RPL8

Functionⁱ

Component of the large ribosomal subunit.1 Publication

Miscellaneous

This protein can be partially incorporated into E.coli polysomes in vivo, indicating it can replace the endogenous protein.

GO - Molecular functionⁱ

5.8S rRNA binding Source: Ensembl
RNA binding
Source: UniProtKB
Inferred from high throughput direct assayⁱ
- 22658674
- 22681889
structural constituent of ribosome Source: GO_Central

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cellular response to nerve growth factor stimulus Source: Ensembl
cytoplasmic translation
Source: UniProtKB
Inferred from direct assayⁱ
- 25957688
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay Source: Reactome
SRP-dependent cotranslational protein targeting to membrane Source: Reactome
translation
Source: ProtInc
Traceable author statementⁱ
- 7506540
translational initiation Source: Reactome

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Ribonucleoprotein, Ribosomal protein, RNA-binding, rRNA-binding

Molecular function

Ribonucleoprotein, Ribosomal protein, RNA-binding, rRNA-binding

Enzyme and pathway databases

Reactomeⁱ	R-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156902 Peptide chain elongation R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane R-HSA-192823 Viral mRNA Translation R-HSA-2408557 Selenocysteine synthesis R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-72689 Formation of a pool of free 40S subunits R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72764 Eukaryotic Translation Termination R-HSA-9010553 Regulation of expression of SLITs and ROBOs R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Reactomeⁱ

R-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-HSA-156902 Peptide chain elongation
R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane
R-HSA-192823 Viral mRNA Translation
R-HSA-2408557 Selenocysteine synthesis
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol
R-HSA-72689 Formation of a pool of free 40S subunits
R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit
R-HSA-72764 Eukaryotic Translation Termination
R-HSA-9010553 Regulation of expression of SLITs and ROBOs
R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: 60S ribosomal protein L8 Alternative name(s): Large ribosomal subunit protein uL21 Publication
Gene namesⁱ	Name:RPL8
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 8

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000161016.15
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:10368 RPL8
MIMⁱ	604177 gene
neXtProtⁱ	NX_P62917

Keywords - Cellular componentⁱ

Cytoplasm

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	209	H → A or G: No incorporation into translating E.coli polysomes; ribosomes assembled normally. Significantly reduced translational activity. 1 Publication		1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	6132
Open Targets More...OpenTargetsⁱ	ENSG00000161016
PharmGKBⁱ	PA34768

Chemistry databases

Drug and drug target database More...DrugBankⁱ	DB02494 Alpha-Hydroxy-Beta-Phenyl-Propionic Acid DB07374 Anisomycin DB08437 Puromycin

DrugBankⁱ

DB02494 Alpha-Hydroxy-Beta-Phenyl-Propionic Acid
DB07374 Anisomycin
DB08437 Puromycin

Polymorphism and mutation databases

BioMutaⁱ	RPL8
DMDMⁱ	51702823

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		Removed1 Publication
ChainⁱPRO_0000129743	2 – 257	60S ribosomal protein L8Add BLAST		256

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Cross-linkⁱ	42	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	149	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residueⁱ	216	(3S)-3-hydroxyhistidine1 Publication	1
Cross-linkⁱ	234	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	250	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Post-translational modificationⁱ

Hydroxylated on His-216 by RIOX1. The modification is impaired by hypoxia.1 Publication

Keywords - PTMⁱ

Hydroxylation, Isopeptide bond, Ubl conjugation

Proteomic databases

EPDⁱ	P62917
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P62917
PaxDbⁱ	P62917
PeptideAtlas More...PeptideAtlasⁱ	P62917
PRIDEⁱ	P62917
ProteomicsDBⁱ	57454
TopDownProteomicsⁱ	P62917

PTM databases

iPTMnetⁱ	P62917
PhosphoSitePlusⁱ	P62917
SwissPalmⁱ	P62917

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000161016
CleanExⁱ	HS_RPL8
ExpressionAtlasⁱ	P62917 baseline and differential
Genevisibleⁱ	P62917 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA045095 HPA050165

HPAⁱ

HPA045095
HPA050165

Interactionⁱ

Subunit structureⁱ

Component of the large ribosomal subunit (Probable). Interacts with CRY1 (By similarity).By similarity1 Publication

Protein-protein interaction databases

BioGridⁱ	112052, 223 interactors
CORUMⁱ	P62917
Database of interacting proteins More...DIPⁱ	DIP-37967N
IntActⁱ	P62917, 59 interactors
Molecular INTeraction database More...MINTⁱ	P62917
STRINGⁱ	9606.ENSP00000262584

Structureⁱ

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	4CCM	X-ray	2.51	C/D	205-239	[»]
	4CCN	X-ray	2.23	C/D	205-239	[»]
	4CCO	X-ray	2.30	C/D	205-224	[»]
	4UG0	electron microscopy	-	LA	1-257	[»]
	4V6X	electron microscopy	5.00	CA	1-257	[»]
	4Y3O	X-ray	2.20	C/D	212-222	[»]
	5AJ0	electron microscopy	3.50	AA	1-257	[»]
	5LKS	electron microscopy	3.60	LA	1-257	[»]
	5T2C	electron microscopy	3.60	D	1-257	[»]
	6EK0	electron microscopy	2.90	LA	1-257	[»]
ProteinModelPortalⁱ	P62917
SMRⁱ	P62917
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the universal ribosomal protein uL2 family.Curated

Phylogenomic databases

eggNOGⁱ	KOG2309 Eukaryota COG0090 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000009907
HOVERGENⁱ	HBG079431
InParanoidⁱ	P62917
KEGG Orthology (KO) More...KOⁱ	K02938
OMAⁱ	HGYIKGV
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0K1G
PhylomeDBⁱ	P62917
TreeFamⁱ	TF300748

Family and domain databases

Gene3Dⁱ	2.30.30.30, 1 hit 4.10.950.10, 1 hit
HAMAPⁱ	MF_01320_A Ribosomal_L2_A, 1 hit
InterProⁱ	View protein in InterPro IPR012340 NA-bd_OB-fold IPR022666 Rbsml_prot_L2_RNA-bd_dom IPR014722 Rib_L2_dom2 IPR002171 Ribosomal_L2 IPR023672 Ribosomal_L2_arc IPR022669 Ribosomal_L2_C IPR022671 Ribosomal_L2_CS IPR014726 Ribosomal_L2_dom3 IPR008991 Translation_prot_SH3-like_sf
PANTHERⁱ	PTHR13691 PTHR13691, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00181 Ribosomal_L2, 1 hit PF03947 Ribosomal_L2_C, 1 hit
PIRSFⁱ	PIRSF002158 Ribosomal_L2, 1 hit
SMARTⁱ	View protein in SMART SM01383 Ribosomal_L2, 1 hit SM01382 Ribosomal_L2_C, 1 hit
SUPFAMⁱ	SSF50104 SSF50104, 1 hit SSF50249 SSF50249, 1 hit
PROSITEⁱ	View protein in PROSITE PS00467 RIBOSOMAL_L2, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

P62917-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MGRVIRGQRK GAGSVFRAHV KHRKGAARLR AVDFAERHGY IKGIVKDIIH 
        60         70         80         90        100
DPGRGAPLAK VVFRDPYRFK KRTELFIAAE GIHTGQFVYC GKKAQLNIGN 
       110        120        130        140        150
VLPVGTMPEG TIVCCLEEKP GDRGKLARAS GNYATVISHN PETKKTRVKL 
       160        170        180        190        200
PSGSKKVISS ANRAVVGVVA GGGRIDKPIL KAGRAYHKYK AKRNCWPRVR 
       210        220        230        240        250
GVAMNPVEHP FGGGNHQHIG KPSTIRRDAP AGRKVGLIAA RRTGRLRGTK 

TVQEKEN

Length:257

Mass (Da):28,025

Last modified:January 23, 2007 - v2

Checksum:ⁱCE1610449749318B

GO

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_019658	98	I → V2 PublicationsCorresponds to variant dbSNP:rs11539893Ensembl.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	Z28407 mRNA Translation: CAA82248.1 AB061821 Genomic DNA Translation: BAB79459.1 BT007379 mRNA Translation: AAP36043.1 CR457046 mRNA Translation: CAG33327.1 AK289459 mRNA Translation: BAF82148.1 CH471162 Genomic DNA Translation: EAW82048.1 CH471162 Genomic DNA Translation: EAW82051.1 CH471162 Genomic DNA Translation: EAW82052.1 BC000047 mRNA Translation: AAH00047.2 BC000077 mRNA Translation: AAH00077.1 BC012197 mRNA Translation: AAH12197.1 BC013104 mRNA Translation: AAH13104.1 BC093064 mRNA Translation: AAH93064.1 AB007168 Genomic DNA Translation: BAA25829.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS6433.1
PIRⁱ	JN0923
NCBI Reference Sequences More...RefSeqⁱ	NP_000964.1, NM_000973.4 NP_001304700.1, NM_001317771.1 NP_001304711.1, NM_001317782.1 NP_150644.1, NM_033301.2
UniGeneⁱ	Hs.178551

Genome annotation databases

Ensemblⁱ	ENST00000262584; ENSP00000262584; ENSG00000161016 ENST00000394920; ENSP00000378378; ENSG00000161016 ENST00000528957; ENSP00000433464; ENSG00000161016
GeneIDⁱ	6132
KEGGⁱ	hsa:6132
UCSC genome browser More...UCSCⁱ	uc003zeb.4 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length
P62917	60S ribosomal protein L8		BOVIN		257
60S ribosomal protein L8		MOUSE		257
60S ribosomal protein L8		RAT		257
60S ribosomal protein L8		Daphnia magna		257
RPL8 isoform 1		PANTR		257
+53

Protein	Similar proteins		Species	Score	Length
P62917	60S ribosomal protein L8		BOVIN		257
60S ribosomal protein L8		MOUSE		257
60S ribosomal protein L8		RAT		257
60S ribosomal protein L8		Daphnia magna		257
RPL8 isoform 1		PANTR		257
+60

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	Z28407 mRNA Translation: CAA82248.1 AB061821 Genomic DNA Translation: BAB79459.1 BT007379 mRNA Translation: AAP36043.1 CR457046 mRNA Translation: CAG33327.1 AK289459 mRNA Translation: BAF82148.1 CH471162 Genomic DNA Translation: EAW82048.1 CH471162 Genomic DNA Translation: EAW82051.1 CH471162 Genomic DNA Translation: EAW82052.1 BC000047 mRNA Translation: AAH00047.2 BC000077 mRNA Translation: AAH00077.1 BC012197 mRNA Translation: AAH12197.1 BC013104 mRNA Translation: AAH13104.1 BC093064 mRNA Translation: AAH93064.1 AB007168 Genomic DNA Translation: BAA25829.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS6433.1
PIRⁱ	JN0923
NCBI Reference Sequences More...RefSeqⁱ	NP_000964.1, NM_000973.4 NP_001304700.1, NM_001317771.1 NP_001304711.1, NM_001317782.1 NP_150644.1, NM_033301.2
UniGeneⁱ	Hs.178551

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	4CCM	X-ray	2.51	C/D	205-239	[»]
	4CCN	X-ray	2.23	C/D	205-239	[»]
	4CCO	X-ray	2.30	C/D	205-224	[»]
	4UG0	electron microscopy	-	LA	1-257	[»]
	4V6X	electron microscopy	5.00	CA	1-257	[»]
	4Y3O	X-ray	2.20	C/D	212-222	[»]
	5AJ0	electron microscopy	3.50	AA	1-257	[»]
	5LKS	electron microscopy	3.60	LA	1-257	[»]
	5T2C	electron microscopy	3.60	D	1-257	[»]
	6EK0	electron microscopy	2.90	LA	1-257	[»]
ProteinModelPortalⁱ	P62917
SMRⁱ	P62917
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	112052, 223 interactors
CORUMⁱ	P62917
Database of interacting proteins More...DIPⁱ	DIP-37967N
IntActⁱ	P62917, 59 interactors
Molecular INTeraction database More...MINTⁱ	P62917
STRINGⁱ	9606.ENSP00000262584

Chemistry databases

Drug and drug target database More...DrugBankⁱ	DB02494 Alpha-Hydroxy-Beta-Phenyl-Propionic Acid DB07374 Anisomycin DB08437 Puromycin

DrugBankⁱ

DB02494 Alpha-Hydroxy-Beta-Phenyl-Propionic Acid
DB07374 Anisomycin
DB08437 Puromycin

PTM databases

iPTMnetⁱ	P62917
PhosphoSitePlusⁱ	P62917
SwissPalmⁱ	P62917

Polymorphism and mutation databases

BioMutaⁱ	RPL8
DMDMⁱ	51702823

Proteomic databases

EPDⁱ	P62917
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P62917
PaxDbⁱ	P62917
PeptideAtlas More...PeptideAtlasⁱ	P62917
PRIDEⁱ	P62917
ProteomicsDBⁱ	57454
TopDownProteomicsⁱ	P62917

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	6132
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000262584; ENSP00000262584; ENSG00000161016 ENST00000394920; ENSP00000378378; ENSG00000161016 ENST00000528957; ENSP00000433464; ENSG00000161016
GeneIDⁱ	6132
KEGGⁱ	hsa:6132
UCSC genome browser More...UCSCⁱ	uc003zeb.4 human

Organism-specific databases

CTDⁱ	6132
DisGeNET More...DisGeNETⁱ	6132
EuPathDBⁱ	HostDB:ENSG00000161016.15
GeneCardsⁱ	RPL8
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:10368 RPL8
Human Protein Atlas More...HPAⁱ	HPA045095 HPA050165
MIMⁱ	604177 gene
neXtProtⁱ	NX_P62917
Open Targets More...OpenTargetsⁱ	ENSG00000161016
PharmGKBⁱ	PA34768
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG2309 Eukaryota COG0090 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000009907
HOVERGENⁱ	HBG079431
InParanoidⁱ	P62917
KEGG Orthology (KO) More...KOⁱ	K02938
OMAⁱ	HGYIKGV
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0K1G
PhylomeDBⁱ	P62917
TreeFamⁱ	TF300748

Enzyme and pathway databases

Reactomeⁱ	R-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156902 Peptide chain elongation R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane R-HSA-192823 Viral mRNA Translation R-HSA-2408557 Selenocysteine synthesis R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-72689 Formation of a pool of free 40S subunits R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72764 Eukaryotic Translation Termination R-HSA-9010553 Regulation of expression of SLITs and ROBOs R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Reactomeⁱ

R-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-HSA-156902 Peptide chain elongation
R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane
R-HSA-192823 Viral mRNA Translation
R-HSA-2408557 Selenocysteine synthesis
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol
R-HSA-72689 Formation of a pool of free 40S subunits
R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit
R-HSA-72764 Eukaryotic Translation Termination
R-HSA-9010553 Regulation of expression of SLITs and ROBOs
R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Miscellaneous databases

ChiTaRSⁱ	RPL8 human
GeneWikiⁱ	RPL8
GenomeRNAiⁱ	6132
Protein Ontology More...PROⁱ	PR:P62917
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000161016
CleanExⁱ	HS_RPL8
ExpressionAtlasⁱ	P62917 baseline and differential
Genevisibleⁱ	P62917 HS

Family and domain databases

Gene3Dⁱ	2.30.30.30, 1 hit 4.10.950.10, 1 hit
HAMAPⁱ	MF_01320_A Ribosomal_L2_A, 1 hit
InterProⁱ	View protein in InterPro IPR012340 NA-bd_OB-fold IPR022666 Rbsml_prot_L2_RNA-bd_dom IPR014722 Rib_L2_dom2 IPR002171 Ribosomal_L2 IPR023672 Ribosomal_L2_arc IPR022669 Ribosomal_L2_C IPR022671 Ribosomal_L2_CS IPR014726 Ribosomal_L2_dom3 IPR008991 Translation_prot_SH3-like_sf
PANTHERⁱ	PTHR13691 PTHR13691, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00181 Ribosomal_L2, 1 hit PF03947 Ribosomal_L2_C, 1 hit
PIRSFⁱ	PIRSF002158 Ribosomal_L2, 1 hit
SMARTⁱ	View protein in SMART SM01383 Ribosomal_L2, 1 hit SM01382 Ribosomal_L2_C, 1 hit
SUPFAMⁱ	SSF50104 SSF50104, 1 hit SSF50249 SSF50249, 1 hit
PROSITEⁱ	View protein in PROSITE PS00467 RIBOSOMAL_L2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	RL8_HUMAN
Accessionⁱ	P62917Primary (citable) accession number: P62917 Secondary accession number(s): A8K094 , D3DWN2, P25120, Q567Q7, Q969V7, Q9BWQ9
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	August 31, 2004
	Last sequence update:	January 23, 2007
	Last modified:	June 20, 2018
	This is version 150 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

Human chromosome 8
Human chromosome 8: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Ribosomal proteins
Ribosomal proteins families and list of entries
SIMILARITY comments
Index of protein domains and families

UniProtKB

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Supporting data

UniProtKB - P62917 (RL8_HUMAN)

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60S ribosomal protein L8

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Cytosol

Other locations

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Natural variant

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

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<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ