coding sequence diversityi

RNA editing

Similar proteinsi

Entry informationi

Entry nameiBLCAP_HUMAN
AccessioniPrimary (citable) accession number: P62952
Secondary accession number(s): A2A2K7, O60629, Q9D3B5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: August 31, 2004
Last modified: June 20, 2018
This is version 106 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

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