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UniProtKB - P62908 (RS3_MOUSE)

Entry version 162 (02 Jun 2021)
Sequence version 1 (31 Aug 2004)
Previous versions | rss
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Protein

40S ribosomal protein S3

Gene

Rps3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in translation as a component of the 40S small ribosomal subunit (By similarity).

Has endonuclease activity and plays a role in repair of damaged DNA (PubMed:7775413).

Cleaves phosphodiester bonds of DNAs containing altered bases with broad specificity and cleaves supercoiled DNA more efficiently than relaxed DNA (By similarity).

Displays high binding affinity for 7,8-dihydro-8-oxoguanine (8-oxoG), a common DNA lesion caused by reactive oxygen species (ROS) (By similarity).

Has also been shown to bind with similar affinity to intact and damaged DNA (By similarity).

Stimulates the N-glycosylase activity of the base excision protein OGG1 (By similarity).

Enhances the uracil excision activity of UNG1 (By similarity).

Also stimulates the cleavage of the phosphodiester backbone by APEX1 (By similarity).

When located in the mitochondrion, reduces cellular ROS levels and mitochondrial DNA damage (By similarity).

Has also been shown to negatively regulate DNA repair in cells exposed to hydrogen peroxide (By similarity).

Plays a role in regulating transcription as part of the NF-kappa-B p65-p50 complex where it binds to the RELA/p65 subunit, enhances binding of the complex to DNA and promotes transcription of target genes (By similarity).

Represses its own translation by binding to its cognate mRNA (By similarity).

Binds to and protects TP53/p53 from MDM2-mediated ubiquitination (By similarity).

Involved in spindle formation and chromosome movement during mitosis by regulating microtubule polymerization (By similarity).

Involved in induction of apoptosis through its role in activation of CASP8 (PubMed:14988002).

Induces neuronal apoptosis by interacting with the E2F1 transcription factor and acting synergistically with it to up-regulate pro-apoptotic proteins BCL2L11/BIM and HRK/Dp5 (By similarity).

Interacts with TRADD following exposure to UV radiation and induces apoptosis by caspase-dependent JNK activation (By similarity).

By similarity2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding, Lyase, Ribonucleoprotein, Ribosomal protein, RNA-binding
Biological processApoptosis, Cell cycle, Cell division, DNA damage, DNA repair, Mitosis, Transcription, Transcription regulation, Translation regulation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-MMU-156827, L13a-mediated translational silencing of Ceruloplasmin expression
R-MMU-1799339, SRP-dependent cotranslational protein targeting to membrane
R-MMU-6791226, Major pathway of rRNA processing in the nucleolus and cytosol
R-MMU-72649, Translation initiation complex formation
R-MMU-72689, Formation of a pool of free 40S subunits
R-MMU-72695, Formation of the ternary complex, and subsequently, the 43S complex
R-MMU-72702, Ribosomal scanning and start codon recognition
R-MMU-72706, GTP hydrolysis and joining of the 60S ribosomal subunit
R-MMU-975956, Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-MMU-975957, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
40S ribosomal protein S3 (EC:4.2.99.181 Publication)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Rps3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...MGIi		MGI:1350917, Rps3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Membrane, Mitochondrion, Mitochondrion inner membrane, Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedBy similarity
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001303212 – 24340S ribosomal protein S3Add BLAST242

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineBy similarity1
Modified residuei6Phosphoserine; by PKC/PRKCDBy similarity1
Modified residuei35PhosphoserineBy similarity1
Modified residuei42Phosphothreonine; by MAPKBy similarity1
Modified residuei62N6-acetyllysineBy similarity1
Modified residuei64Asymmetric dimethylarginine; by PRMT1By similarity1
Modified residuei65Asymmetric dimethylarginine; by PRMT1By similarity1
Modified residuei67Asymmetric dimethylarginine; by PRMT1By similarity1
Modified residuei70Phosphothreonine; by PKBBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki90Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Modified residuei104PhosphoserineBy similarity1
Modified residuei132N6-succinyllysineCombined sources1
Cross-linki202Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Modified residuei209Phosphoserine; by IKKBBy similarity1
Cross-linki214Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity
Cross-linki214Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternateBy similarity
Modified residuei220PhosphothreonineBy similarity1
Modified residuei221PhosphothreonineCombined sources1
Modified residuei224PhosphoserineBy similarity1
Cross-linki230Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei242PhosphothreonineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Methylation by PRMT1 is required for import into the nucleolus and for ribosome assembly.By similarity
Sumoylation by SUMO1 enhances protein stability through increased resistance to proteolysis. Sumoylation occurs at one or more of the three consensus sites, Lys-18, Lys-214 and Lys-230.By similarity
Phosphorylation at Thr-221 by CDK1 occurs mainly in G2/M phase. Phosphorylation by PRKCD occurs on a non-ribosomal-associated form which results in translocation of RPS3 to the nucleus and enhances its endonuclease activity. Phosphorylated on Ser-209 by IKKB in response to activation of the NF-kappa-B p65-p50 complex which enhances the association of RPS3 with importin-alpha and mediates the nuclear translocation of RPS3. Phosphorylation by MAPK is required for translocation to the nucleus following exposure of cells to DNA damaging agents such as hydrogen peroxide. Phosphorylation by PKB/AKT mediates RPS3 nuclear translocation, enhances RPS3 endonuclease activity and suppresses RPS3-induced neuronal apoptosis.By similarity
Ubiquitinated. This is prevented by interaction with HSP90 which stabilizes the protein. Monoubiquitinated at Lys-214 by ZNF598 when a ribosome has stalled during translation of poly(A) sequences, leading to preclude synthesis of a long poly-lysine tail and initiate the ribosome quality control (RQC) pathway to degrade the potentially detrimental aberrant nascent polypeptide.By similarity
Ufmylated by UFL1.1 Publication

Keywords - PTMi

Acetylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

The CPTAC Assay portal

More...CPTACi		non-CPTAC-3873

Encyclopedia of Proteome Dynamics

More...EPDi		P62908

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P62908

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P62908

PeptideAtlas

More...PeptideAtlasi		P62908

PRoteomics IDEntifications database

More...PRIDEi		P62908

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		260854

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P62908

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P62908

SwissPalm database of S-palmitoylation events

More...SwissPalmi		P62908

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSMUSG00000030744, Expressed in dorsal pancreas and 283 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P62908, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the 40S small ribosomal subunit.

Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs.

Interacts with HNRPD.

Interacts with PRMT1; the interaction methylates RPS3.

Interacts with SUMO1; the interaction sumoylates RPS3.

Interacts with UBC9.

Interacts with CDK1; the interaction phosphorylates RPS3.

Interacts with PRKCD; the interaction phosphorylates RPS3.

Interacts with PKB/AKT; the interaction phosphorylates RPS3.

Interacts with E2F1; the interaction occurs in the absence of nerve growth factor and increases transcription of pro-apoptotic proteins BCL2L11/BIM and HRK/Dp5.

Interacts with the base excision repair proteins APEX1 and OGG1; interaction with OGG1 increases OGG1 N-glycosylase activity.

Interacts with UNG; the interaction increases the uracil excision activity of UNG1.

Interacts with HSP90; the interaction prevents the ubiquitination and proteasome-dependent degradation of RPS3 and is suppressed by increased ROS levels.

Interacts with TOM70; the interaction promotes translocation of RPS3 to the mitochondrion.

Interacts (via N-terminus) with RELA (via N-terminus); the interaction enhances the DNA-binding activity of the NF-kappa-B p65-p50 complex.

Interacts with NFKBIA; the interaction is direct and may bridge the interaction between RPS3 and RELA.

Interacts with IKKB; the interaction phosphorylates RPS3 and enhances its translocation to the nucleus.

Interacts (via KH domain) with MDM2 and TP53.

Interacts with TRADD.

Interacts with CRY1.

By similarity1 Publication

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		205106, 119 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...ComplexPortali		CPX-5261, 40S cytosolic small ribosomal subunit

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		P62908

Protein interaction database and analysis system

More...IntActi		P62908, 15 interactors

Molecular INTeraction database

More...MINTi		P62908

STRING: functional protein association networks

More...STRINGi		10090.ENSMUSP00000032998

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P62908, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Biological Magnetic Resonance Data Bank

More...BMRBi		P62908

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P62908

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini21 – 92KH type-2PROSITE-ProRule annotationAdd BLAST72

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni200 – 243DisorderedSequence analysisAdd BLAST44

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the universal ribosomal protein uS3 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3181, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000008610

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_058591_2_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P62908

Identification of Orthologs from Complete Genome Data

More...OMAi		MLPHDPE

Database of Orthologous Groups

More...OrthoDBi		1135751at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P62908

TreeFam database of animal gene trees

More...TreeFami		TF300901

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.30.1140.32, 1 hit
3.30.300.20, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR015946, KH_dom-like_a/b
IPR004044, KH_dom_type_2
IPR009019, KH_sf_prok-type
IPR001351, Ribosomal_S3_C
IPR036419, Ribosomal_S3_C_sf
IPR018280, Ribosomal_S3_CS
IPR005703, Ribosomal_S3_euk/arc

Pfam protein domain database

More...Pfami		View protein in Pfam
PF07650, KH_2, 1 hit
PF00189, Ribosomal_S3_C, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF54814, SSF54814, 1 hit
SSF54821, SSF54821, 1 hit

TIGRFAMs; a protein family database

More...TIGRFAMsi		TIGR01008, uS3_euk_arch, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50823, KH_TYPE_2, 1 hit
PS00548, RIBOSOMAL_S3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

P62908-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAVQISKKRK FVADGIFKAE LNEFLTRELA EDGYSGVEVR VTPTRTEIII 
        60         70         80         90        100
LATRTQNVLG EKGRRIRELT AVVQKRFGFP EGSVELYAEK VATRGLCAIA 
       110        120        130        140        150
QAESLRYKLL GGLAVRRACY GVLRFIMESG AKGCEVVVSG KLRGQRAKSM 
       160        170        180        190        200
KFVDGLMIHS GDPVNYYVDT AVRHVLLRQG VLGIKVKIML PWDPSGKIGP 
       210        220        230        240 
KKPLPDHVSI VEPKDEILPT TPISEQKGGK PEPPAMPQPV PTA
Length:243
Mass (Da):26,674
Last modified:August 31, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6B9BB34FDEE04AAF
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3YV43D3YV43_MOUSE
40S ribosomal protein S3
Rps3
191Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A140LI77A0A140LI77_MOUSE
40S ribosomal protein S3
Rps3
144Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
X76772 mRNA Translation: CAA54167.1
BC010721 mRNA Translation: AAH10721.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS40031.1

Protein sequence database of the Protein Information Resource

More...PIRi		S41170

NCBI Reference Sequences

More...RefSeqi		NP_036182.1, NM_012052.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSMUST00000032998; ENSMUSP00000032998; ENSMUSG00000030744

Database of genes from NCBI RefSeq genomes

More...GeneIDi		27050

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		mmu:27050

UCSC genome browser

More...UCSCi		uc009ilr.2, mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X76772 mRNA Translation: CAA54167.1
BC010721 mRNA Translation: AAH10721.1
CCDSiCCDS40031.1
PIRiS41170
RefSeqiNP_036182.1, NM_012052.2

3D structure databases

BMRBiP62908
SMRiP62908
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi205106, 119 interactors
ComplexPortaliCPX-5261, 40S cytosolic small ribosomal subunit
CORUMiP62908
IntActiP62908, 15 interactors
MINTiP62908
STRINGi10090.ENSMUSP00000032998

PTM databases

iPTMnetiP62908
PhosphoSitePlusiP62908
SwissPalmiP62908

Proteomic databases

CPTACinon-CPTAC-3873
EPDiP62908
jPOSTiP62908
PaxDbiP62908
PeptideAtlasiP62908
PRIDEiP62908
ProteomicsDBi260854

Protocols and materials databases

The DNASU plasmid repository

More...DNASUi		27050

Genome annotation databases

EnsembliENSMUST00000032998; ENSMUSP00000032998; ENSMUSG00000030744
GeneIDi27050
KEGGimmu:27050
UCSCiuc009ilr.2, mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		6188
MGIiMGI:1350917, Rps3

Phylogenomic databases

eggNOGiKOG3181, Eukaryota
GeneTreeiENSGT00390000008610
HOGENOMiCLU_058591_2_1_1
InParanoidiP62908
OMAiMLPHDPE
OrthoDBi1135751at2759
PhylomeDBiP62908
TreeFamiTF300901

Enzyme and pathway databases

ReactomeiR-MMU-156827, L13a-mediated translational silencing of Ceruloplasmin expression
R-MMU-1799339, SRP-dependent cotranslational protein targeting to membrane
R-MMU-6791226, Major pathway of rRNA processing in the nucleolus and cytosol
R-MMU-72649, Translation initiation complex formation
R-MMU-72689, Formation of a pool of free 40S subunits
R-MMU-72695, Formation of the ternary complex, and subsequently, the 43S complex
R-MMU-72702, Ribosomal scanning and start codon recognition
R-MMU-72706, GTP hydrolysis and joining of the 60S ribosomal subunit
R-MMU-975956, Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-MMU-975957, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		27050, 21 hits in 43 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		Rps3, mouse

Protein Ontology

More...PROi		PR:P62908
RNActiP62908, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSMUSG00000030744, Expressed in dorsal pancreas and 283 other tissues
GenevisibleiP62908, MM

Family and domain databases

Gene3Di3.30.1140.32, 1 hit
3.30.300.20, 1 hit
InterProiView protein in InterPro
IPR015946, KH_dom-like_a/b
IPR004044, KH_dom_type_2
IPR009019, KH_sf_prok-type
IPR001351, Ribosomal_S3_C
IPR036419, Ribosomal_S3_C_sf
IPR018280, Ribosomal_S3_CS
IPR005703, Ribosomal_S3_euk/arc
PfamiView protein in Pfam
PF07650, KH_2, 1 hit
PF00189, Ribosomal_S3_C, 1 hit
SUPFAMiSSF54814, SSF54814, 1 hit
SSF54821, SSF54821, 1 hit
TIGRFAMsiTIGR01008, uS3_euk_arch, 1 hit
PROSITEiView protein in PROSITE
PS50823, KH_TYPE_2, 1 hit
PS00548, RIBOSOMAL_S3, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRS3_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P62908
Secondary accession number(s): P17073, P47933
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: August 31, 2004
Last modified: June 2, 2021
This is version 162 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Reference proteome

Documents

  1. Ribosomal proteins
    Ribosomal proteins families and list of entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
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