RPL30

Functionⁱ

GO - Molecular functionⁱ

RNA binding
Source: UniProtKB
Inferred from high throughput direct assayⁱ
- 22658674
- 22681889
structural constituent of ribosome
Source: UniProtKB
Traceable author statementⁱ
- 1577483

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

antimicrobial humoral immune response mediated by antimicrobial peptide
Source: UniProtKB
Inferred from direct assayⁱ
- 15019208
cytoplasmic translation
Source: UniProtKB
Inferred from direct assayⁱ
- 25957688
defense response to Gram-negative bacterium
Source: UniProtKB
Inferred from direct assayⁱ
- 15019208
killing of cells of other organism
Source: UniProtKB
Inferred from direct assayⁱ
- 15019208
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay Source: Reactome
SRP-dependent cotranslational protein targeting to membrane Source: Reactome
translation
Source: UniProtKB
Traceable author statementⁱ
- 1577483
translational initiation Source: Reactome

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Ribonucleoprotein, Ribosomal protein

Molecular function

Ribonucleoprotein, Ribosomal protein

Enzyme and pathway databases

Reactomeⁱ	R-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156902 Peptide chain elongation R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane R-HSA-192823 Viral mRNA Translation R-HSA-2408557 Selenocysteine synthesis R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-72689 Formation of a pool of free 40S subunits R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72764 Eukaryotic Translation Termination R-HSA-9010553 Regulation of expression of SLITs and ROBOs R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Reactomeⁱ

R-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-HSA-156902 Peptide chain elongation
R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane
R-HSA-192823 Viral mRNA Translation
R-HSA-2408557 Selenocysteine synthesis
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol
R-HSA-72689 Formation of a pool of free 40S subunits
R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit
R-HSA-72764 Eukaryotic Translation Termination
R-HSA-9010553 Regulation of expression of SLITs and ROBOs
R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: 60S ribosomal protein L30 Alternative name(s): Large ribosomal subunit protein eL301 Publication
Gene namesⁱ	Name:RPL30
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 8

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000156482.10
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:10333 RPL30
MIMⁱ	180467 gene
neXtProtⁱ	NX_P62888

Subcellular locationⁱ

GO - Cellular component

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	6156
Open Targets More...OpenTargetsⁱ	ENSG00000156482
PharmGKBⁱ	PA34714

Polymorphism and mutation databases

BioMutaⁱ	RPL30
DMDMⁱ	51702805

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000146120	1 – 115	60S ribosomal protein L30Add BLAST		115

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	10	PhosphoserineCombined sources	1
Modified residueⁱ	16	PhosphoserineCombined sources	1
Modified residueⁱ	26	N6-acetyllysine; alternateCombined sources	1
Cross-linkⁱ	26	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources

Keywords - PTMⁱ

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDⁱ	P62888
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P62888
PaxDbⁱ	P62888
PeptideAtlas More...PeptideAtlasⁱ	P62888
PRIDEⁱ	P62888
ProteomicsDBⁱ	57445
TopDownProteomicsⁱ	P62888

2D gel databases

SWISS-2DPAGEⁱ	P62888

SWISS-2DPAGEⁱ

P62888

PTM databases

iPTMnetⁱ	P62888
PhosphoSitePlusⁱ	P62888
SwissPalmⁱ	P62888

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000156482 Expressed in 236 organ(s), highest expression level in endometrium
CleanExⁱ	HS_RPL30
ExpressionAtlasⁱ	P62888 baseline and differential
Genevisibleⁱ	P62888 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA002651

HPAⁱ

HPA002651

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	112075, 228 interactors
CORUMⁱ	P62888
IntActⁱ	P62888, 53 interactors
Molecular INTeraction database More...MINTⁱ	P62888
STRINGⁱ	9606.ENSP00000287038

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	15 – 24	Combined sources	10
Beta strandⁱ	25 – 30	Combined sources	6
Helixⁱ	31 – 39	Combined sources	9
Beta strandⁱ	44 – 48	Combined sources	5
Helixⁱ	54 – 66	Combined sources	13
Beta strandⁱ	70 – 73	Combined sources	4
Helixⁱ	78 – 84	Combined sources	7
Beta strandⁱ	93 – 98	Combined sources	6

Show more details

3D structure databases

ProteinModelPortalⁱ	P62888
SMRⁱ	P62888
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the eukaryotic ribosomal protein eL30 family.Curated

Phylogenomic databases

eggNOGⁱ	KOG2988 Eukaryota COG1911 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000012138
HOGENOMⁱ	HOG000055224
HOVERGENⁱ	HBG000449
InParanoidⁱ	P62888
KEGG Orthology (KO) More...KOⁱ	K02908
OMAⁱ	YEFEGTS
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0W6G
PhylomeDBⁱ	P62888
TreeFamⁱ	TF300252

Family and domain databases

Gene3Dⁱ	3.30.1330.30, 1 hit
HAMAPⁱ	MF_00481 Ribosomal_L30e, 1 hit
InterProⁱ	View protein in InterPro IPR039109 L30/L30e/YlxQ IPR029064 L30e-like IPR000231 Ribosomal_L30e IPR022991 Ribosomal_L30e_CS IPR004038 Ribosomal_L7Ae/L30e/S12e/Gad45
PANTHERⁱ	PTHR11449 PTHR11449, 1 hit PTHR11449:SF1 PTHR11449:SF1, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01248 Ribosomal_L7Ae, 1 hit
SUPFAMⁱ	SSF55315 SSF55315, 1 hit
PROSITEⁱ	View protein in PROSITE PS00709 RIBOSOMAL_L30E_1, 1 hit PS00993 RIBOSOMAL_L30E_2, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.ⁱShow all

P62888-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MVAAKKTKKS LESINSRLQL VMKSGKYVLG YKQTLKMIRQ GKAKLVILAN 
        60         70         80         90        100
NCPALRKSEI EYYAMLAKTG VHHYSGNNIE LGTACGKYYR VCTLAIIDPG 
       110 
DSDIIRSMPE QTGEK

Length:115

Mass (Da):12,784

Last modified:January 23, 2007 - v2

Checksum:ⁱ95186B081E39748C

GO

Computationally mapped potential isoform sequencesⁱ

There are 4 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation
E5RI99	E5RI99_HUMAN	60S ribosomal protein L30 60S ribosomal protein L30	RPL30	114	Annotation score:
E5RJH3	E5RJH3_HUMAN	60S ribosomal protein L30 60S ribosomal protein L30	RPL30	56	Annotation score:
A0A0B4J213	A0A0B4J213_HUMAN	60S ribosomal protein L30 60S ribosomal protein L30	RPL30	51	Annotation score:
A0A0C4DH44	A0A0C4DH44_HUMAN	60S ribosomal protein L30 60S ribosomal protein L30	RPL30	96	Annotation score:

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	L05095 mRNA Translation: AAC15858.1 X79238 mRNA Translation: CAA55820.1 AB070559 Genomic DNA Translation: BAB79491.1 AK312102 mRNA Translation: BAG35038.1 CH471060 Genomic DNA Translation: EAW91770.1 BC032700 mRNA Translation: AAH32700.1 BC095426 mRNA Translation: AAH95426.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS34928.1
PIRⁱ	S45004
NCBI Reference Sequences More...RefSeqⁱ	NP_000980.1, NM_000989.3
UniGeneⁱ	Hs.400295

Genome annotation databases

Ensemblⁱ	ENST00000287038; ENSP00000287038; ENSG00000156482 ENST00000521291; ENSP00000428085; ENSG00000156482
GeneIDⁱ	6156
KEGGⁱ	hsa:6156
UCSC genome browser More...UCSCⁱ	uc003yif.4 human

Protein	Similar proteins		Species	Score	Length	Source
P62888	60S ribosomal protein L30		BOVIN		115	UniRef100_P62888
60S ribosomal protein L30		MACFA		115
60S ribosomal protein L30		MOUSE		115
60S ribosomal protein L30		RAT		115
Ribosomal protein L30, isoform CRA_b		HUMAN		115
+37

Protein	Similar proteins		Species	Score	Length	Source
P62888	60S ribosomal protein L30		BOVIN		115	UniRef90_P62888
60S ribosomal protein L30		MACFA		115
60S ribosomal protein L30		MOUSE		115
60S ribosomal protein L30		RAT		115
Ribosomal protein L30, isoform CRA_b		HUMAN		115
+39

Protein	Similar proteins		Species	Score	Length	Source
P62888	60S ribosomal protein L30		BOVIN		115	UniRef50_P62888
60S ribosomal protein L30		MACFA		115
60S ribosomal protein L30		MOUSE		115
60S ribosomal protein L30		RAT		115
Ribosomal protein L30, isoform CRA_b		HUMAN		115
+40

Entry informationⁱ

Entry nameⁱ	RL30_HUMAN
Accessionⁱ	P62888Primary (citable) accession number: P62888 Secondary accession number(s): B2R591, P04645, Q502Z6
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	August 13, 1987
	Last sequence update:	January 23, 2007
	Last modified:	September 12, 2018
	This is version 140 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P62888 (RL30_HUMAN)

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60S ribosomal protein L30

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Cytosol

Extracellular region or secreted

Nucleus

Other locations

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

2D gel databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Computationally mapped potential isoform sequencesi

Sequence databases

Genome annotation databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Computationally mapped potential isoform sequencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ