Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

UniProtKB - P62913 (RL11_HUMAN)

Entry version 172 (02 Jun 2021)
Sequence version 2 (23 Jan 2007)
Previous versions | rss
Add a publicationFeedback
Protein

60S ribosomal protein L11

Gene

RPL11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. As part of the 5S RNP/5S ribonucleoprotein particle it is an essential component of the LSU, required for its formation and the maturation of rRNAs (PubMed:19061985, PubMed:12962325, PubMed:24120868).

It also couples ribosome biogenesis to p53/TP53 activation. As part of the 5S RNP it accumulates in the nucleoplasm and inhibits MDM2, when ribosome biogenesis is perturbed, mediating the stabilization and the activation of TP53 (PubMed:24120868).

Promotes nucleolar location of PML (By similarity).

By similarity3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein, RNA-binding, rRNA-binding

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P62913

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-156827, L13a-mediated translational silencing of Ceruloplasmin expression
R-HSA-156902, Peptide chain elongation
R-HSA-1799339, SRP-dependent cotranslational protein targeting to membrane
R-HSA-192823, Viral mRNA Translation
R-HSA-2408557, Selenocysteine synthesis
R-HSA-6791226, Major pathway of rRNA processing in the nucleolus and cytosol
R-HSA-72689, Formation of a pool of free 40S subunits
R-HSA-72706, GTP hydrolysis and joining of the 60S ribosomal subunit
R-HSA-72764, Eukaryotic Translation Termination
R-HSA-9010553, Regulation of expression of SLITs and ROBOs
R-HSA-9633012, Response of EIF2AK4 (GCN2) to amino acid deficiency
R-HSA-975956, Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-HSA-975957, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

SIGNOR Signaling Network Open Resource

More...SIGNORi		P62913

Protein family/group databases

MoonProt database of moonlighting proteins

More...MoonProti		P62913

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
60S ribosomal protein L11
Alternative name(s):
CLL-associated antigen KW-12
Large ribosomal subunit protein uL51 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RPL11
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:10301, RPL11

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		604175, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P62913

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000142676.12

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Diamond-Blackfan anemia 7 (DBA7)2 Publications
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA form of Diamond-Blackfan anemia, a congenital non-regenerative hypoplastic anemia that usually presents early in infancy. Diamond-Blackfan anemia is characterized by a moderate to severe macrocytic anemia, erythroblastopenia, and an increased risk of malignancy. 30 to 40% of Diamond-Blackfan anemia patients present with short stature and congenital anomalies, the most frequent being craniofacial (Pierre-Robin syndrome and cleft palate), thumb and urogenital anomalies.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05544820L → H in DBA7. 1 Publication1
Natural variantiVAR_055449161Missing in DBA7. 1 Publication1

Keywords - Diseasei

Diamond-Blackfan anemia, Disease variant

Organism-specific databases

DisGeNET

More...DisGeNETi		6135

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...GeneReviewsi		RPL11

MalaCards human disease database

More...MalaCardsi		RPL11
MIMi612562, phenotype

Open Targets

More...OpenTargetsi		ENSG00000142676

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		124, Blackfan-Diamond anemia

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA34664

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P62913, Tbio

Chemistry databases

Drug and drug target database

More...DrugBanki		DB02494, (S)-3-phenyllactic acid
DB07374, Anisomycin
DB08437, Puromycin

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		RPL11

Domain mapping of disease mutations (DMDM)

More...DMDMi		51702795

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources2 Publications
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001250822 – 17860S ribosomal protein L11Add BLAST177

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineCombined sources2 Publications1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki38Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei44PhosphothreonineCombined sources1
Modified residuei47PhosphothreonineCombined sources1
Modified residuei52N6-acetyllysine; alternateCombined sources1
Cross-linki52Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Modified residuei85N6-acetyllysineCombined sources1
Cross-linki154Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		P62913

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P62913

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P62913

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P62913

PeptideAtlas

More...PeptideAtlasi		P62913

PRoteomics IDEntifications database

More...PRIDEi		P62913

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		57452
57453 [P62913-2]

Consortium for Top Down Proteomics

More...TopDownProteomicsi		P62913-1 [P62913-1]

2D gel databases

Two-dimensional polyacrylamide gel electrophoresis database from the Geneva University Hospital

More...SWISS-2DPAGEi		P62913

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P62913

MetOSite database of methionine sulfoxide sites

More...MetOSitei		P62913

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P62913

SwissPalm database of S-palmitoylation events

More...SwissPalmi		P62913

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000142676, Expressed in epithelium of bronchus and 243 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P62913, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P62913, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000142676, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the large ribosomal subunit (LSU).

Part of a LSU subcomplex, the 5S RNP which is composed of the 5S RNA, RPL5 and RPL11 (PubMed:24120868).

Interacts with PML (By similarity).

Interacts with MDM2; negatively regulates MDM2-mediated TP53 ubiquitination and degradation (PubMed:24120868).

Interacts with NOP53; retains RPL11 into the nucleolus (PubMed:24556985, PubMed:27829214).

By similarity3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		112055, 375 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...ComplexPortali		CPX-5183, 60S cytosolic large ribosomal subunit

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		P62913

Protein interaction database and analysis system

More...IntActi		P62913, 100 interactors

Molecular INTeraction database

More...MINTi		P62913

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000363676

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P62913, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1178
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P62913

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the universal ribosomal protein uL5 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0397, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00910000144211

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_061015_3_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P62913

Identification of Orthologs from Complete Genome Data

More...OMAi		EDTMAWF

Database for complete collections of gene phylogenies

More...PhylomeDBi		P62913

TreeFam database of animal gene trees

More...TreeFami		TF300017

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.30.1440.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR002132, Ribosomal_L5
IPR031309, Ribosomal_L5_C
IPR020929, Ribosomal_L5_CS
IPR022803, Ribosomal_L5_dom_sf
IPR031310, Ribosomal_L5_N

The PANTHER Classification System

More...PANTHERi		PTHR11994, PTHR11994, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00281, Ribosomal_L5, 1 hit
PF00673, Ribosomal_L5_C, 1 hit

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF002161, Ribosomal_L5, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF55282, SSF55282, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00358, RIBOSOMAL_L5, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P62913-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAQDQGEKEN PMRELRIRKL CLNICVGESG DRLTRAAKVL EQLTGQTPVF 
        60         70         80         90        100
SKARYTVRSF GIRRNEKIAV HCTVRGAKAE EILEKGLKVR EYELRKNNFS 
       110        120        130        140        150
DTGNFGFGIQ EHIDLGIKYD PSIGIYGLDF YVVLGRPGFS IADKKRRTGC 
       160        170 
IGAKHRISKE EAMRWFQQKY DGIILPGK
Length:178
Mass (Da):20,252
Last modified:January 23, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i26EC965C9239774E
GO
Isoform 2 (identifier: P62913-2) [UniParc] [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     3-3: Missing.

Show »
Length:177
Mass (Da):20,124
Checksum:i534FC28B1D3CF195
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5VVC8Q5VVC8_HUMAN
60S ribosomal protein L11
RPL11
167Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8Y447A0A2R8Y447_HUMAN
60S ribosomal protein L11
RPL11
44Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti31D → G in CAA55816 (PubMed:7748210).Curated1
Sequence conflicti73T → A in CAA55816 (PubMed:7748210).Curated1
Sequence conflicti92Y → L in CAA55816 (PubMed:7748210).Curated1
Sequence conflicti118K → E in CAA55816 (PubMed:7748210).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05544820L → H in DBA7. 1 Publication1
Natural variantiVAR_055449161Missing in DBA7. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0083203Missing in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
X79234 mRNA Translation: CAA55816.1
L05092 mRNA Translation: AAC15856.1
AF101385 Genomic DNA Translation: AAD20460.3
BC018970 mRNA Translation: AAH18970.1
AF432212 mRNA Translation: AAL99919.1
AB007171 Genomic DNA Translation: BAA25831.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS238.1
CCDS85940.1 [P62913-2]

Protein sequence database of the Protein Information Resource

More...PIRi		S45049

NCBI Reference Sequences

More...RefSeqi		NP_000966.2, NM_000975.3 [P62913-1]
NP_001186731.1, NM_001199802.1 [P62913-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000374550; ENSP00000363676; ENSG00000142676 [P62913-2]
ENST00000643754; ENSP00000496250; ENSG00000142676 [P62913-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		6135

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:6135

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Diamond-Blackfan Anemia mutation database

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X79234 mRNA Translation: CAA55816.1
L05092 mRNA Translation: AAC15856.1
AF101385 Genomic DNA Translation: AAD20460.3
BC018970 mRNA Translation: AAH18970.1
AF432212 mRNA Translation: AAL99919.1
AB007171 Genomic DNA Translation: BAA25831.1
CCDSiCCDS238.1
CCDS85940.1 [P62913-2]
PIRiS45049
RefSeqiNP_000966.2, NM_000975.3 [P62913-1]
NP_001186731.1, NM_001199802.1 [P62913-2]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4UG0electron microscopy-LJ1-178[»]
4V6Xelectron microscopy5.00CJ1-178[»]
4XXBX-ray2.40A1-178[»]
5AJ0electron microscopy3.50AJ1-178[»]
5LKSelectron microscopy3.60LJ1-178[»]
5T2Celectron microscopy3.60q1-178[»]
6EK0electron microscopy2.90LJ1-178[»]
6IP5electron microscopy3.902E1-178[»]
6IP6electron microscopy4.502E1-178[»]
6IP8electron microscopy3.902E1-178[»]
6LQMelectron microscopy3.09N1-178[»]
6LSRelectron microscopy3.13N1-178[»]
6LSSelectron microscopy3.23N1-178[»]
6LU8electron microscopy3.13N1-178[»]
6OLEelectron microscopy3.10L9-177[»]
6OLFelectron microscopy3.90L9-177[»]
6OLGelectron microscopy3.40AJ9-177[»]
6OLIelectron microscopy3.50L9-177[»]
6OLZelectron microscopy3.90AJ9-177[»]
6OM0electron microscopy3.10L9-177[»]
6OM7electron microscopy3.70L9-177[»]
6QZPelectron microscopy2.90LJ3-178[»]
6W6Lelectron microscopy3.84L1-178[»]
6XA1electron microscopy2.80LJ3-178[»]
6Y0Gelectron microscopy3.20LJ1-178[»]
6Y2Lelectron microscopy3.00LJ1-178[»]
6Y57electron microscopy3.50LJ1-178[»]
6Y6Xelectron microscopy2.80LJ3-178[»]
6Z6Lelectron microscopy3.00LJ1-178[»]
6Z6Melectron microscopy3.10LJ1-178[»]
6Z6Nelectron microscopy2.90LJ1-178[»]
6ZM7electron microscopy2.70LJ1-178[»]
6ZMEelectron microscopy3.00LJ1-178[»]
6ZMIelectron microscopy2.60LJ1-178[»]
6ZMOelectron microscopy3.10LJ1-178[»]
7BHPelectron microscopy3.30LJ1-178[»]
SMRiP62913
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi112055, 375 interactors
ComplexPortaliCPX-5183, 60S cytosolic large ribosomal subunit
CORUMiP62913
IntActiP62913, 100 interactors
MINTiP62913
STRINGi9606.ENSP00000363676

Chemistry databases

DrugBankiDB02494, (S)-3-phenyllactic acid
DB07374, Anisomycin
DB08437, Puromycin

Protein family/group databases

MoonProtiP62913

PTM databases

iPTMnetiP62913
MetOSiteiP62913
PhosphoSitePlusiP62913
SwissPalmiP62913

Genetic variation databases

BioMutaiRPL11
DMDMi51702795

2D gel databases

SWISS-2DPAGEiP62913

Proteomic databases

EPDiP62913
jPOSTiP62913
MassIVEiP62913
PaxDbiP62913
PeptideAtlasiP62913
PRIDEiP62913
ProteomicsDBi57452
57453 [P62913-2]
TopDownProteomicsiP62913-1 [P62913-1]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		1241, 318 antibodies

The DNASU plasmid repository

More...DNASUi		6135

Genome annotation databases

EnsembliENST00000374550; ENSP00000363676; ENSG00000142676 [P62913-2]
ENST00000643754; ENSP00000496250; ENSG00000142676 [P62913-1]
GeneIDi6135
KEGGihsa:6135

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		6135
DisGeNETi6135

GeneCards: human genes, protein and diseases

More...GeneCardsi		RPL11
GeneReviewsiRPL11
HGNCiHGNC:10301, RPL11
HPAiENSG00000142676, Low tissue specificity
MalaCardsiRPL11
MIMi604175, gene
612562, phenotype
neXtProtiNX_P62913
OpenTargetsiENSG00000142676
Orphaneti124, Blackfan-Diamond anemia
PharmGKBiPA34664
VEuPathDBiHostDB:ENSG00000142676.12

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0397, Eukaryota
GeneTreeiENSGT00910000144211
HOGENOMiCLU_061015_3_0_1
InParanoidiP62913
OMAiEDTMAWF
PhylomeDBiP62913
TreeFamiTF300017

Enzyme and pathway databases

PathwayCommonsiP62913
ReactomeiR-HSA-156827, L13a-mediated translational silencing of Ceruloplasmin expression
R-HSA-156902, Peptide chain elongation
R-HSA-1799339, SRP-dependent cotranslational protein targeting to membrane
R-HSA-192823, Viral mRNA Translation
R-HSA-2408557, Selenocysteine synthesis
R-HSA-6791226, Major pathway of rRNA processing in the nucleolus and cytosol
R-HSA-72689, Formation of a pool of free 40S subunits
R-HSA-72706, GTP hydrolysis and joining of the 60S ribosomal subunit
R-HSA-72764, Eukaryotic Translation Termination
R-HSA-9010553, Regulation of expression of SLITs and ROBOs
R-HSA-9633012, Response of EIF2AK4 (GCN2) to amino acid deficiency
R-HSA-975956, Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-HSA-975957, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
SIGNORiP62913

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		6135, 814 hits in 993 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		RPL11, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		RPL11

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		6135
PharosiP62913, Tbio

Protein Ontology

More...PROi		PR:P62913
RNActiP62913, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000142676, Expressed in epithelium of bronchus and 243 other tissues
ExpressionAtlasiP62913, baseline and differential
GenevisibleiP62913, HS

Family and domain databases

Gene3Di3.30.1440.10, 1 hit
InterProiView protein in InterPro
IPR002132, Ribosomal_L5
IPR031309, Ribosomal_L5_C
IPR020929, Ribosomal_L5_CS
IPR022803, Ribosomal_L5_dom_sf
IPR031310, Ribosomal_L5_N
PANTHERiPTHR11994, PTHR11994, 1 hit
PfamiView protein in Pfam
PF00281, Ribosomal_L5, 1 hit
PF00673, Ribosomal_L5_C, 1 hit
PIRSFiPIRSF002161, Ribosomal_L5, 1 hit
SUPFAMiSSF55282, SSF55282, 1 hit
PROSITEiView protein in PROSITE
PS00358, RIBOSOMAL_L5, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRL11_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P62913
Secondary accession number(s): P25121
, P39026, Q8TDH2, Q9Y674
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: January 23, 2007
Last modified: June 2, 2021
This is version 172 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Ribosomal proteins
    Ribosomal proteins families and list of entries
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with genetic variants
    List of human entries with genetic variants
  4. Human variants curated from literature reports
    Index of human variants curated from literature reports
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again