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Protein

F-box only protein 40

Gene

Fbxo40

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probable substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex that may function in myogenesis.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri53 – 114TRAF-typePROSITE-ProRule annotationAdd BLAST62

GO - Molecular functioni

GO - Biological processi

  • muscle cell differentiation Source: UniProtKB

Keywordsi

Biological processUbl conjugation pathway
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-MMU-8951664 Neddylation
R-MMU-983168 Antigen processing: Ubiquitination & Proteasome degradation

Names & Taxonomyi

Protein namesi
Recommended name:
F-box only protein 40
Gene namesi
Name:Fbxo40
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:2443753 Fbxo40

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001199391 – 710F-box only protein 40Add BLAST710

Proteomic databases

EPDiP62932
PaxDbiP62932
PeptideAtlasiP62932
PRIDEiP62932

PTM databases

iPTMnetiP62932
PhosphoSitePlusiP62932

Expressioni

Tissue specificityi

Expressed only in heart and skeletal muscle.1 Publication

Developmental stagei

During the development of skeletal muscle, can only be detected 2 weeks after birth.1 Publication

Gene expression databases

BgeeiENSMUSG00000047746 Expressed in 16 organ(s), highest expression level in skeletal muscle tissue
CleanExiMM_FBXO40
ExpressionAtlasiP62932 baseline and differential

Interactioni

Subunit structurei

Directly interacts with SKP1 and CUL1.By similarity

Protein-protein interaction databases

BioGridi228886, 4 interactors
STRINGi10090.ENSMUSP00000075266

Structurei

3D structure databases

ProteinModelPortaliP62932
SMRiP62932
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini572 – 626F-boxPROSITE-ProRule annotationAdd BLAST55

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri53 – 114TRAF-typePROSITE-ProRule annotationAdd BLAST62

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiENOG410IEIY Eukaryota
ENOG410ZQ6P LUCA
GeneTreeiENSGT00410000025582
HOVERGENiHBG100177
InParanoidiP62932
KOiK10315
OMAiMLIHFGQ
OrthoDBiEOG091G06SE
PhylomeDBiP62932
TreeFamiTF343227

Family and domain databases

Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR036047 F-box-like_dom_sf
IPR001810 F-box_dom
IPR031890 Fbxo30/Fbxo40
IPR008974 TRAF-like
IPR013083 Znf_RING/FYVE/PHD
IPR001293 Znf_TRAF
PANTHERiPTHR15933 PTHR15933, 1 hit
PfamiView protein in Pfam
PF15966 F-box_4, 1 hit
PF15965 zf-TRAF_2, 1 hit
SUPFAMiSSF49599 SSF49599, 1 hit
SSF81383 SSF81383, 1 hit
PROSITEiView protein in PROSITE
PS50181 FBOX, 1 hit
PS50145 ZF_TRAF, 1 hit

Sequencei

Sequence statusi: Complete.

P62932-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGRARKPPPA LHRHCEGCFN RHCHVPVEPS VSCLVISCHL LCGATFHMCK
60 70 80 90 100
ESEHTLLCPL EQVPCLNSEY GCPLSMARHK LAKHLQVCPA SVVCCSMEWI
110 120 130 140 150
RWPNVDSETF LHENIMKETP SEECLDTALA LQDQKVLFRS LKMVELFPET
160 170 180 190 200
RDATEEEPDM NGDTSWEETG GAVGGVDARL APNSCLPATS RQMMELSQEE
210 220 230 240 250
RDALAKTKEG MDLDKFGKWE SMFSKEHAAS VLTGSLGKSE DKNGDVAGKE
260 270 280 290 300
QCSSNVRIGD AEGSAERRGP QESQKSQELP ATMEMTGLAP WQDGVLERLK
310 320 330 340 350
TAVDAKDYNM YLVHNGRMLI HFGQMPACTP KERDFVYGNL EAQEVKTVYT
360 370 380 390 400
FKIPVSYCGK RARLGDAMLK CRPSEHKAVD TSDLGISVED LPKSDLIKTT
410 420 430 440 450
LQCALERELK GHVISESRSI DGLFMDLATQ TYNFEPEQFS SETVLADLLG
460 470 480 490 500
TAQPGGLHVE LHSECVTRRH NKSSSAFTFT CNKFFRRDEF PLHFKNVHTD
510 520 530 540 550
IQSSLDGWFQ HRCPLAYLGC TFVQNHFRPP GQKAKVIYSQ ELKTFAIKPE
560 570 580 590 600
VAPELSEKWK SDHLSGRDGK SLNSLTSLPL EVLQYIAGFL DSISLSQLSQ
610 620 630 640 650
VSVLMRNICA TLLQERGMVL SQWKKKRYSH GGTSWKVHNQ IWQFSSLFSK
660 670 680 690 700
INSWEFNDVT SMSEHLKTCP FNIVERKTDP IRLTSMCQPQ EKARESLVST
710
FRARPRGRHF
Length:710
Mass (Da):79,951
Last modified:August 31, 2004 - v1
Checksum:i0315C62EBA9BFC45
GO

Sequence cautioni

The sequence AK036385 differs from that shown. Reason: Frameshift at position 77.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK036385 mRNA No translation available.
CCDSiCCDS37337.1
RefSeqiNP_001032398.1, NM_001037321.1
XP_006521944.1, XM_006521881.2
XP_006521945.1, XM_006521882.3
UniGeneiMm.211899

Genome annotation databases

EnsembliENSMUST00000075869; ENSMUSP00000075266; ENSMUSG00000047746
ENSMUST00000114806; ENSMUSP00000110454; ENSMUSG00000047746
GeneIDi207215
KEGGimmu:207215
UCSCiuc007zdj.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK036385 mRNA No translation available.
CCDSiCCDS37337.1
RefSeqiNP_001032398.1, NM_001037321.1
XP_006521944.1, XM_006521881.2
XP_006521945.1, XM_006521882.3
UniGeneiMm.211899

3D structure databases

ProteinModelPortaliP62932
SMRiP62932
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi228886, 4 interactors
STRINGi10090.ENSMUSP00000075266

PTM databases

iPTMnetiP62932
PhosphoSitePlusiP62932

Proteomic databases

EPDiP62932
PaxDbiP62932
PeptideAtlasiP62932
PRIDEiP62932

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000075869; ENSMUSP00000075266; ENSMUSG00000047746
ENSMUST00000114806; ENSMUSP00000110454; ENSMUSG00000047746
GeneIDi207215
KEGGimmu:207215
UCSCiuc007zdj.1 mouse

Organism-specific databases

CTDi51725
MGIiMGI:2443753 Fbxo40

Phylogenomic databases

eggNOGiENOG410IEIY Eukaryota
ENOG410ZQ6P LUCA
GeneTreeiENSGT00410000025582
HOVERGENiHBG100177
InParanoidiP62932
KOiK10315
OMAiMLIHFGQ
OrthoDBiEOG091G06SE
PhylomeDBiP62932
TreeFamiTF343227

Enzyme and pathway databases

ReactomeiR-MMU-8951664 Neddylation
R-MMU-983168 Antigen processing: Ubiquitination & Proteasome degradation

Miscellaneous databases

PROiPR:P62932
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000047746 Expressed in 16 organ(s), highest expression level in skeletal muscle tissue
CleanExiMM_FBXO40
ExpressionAtlasiP62932 baseline and differential

Family and domain databases

Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR036047 F-box-like_dom_sf
IPR001810 F-box_dom
IPR031890 Fbxo30/Fbxo40
IPR008974 TRAF-like
IPR013083 Znf_RING/FYVE/PHD
IPR001293 Znf_TRAF
PANTHERiPTHR15933 PTHR15933, 1 hit
PfamiView protein in Pfam
PF15966 F-box_4, 1 hit
PF15965 zf-TRAF_2, 1 hit
SUPFAMiSSF49599 SSF49599, 1 hit
SSF81383 SSF81383, 1 hit
PROSITEiView protein in PROSITE
PS50181 FBOX, 1 hit
PS50145 ZF_TRAF, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiFBX40_MOUSE
AccessioniPrimary (citable) accession number: P62932
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: August 31, 2004
Last modified: September 12, 2018
This is version 103 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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