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Entry version 168 (05 Jun 2019)
Sequence version 2 (23 Jan 2007)
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Protein

Peptidyl-prolyl cis-trans isomerase FKBP1A

Gene

FKBP1A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Keeps in an inactive conformation TGFBR1, the TGF-beta type I serine/threonine kinase receptor, preventing TGF-beta receptor activation in absence of ligand. Recruits SMAD7 to ACVR1B which prevents the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. May modulate the RYR1 calcium channel activity. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.4 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Inhibited by both FK506 and rapamycin.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIsomerase, Rotamase

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

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BRENDAi
5.2.1.8 2681

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-2025928 Calcineurin activates NFAT
R-HSA-2173789 TGF-beta receptor signaling activates SMADs
R-HSA-2173791 TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
R-HSA-3656535 TGFBR1 LBD Mutants in Cancer

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
P62942

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P62942

Protein family/group databases

Transport Classification Database

More...
TCDBi
8.A.11.1.2 the immunophilin-like prolyl:peptidyl isomerase regulator (i-ppi) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Peptidyl-prolyl cis-trans isomerase FKBP1A (EC:5.2.1.82 Publications)
Short name:
PPIase FKBP1A
Alternative name(s):
12 kDa FK506-binding protein
Short name:
12 kDa FKBP
Short name:
FKBP-12
Calstabin-1
FK506-binding protein 1A
Short name:
FKBP-1A
Immunophilin FKBP12
Rotamase
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FKBP1A
Synonyms:FKBP1, FKBP12
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 20

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:3711 FKBP1A

Online Mendelian Inheritance in Man (OMIM)

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MIMi
186945 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P62942

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Membrane, Sarcoplasmic reticulum

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
2280

Open Targets

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OpenTargetsi
ENSG00000088832

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA28153

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL1902

Drug and drug target database

More...
DrugBanki
DB04094 4-Hydroxy-2-Butanone
DB02888 FKB-001
DB01951 Gpi-1046
DB05814 GPI-1485
DB03338 Heptyl-Beta-D-Glucopyranoside
DB02311 Methyl Methylsulfinylmethyl Sulfide
DB08231 MYRISTIC ACID
DB00337 Pimecrolimus
DB00877 Sirolimus
DB00864 Tacrolimus

IUPHAR/BPS Guide to PHARMACOLOGY

More...
GuidetoPHARMACOLOGYi
2609

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
FKBP1A

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemoved3 Publications
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000752892 – 108Peptidyl-prolyl cis-trans isomerase FKBP1AAdd BLAST107

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei53N6-acetyllysine; alternateBy similarity1
Modified residuei53N6-succinyllysine; alternateBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P62942

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
P62942

MaxQB - The MaxQuant DataBase

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MaxQBi
P62942

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P62942

PeptideAtlas

More...
PeptideAtlasi
P62942

PRoteomics IDEntifications database

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PRIDEi
P62942

ProteomicsDB human proteome resource

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ProteomicsDBi
57456

Consortium for Top Down Proteomics

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TopDownProteomicsi
P62942

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P62942

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P62942

Miscellaneous databases

CutDB - Proteolytic event database

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PMAP-CutDBi
P62942

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000088832 Expressed in 231 organ(s), highest expression level in caudate nucleus

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P62942 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P62942 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB004639
HPA051798

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with TGFBR1; prevents TGFBR1 phosphorylation by TGFBR2 and stabilizes it in the inactive conformation (PubMed:9233797).

Interacts with ACVR1B and SMAD7 (PubMed:16720724).

Identified in a complex composed of RYR1, PDE4D, PKA, FKBP1A and protein phosphatase 1 (PP1) (By similarity).

Interacts directly with RYR2 and RYR3 (PubMed:10358090, PubMed:22100703).

Interacts with GLMN; rapamycin and FK506 abolish the interaction with GLMN in a dose dependent manner (PubMed:8955134).

Interacts directly with RYR1 (By similarity).

By similarity6 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
108570, 65 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
P62942

Database of interacting proteins

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DIPi
DIP-29710N

Protein interaction database and analysis system

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IntActi
P62942, 19 interactors

Molecular INTeraction database

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MINTi
P62942

STRING: functional protein association networks

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STRINGi
9606.ENSP00000383003

Chemistry databases

BindingDB database of measured binding affinities

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BindingDBi
P62942

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1108
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P62942

Database of comparative protein structure models

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ModBasei
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P62942

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini20 – 108PPIase FKBP-typePROSITE-ProRule annotationAdd BLAST89

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG0544 Eukaryota
COG0545 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153311

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P62942

KEGG Orthology (KO)

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KOi
K09568

Identification of Orthologs from Complete Genome Data

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OMAi
RVIAGWD

Database of Orthologous Groups

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OrthoDBi
1328688at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
P62942

TreeFam database of animal gene trees

More...
TreeFami
TF105291

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR023566 PPIase_FKBP
IPR001179 PPIase_FKBP_dom

The PANTHER Classification System

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PANTHERi
PTHR10516 PTHR10516, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF00254 FKBP_C, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS50059 FKBP_PPIASE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

P62942-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGVQVETISP GDGRTFPKRG QTCVVHYTGM LEDGKKFDSS RDRNKPFKFM
60 70 80 90 100
LGKQEVIRGW EEGVAQMSVG QRAKLTISPD YAYGATGHPG IIPPHATLVF

DVELLKLE
Length:108
Mass (Da):11,951
Last modified:January 23, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9CC8493C802540B4
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WZM5A0A087WZM5_HUMAN
Peptidylprolyl isomerase
FKBP1A
129Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q1JUQ5Q1JUQ5_HUMAN
Peptidylprolyl isomerase
FKBP1A FKBP12-Exip2
92Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5W0X3Q5W0X3_HUMAN
Peptidylprolyl isomerase
FKBP1A
103Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q1JUQ3Q1JUQ3_HUMAN
FK506 binding protein12
FKBP1A FKBP12-Exin
37Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WTS4A0A087WTS4_HUMAN
Peptidyl-prolyl cis-trans isomerase...
FKBP1A
97Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti60W → R in CAG28541 (Ref. 6) Curated1
Sequence conflicti91I → V in CAG28541 (Ref. 6) Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M34539 mRNA Translation: AAA35844.1
M92423, M92422 Genomic DNA Translation: AAA58476.1
M93060 Genomic DNA No translation available.
X55741 Genomic DNA Translation: CAA39272.1
M80199 Genomic DNA Translation: AAA58472.1
X52220 mRNA Translation: CAA36462.1
BT007066 mRNA Translation: AAP35729.1
CR407613 mRNA Translation: CAG28541.1
CR542168 mRNA Translation: CAG46965.1
AL136531 Genomic DNA No translation available.
AL109658 Genomic DNA No translation available.
CH471133 Genomic DNA Translation: EAX10633.1
CH471133 Genomic DNA Translation: EAX10634.1
CH471133 Genomic DNA Translation: EAX10635.1
BC001925 mRNA Translation: AAH01925.3
BC005147 mRNA Translation: AAH05147.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS13014.1

Protein sequence database of the Protein Information Resource

More...
PIRi
I65284 A35780

NCBI Reference Sequences

More...
RefSeqi
NP_000792.1, NM_000801.4
NP_463460.1, NM_054014.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000381719; ENSP00000371138; ENSG00000088832
ENST00000400137; ENSP00000383003; ENSG00000088832

Database of genes from NCBI RefSeq genomes

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GeneIDi
2280

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:2280

UCSC genome browser

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UCSCi
uc002wey.4 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M34539 mRNA Translation: AAA35844.1
M92423, M92422 Genomic DNA Translation: AAA58476.1
M93060 Genomic DNA No translation available.
X55741 Genomic DNA Translation: CAA39272.1
M80199 Genomic DNA Translation: AAA58472.1
X52220 mRNA Translation: CAA36462.1
BT007066 mRNA Translation: AAP35729.1
CR407613 mRNA Translation: CAG28541.1
CR542168 mRNA Translation: CAG46965.1
AL136531 Genomic DNA No translation available.
AL109658 Genomic DNA No translation available.
CH471133 Genomic DNA Translation: EAX10633.1
CH471133 Genomic DNA Translation: EAX10634.1
CH471133 Genomic DNA Translation: EAX10635.1
BC001925 mRNA Translation: AAH01925.3
BC005147 mRNA Translation: AAH05147.1
CCDSiCCDS13014.1
PIRiI65284 A35780
RefSeqiNP_000792.1, NM_000801.4
NP_463460.1, NM_054014.3

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1A7XX-ray2.00A/B2-108[»]
1B6CX-ray2.60A/C/E/G2-108[»]
1BKFX-ray1.60A2-108[»]
1BL4X-ray1.90A/B2-108[»]
1D6OX-ray1.85A/B2-108[»]
1D7HX-ray1.90A/B2-108[»]
1D7IX-ray1.90A/B2-108[»]
1D7JX-ray1.85A/B2-108[»]
1EYMX-ray2.00A/B2-108[»]
1F40NMR-A2-108[»]
1FAPX-ray2.70A2-108[»]
1FKBX-ray1.70A2-108[»]
1FKDX-ray1.72A2-108[»]
1FKFX-ray1.70A2-108[»]
1FKGX-ray2.00A2-108[»]
1FKHX-ray1.95A2-108[»]
1FKIX-ray2.20A/B2-108[»]
1FKJX-ray1.70A2-108[»]
1FKRNMR-A2-108[»]
1FKSNMR-A2-108[»]
1FKTNMR-A2-108[»]
1J4HX-ray1.80A2-108[»]
1J4IX-ray1.80A2-108[»]
1J4RX-ray1.80A/B/D2-108[»]
1NSGX-ray2.20A2-108[»]
1QPFX-ray2.50A/D2-108[»]
1QPLX-ray2.90A/C2-108[»]
2DG3X-ray1.70A2-108[»]
2DG4X-ray1.70A2-108[»]
2DG9X-ray1.70A2-108[»]
2FAPX-ray2.20A2-108[»]
2FKEX-ray1.72A2-108[»]
2ND5NMR-A1-108[»]
2PPNX-ray0.92A2-108[»]
2PPOX-ray1.29A2-108[»]
2PPPX-ray0.94A2-108[»]
2RSENMR-A2-108[»]
3FAPX-ray1.85A2-108[»]
3H9RX-ray2.35B1-108[»]
3MDYX-ray2.05B/D1-108[»]
4DH0X-ray2.10A2-108[»]
4FAPX-ray2.80A2-108[»]
4IPXX-ray1.70A2-108[»]
4N19X-ray1.20A2-108[»]
4ODPX-ray1.75A85-97[»]
4ODQX-ray2.00A85-97[»]
4ODRX-ray1.93A/B85-97[»]
5I7PX-ray2.00A2-84[»]
A98-108[»]
5I7QX-ray1.90A2-84[»]
A97-108[»]
SMRiP62942
ModBaseiSearch...

Protein-protein interaction databases

BioGridi108570, 65 interactors
CORUMiP62942
DIPiDIP-29710N
IntActiP62942, 19 interactors
MINTiP62942
STRINGi9606.ENSP00000383003

Chemistry databases

BindingDBiP62942
ChEMBLiCHEMBL1902
DrugBankiDB04094 4-Hydroxy-2-Butanone
DB02888 FKB-001
DB01951 Gpi-1046
DB05814 GPI-1485
DB03338 Heptyl-Beta-D-Glucopyranoside
DB02311 Methyl Methylsulfinylmethyl Sulfide
DB08231 MYRISTIC ACID
DB00337 Pimecrolimus
DB00877 Sirolimus
DB00864 Tacrolimus
GuidetoPHARMACOLOGYi2609

Protein family/group databases

TCDBi8.A.11.1.2 the immunophilin-like prolyl:peptidyl isomerase regulator (i-ppi) family

PTM databases

iPTMnetiP62942
PhosphoSitePlusiP62942

Polymorphism and mutation databases

BioMutaiFKBP1A

Proteomic databases

EPDiP62942
jPOSTiP62942
MaxQBiP62942
PaxDbiP62942
PeptideAtlasiP62942
PRIDEiP62942
ProteomicsDBi57456
TopDownProteomicsiP62942

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
2280
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000381719; ENSP00000371138; ENSG00000088832
ENST00000400137; ENSP00000383003; ENSG00000088832
GeneIDi2280
KEGGihsa:2280
UCSCiuc002wey.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
2280
DisGeNETi2280

GeneCards: human genes, protein and diseases

More...
GeneCardsi
FKBP1A
HGNCiHGNC:3711 FKBP1A
HPAiCAB004639
HPA051798
MIMi186945 gene
neXtProtiNX_P62942
OpenTargetsiENSG00000088832
PharmGKBiPA28153

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0544 Eukaryota
COG0545 LUCA
GeneTreeiENSGT00940000153311
InParanoidiP62942
KOiK09568
OMAiRVIAGWD
OrthoDBi1328688at2759
PhylomeDBiP62942
TreeFamiTF105291

Enzyme and pathway databases

BRENDAi5.2.1.8 2681
ReactomeiR-HSA-2025928 Calcineurin activates NFAT
R-HSA-2173789 TGF-beta receptor signaling activates SMADs
R-HSA-2173791 TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
R-HSA-3656535 TGFBR1 LBD Mutants in Cancer
SignaLinkiP62942
SIGNORiP62942

Miscellaneous databases

EvolutionaryTraceiP62942

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
FKBP1A

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
2280
PMAP-CutDBiP62942

Protein Ontology

More...
PROi
PR:P62942

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000088832 Expressed in 231 organ(s), highest expression level in caudate nucleus
ExpressionAtlasiP62942 baseline and differential
GenevisibleiP62942 HS

Family and domain databases

InterProiView protein in InterPro
IPR023566 PPIase_FKBP
IPR001179 PPIase_FKBP_dom
PANTHERiPTHR10516 PTHR10516, 1 hit
PfamiView protein in Pfam
PF00254 FKBP_C, 1 hit
PROSITEiView protein in PROSITE
PS50059 FKBP_PPIASE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFKB1A_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P62942
Secondary accession number(s): D3DVW6
, P20071, Q4VC47, Q6FGD9, Q6LEU3, Q9H103, Q9H566
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: January 23, 2007
Last modified: June 5, 2019
This is version 168 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
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