Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

60S ribosomal protein L30

Gene

RPL30

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • RNA binding Source: UniProtKB
  • structural constituent of ribosome Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-HSA-156902 Peptide chain elongation
R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane
R-HSA-192823 Viral mRNA Translation
R-HSA-2408557 Selenocysteine synthesis
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol
R-HSA-72689 Formation of a pool of free 40S subunits
R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit
R-HSA-72764 Eukaryotic Translation Termination
R-HSA-9010553 Regulation of expression of SLITs and ROBOs
R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L30
Alternative name(s):
Large ribosomal subunit protein eL301 Publication
Gene namesi
Name:RPL30
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000156482.10
HGNCiHGNC:10333 RPL30
MIMi180467 gene
neXtProtiNX_P62888

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi6156
OpenTargetsiENSG00000156482
PharmGKBiPA34714

Polymorphism and mutation databases

BioMutaiRPL30
DMDMi51702805

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001461201 – 11560S ribosomal protein L30Add BLAST115

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei10PhosphoserineCombined sources1
Modified residuei16PhosphoserineCombined sources1
Modified residuei26N6-acetyllysine; alternateCombined sources1
Cross-linki26Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP62888
MaxQBiP62888
PaxDbiP62888
PeptideAtlasiP62888
PRIDEiP62888
ProteomicsDBi57445
TopDownProteomicsiP62888

2D gel databases

SWISS-2DPAGEiP62888

PTM databases

iPTMnetiP62888
PhosphoSitePlusiP62888
SwissPalmiP62888

Expressioni

Gene expression databases

BgeeiENSG00000156482 Expressed in 236 organ(s), highest expression level in endometrium
CleanExiHS_RPL30
ExpressionAtlasiP62888 baseline and differential
GenevisibleiP62888 HS

Organism-specific databases

HPAiHPA002651

Interactioni

Protein-protein interaction databases

BioGridi112075, 228 interactors
CORUMiP62888
IntActiP62888, 53 interactors
MINTiP62888
STRINGi9606.ENSP00000287038

Structurei

Secondary structure

1115
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP62888
SMRiP62888
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG2988 Eukaryota
COG1911 LUCA
GeneTreeiENSGT00390000012138
HOGENOMiHOG000055224
HOVERGENiHBG000449
InParanoidiP62888
KOiK02908
OMAiYEFEGTS
OrthoDBiEOG091G0W6G
PhylomeDBiP62888
TreeFamiTF300252

Family and domain databases

Gene3Di3.30.1330.30, 1 hit
HAMAPiMF_00481 Ribosomal_L30e, 1 hit
InterProiView protein in InterPro
IPR039109 L30/L30e/YlxQ
IPR029064 L30e-like
IPR000231 Ribosomal_L30e
IPR022991 Ribosomal_L30e_CS
IPR004038 Ribosomal_L7Ae/L30e/S12e/Gad45
PANTHERiPTHR11449 PTHR11449, 1 hit
PTHR11449:SF1 PTHR11449:SF1, 1 hit
PfamiView protein in Pfam
PF01248 Ribosomal_L7Ae, 1 hit
SUPFAMiSSF55315 SSF55315, 1 hit
PROSITEiView protein in PROSITE
PS00709 RIBOSOMAL_L30E_1, 1 hit
PS00993 RIBOSOMAL_L30E_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.iShow all

P62888-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVAAKKTKKS LESINSRLQL VMKSGKYVLG YKQTLKMIRQ GKAKLVILAN
60 70 80 90 100
NCPALRKSEI EYYAMLAKTG VHHYSGNNIE LGTACGKYYR VCTLAIIDPG
110
DSDIIRSMPE QTGEK
Length:115
Mass (Da):12,784
Last modified:January 23, 2007 - v2
Checksum:i95186B081E39748C
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E5RI99E5RI99_HUMAN
60S ribosomal protein L30
RPL30
114Annotation score:
E5RJH3E5RJH3_HUMAN
60S ribosomal protein L30
RPL30
56Annotation score:
A0A0B4J213A0A0B4J213_HUMAN
60S ribosomal protein L30
RPL30
51Annotation score:
A0A0C4DH44A0A0C4DH44_HUMAN
60S ribosomal protein L30
RPL30
96Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L05095 mRNA Translation: AAC15858.1
X79238 mRNA Translation: CAA55820.1
AB070559 Genomic DNA Translation: BAB79491.1
AK312102 mRNA Translation: BAG35038.1
CH471060 Genomic DNA Translation: EAW91770.1
BC032700 mRNA Translation: AAH32700.1
BC095426 mRNA Translation: AAH95426.1
CCDSiCCDS34928.1
PIRiS45004
RefSeqiNP_000980.1, NM_000989.3
UniGeneiHs.400295

Genome annotation databases

EnsembliENST00000287038; ENSP00000287038; ENSG00000156482
ENST00000521291; ENSP00000428085; ENSG00000156482
GeneIDi6156
KEGGihsa:6156
UCSCiuc003yif.4 human

Similar proteinsi

Entry informationi

Entry nameiRL30_HUMAN
AccessioniPrimary (citable) accession number: P62888
Secondary accession number(s): B2R591, P04645, Q502Z6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: January 23, 2007
Last modified: September 12, 2018
This is version 140 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again