RPL39

Functionⁱ

Miscellaneous

This protein is the smallest and one of the most basic of the proteins in liver ribosomes.By similarity

GO - Molecular functionⁱ

RNA binding
Source: UniProtKB
Traceable author statementⁱ
- 8764829
structural constituent of ribosome
Source: UniProtKB
Traceable author statementⁱ
- 8764829

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

antibacterial humoral response
Source: UniProtKB
Inferred from direct assayⁱ
- 12860195
antimicrobial humoral immune response mediated by antimicrobial peptide
Source: UniProtKB
Inferred from direct assayⁱ
- 12860195
cytoplasmic translation
Source: UniProtKB
Inferred from direct assayⁱ
- 25957688
defense response to Gram-positive bacterium
Source: UniProtKB
Inferred from direct assayⁱ
- 12860195
innate immune response in mucosa
Source: UniProtKB
Inferred from direct assayⁱ
- 12860195
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay Source: Reactome
SRP-dependent cotranslational protein targeting to membrane Source: Reactome
translation
Source: UniProtKB
Traceable author statementⁱ
- 8764829
translational initiation Source: Reactome

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Ribonucleoprotein, Ribosomal protein

Molecular function

Ribonucleoprotein, Ribosomal protein

Enzyme and pathway databases

Reactomeⁱ	R-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156902 Peptide chain elongation R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane R-HSA-192823 Viral mRNA Translation R-HSA-2408557 Selenocysteine synthesis R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-72689 Formation of a pool of free 40S subunits R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72764 Eukaryotic Translation Termination R-HSA-9010553 Regulation of expression of SLITs and ROBOs R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Reactomeⁱ

R-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-HSA-156902 Peptide chain elongation
R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane
R-HSA-192823 Viral mRNA Translation
R-HSA-2408557 Selenocysteine synthesis
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol
R-HSA-72689 Formation of a pool of free 40S subunits
R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit
R-HSA-72764 Eukaryotic Translation Termination
R-HSA-9010553 Regulation of expression of SLITs and ROBOs
R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: 60S ribosomal protein L39 Alternative name(s): Large ribosomal subunit protein eL391 Publication
Gene namesⁱ	Name:RPL39
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome X

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000198918.7
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:10350 RPL39
MIMⁱ	300899 gene
neXtProtⁱ	NX_P62891

Subcellular locationⁱ

GO - Cellular component

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	6170
Open Targets More...OpenTargetsⁱ	ENSG00000198918
PharmGKBⁱ	PA34743

Polymorphism and mutation databases

DMDMⁱ	51702812

DMDMⁱ

51702812

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000127024	1 – 51	60S ribosomal protein L39Add BLAST		51

Proteomic databases

EPDⁱ	P62891
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P62891
PaxDbⁱ	P62891
PeptideAtlas More...PeptideAtlasⁱ	P62891
PRIDEⁱ	P62891
ProteomicsDBⁱ	57446
TopDownProteomicsⁱ	P62891

PTM databases

iPTMnetⁱ	P62891
PhosphoSitePlusⁱ	P62891

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000198918 Expressed in 89 organ(s), highest expression level in female gonad
CleanExⁱ	HS_RPL39
Genevisibleⁱ	P62891 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA047105

HPAⁱ

HPA047105

Interactionⁱ

Subunit structureⁱ

Interacts with IMPACT.By similarity

Protein-protein interaction databases

BioGridⁱ	112089, 20 interactors
CORUMⁱ	P62891
IntActⁱ	P62891, 19 interactors
Molecular INTeraction database More...MINTⁱ	P62891
STRINGⁱ	9606.ENSP00000355315

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P62891
SMRⁱ	P62891
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the eukaryotic ribosomal protein eL39 family.Curated

Phylogenomic databases

eggNOGⁱ	KOG0002 Eukaryota COG2167 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000014814
HOVERGENⁱ	HBG001245
InParanoidⁱ	P62891
KEGG Orthology (KO) More...KOⁱ	K02924
OMAⁱ	ARQNRPI
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G18Y7
PhylomeDBⁱ	P62891
TreeFamⁱ	TF300223

Family and domain databases

Gene3Dⁱ	1.10.1620.10, 1 hit
HAMAPⁱ	MF_00629 Ribosomal_L39e, 1 hit
InterProⁱ	View protein in InterPro IPR000077 Ribosomal_L39 IPR020083 Ribosomal_L39_CS IPR023626 Ribosomal_L39e_dom_sf
PANTHERⁱ	PTHR19970 PTHR19970, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00832 Ribosomal_L39, 1 hit
SUPFAMⁱ	SSF48662 SSF48662, 1 hit
PROSITEⁱ	View protein in PROSITE PS00051 RIBOSOMAL_L39E, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

P62891-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSSHKTFRIK RFLAKKQKQN RPIPQWIRMK TGNKIRYNSK RRHWRRTKLG 

L

Length:51

Mass (Da):6,407

Last modified:January 23, 2007 - v2

Checksum:ⁱ2023CA8590C7752C

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U57846 mRNA Translation: AAB02265.1 D79205 mRNA Translation: BAA11465.1 AB061835 Genomic DNA Translation: BAB79473.1 BC001019 mRNA Translation: AAH01019.1 BC070205 mRNA Translation: AAH70205.1 AB046411 Genomic DNA Translation: BAB21257.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS14586.1
PIRⁱ	G02654
NCBI Reference Sequences More...RefSeqⁱ	NP_000991.1, NM_001000.3
UniGeneⁱ	Hs.300141 Hs.558387

Genome annotation databases

Ensemblⁱ	ENST00000361575; ENSP00000355315; ENSG00000198918
GeneIDⁱ	6170
KEGGⁱ	hsa:6170
UCSC genome browser More...UCSCⁱ	uc004erx.3 human

Protein	Similar proteins		Species	Score	Length	Source
P62891	60S ribosomal protein L39		BOVIN		51	UniRef100_P62891
60S ribosomal protein L39		MOUSE		51
60S ribosomal protein L39		RAT		51
Uncharacterized protein		PAPAN		51
60S ribosomal protein L39		CALJA		51
+51

Protein	Similar proteins		Species	Score	Length	Source
P62891	60S ribosomal protein L39		BOVIN		51	UniRef90_P62891
60S ribosomal protein L39		MOUSE		51
60S ribosomal protein L39		RAT		51
Uncharacterized protein		PAPAN		51
60S ribosomal protein L39		CALJA		51
+51

Protein	Similar proteins		Species	Score	Length	Source
P62891	60S ribosomal protein L39		BOVIN		51	UniRef50_P62891
60S ribosomal protein L39		MOUSE		51
60S ribosomal protein L39		RAT		51
Uncharacterized protein		PAPAN		51
60S ribosomal protein L39		CALJA		51
+51

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U57846 mRNA Translation: AAB02265.1 D79205 mRNA Translation: BAA11465.1 AB061835 Genomic DNA Translation: BAB79473.1 BC001019 mRNA Translation: AAH01019.1 BC070205 mRNA Translation: AAH70205.1 AB046411 Genomic DNA Translation: BAB21257.1
CCDSⁱ	CCDS14586.1
PIRⁱ	G02654
RefSeqⁱ	NP_000991.1, NM_001000.3
UniGeneⁱ	Hs.300141 Hs.558387

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	4UG0	electron microscopy	-	Ll	1-51	[»]
	4V6X	electron microscopy	5.00	Cl	1-51	[»]
	5AJ0	electron microscopy	3.50	Al	1-51	[»]
	5LKS	electron microscopy	3.60	Ll	1-51	[»]
	5T2C	electron microscopy	3.60	f	1-51	[»]
	6EK0	electron microscopy	2.90	Ll	1-51	[»]
ProteinModelPortalⁱ	P62891
SMRⁱ	P62891
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	112089, 20 interactors
CORUMⁱ	P62891
IntActⁱ	P62891, 19 interactors
MINTⁱ	P62891
STRINGⁱ	9606.ENSP00000355315

PTM databases

iPTMnetⁱ	P62891
PhosphoSitePlusⁱ	P62891

Polymorphism and mutation databases

DMDMⁱ	51702812

DMDMⁱ

51702812

Proteomic databases

EPDⁱ	P62891
MaxQBⁱ	P62891
PaxDbⁱ	P62891
PeptideAtlasⁱ	P62891
PRIDEⁱ	P62891
ProteomicsDBⁱ	57446
TopDownProteomicsⁱ	P62891

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	6170
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000361575; ENSP00000355315; ENSG00000198918
GeneIDⁱ	6170
KEGGⁱ	hsa:6170
UCSCⁱ	uc004erx.3 human

Organism-specific databases

CTDⁱ	6170
DisGeNETⁱ	6170
EuPathDBⁱ	HostDB:ENSG00000198918.7
GeneCardsⁱ	RPL39
HGNCⁱ	HGNC:10350 RPL39
HPAⁱ	HPA047105
MIMⁱ	300899 gene
neXtProtⁱ	NX_P62891
OpenTargetsⁱ	ENSG00000198918
PharmGKBⁱ	PA34743
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0002 Eukaryota COG2167 LUCA
GeneTreeⁱ	ENSGT00390000014814
HOVERGENⁱ	HBG001245
InParanoidⁱ	P62891
KOⁱ	K02924
OMAⁱ	ARQNRPI
OrthoDBⁱ	EOG091G18Y7
PhylomeDBⁱ	P62891
TreeFamⁱ	TF300223

Enzyme and pathway databases

Reactomeⁱ	R-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156902 Peptide chain elongation R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane R-HSA-192823 Viral mRNA Translation R-HSA-2408557 Selenocysteine synthesis R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-72689 Formation of a pool of free 40S subunits R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72764 Eukaryotic Translation Termination R-HSA-9010553 Regulation of expression of SLITs and ROBOs R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Reactomeⁱ

R-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-HSA-156902 Peptide chain elongation
R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane
R-HSA-192823 Viral mRNA Translation
R-HSA-2408557 Selenocysteine synthesis
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol
R-HSA-72689 Formation of a pool of free 40S subunits
R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit
R-HSA-72764 Eukaryotic Translation Termination
R-HSA-9010553 Regulation of expression of SLITs and ROBOs
R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Miscellaneous databases

ChiTaRSⁱ	RPL39 human
GeneWikiⁱ	RPL39
GenomeRNAiⁱ	6170
Protein Ontology More...PROⁱ	PR:P62891
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000198918 Expressed in 89 organ(s), highest expression level in female gonad
CleanExⁱ	HS_RPL39
Genevisibleⁱ	P62891 HS

Family and domain databases

Gene3Dⁱ	1.10.1620.10, 1 hit
HAMAPⁱ	MF_00629 Ribosomal_L39e, 1 hit
InterProⁱ	View protein in InterPro IPR000077 Ribosomal_L39 IPR020083 Ribosomal_L39_CS IPR023626 Ribosomal_L39e_dom_sf
PANTHERⁱ	PTHR19970 PTHR19970, 1 hit
Pfamⁱ	View protein in Pfam PF00832 Ribosomal_L39, 1 hit
SUPFAMⁱ	SSF48662 SSF48662, 1 hit
PROSITEⁱ	View protein in PROSITE PS00051 RIBOSOMAL_L39E, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	RL39_HUMAN
Accessionⁱ	P62891Primary (citable) accession number: P62891 Secondary accession number(s): P02404, P39025, Q9BYF2
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 21, 1986
	Last sequence update:	January 23, 2007
	Last modified:	September 12, 2018
	This is version 133 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome X
Human chromosome X: entries, gene names and cross-references to MIM
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Ribosomal proteins
Ribosomal proteins families and list of entries
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P62891 (RL39_HUMAN)

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60S ribosomal protein L39

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Cytosol

Extracellular region or secreted

Other locations

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ