UniProtKB - P62913 (RL11_HUMAN)
60S ribosomal protein L11
RPL11
Functioni
GO - Molecular functioni
- 5S rRNA binding Source: CAFA
- RNA binding Source: UniProtKB
- structural constituent of ribosome Source: GO_Central
- ubiquitin ligase inhibitor activity Source: CAFA
- ubiquitin protein ligase binding Source: CAFA
GO - Biological processi
- cytoplasmic translation Source: UniProtKB
- negative regulation of proteasomal ubiquitin-dependent protein catabolic process Source: UniProtKB
- negative regulation of protein neddylation Source: CAFA
- negative regulation of ubiquitin-dependent protein catabolic process Source: CAFA
- negative regulation of ubiquitin protein ligase activity Source: CAFA
- nuclear-transcribed mRNA catabolic process, nonsense-mediated decay Source: Reactome
- positive regulation of gene expression Source: CAFA
- positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator Source: Ensembl
- positive regulation of protein binding Source: CAFA
- protein localization to nucleus Source: UniProtKB
- protein stabilization Source: CAFA
- protein targeting Source: UniProtKB
- regulation of signal transduction by p53 class mediator Source: UniProtKB
- ribosomal large subunit assembly Source: UniProtKB
- ribosomal large subunit biogenesis Source: UniProtKB
- rRNA processing Source: UniProtKB
- SRP-dependent cotranslational protein targeting to membrane Source: Reactome
- translation Source: ProtInc
- translational initiation Source: Reactome
- viral transcription Source: Reactome
Keywordsi
Molecular function | Ribonucleoprotein, Ribosomal protein, RNA-binding, rRNA-binding |
Enzyme and pathway databases
Reactomei | R-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156902 Peptide chain elongation R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane R-HSA-192823 Viral mRNA Translation R-HSA-2408557 Selenocysteine synthesis R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-72689 Formation of a pool of free 40S subunits R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72764 Eukaryotic Translation Termination R-HSA-9010553 Regulation of expression of SLITs and ROBOs R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) |
SIGNORi | P62913 |
Protein family/group databases
MoonProti | P62913 |
Names & Taxonomyi
Protein namesi | Recommended name: 60S ribosomal protein L11Alternative name(s): CLL-associated antigen KW-12 Large ribosomal subunit protein uL51 Publication |
Gene namesi | Name:RPL11 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:10301 RPL11 |
MIMi | 604175 gene |
neXtProti | NX_P62913 |
Subcellular locationi
Cytosol
- cytosol Source: Reactome
- cytosolic large ribosomal subunit Source: UniProtKB
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
Nucleus
- nucleolus Source: UniProtKB
- nucleoplasm Source: UniProtKB
Other locations
- cytoplasm Source: UniProtKB
- membrane Source: UniProtKB
- polysomal ribosome Source: UniProtKB
- protein-containing complex Source: CAFA
Keywords - Cellular componenti
Cytoplasm, NucleusPathology & Biotechi
Involvement in diseasei
Diamond-Blackfan anemia 7 (DBA7)2 Publications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_055448 | 20 | L → H in DBA7. 1 Publication | 1 | |
Natural variantiVAR_055449 | 161 | Missing in DBA7. 1 Publication | 1 |
Keywords - Diseasei
Diamond-Blackfan anemia, Disease mutationOrganism-specific databases
DisGeNETi | 6135 |
GeneReviewsi | RPL11 |
MalaCardsi | RPL11 |
MIMi | 612562 phenotype |
OpenTargetsi | ENSG00000142676 |
Orphaneti | 124 Blackfan-Diamond anemia |
PharmGKBi | PA34664 |
Miscellaneous databases
Pharosi | P62913 |
Chemistry databases
DrugBanki | DB02494 Alpha-Hydroxy-Beta-Phenyl-Propionic Acid DB07374 Anisomycin DB08437 Puromycin |
Polymorphism and mutation databases
BioMutai | RPL11 |
DMDMi | 51702795 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources2 Publications | |||
ChainiPRO_0000125082 | 2 – 178 | 60S ribosomal protein L11Add BLAST | 177 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylalanineCombined sources2 Publications | 1 | |
Cross-linki | 38 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 44 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 47 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 52 | N6-acetyllysine; alternateCombined sources | 1 | |
Cross-linki | 52 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources | ||
Modified residuei | 85 | N6-acetyllysineCombined sources | 1 | |
Cross-linki | 154 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources |
Keywords - PTMi
Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | P62913 |
jPOSTi | P62913 |
MassIVEi | P62913 |
PaxDbi | P62913 |
PeptideAtlasi | P62913 |
PRIDEi | P62913 |
ProteomicsDBi | 57452 57453 [P62913-2] |
TopDownProteomicsi | P62913-1 [P62913-1] |
2D gel databases
SWISS-2DPAGEi | P62913 |
PTM databases
iPTMneti | P62913 |
PhosphoSitePlusi | P62913 |
SwissPalmi | P62913 |
Miscellaneous databases
PMAP-CutDBi | P62913 |
Expressioni
Gene expression databases
Bgeei | ENSG00000142676 Expressed in 232 organ(s), highest expression level in epithelium of bronchus |
ExpressionAtlasi | P62913 baseline and differential |
Genevisiblei | P62913 HS |
Organism-specific databases
HPAi | HPA002734 HPA074839 |
Interactioni
Subunit structurei
Component of the large ribosomal subunit (LSU).
Part of a LSU subcomplex, the 5S RNP which is composed of the 5S RNA, RPL5 and RPL11 (PubMed:24120868).
Interacts with PML (By similarity).
Interacts with MDM2; negatively regulates MDM2-mediated TP53 ubiquitination and degradation (PubMed:24120868).
Interacts with NOP53; retains RPL11 into the nucleolus (PubMed:24556985, PubMed:27829214).
By similarity3 PublicationsBinary interactionsi
GO - Molecular functioni
- ubiquitin protein ligase binding Source: CAFA
Protein-protein interaction databases
BioGridi | 112055, 309 interactors |
CORUMi | P62913 |
IntActi | P62913, 77 interactors |
MINTi | P62913 |
STRINGi | 9606.ENSP00000363676 |
Structurei
Secondary structure
3D structure databases
SMRi | P62913 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG0397 Eukaryota COG0094 LUCA |
GeneTreei | ENSGT00910000144211 |
HOGENOMi | HOG000231312 |
InParanoidi | P62913 |
KOi | K02868 |
OMAi | EDTMAWF |
OrthoDBi | 664798at2759 |
PhylomeDBi | P62913 |
TreeFami | TF300017 |
Family and domain databases
Gene3Di | 3.30.1440.10, 1 hit |
InterProi | View protein in InterPro IPR002132 Ribosomal_L5 IPR031309 Ribosomal_L5_C IPR020929 Ribosomal_L5_CS IPR022803 Ribosomal_L5_dom_sf IPR031310 Ribosomal_L5_N |
PANTHERi | PTHR11994 PTHR11994, 1 hit |
Pfami | View protein in Pfam PF00281 Ribosomal_L5, 1 hit PF00673 Ribosomal_L5_C, 1 hit |
PIRSFi | PIRSF002161 Ribosomal_L5, 1 hit |
SUPFAMi | SSF55282 SSF55282, 1 hit |
PROSITEi | View protein in PROSITE PS00358 RIBOSOMAL_L5, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAQDQGEKEN PMRELRIRKL CLNICVGESG DRLTRAAKVL EQLTGQTPVF
60 70 80 90 100
SKARYTVRSF GIRRNEKIAV HCTVRGAKAE EILEKGLKVR EYELRKNNFS
110 120 130 140 150
DTGNFGFGIQ EHIDLGIKYD PSIGIYGLDF YVVLGRPGFS IADKKRRTGC
160 170
IGAKHRISKE EAMRWFQQKY DGIILPGK
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ5VVC8 | Q5VVC8_HUMAN | 60S ribosomal protein L11 | RPL11 | 167 | Annotation score: | ||
A0A2R8Y447 | A0A2R8Y447_HUMAN | 60S ribosomal protein L11 | RPL11 | 44 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 31 | D → G in CAA55816 (PubMed:7748210).Curated | 1 | |
Sequence conflicti | 73 | T → A in CAA55816 (PubMed:7748210).Curated | 1 | |
Sequence conflicti | 92 | Y → L in CAA55816 (PubMed:7748210).Curated | 1 | |
Sequence conflicti | 118 | K → E in CAA55816 (PubMed:7748210).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_055448 | 20 | L → H in DBA7. 1 Publication | 1 | |
Natural variantiVAR_055449 | 161 | Missing in DBA7. 1 Publication | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_008320 | 3 | Missing in isoform 2. 1 Publication | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X79234 mRNA Translation: CAA55816.1 L05092 mRNA Translation: AAC15856.1 AF101385 Genomic DNA Translation: AAD20460.3 BC018970 mRNA Translation: AAH18970.1 AF432212 mRNA Translation: AAL99919.1 AB007171 Genomic DNA Translation: BAA25831.1 |
CCDSi | CCDS238.1 CCDS85940.1 [P62913-2] |
PIRi | S45049 |
RefSeqi | NP_000966.2, NM_000975.3 [P62913-1] NP_001186731.1, NM_001199802.1 [P62913-2] |
Genome annotation databases
Ensembli | ENST00000374550; ENSP00000363676; ENSG00000142676 [P62913-2] ENST00000643754; ENSP00000496250; ENSG00000142676 [P62913-1] |
GeneIDi | 6135 |
KEGGi | hsa:6135 |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Web resourcesi
Diamond-Blackfan Anemia mutation database |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X79234 mRNA Translation: CAA55816.1 L05092 mRNA Translation: AAC15856.1 AF101385 Genomic DNA Translation: AAD20460.3 BC018970 mRNA Translation: AAH18970.1 AF432212 mRNA Translation: AAL99919.1 AB007171 Genomic DNA Translation: BAA25831.1 |
CCDSi | CCDS238.1 CCDS85940.1 [P62913-2] |
PIRi | S45049 |
RefSeqi | NP_000966.2, NM_000975.3 [P62913-1] NP_001186731.1, NM_001199802.1 [P62913-2] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
4UG0 | electron microscopy | - | LJ | 1-178 | [»] | |
4V6X | electron microscopy | 5.00 | CJ | 1-178 | [»] | |
4XXB | X-ray | 2.40 | A | 1-178 | [»] | |
5AJ0 | electron microscopy | 3.50 | AJ | 1-178 | [»] | |
5LKS | electron microscopy | 3.60 | LJ | 1-178 | [»] | |
5T2C | electron microscopy | 3.60 | q | 1-178 | [»] | |
6EK0 | electron microscopy | 2.90 | LJ | 1-178 | [»] | |
6IP5 | electron microscopy | 3.90 | 2E | 1-178 | [»] | |
6IP6 | electron microscopy | 4.50 | 2E | 1-178 | [»] | |
6IP8 | electron microscopy | 3.90 | 2E | 1-178 | [»] | |
6OLE | electron microscopy | 3.10 | L | 9-177 | [»] | |
6OLF | electron microscopy | 3.90 | L | 9-177 | [»] | |
6OLG | electron microscopy | 3.40 | AJ | 9-177 | [»] | |
6OLI | electron microscopy | 3.50 | L | 9-177 | [»] | |
6OLZ | electron microscopy | 3.90 | AJ | 9-177 | [»] | |
6OM0 | electron microscopy | 3.10 | L | 9-177 | [»] | |
6OM7 | electron microscopy | 3.70 | L | 9-177 | [»] | |
6QZP | electron microscopy | 2.90 | LJ | 3-178 | [»] | |
SMRi | P62913 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGridi | 112055, 309 interactors |
CORUMi | P62913 |
IntActi | P62913, 77 interactors |
MINTi | P62913 |
STRINGi | 9606.ENSP00000363676 |
Chemistry databases
DrugBanki | DB02494 Alpha-Hydroxy-Beta-Phenyl-Propionic Acid DB07374 Anisomycin DB08437 Puromycin |
Protein family/group databases
MoonProti | P62913 |
PTM databases
iPTMneti | P62913 |
PhosphoSitePlusi | P62913 |
SwissPalmi | P62913 |
Polymorphism and mutation databases
BioMutai | RPL11 |
DMDMi | 51702795 |
2D gel databases
SWISS-2DPAGEi | P62913 |
Proteomic databases
EPDi | P62913 |
jPOSTi | P62913 |
MassIVEi | P62913 |
PaxDbi | P62913 |
PeptideAtlasi | P62913 |
PRIDEi | P62913 |
ProteomicsDBi | 57452 57453 [P62913-2] |
TopDownProteomicsi | P62913-1 [P62913-1] |
Protocols and materials databases
DNASUi | 6135 |
Genome annotation databases
Ensembli | ENST00000374550; ENSP00000363676; ENSG00000142676 [P62913-2] ENST00000643754; ENSP00000496250; ENSG00000142676 [P62913-1] |
GeneIDi | 6135 |
KEGGi | hsa:6135 |
Organism-specific databases
CTDi | 6135 |
DisGeNETi | 6135 |
GeneCardsi | RPL11 |
GeneReviewsi | RPL11 |
HGNCi | HGNC:10301 RPL11 |
HPAi | HPA002734 HPA074839 |
MalaCardsi | RPL11 |
MIMi | 604175 gene 612562 phenotype |
neXtProti | NX_P62913 |
OpenTargetsi | ENSG00000142676 |
Orphaneti | 124 Blackfan-Diamond anemia |
PharmGKBi | PA34664 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0397 Eukaryota COG0094 LUCA |
GeneTreei | ENSGT00910000144211 |
HOGENOMi | HOG000231312 |
InParanoidi | P62913 |
KOi | K02868 |
OMAi | EDTMAWF |
OrthoDBi | 664798at2759 |
PhylomeDBi | P62913 |
TreeFami | TF300017 |
Enzyme and pathway databases
Reactomei | R-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156902 Peptide chain elongation R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane R-HSA-192823 Viral mRNA Translation R-HSA-2408557 Selenocysteine synthesis R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-72689 Formation of a pool of free 40S subunits R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72764 Eukaryotic Translation Termination R-HSA-9010553 Regulation of expression of SLITs and ROBOs R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) |
SIGNORi | P62913 |
Miscellaneous databases
ChiTaRSi | RPL11 human |
GeneWikii | RPL11 |
GenomeRNAii | 6135 |
Pharosi | P62913 |
PMAP-CutDBi | P62913 |
PROi | PR:P62913 |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000142676 Expressed in 232 organ(s), highest expression level in epithelium of bronchus |
ExpressionAtlasi | P62913 baseline and differential |
Genevisiblei | P62913 HS |
Family and domain databases
Gene3Di | 3.30.1440.10, 1 hit |
InterProi | View protein in InterPro IPR002132 Ribosomal_L5 IPR031309 Ribosomal_L5_C IPR020929 Ribosomal_L5_CS IPR022803 Ribosomal_L5_dom_sf IPR031310 Ribosomal_L5_N |
PANTHERi | PTHR11994 PTHR11994, 1 hit |
Pfami | View protein in Pfam PF00281 Ribosomal_L5, 1 hit PF00673 Ribosomal_L5_C, 1 hit |
PIRSFi | PIRSF002161 Ribosomal_L5, 1 hit |
SUPFAMi | SSF55282 SSF55282, 1 hit |
PROSITEi | View protein in PROSITE PS00358 RIBOSOMAL_L5, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | RL11_HUMAN | |
Accessioni | P62913Primary (citable) accession number: P62913 Secondary accession number(s): P25121 Q9Y674 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 31, 2004 |
Last sequence update: | January 23, 2007 | |
Last modified: | November 13, 2019 | |
This is version 162 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Complete proteome, Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations - Ribosomal proteins
Ribosomal proteins families and list of entries - SIMILARITY comments
Index of protein domains and families - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references