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Protein

60S ribosomal protein L31

Gene

RPL31

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-HSA-156902 Peptide chain elongation
R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane
R-HSA-192823 Viral mRNA Translation
R-HSA-2408557 Selenocysteine synthesis
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol
R-HSA-72689 Formation of a pool of free 40S subunits
R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit
R-HSA-72764 Eukaryotic Translation Termination
R-HSA-9010553 Regulation of expression of SLITs and ROBOs
R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L31
Alternative name(s):
Large ribosomal subunit protein eL311 Publication
Gene namesi
Name:RPL31
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000071082.10
HGNCiHGNC:10334 RPL31
MIMi617415 gene
neXtProtiNX_P62899

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi6160
OpenTargetsiENSG00000071082
PharmGKBiPA34715

Polymorphism and mutation databases

BioMutaiRPL31
DMDMi51702807

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001537631 – 12560S ribosomal protein L31Add BLAST125

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei15PhosphoserineBy similarity1
Modified residuei55N6-succinyllysineBy similarity1
Modified residuei70N6-succinyllysineBy similarity1
Modified residuei75N6-acetyllysine; alternateCombined sources1
Modified residuei75N6-succinyllysine; alternateBy similarity1
Modified residuei98PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP62899
MaxQBiP62899
PaxDbiP62899
PeptideAtlasiP62899
PRIDEiP62899
ProteomicsDBi57447
57448 [P62899-2]
57449 [P62899-3]
TopDownProteomicsiP62899-1 [P62899-1]

2D gel databases

SWISS-2DPAGEiP62899

PTM databases

iPTMnetiP62899
PhosphoSitePlusiP62899
SwissPalmiP62899

Expressioni

Gene expression databases

BgeeiENSG00000071082
CleanExiHS_RPL31
ExpressionAtlasiP62899 baseline and differential
GenevisibleiP62899 HS

Organism-specific databases

HPAiHPA072263

Interactioni

Protein-protein interaction databases

BioGridi112079, 159 interactors
CORUMiP62899
IntActiP62899, 51 interactors
MINTiP62899
STRINGi9606.ENSP00000386717

Structurei

3D structure databases

ProteinModelPortaliP62899
SMRiP62899
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0893 Eukaryota
COG2097 LUCA
GeneTreeiENSGT00390000005200
HOGENOMiHOG000216660
HOVERGENiHBG001549
InParanoidiP62899
KOiK02910
PhylomeDBiP62899
TreeFamiTF314858

Family and domain databases

CDDicd00463 Ribosomal_L31e, 1 hit
Gene3Di3.10.440.10, 1 hit
InterProiView protein in InterPro
IPR000054 Ribosomal_L31e
IPR020052 Ribosomal_L31e_CS
IPR023621 Ribosomal_L31e_dom_sf
PANTHERiPTHR10956 PTHR10956, 1 hit
PfamiView protein in Pfam
PF01198 Ribosomal_L31e, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD006030 Ribosomal_L31e, 1 hit
SMARTiView protein in SMART
SM01380 Ribosomal_L31e, 1 hit
SUPFAMiSSF54575 SSF54575, 1 hit
PROSITEiView protein in PROSITE
PS01144 RIBOSOMAL_L31E, 1 hit

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P62899-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAPAKKGGEK KKGRSAINEV VTREYTINIH KRIHGVGFKK RAPRALKEIR
60 70 80 90 100
KFAMKEMGTP DVRIDTRLNK AVWAKGIRNV PYRIRVRLSR KRNEDEDSPN
110 120
KLYTLVTYVP VTTFKNLQTV NVDEN
Length:125
Mass (Da):14,463
Last modified:August 31, 2004 - v1
Checksum:iBA9DBE79B9E1C071
GO
Isoform 2 (identifier: P62899-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     116-125: NLQTVNVDEN → ISVLNSVTVAKSP

Note: No experimental confirmation available.
Show »
Length:128
Mass (Da):14,632
Checksum:i73178D90B1AE79A8
GO
Isoform 3 (identifier: P62899-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     116-125: NLQTVNVDEN → SKFSIP

Note: No experimental confirmation available.
Show »
Length:121
Mass (Da):13,995
Checksum:iBAD3547E9019CF61
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_042572116 – 125NLQTVNVDEN → ISVLNSVTVAKSP in isoform 2. 1 Publication10
Alternative sequenceiVSP_043224116 – 125NLQTVNVDEN → SKFSIP in isoform 3. 1 Publication10

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X15940 mRNA Translation: CAA34066.1
AB061830 Genomic DNA Translation: BAB79468.1
AK297483 mRNA Translation: BAH12588.1
AC016738 Genomic DNA Translation: AAY14823.1
CH471127 Genomic DNA Translation: EAX01826.1
CH471127 Genomic DNA Translation: EAX01827.1
CH471127 Genomic DNA Translation: EAX01829.1
BC017343 mRNA Translation: AAH17343.1
BC070210 mRNA Translation: AAH70210.1
BC070373 mRNA Translation: AAH70373.1
X69181 mRNA Translation: CAA48925.1
CCDSiCCDS2049.1 [P62899-1]
CCDS46373.1 [P62899-2]
CCDS46374.1 [P62899-3]
PIRiS05576 R5HU31
RefSeqiNP_000984.1, NM_000993.4 [P62899-1]
NP_001092047.1, NM_001098577.2 [P62899-2]
NP_001093163.1, NM_001099693.1 [P62899-3]
UniGeneiHs.469473

Genome annotation databases

EnsembliENST00000264258; ENSP00000264258; ENSG00000071082 [P62899-1]
ENST00000409028; ENSP00000386717; ENSG00000071082 [P62899-2]
ENST00000409320; ENSP00000387163; ENSG00000071082 [P62899-3]
ENST00000409733; ENSP00000386681; ENSG00000071082 [P62899-1]
GeneIDi6160
KEGGihsa:6160
UCSCiuc002taq.5 human [P62899-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiRL31_HUMAN
AccessioniPrimary (citable) accession number: P62899
Secondary accession number(s): B7Z4K2
, D3DVJ4, P12947, Q53SQ5, Q6IRZ0, Q6LBJ6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: August 31, 2004
Last modified: July 18, 2018
This is version 147 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Ribosomal proteins
    Ribosomal proteins families and list of entries
  5. SIMILARITY comments
    Index of protein domains and families

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