UniProtKB - P62891 (RL39_HUMAN)
Protein
60S ribosomal protein L39
Gene
RPL39
Organism
Homo sapiens (Human)
Status
Functioni
Miscellaneous
This protein is the smallest and one of the most basic of the proteins in liver ribosomes.By similarity
GO - Molecular functioni
- RNA binding Source: UniProtKB
- structural constituent of ribosome Source: UniProtKB
GO - Biological processi
- antibacterial humoral response Source: UniProtKB
- antimicrobial humoral immune response mediated by antimicrobial peptide Source: UniProtKB
- cytoplasmic translation Source: UniProtKB
- defense response to Gram-positive bacterium Source: UniProtKB
- innate immune response in mucosa Source: UniProtKB
- nuclear-transcribed mRNA catabolic process, nonsense-mediated decay Source: Reactome
- SRP-dependent cotranslational protein targeting to membrane Source: Reactome
- translation Source: UniProtKB
- translational initiation Source: Reactome
- viral transcription Source: Reactome
Keywordsi
Molecular function | Ribonucleoprotein, Ribosomal protein |
Enzyme and pathway databases
PathwayCommonsi | P62891 |
Reactomei | R-HSA-156827, L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156902, Peptide chain elongation R-HSA-1799339, SRP-dependent cotranslational protein targeting to membrane R-HSA-192823, Viral mRNA Translation R-HSA-2408557, Selenocysteine synthesis R-HSA-6791226, Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-72689, Formation of a pool of free 40S subunits R-HSA-72706, GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72764, Eukaryotic Translation Termination R-HSA-9010553, Regulation of expression of SLITs and ROBOs R-HSA-9633012, Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-975956, Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975957, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) |
Names & Taxonomyi
Protein namesi | Recommended name: 60S ribosomal protein L39Alternative name(s): Large ribosomal subunit protein eL391 Publication |
Gene namesi | Name:RPL39 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:10350, RPL39 |
MIMi | 300899, gene |
neXtProti | NX_P62891 |
VEuPathDBi | HostDB:ENSG00000198918.7 |
Subcellular locationi
Cytosol
- cytosol Source: Reactome
- cytosolic large ribosomal subunit Source: UniProtKB
Extracellular region or secreted
- extracellular space Source: UniProtKB
Other locations
- polysomal ribosome Source: UniProtKB
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 6170 |
OpenTargetsi | ENSG00000198918 |
PharmGKBi | PA34743 |
Miscellaneous databases
Pharosi | P62891, Tbio |
Genetic variation databases
BioMutai | RPL39 |
DMDMi | 51702812 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000127024 | 1 – 51 | 60S ribosomal protein L39Add BLAST | 51 |
Proteomic databases
EPDi | P62891 |
jPOSTi | P62891 |
MassIVEi | P62891 |
MaxQBi | P62891 |
PaxDbi | P62891 |
PeptideAtlasi | P62891 |
PRIDEi | P62891 |
ProteomicsDBi | 57446 |
TopDownProteomicsi | P62891 |
PTM databases
iPTMneti | P62891 |
PhosphoSitePlusi | P62891 |
Expressioni
Gene expression databases
Bgeei | ENSG00000198918, Expressed in subventricular zone (outer) (primate) and 114 other tissues |
Genevisiblei | P62891, HS |
Organism-specific databases
HPAi | ENSG00000198918, Tissue enhanced (lymphoid) |
Interactioni
Subunit structurei
Interacts with IMPACT.
By similarityProtein-protein interaction databases
BioGRIDi | 112089, 58 interactors |
CORUMi | P62891 |
IntActi | P62891, 30 interactors |
MINTi | P62891 |
STRINGi | 9606.ENSP00000355315 |
Miscellaneous databases
RNActi | P62891, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the eukaryotic ribosomal protein eL39 family.Curated
Phylogenomic databases
eggNOGi | KOG0002, Eukaryota |
GeneTreei | ENSGT00390000014814 |
HOGENOMi | CLU_181948_3_0_1 |
InParanoidi | P62891 |
OMAi | MKRRHWR |
OrthoDBi | 1618745at2759 |
PhylomeDBi | P62891 |
TreeFami | TF300223 |
Family and domain databases
Gene3Di | 1.10.1620.10, 1 hit |
HAMAPi | MF_00629, Ribosomal_L39e, 1 hit |
InterProi | View protein in InterPro IPR000077, Ribosomal_L39 IPR020083, Ribosomal_L39_CS IPR023626, Ribosomal_L39e_dom_sf |
Pfami | View protein in Pfam PF00832, Ribosomal_L39, 1 hit |
SUPFAMi | SSF48662, SSF48662, 1 hit |
PROSITEi | View protein in PROSITE PS00051, RIBOSOMAL_L39E, 1 hit |
i Sequence
Sequence statusi: Complete.
P62891-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSSHKTFRIK RFLAKKQKQN RPIPQWIRMK TGNKIRYNSK RRHWRRTKLG
L
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U57846 mRNA Translation: AAB02265.1 D79205 mRNA Translation: BAA11465.1 AB061835 Genomic DNA Translation: BAB79473.1 BC001019 mRNA Translation: AAH01019.1 BC070205 mRNA Translation: AAH70205.1 AB046411 Genomic DNA Translation: BAB21257.1 |
CCDSi | CCDS14586.1 |
PIRi | G02654 |
RefSeqi | NP_000991.1, NM_001000.3 |
Genome annotation databases
Ensembli | ENST00000361575; ENSP00000355315; ENSG00000198918 |
GeneIDi | 6170 |
KEGGi | hsa:6170 |
UCSCi | uc004erx.3, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U57846 mRNA Translation: AAB02265.1 D79205 mRNA Translation: BAA11465.1 AB061835 Genomic DNA Translation: BAB79473.1 BC001019 mRNA Translation: AAH01019.1 BC070205 mRNA Translation: AAH70205.1 AB046411 Genomic DNA Translation: BAB21257.1 |
CCDSi | CCDS14586.1 |
PIRi | G02654 |
RefSeqi | NP_000991.1, NM_001000.3 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
4UG0 | electron microscopy | - | Ll | 1-51 | [»] | |
4V6X | electron microscopy | 5.00 | Cl | 1-51 | [»] | |
5AJ0 | electron microscopy | 3.50 | Al | 1-51 | [»] | |
5LKS | electron microscopy | 3.60 | Ll | 1-51 | [»] | |
5T2C | electron microscopy | 3.60 | f | 1-51 | [»] | |
6EK0 | electron microscopy | 2.90 | Ll | 1-51 | [»] | |
6IP5 | electron microscopy | 3.90 | 2f | 1-51 | [»] | |
6IP6 | electron microscopy | 4.50 | 2f | 1-51 | [»] | |
6IP8 | electron microscopy | 3.90 | 2f | 1-51 | [»] | |
6LQM | electron microscopy | 3.09 | P | 1-51 | [»] | |
6LSR | electron microscopy | 3.13 | P | 1-51 | [»] | |
6LSS | electron microscopy | 3.23 | P | 1-51 | [»] | |
6LU8 | electron microscopy | 3.13 | P | 1-51 | [»] | |
6OLE | electron microscopy | 3.10 | m | 2-51 | [»] | |
6OLF | electron microscopy | 3.90 | m | 2-51 | [»] | |
6OLG | electron microscopy | 3.40 | Al | 2-51 | [»] | |
6OLI | electron microscopy | 3.50 | m | 2-51 | [»] | |
6OLZ | electron microscopy | 3.90 | Al | 2-51 | [»] | |
6OM0 | electron microscopy | 3.10 | m | 2-51 | [»] | |
6OM7 | electron microscopy | 3.70 | m | 2-51 | [»] | |
6QZP | electron microscopy | 2.90 | Ll | 2-51 | [»] | |
6W6L | electron microscopy | 3.84 | m | 1-51 | [»] | |
6XA1 | electron microscopy | 2.80 | Ll | 2-51 | [»] | |
6Y0G | electron microscopy | 3.20 | Ll | 1-51 | [»] | |
6Y2L | electron microscopy | 3.00 | Ll | 1-51 | [»] | |
6Y57 | electron microscopy | 3.50 | Ll | 1-51 | [»] | |
6Y6X | electron microscopy | 2.80 | Ll | 2-51 | [»] | |
6Z6L | electron microscopy | 3.00 | Ll | 1-51 | [»] | |
6Z6M | electron microscopy | 3.10 | Ll | 1-51 | [»] | |
6Z6N | electron microscopy | 2.90 | Ll | 1-51 | [»] | |
6ZM7 | electron microscopy | 2.70 | Ll | 1-51 | [»] | |
6ZME | electron microscopy | 3.00 | Ll | 1-51 | [»] | |
6ZMI | electron microscopy | 2.60 | Ll | 1-51 | [»] | |
6ZMO | electron microscopy | 3.10 | Ll | 1-51 | [»] | |
SMRi | P62891 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 112089, 58 interactors |
CORUMi | P62891 |
IntActi | P62891, 30 interactors |
MINTi | P62891 |
STRINGi | 9606.ENSP00000355315 |
PTM databases
iPTMneti | P62891 |
PhosphoSitePlusi | P62891 |
Genetic variation databases
BioMutai | RPL39 |
DMDMi | 51702812 |
Proteomic databases
EPDi | P62891 |
jPOSTi | P62891 |
MassIVEi | P62891 |
MaxQBi | P62891 |
PaxDbi | P62891 |
PeptideAtlasi | P62891 |
PRIDEi | P62891 |
ProteomicsDBi | 57446 |
TopDownProteomicsi | P62891 |
Protocols and materials databases
Antibodypediai | 29833, 148 antibodies |
DNASUi | 6170 |
Genome annotation databases
Ensembli | ENST00000361575; ENSP00000355315; ENSG00000198918 |
GeneIDi | 6170 |
KEGGi | hsa:6170 |
UCSCi | uc004erx.3, human |
Organism-specific databases
CTDi | 6170 |
DisGeNETi | 6170 |
GeneCardsi | RPL39 |
HGNCi | HGNC:10350, RPL39 |
HPAi | ENSG00000198918, Tissue enhanced (lymphoid) |
MIMi | 300899, gene |
neXtProti | NX_P62891 |
OpenTargetsi | ENSG00000198918 |
PharmGKBi | PA34743 |
VEuPathDBi | HostDB:ENSG00000198918.7 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0002, Eukaryota |
GeneTreei | ENSGT00390000014814 |
HOGENOMi | CLU_181948_3_0_1 |
InParanoidi | P62891 |
OMAi | MKRRHWR |
OrthoDBi | 1618745at2759 |
PhylomeDBi | P62891 |
TreeFami | TF300223 |
Enzyme and pathway databases
PathwayCommonsi | P62891 |
Reactomei | R-HSA-156827, L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156902, Peptide chain elongation R-HSA-1799339, SRP-dependent cotranslational protein targeting to membrane R-HSA-192823, Viral mRNA Translation R-HSA-2408557, Selenocysteine synthesis R-HSA-6791226, Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-72689, Formation of a pool of free 40S subunits R-HSA-72706, GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72764, Eukaryotic Translation Termination R-HSA-9010553, Regulation of expression of SLITs and ROBOs R-HSA-9633012, Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-975956, Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975957, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) |
Miscellaneous databases
BioGRID-ORCSi | 6170, 19 hits in 103 CRISPR screens |
ChiTaRSi | RPL39, human |
GeneWikii | RPL39 |
GenomeRNAii | 6170 |
Pharosi | P62891, Tbio |
PROi | PR:P62891 |
RNActi | P62891, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000198918, Expressed in subventricular zone (outer) (primate) and 114 other tissues |
Genevisiblei | P62891, HS |
Family and domain databases
Gene3Di | 1.10.1620.10, 1 hit |
HAMAPi | MF_00629, Ribosomal_L39e, 1 hit |
InterProi | View protein in InterPro IPR000077, Ribosomal_L39 IPR020083, Ribosomal_L39_CS IPR023626, Ribosomal_L39e_dom_sf |
Pfami | View protein in Pfam PF00832, Ribosomal_L39, 1 hit |
SUPFAMi | SSF48662, SSF48662, 1 hit |
PROSITEi | View protein in PROSITE PS00051, RIBOSOMAL_L39E, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | RL39_HUMAN | |
Accessioni | P62891Primary (citable) accession number: P62891 Secondary accession number(s): P02404, P39025, Q9BYF2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 21, 1986 |
Last sequence update: | January 23, 2007 | |
Last modified: | February 10, 2021 | |
This is version 150 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Ribosomal proteins
Ribosomal proteins families and list of entries - Human chromosome X
Human chromosome X: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families