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Protein

60S ribosomal protein L39

Gene

RPL39

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Miscellaneous

This protein is the smallest and one of the most basic of the proteins in liver ribosomes.By similarity

GO - Molecular functioni

  • RNA binding Source: UniProtKB
  • structural constituent of ribosome Source: UniProtKB

GO - Biological processi

  • antibacterial humoral response Source: UniProtKB
  • antimicrobial humoral immune response mediated by antimicrobial peptide Source: UniProtKB
  • cytoplasmic translation Source: UniProtKB
  • defense response to Gram-positive bacterium Source: UniProtKB
  • innate immune response in mucosa Source: UniProtKB
  • nuclear-transcribed mRNA catabolic process, nonsense-mediated decay Source: Reactome
  • SRP-dependent cotranslational protein targeting to membrane Source: Reactome
  • translation Source: UniProtKB
  • translational initiation Source: Reactome

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-HSA-156902 Peptide chain elongation
R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane
R-HSA-192823 Viral mRNA Translation
R-HSA-2408557 Selenocysteine synthesis
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol
R-HSA-72689 Formation of a pool of free 40S subunits
R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit
R-HSA-72764 Eukaryotic Translation Termination
R-HSA-9010553 Regulation of expression of SLITs and ROBOs
R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L39
Alternative name(s):
Large ribosomal subunit protein eL391 Publication
Gene namesi
Name:RPL39
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000198918.7
HGNCiHGNC:10350 RPL39
MIMi300899 gene
neXtProtiNX_P62891

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi6170
OpenTargetsiENSG00000198918
PharmGKBiPA34743

Polymorphism and mutation databases

DMDMi51702812

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001270241 – 5160S ribosomal protein L39Add BLAST51

Proteomic databases

EPDiP62891
MaxQBiP62891
PaxDbiP62891
PeptideAtlasiP62891
PRIDEiP62891
ProteomicsDBi57446
TopDownProteomicsiP62891

PTM databases

iPTMnetiP62891
PhosphoSitePlusiP62891

Expressioni

Gene expression databases

BgeeiENSG00000198918
CleanExiHS_RPL39
GenevisibleiP62891 HS

Organism-specific databases

HPAiHPA047105

Interactioni

Subunit structurei

Interacts with IMPACT.By similarity

Protein-protein interaction databases

BioGridi112089, 20 interactors
CORUMiP62891
IntActiP62891, 19 interactors
MINTiP62891
STRINGi9606.ENSP00000355315

Structurei

3D structure databases

ProteinModelPortaliP62891
SMRiP62891
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0002 Eukaryota
COG2167 LUCA
GeneTreeiENSGT00390000014814
HOVERGENiHBG001245
InParanoidiP62891
KOiK02924
OMAiARQNRPI
OrthoDBiEOG091G18Y7
PhylomeDBiP62891
TreeFamiTF300223

Family and domain databases

Gene3Di1.10.1620.10, 1 hit
HAMAPiMF_00629 Ribosomal_L39e, 1 hit
InterProiView protein in InterPro
IPR000077 Ribosomal_L39
IPR020083 Ribosomal_L39_CS
IPR023626 Ribosomal_L39e_dom_sf
PANTHERiPTHR19970 PTHR19970, 1 hit
PfamiView protein in Pfam
PF00832 Ribosomal_L39, 1 hit
SUPFAMiSSF48662 SSF48662, 1 hit
PROSITEiView protein in PROSITE
PS00051 RIBOSOMAL_L39E, 1 hit

Sequencei

Sequence statusi: Complete.

P62891-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSHKTFRIK RFLAKKQKQN RPIPQWIRMK TGNKIRYNSK RRHWRRTKLG

L
Length:51
Mass (Da):6,407
Last modified:January 23, 2007 - v2
Checksum:i2023CA8590C7752C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U57846 mRNA Translation: AAB02265.1
D79205 mRNA Translation: BAA11465.1
AB061835 Genomic DNA Translation: BAB79473.1
BC001019 mRNA Translation: AAH01019.1
BC070205 mRNA Translation: AAH70205.1
AB046411 Genomic DNA Translation: BAB21257.1
CCDSiCCDS14586.1
PIRiG02654
RefSeqiNP_000991.1, NM_001000.3
UniGeneiHs.300141
Hs.558387

Genome annotation databases

EnsembliENST00000361575; ENSP00000355315; ENSG00000198918
GeneIDi6170
KEGGihsa:6170
UCSCiuc004erx.3 human

Similar proteinsi

Entry informationi

Entry nameiRL39_HUMAN
AccessioniPrimary (citable) accession number: P62891
Secondary accession number(s): P02404, P39025, Q9BYF2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: June 20, 2018
This is version 132 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Ribosomal proteins
    Ribosomal proteins families and list of entries
  5. SIMILARITY comments
    Index of protein domains and families

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