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Protein

60S ribosomal protein L8

Gene

Rpl8

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the large ribosomal subunit.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein, RNA-binding, rRNA-binding

Enzyme and pathway databases

ReactomeiR-MMU-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L8
Gene namesi
Name:Rpl8
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:1350927 Rpl8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001297441 – 25760S ribosomal protein L8Add BLAST257

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki42Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki149Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei216(3S)-3-hydroxyhistidineBy similarity1
Cross-linki234Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki250Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Post-translational modificationi

Hydroxylated on His-216 by RIOX1. The modification is impaired by hypoxia.By similarity

Keywords - PTMi

Hydroxylation, Isopeptide bond, Ubl conjugation

Proteomic databases

EPDiP62918
MaxQBiP62918
PaxDbiP62918
PeptideAtlasiP62918
PRIDEiP62918
TopDownProteomicsiP62918

PTM databases

iPTMnetiP62918
PhosphoSitePlusiP62918
SwissPalmiP62918

Expressioni

Gene expression databases

BgeeiENSMUSG00000003970
CleanExiMM_RPL8
GenevisibleiP62918 MM

Interactioni

Subunit structurei

Component of the large ribosomal subunit (By similarity). Interacts with CRY1 (By similarity).By similarity

Protein-protein interaction databases

BioGridi205087, 3 interactors
CORUMiP62918
IntActiP62918, 8 interactors
MINTiP62918
STRINGi10090.ENSMUSP00000004072

Structurei

3D structure databases

ProteinModelPortaliP62918
SMRiP62918
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG2309 Eukaryota
COG0090 LUCA
GeneTreeiENSGT00390000009907
HOGENOMiHOG000232983
HOVERGENiHBG079431
InParanoidiP62918
KOiK02938
OMAiHGYIKGV
OrthoDBiEOG091G0K1G
PhylomeDBiP62918
TreeFamiTF300748

Family and domain databases

Gene3Di2.30.30.30, 1 hit
4.10.950.10, 1 hit
HAMAPiMF_01320_A Ribosomal_L2_A, 1 hit
InterProiView protein in InterPro
IPR012340 NA-bd_OB-fold
IPR022666 Rbsml_prot_L2_RNA-bd_dom
IPR014722 Rib_L2_dom2
IPR002171 Ribosomal_L2
IPR023672 Ribosomal_L2_arc
IPR022669 Ribosomal_L2_C
IPR022671 Ribosomal_L2_CS
IPR014726 Ribosomal_L2_dom3
IPR008991 Translation_prot_SH3-like_sf
PANTHERiPTHR13691 PTHR13691, 1 hit
PfamiView protein in Pfam
PF00181 Ribosomal_L2, 1 hit
PF03947 Ribosomal_L2_C, 1 hit
PIRSFiPIRSF002158 Ribosomal_L2, 1 hit
SMARTiView protein in SMART
SM01383 Ribosomal_L2, 1 hit
SM01382 Ribosomal_L2_C, 1 hit
SUPFAMiSSF50104 SSF50104, 1 hit
SSF50249 SSF50249, 1 hit
PROSITEiView protein in PROSITE
PS00467 RIBOSOMAL_L2, 1 hit

Sequencei

Sequence statusi: Complete.

P62918-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGRVIRGQRK GAGSVFRAHV KHRKGAARLR AVDFAERHGY IKGIVKDIIH
60 70 80 90 100
DPGRGAPLAK VVFRDPYRFK KRTELFIAAE GIHTGQFVYC GKKAQLNIGN
110 120 130 140 150
VLPVGTMPEG TIVCCLEEKP GDRGKLARAS GNYATVISHN PETKKTRVKL
160 170 180 190 200
PSGSKKVISS ANRAVVGVVA GGGRIDKPIL KAGRAYHKYK AKRNCWPRVR
210 220 230 240 250
GVAMNPVEHP FGGGNHQHIG KPSTIRRDAP AGRKVGLIAA RRTGRLRGTK

TVQEKEN
Length:257
Mass (Da):28,025
Last modified:January 23, 2007 - v2
Checksum:iCE1610449749318B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U67771 mRNA Translation: AAC35587.1
AK088263 mRNA Translation: BAC40244.1
AK131970 mRNA Translation: BAE20910.1
AK145498 mRNA Translation: BAE26472.1
AK167775 mRNA Translation: BAE39807.1
AK168769 mRNA Translation: BAE40605.1
BC043017 mRNA Translation: AAH43017.1
CCDSiCCDS27595.1
RefSeqiNP_036183.1, NM_012053.2
UniGeneiMm.30066

Genome annotation databases

EnsembliENSMUST00000004072; ENSMUSP00000004072; ENSMUSG00000003970
ENSMUST00000229183; ENSMUSP00000155657; ENSMUSG00000003970
GeneIDi26961
KEGGimmu:26961
UCSCiuc007wmt.2 mouse

Similar proteinsi

Entry informationi

Entry nameiRL8_MOUSE
AccessioniPrimary (citable) accession number: P62918
Secondary accession number(s): P25120, Q3V288
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: January 23, 2007
Last modified: June 20, 2018
This is version 126 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

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