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Protein

60S ribosomal protein L10a

Gene

RPL10A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the large ribosomal subunit.1 Publication

GO - Molecular functioni

  • RNA binding Source: UniProtKB
  • structural constituent of ribosome Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-HSA-156902 Peptide chain elongation
R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane
R-HSA-192823 Viral mRNA Translation
R-HSA-2408557 Selenocysteine synthesis
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol
R-HSA-72689 Formation of a pool of free 40S subunits
R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit
R-HSA-72764 Eukaryotic Translation Termination
R-HSA-9010553 Regulation of expression of SLITs and ROBOs
R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L10a
Alternative name(s):
CSA-19
Large ribosomal subunit protein uL11 Publication
Neural precursor cell expressed developmentally down-regulated protein 6
Short name:
NEDD-6
Gene namesi
Name:RPL10A
Synonyms:NEDD6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000198755.10
HGNCiHGNC:10299 RPL10A
MIMi615660 gene
neXtProtiNX_P62906

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi4736
OpenTargetsiENSG00000198755
PharmGKBiPA34661

Polymorphism and mutation databases

BioMutaiRPL10A
DMDMi51702773

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001258182 – 21760S ribosomal protein L10aAdd BLAST216

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserine1 Publication1
Modified residuei11PhosphotyrosineBy similarity1
Modified residuei91N6-acetyllysineBy similarity1
Modified residuei106N6-acetyllysineCombined sources1
Modified residuei118N6-acetyllysine; alternateCombined sources1
Cross-linki118Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateCombined sources
Cross-linki118Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Cross-linki161Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP62906
MaxQBiP62906
PaxDbiP62906
PeptideAtlasiP62906
PRIDEiP62906
ProteomicsDBi57450
TopDownProteomicsiP62906

2D gel databases

SWISS-2DPAGEiP62906

PTM databases

iPTMnetiP62906
PhosphoSitePlusiP62906
SwissPalmiP62906

Expressioni

Gene expression databases

BgeeiENSG00000198755
CleanExiHS_RPL10A
GenevisibleiP62906 HS

Organism-specific databases

HPAiHPA053803

Interactioni

Subunit structurei

Component of the large ribosomal subunit.1 Publication

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi110813, 190 interactors
CORUMiP62906
IntActiP62906, 41 interactors
MINTiP62906
STRINGi9606.ENSP00000363018

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4UG0electron microscopy-Lz1-217[»]
4V6Xelectron microscopy5.00Cz1-217[»]
5AJ0electron microscopy3.50Au1-217[»]
5LKSelectron microscopy3.60Lz1-217[»]
5T2Celectron microscopy3.60l1-217[»]
6EK0electron microscopy2.90Lz1-217[»]
ProteinModelPortaliP62906
SMRiP62906
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1570 Eukaryota
COG0081 LUCA
GeneTreeiENSGT00390000008767
HOGENOMiHOG000207014
HOVERGENiHBG055239
InParanoidiP62906
KOiK02865
OMAiIHLAINF
OrthoDBiEOG091G0KUI
PhylomeDBiP62906
TreeFamiTF300791

Family and domain databases

CDDicd00403 Ribosomal_L1, 1 hit
Gene3Di3.40.50.790, 1 hit
InterProiView protein in InterPro
IPR002143 Ribosomal_L1
IPR023674 Ribosomal_L1-like
IPR028364 Ribosomal_L1/biogenesis
IPR016095 Ribosomal_L1_3-a/b-sand
IPR023673 Ribosomal_L1_CS
PfamiView protein in Pfam
PF00687 Ribosomal_L1, 1 hit
PIRSFiPIRSF002155 Ribosomal_L1, 1 hit
SUPFAMiSSF56808 SSF56808, 1 hit
PROSITEiView protein in PROSITE
PS01199 RIBOSOMAL_L1, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P62906-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSKVSRDTL YEAVREVLHG NQRKRRKFLE TVELQISLKN YDPQKDKRFS
60 70 80 90 100
GTVRLKSTPR PKFSVCVLGD QQHCDEAKAV DIPHMDIEAL KKLNKNKKLV
110 120 130 140 150
KKLAKKYDAF LASESLIKQI PRILGPGLNK AGKFPSLLTH NENMVAKVDE
160 170 180 190 200
VKSTIKFQMK KVLCLAVAVG HVKMTDDELV YNIHLAVNFL VSLLKKNWQN
210
VRALYIKSTM GKPQRLY
Length:217
Mass (Da):24,831
Last modified:January 23, 2007 - v2
Checksum:i38F1A31119A751D3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti104A → V in AAA86463 (PubMed:7609734).Curated1
Sequence conflicti209T → P in BAC16802 (Ref. 2) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_034458154T → P. Corresponds to variant dbSNP:rs17838763Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U12404 mRNA Translation: AAA86463.1
AB082926 mRNA Translation: BAC16802.1
BT020040 mRNA Translation: AAV38843.1
BT020041 mRNA Translation: AAV38844.1
AK313181 mRNA Translation: BAG35998.1
AL022721 Genomic DNA No translation available.
CH471081 Genomic DNA Translation: EAX03831.1
BC006791 mRNA Translation: AAH06791.1
BC011366 mRNA Translation: AAH11366.1
BC070216 mRNA Translation: AAH70216.1
CCDSiCCDS4806.1
RefSeqiNP_009035.3, NM_007104.4
UniGeneiHs.148340
Hs.546269

Genome annotation databases

EnsembliENST00000322203; ENSP00000363018; ENSG00000198755
GeneIDi4736
KEGGihsa:4736
UCSCiuc003okp.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiRL10A_HUMAN
AccessioniPrimary (citable) accession number: P62906
Secondary accession number(s): B2R801
, P52859, P53025, Q5TZT6, Q8J013
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: January 23, 2007
Last modified: June 20, 2018
This is version 146 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Ribosomal proteins
    Ribosomal proteins families and list of entries
  7. SIMILARITY comments
    Index of protein domains and families

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