UniProtKB - P62918 (RL8_MOUSE)
Protein
60S ribosomal protein L8
Gene
Rpl8
Organism
Mus musculus (Mouse)
Status
Functioni
Component of the large ribosomal subunit.By similarity
GO - Molecular functioni
- 5.8S rRNA binding Source: Ensembl
- RNA binding Source: GO_Central
- structural constituent of ribosome Source: GO_Central
GO - Biological processi
- cellular response to nerve growth factor stimulus Source: Ensembl
- cytoplasmic translation Source: MGI
Keywordsi
Molecular function | Ribonucleoprotein, Ribosomal protein, RNA-binding, rRNA-binding |
Enzyme and pathway databases
Reactomei | R-MMU-156827, L13a-mediated translational silencing of Ceruloplasmin expression R-MMU-1799339, SRP-dependent cotranslational protein targeting to membrane R-MMU-6791226, Major pathway of rRNA processing in the nucleolus and cytosol R-MMU-72689, Formation of a pool of free 40S subunits R-MMU-72706, GTP hydrolysis and joining of the 60S ribosomal subunit R-MMU-975956, Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-MMU-975957, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) |
Names & Taxonomyi
Protein namesi | Recommended name: 60S ribosomal protein L8 |
Gene namesi | Name:Rpl8 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1350927, Rpl8 |
Subcellular locationi
Other locations
- Cytoplasm By similarity
Cytosol
- cytosolic large ribosomal subunit Source: MGI
Other locations
- polysomal ribosome Source: MGI
- postsynapse Source: MGI
- postsynaptic density Source: MGI
- synapse Source: SynGO
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000129744 | 1 – 257 | 60S ribosomal protein L8Add BLAST | 257 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Cross-linki | 42 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 149 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Modified residuei | 216 | (3S)-3-hydroxyhistidineBy similarity | 1 | |
Cross-linki | 234 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 250 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity |
Post-translational modificationi
Hydroxylated on His-216 by RIOX1. The modification is impaired by hypoxia.By similarity
Keywords - PTMi
Hydroxylation, Isopeptide bond, Ubl conjugationProteomic databases
EPDi | P62918 |
jPOSTi | P62918 |
MaxQBi | P62918 |
PaxDbi | P62918 |
PeptideAtlasi | P62918 |
PRIDEi | P62918 |
TopDownProteomicsi | P62918 |
PTM databases
iPTMneti | P62918 |
PhosphoSitePlusi | P62918 |
SwissPalmi | P62918 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000003970, Expressed in embryo and 306 other tissues |
Genevisiblei | P62918, MM |
Interactioni
Subunit structurei
Component of the large ribosomal subunit (By similarity).
Interacts with CRY1 (PubMed:19129230).
By similarity1 PublicationProtein-protein interaction databases
BioGRIDi | 205087, 88 interactors |
ComplexPortali | CPX-5262, 60S cytosolic large ribosomal subunit |
CORUMi | P62918 |
IntActi | P62918, 12 interactors |
MINTi | P62918 |
STRINGi | 10090.ENSMUSP00000004072 |
Miscellaneous databases
RNActi | P62918, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the universal ribosomal protein uL2 family.Curated
Phylogenomic databases
eggNOGi | KOG2309, Eukaryota |
GeneTreei | ENSGT00940000153244 |
HOGENOMi | CLU_036235_0_3_1 |
InParanoidi | P62918 |
OMAi | SCIELRP |
OrthoDBi | 1156335at2759 |
PhylomeDBi | P62918 |
TreeFami | TF300748 |
Family and domain databases
Gene3Di | 2.30.30.30, 1 hit 4.10.950.10, 1 hit |
HAMAPi | MF_01320_A, Ribosomal_L2_A, 1 hit |
InterProi | View protein in InterPro IPR012340, NA-bd_OB-fold IPR022666, Rbsml_prot_L2_RNA-bd_dom IPR014722, Rib_L2_dom2 IPR002171, Ribosomal_L2 IPR023672, Ribosomal_L2_arc IPR022669, Ribosomal_L2_C IPR022671, Ribosomal_L2_CS IPR014726, Ribosomal_L2_dom3 IPR008991, Translation_prot_SH3-like_sf |
PANTHERi | PTHR13691, PTHR13691, 1 hit |
Pfami | View protein in Pfam PF00181, Ribosomal_L2, 1 hit PF03947, Ribosomal_L2_C, 1 hit |
PIRSFi | PIRSF002158, Ribosomal_L2, 1 hit |
SMARTi | View protein in SMART SM01383, Ribosomal_L2, 1 hit SM01382, Ribosomal_L2_C, 1 hit |
SUPFAMi | SSF50104, SSF50104, 1 hit SSF50249, SSF50249, 1 hit |
PROSITEi | View protein in PROSITE PS00467, RIBOSOMAL_L2, 1 hit |
i Sequence
Sequence statusi: Complete.
P62918-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGRVIRGQRK GAGSVFRAHV KHRKGAARLR AVDFAERHGY IKGIVKDIIH
60 70 80 90 100
DPGRGAPLAK VVFRDPYRFK KRTELFIAAE GIHTGQFVYC GKKAQLNIGN
110 120 130 140 150
VLPVGTMPEG TIVCCLEEKP GDRGKLARAS GNYATVISHN PETKKTRVKL
160 170 180 190 200
PSGSKKVISS ANRAVVGVVA GGGRIDKPIL KAGRAYHKYK AKRNCWPRVR
210 220 230 240 250
GVAMNPVEHP FGGGNHQHIG KPSTIRRDAP AGRKVGLIAA RRTGRLRGTK
TVQEKEN
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U67771 mRNA Translation: AAC35587.1 AK088263 mRNA Translation: BAC40244.1 AK131970 mRNA Translation: BAE20910.1 AK145498 mRNA Translation: BAE26472.1 AK167775 mRNA Translation: BAE39807.1 AK168769 mRNA Translation: BAE40605.1 BC043017 mRNA Translation: AAH43017.1 |
CCDSi | CCDS27595.1 |
RefSeqi | NP_036183.1, NM_012053.2 |
Genome annotation databases
Ensembli | ENSMUST00000004072; ENSMUSP00000004072; ENSMUSG00000003970 ENSMUST00000229183; ENSMUSP00000155657; ENSMUSG00000003970 |
GeneIDi | 26961 |
KEGGi | mmu:26961 |
UCSCi | uc007wmt.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U67771 mRNA Translation: AAC35587.1 AK088263 mRNA Translation: BAC40244.1 AK131970 mRNA Translation: BAE20910.1 AK145498 mRNA Translation: BAE26472.1 AK167775 mRNA Translation: BAE39807.1 AK168769 mRNA Translation: BAE40605.1 BC043017 mRNA Translation: AAH43017.1 |
CCDSi | CCDS27595.1 |
RefSeqi | NP_036183.1, NM_012053.2 |
3D structure databases
SMRi | P62918 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 205087, 88 interactors |
ComplexPortali | CPX-5262, 60S cytosolic large ribosomal subunit |
CORUMi | P62918 |
IntActi | P62918, 12 interactors |
MINTi | P62918 |
STRINGi | 10090.ENSMUSP00000004072 |
PTM databases
iPTMneti | P62918 |
PhosphoSitePlusi | P62918 |
SwissPalmi | P62918 |
Proteomic databases
EPDi | P62918 |
jPOSTi | P62918 |
MaxQBi | P62918 |
PaxDbi | P62918 |
PeptideAtlasi | P62918 |
PRIDEi | P62918 |
TopDownProteomicsi | P62918 |
Protocols and materials databases
Antibodypediai | 14991, 284 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000004072; ENSMUSP00000004072; ENSMUSG00000003970 ENSMUST00000229183; ENSMUSP00000155657; ENSMUSG00000003970 |
GeneIDi | 26961 |
KEGGi | mmu:26961 |
UCSCi | uc007wmt.2, mouse |
Organism-specific databases
CTDi | 6132 |
MGIi | MGI:1350927, Rpl8 |
Phylogenomic databases
eggNOGi | KOG2309, Eukaryota |
GeneTreei | ENSGT00940000153244 |
HOGENOMi | CLU_036235_0_3_1 |
InParanoidi | P62918 |
OMAi | SCIELRP |
OrthoDBi | 1156335at2759 |
PhylomeDBi | P62918 |
TreeFami | TF300748 |
Enzyme and pathway databases
Reactomei | R-MMU-156827, L13a-mediated translational silencing of Ceruloplasmin expression R-MMU-1799339, SRP-dependent cotranslational protein targeting to membrane R-MMU-6791226, Major pathway of rRNA processing in the nucleolus and cytosol R-MMU-72689, Formation of a pool of free 40S subunits R-MMU-72706, GTP hydrolysis and joining of the 60S ribosomal subunit R-MMU-975956, Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-MMU-975957, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) |
Miscellaneous databases
BioGRID-ORCSi | 26961, 10 hits in 18 CRISPR screens |
ChiTaRSi | Rpl8, mouse |
PROi | PR:P62918 |
RNActi | P62918, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000003970, Expressed in embryo and 306 other tissues |
Genevisiblei | P62918, MM |
Family and domain databases
Gene3Di | 2.30.30.30, 1 hit 4.10.950.10, 1 hit |
HAMAPi | MF_01320_A, Ribosomal_L2_A, 1 hit |
InterProi | View protein in InterPro IPR012340, NA-bd_OB-fold IPR022666, Rbsml_prot_L2_RNA-bd_dom IPR014722, Rib_L2_dom2 IPR002171, Ribosomal_L2 IPR023672, Ribosomal_L2_arc IPR022669, Ribosomal_L2_C IPR022671, Ribosomal_L2_CS IPR014726, Ribosomal_L2_dom3 IPR008991, Translation_prot_SH3-like_sf |
PANTHERi | PTHR13691, PTHR13691, 1 hit |
Pfami | View protein in Pfam PF00181, Ribosomal_L2, 1 hit PF03947, Ribosomal_L2_C, 1 hit |
PIRSFi | PIRSF002158, Ribosomal_L2, 1 hit |
SMARTi | View protein in SMART SM01383, Ribosomal_L2, 1 hit SM01382, Ribosomal_L2_C, 1 hit |
SUPFAMi | SSF50104, SSF50104, 1 hit SSF50249, SSF50249, 1 hit |
PROSITEi | View protein in PROSITE PS00467, RIBOSOMAL_L2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | RL8_MOUSE | |
Accessioni | P62918Primary (citable) accession number: P62918 Secondary accession number(s): P25120, Q3V288 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 31, 2004 |
Last sequence update: | January 23, 2007 | |
Last modified: | December 2, 2020 | |
This is version 141 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Ribosomal proteins
Ribosomal proteins families and list of entries