UniProtKB - P62888 (RL30_HUMAN)
Protein
60S ribosomal protein L30
Gene
RPL30
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- RNA binding Source: UniProtKB
- structural constituent of ribosome Source: GO_Central
GO - Biological processi
- antimicrobial humoral immune response mediated by antimicrobial peptide Source: UniProtKB
- cytoplasmic translation Source: UniProtKB
- defense response to Gram-negative bacterium Source: UniProtKB
- killing of cells of other organism Source: UniProtKB
- nuclear-transcribed mRNA catabolic process, nonsense-mediated decay Source: Reactome
- SRP-dependent cotranslational protein targeting to membrane Source: Reactome
- translation Source: UniProtKB
- translational initiation Source: Reactome
- viral transcription Source: Reactome
Keywordsi
Molecular function | Ribonucleoprotein, Ribosomal protein |
Enzyme and pathway databases
PathwayCommonsi | P62888 |
Reactomei | R-HSA-156827, L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156902, Peptide chain elongation R-HSA-1799339, SRP-dependent cotranslational protein targeting to membrane R-HSA-192823, Viral mRNA Translation R-HSA-2408557, Selenocysteine synthesis R-HSA-6791226, Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-72689, Formation of a pool of free 40S subunits R-HSA-72706, GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72764, Eukaryotic Translation Termination R-HSA-9010553, Regulation of expression of SLITs and ROBOs R-HSA-9633012, Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-975956, Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975957, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) |
Names & Taxonomyi
Protein namesi | Recommended name: 60S ribosomal protein L30Alternative name(s): Large ribosomal subunit protein eL301 Publication |
Gene namesi | Name:RPL30 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:10333, RPL30 |
MIMi | 180467, gene |
neXtProti | NX_P62888 |
VEuPathDBi | HostDB:ENSG00000156482.10 |
Subcellular locationi
Cytosol
- cytosol Source: Reactome
- cytosolic large ribosomal subunit Source: UniProtKB
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
Nucleus
- nucleus Source: UniProtKB
Other locations
- focal adhesion Source: UniProtKB
- membrane Source: UniProtKB
- polysomal ribosome Source: UniProtKB
- postsynaptic density Source: SynGO
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 6156 |
OpenTargetsi | ENSG00000156482 |
PharmGKBi | PA34714 |
Miscellaneous databases
Pharosi | P62888, Tbio |
Genetic variation databases
BioMutai | RPL30 |
DMDMi | 51702805 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000146120 | 1 – 115 | 60S ribosomal protein L30Add BLAST | 115 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 10 | PhosphoserineCombined sources | 1 | |
Modified residuei | 16 | PhosphoserineCombined sources | 1 | |
Modified residuei | 26 | N6-acetyllysine; alternateCombined sources | 1 | |
Cross-linki | 26 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources |
Keywords - PTMi
Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
CPTACi | CPTAC-434 CPTAC-435 |
EPDi | P62888 |
jPOSTi | P62888 |
MassIVEi | P62888 |
MaxQBi | P62888 |
PaxDbi | P62888 |
PeptideAtlasi | P62888 |
PRIDEi | P62888 |
ProteomicsDBi | 57445 |
TopDownProteomicsi | P62888 |
2D gel databases
SWISS-2DPAGEi | P62888 |
PTM databases
iPTMneti | P62888 |
MetOSitei | P62888 |
PhosphoSitePlusi | P62888 |
SwissPalmi | P62888 |
Expressioni
Gene expression databases
Bgeei | ENSG00000156482, Expressed in endometrium and 248 other tissues |
ExpressionAtlasi | P62888, baseline and differential |
Genevisiblei | P62888, HS |
Organism-specific databases
HPAi | ENSG00000156482, Low tissue specificity |
Interactioni
Binary interactionsi
P62888
With | #Exp. | IntAct |
---|---|---|
LRRK2 [Q5S007] | 3 | EBI-353116,EBI-5323863 |
Protein-protein interaction databases
BioGRIDi | 112075, 312 interactors |
ComplexPortali | CPX-5183, 60S cytosolic large ribosomal subunit |
CORUMi | P62888 |
IntActi | P62888, 171 interactors |
MINTi | P62888 |
STRINGi | 9606.ENSP00000428085 |
Miscellaneous databases
RNActi | P62888, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P62888 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Sequence similaritiesi
Belongs to the eukaryotic ribosomal protein eL30 family.Curated
Phylogenomic databases
eggNOGi | KOG2988, Eukaryota |
GeneTreei | ENSGT00390000012138 |
InParanoidi | P62888 |
OMAi | YEFEGTS |
OrthoDBi | 1503991at2759 |
PhylomeDBi | P62888 |
TreeFami | TF300252 |
Family and domain databases
Gene3Di | 3.30.1330.30, 1 hit |
HAMAPi | MF_00481, Ribosomal_L30e, 1 hit |
InterProi | View protein in InterPro IPR039109, L30/L30e/YlxQ IPR029064, L30e-like IPR000231, Ribosomal_L30e IPR022991, Ribosomal_L30e_CS IPR004038, Ribosomal_L7Ae/L30e/S12e/Gad45 |
PANTHERi | PTHR11449, PTHR11449, 1 hit PTHR11449:SF12, PTHR11449:SF12, 1 hit |
Pfami | View protein in Pfam PF01248, Ribosomal_L7Ae, 1 hit |
SUPFAMi | SSF55315, SSF55315, 1 hit |
PROSITEi | View protein in PROSITE PS00709, RIBOSOMAL_L30E_1, 1 hit PS00993, RIBOSOMAL_L30E_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All
P62888-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MVAAKKTKKS LESINSRLQL VMKSGKYVLG YKQTLKMIRQ GKAKLVILAN
60 70 80 90 100
NCPALRKSEI EYYAMLAKTG VHHYSGNNIE LGTACGKYYR VCTLAIIDPG
110
DSDIIRSMPE QTGEK
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketE5RI99 | E5RI99_HUMAN | 60S ribosomal protein L30 | RPL30 | 114 | Annotation score: | ||
E5RJH3 | E5RJH3_HUMAN | 60S ribosomal protein L30 | RPL30 | 56 | Annotation score: | ||
A0A0B4J213 | A0A0B4J213_HUMAN | 60S ribosomal protein L30 | RPL30 | 51 | Annotation score: | ||
A0A0C4DH44 | A0A0C4DH44_HUMAN | 60S ribosomal protein L30 | RPL30 | 96 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L05095 mRNA Translation: AAC15858.1 X79238 mRNA Translation: CAA55820.1 AB070559 Genomic DNA Translation: BAB79491.1 AK312102 mRNA Translation: BAG35038.1 CH471060 Genomic DNA Translation: EAW91770.1 BC032700 mRNA Translation: AAH32700.1 BC095426 mRNA Translation: AAH95426.1 |
CCDSi | CCDS34928.1 |
PIRi | S45004 |
RefSeqi | NP_000980.1, NM_000989.3 |
Genome annotation databases
Ensembli | ENST00000287038; ENSP00000287038; ENSG00000156482 ENST00000521291; ENSP00000428085; ENSG00000156482 |
GeneIDi | 6156 |
KEGGi | hsa:6156 |
UCSCi | uc003yif.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L05095 mRNA Translation: AAC15858.1 X79238 mRNA Translation: CAA55820.1 AB070559 Genomic DNA Translation: BAB79491.1 AK312102 mRNA Translation: BAG35038.1 CH471060 Genomic DNA Translation: EAW91770.1 BC032700 mRNA Translation: AAH32700.1 BC095426 mRNA Translation: AAH95426.1 |
CCDSi | CCDS34928.1 |
PIRi | S45004 |
RefSeqi | NP_000980.1, NM_000989.3 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
3VI6 | X-ray | 1.59 | A | 1-115 | [»] | |
4UG0 | electron microscopy | - | Lc | 1-115 | [»] | |
4V6X | electron microscopy | 5.00 | Cc | 1-115 | [»] | |
5AJ0 | electron microscopy | 3.50 | Ac | 1-115 | [»] | |
5LKS | electron microscopy | 3.60 | Lc | 1-115 | [»] | |
5T2C | electron microscopy | 3.60 | W | 1-115 | [»] | |
6EK0 | electron microscopy | 2.90 | Lc | 1-115 | [»] | |
6IP5 | electron microscopy | 3.90 | 2W | 1-115 | [»] | |
6IP6 | electron microscopy | 4.50 | 2W | 1-115 | [»] | |
6IP8 | electron microscopy | 3.90 | 2W | 1-115 | [»] | |
6LQM | electron microscopy | 3.09 | E | 1-115 | [»] | |
6LSR | electron microscopy | 3.13 | E | 1-115 | [»] | |
6LSS | electron microscopy | 3.23 | E | 1-115 | [»] | |
6LU8 | electron microscopy | 3.13 | E | 1-115 | [»] | |
6OLE | electron microscopy | 3.10 | d | 7-109 | [»] | |
6OLF | electron microscopy | 3.90 | d | 7-109 | [»] | |
6OLG | electron microscopy | 3.40 | Ac | 7-109 | [»] | |
6OLI | electron microscopy | 3.50 | d | 7-109 | [»] | |
6OLZ | electron microscopy | 3.90 | Ac | 7-109 | [»] | |
6OM0 | electron microscopy | 3.10 | d | 7-109 | [»] | |
6OM7 | electron microscopy | 3.70 | d | 7-109 | [»] | |
6QZP | electron microscopy | 2.90 | Lc | 9-106 | [»] | |
6W6L | electron microscopy | 3.84 | d | 1-115 | [»] | |
6XA1 | electron microscopy | 2.80 | Lc | 9-106 | [»] | |
6Y0G | electron microscopy | 3.20 | Lc | 1-115 | [»] | |
6Y2L | electron microscopy | 3.00 | Lc | 1-115 | [»] | |
6Y57 | electron microscopy | 3.50 | Lc | 1-115 | [»] | |
6Y6X | electron microscopy | 2.80 | Lc | 9-106 | [»] | |
6Z6L | electron microscopy | 3.00 | Lc | 1-115 | [»] | |
6Z6M | electron microscopy | 3.10 | Lc | 1-115 | [»] | |
6Z6N | electron microscopy | 2.90 | Lc | 1-115 | [»] | |
6ZM7 | electron microscopy | 2.70 | Lc | 1-115 | [»] | |
6ZME | electron microscopy | 3.00 | Lc | 1-115 | [»] | |
6ZMI | electron microscopy | 2.60 | Lc | 1-115 | [»] | |
6ZMO | electron microscopy | 3.10 | Lc | 1-115 | [»] | |
SMRi | P62888 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 112075, 312 interactors |
ComplexPortali | CPX-5183, 60S cytosolic large ribosomal subunit |
CORUMi | P62888 |
IntActi | P62888, 171 interactors |
MINTi | P62888 |
STRINGi | 9606.ENSP00000428085 |
PTM databases
iPTMneti | P62888 |
MetOSitei | P62888 |
PhosphoSitePlusi | P62888 |
SwissPalmi | P62888 |
Genetic variation databases
BioMutai | RPL30 |
DMDMi | 51702805 |
2D gel databases
SWISS-2DPAGEi | P62888 |
Proteomic databases
CPTACi | CPTAC-434 CPTAC-435 |
EPDi | P62888 |
jPOSTi | P62888 |
MassIVEi | P62888 |
MaxQBi | P62888 |
PaxDbi | P62888 |
PeptideAtlasi | P62888 |
PRIDEi | P62888 |
ProteomicsDBi | 57445 |
TopDownProteomicsi | P62888 |
Protocols and materials databases
Antibodypediai | 1242, 251 antibodies |
DNASUi | 6156 |
Genome annotation databases
Ensembli | ENST00000287038; ENSP00000287038; ENSG00000156482 ENST00000521291; ENSP00000428085; ENSG00000156482 |
GeneIDi | 6156 |
KEGGi | hsa:6156 |
UCSCi | uc003yif.4, human |
Organism-specific databases
CTDi | 6156 |
DisGeNETi | 6156 |
GeneCardsi | RPL30 |
HGNCi | HGNC:10333, RPL30 |
HPAi | ENSG00000156482, Low tissue specificity |
MIMi | 180467, gene |
neXtProti | NX_P62888 |
OpenTargetsi | ENSG00000156482 |
PharmGKBi | PA34714 |
VEuPathDBi | HostDB:ENSG00000156482.10 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2988, Eukaryota |
GeneTreei | ENSGT00390000012138 |
InParanoidi | P62888 |
OMAi | YEFEGTS |
OrthoDBi | 1503991at2759 |
PhylomeDBi | P62888 |
TreeFami | TF300252 |
Enzyme and pathway databases
PathwayCommonsi | P62888 |
Reactomei | R-HSA-156827, L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156902, Peptide chain elongation R-HSA-1799339, SRP-dependent cotranslational protein targeting to membrane R-HSA-192823, Viral mRNA Translation R-HSA-2408557, Selenocysteine synthesis R-HSA-6791226, Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-72689, Formation of a pool of free 40S subunits R-HSA-72706, GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72764, Eukaryotic Translation Termination R-HSA-9010553, Regulation of expression of SLITs and ROBOs R-HSA-9633012, Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-975956, Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975957, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) |
Miscellaneous databases
BioGRID-ORCSi | 6156, 620 hits in 863 CRISPR screens |
ChiTaRSi | RPL30, human |
GeneWikii | RPL30 |
GenomeRNAii | 6156 |
Pharosi | P62888, Tbio |
PROi | PR:P62888 |
RNActi | P62888, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000156482, Expressed in endometrium and 248 other tissues |
ExpressionAtlasi | P62888, baseline and differential |
Genevisiblei | P62888, HS |
Family and domain databases
Gene3Di | 3.30.1330.30, 1 hit |
HAMAPi | MF_00481, Ribosomal_L30e, 1 hit |
InterProi | View protein in InterPro IPR039109, L30/L30e/YlxQ IPR029064, L30e-like IPR000231, Ribosomal_L30e IPR022991, Ribosomal_L30e_CS IPR004038, Ribosomal_L7Ae/L30e/S12e/Gad45 |
PANTHERi | PTHR11449, PTHR11449, 1 hit PTHR11449:SF12, PTHR11449:SF12, 1 hit |
Pfami | View protein in Pfam PF01248, Ribosomal_L7Ae, 1 hit |
SUPFAMi | SSF55315, SSF55315, 1 hit |
PROSITEi | View protein in PROSITE PS00709, RIBOSOMAL_L30E_1, 1 hit PS00993, RIBOSOMAL_L30E_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | RL30_HUMAN | |
Accessioni | P62888Primary (citable) accession number: P62888 Secondary accession number(s): B2R591, P04645, Q502Z6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 13, 1987 |
Last sequence update: | January 23, 2007 | |
Last modified: | February 10, 2021 | |
This is version 161 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Ribosomal proteins
Ribosomal proteins families and list of entries - Human chromosome 8
Human chromosome 8: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families