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Protein

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

Gene

GNB2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

GO - Molecular functioni

  • calcium channel regulator activity Source: Ensembl
  • GTPase activity Source: ProtInc
  • GTPase binding Source: UniProtKB
  • protein-containing complex binding Source: MGI

GO - Biological processi

Keywordsi

Molecular functionTransducer

Enzyme and pathway databases

ReactomeiR-HSA-1296041 Activation of G protein gated Potassium channels
R-HSA-163359 Glucagon signaling in metabolic regulation
R-HSA-202040 G-protein activation
R-HSA-381676 Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
R-HSA-392170 ADP signalling through P2Y purinoceptor 12
R-HSA-392451 G beta:gamma signalling through PI3Kgamma
R-HSA-392851 Prostacyclin signalling through prostacyclin receptor
R-HSA-400042 Adrenaline,noradrenaline inhibits insulin secretion
R-HSA-4086398 Ca2+ pathway
R-HSA-416476 G alpha (q) signalling events
R-HSA-416482 G alpha (12/13) signalling events
R-HSA-418217 G beta:gamma signalling through PLC beta
R-HSA-418555 G alpha (s) signalling events
R-HSA-418592 ADP signalling through P2Y purinoceptor 1
R-HSA-418594 G alpha (i) signalling events
R-HSA-418597 G alpha (z) signalling events
R-HSA-420092 Glucagon-type ligand receptors
R-HSA-428930 Thromboxane signalling through TP receptor
R-HSA-432040 Vasopressin regulates renal water homeostasis via Aquaporins
R-HSA-456926 Thrombin signalling through proteinase activated receptors (PARs)
R-HSA-500657 Presynaptic function of Kainate receptors
R-HSA-6814122 Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
R-HSA-997272 Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
SignaLinkiP62879
SIGNORiP62879

Names & Taxonomyi

Protein namesi
Recommended name:
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2
Alternative name(s):
G protein subunit beta-2
Transducin beta chain 2
Gene namesi
Name:GNB2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000172354.9
HGNCiHGNC:4398 GNB2
MIMi139390 gene
neXtProtiNX_P62879

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000172354
PharmGKBiPA28778

Polymorphism and mutation databases

BioMutaiGNB2
DMDMi51317304

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources1 Publication
ChainiPRO_00001276952 – 340Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2Add BLAST339

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1 Publication1
Modified residuei239PhosphotyrosineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP62879
PaxDbiP62879
PeptideAtlasiP62879
PRIDEiP62879
ProteomicsDBi57444
TopDownProteomicsiP62879-1 [P62879-1]

2D gel databases

OGPiP62879
REPRODUCTION-2DPAGEiP62879

PTM databases

iPTMnetiP62879
PhosphoSitePlusiP62879
SwissPalmiP62879

Expressioni

Gene expression databases

BgeeiENSG00000172354 Expressed in 224 organ(s), highest expression level in blood
CleanExiHS_GNB2
ExpressionAtlasiP62879 baseline and differential
GenevisibleiP62879 HS

Organism-specific databases

HPAiCAB010032
HPA040736

Interactioni

Subunit structurei

G proteins are composed of 3 units, alpha, beta and gamma. Interacts with ARHGEF18 and RASD2. Interacts with ATXN10. Interacts with SCN8A (PubMed:26900580).4 Publications

GO - Molecular functioni

Protein-protein interaction databases

BioGridi109045, 166 interactors
IntActiP62879, 51 interactors
MINTiP62879
STRINGi9606.ENSP00000305260

Structurei

3D structure databases

ProteinModelPortaliP62879
SMRiP62879
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati53 – 83WD 1Add BLAST31
Repeati95 – 125WD 2Add BLAST31
Repeati141 – 170WD 3Add BLAST30
Repeati182 – 212WD 4Add BLAST31
Repeati224 – 254WD 5Add BLAST31
Repeati268 – 298WD 6Add BLAST31
Repeati310 – 340WD 7Add BLAST31

Sequence similaritiesi

Belongs to the WD repeat G protein beta family.Curated

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0286 Eukaryota
ENOG410XQUX LUCA
GeneTreeiENSGT00760000119239
HOGENOMiHOG000176356
HOVERGENiHBG000188
InParanoidiP62879
KOiK04537
OMAiLYCHDNI
OrthoDBiEOG091G0A7T
PhylomeDBiP62879
TreeFamiTF106149

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR020472 G-protein_beta_WD-40_rep
IPR001632 Gprotein_B
IPR016346 Guanine_nucleotide-bd_bsu
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PANTHERiPTHR19850 PTHR19850, 1 hit
PfamiView protein in Pfam
PF00400 WD40, 7 hits
PRINTSiPR00319 GPROTEINB
PR00320 GPROTEINBRPT
SMARTiView protein in SMART
SM00320 WD40, 7 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 3 hits
PS50082 WD_REPEATS_2, 6 hits
PS50294 WD_REPEATS_REGION, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P62879-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSELEQLRQE AEQLRNQIRD ARKACGDSTL TQITAGLDPV GRIQMRTRRT
60 70 80 90 100
LRGHLAKIYA MHWGTDSRLL VSASQDGKLI IWDSYTTNKV HAIPLRSSWV
110 120 130 140 150
MTCAYAPSGN FVACGGLDNI CSIYSLKTRE GNVRVSRELP GHTGYLSCCR
160 170 180 190 200
FLDDNQIITS SGDTTCALWD IETGQQTVGF AGHSGDVMSL SLAPDGRTFV
210 220 230 240 250
SGACDASIKL WDVRDSMCRQ TFIGHESDIN AVAFFPNGYA FTTGSDDATC
260 270 280 290 300
RLFDLRADQE LLMYSHDNII CGITSVAFSR SGRLLLAGYD DFNCNIWDAM
310 320 330 340
KGDRAGVLAG HDNRVSCLGV TDDGMAVATG SWDSFLKIWN
Length:340
Mass (Da):37,331
Last modified:January 23, 2007 - v3
Checksum:i5D08FFA240ADEEE6
GO
Isoform 2 (identifier: P62879-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-100: Missing.

Note: No experimental confirmation available.
Show »
Length:240
Mass (Da):25,931
Checksum:i88597902259DAF68
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JXA5C9JXA5_HUMAN
Guanine nucleotide-binding protein ...
GNB2
251Annotation score:
C9JIS1C9JIS1_HUMAN
Guanine nucleotide-binding protein ...
GNB2
232Annotation score:
C9JZN1C9JZN1_HUMAN
Guanine nucleotide-binding protein ...
GNB2
152Annotation score:
E7EP32E7EP32_HUMAN
Guanine nucleotide-binding protein ...
GNB2
296Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti195D → N in AAA35922 (PubMed:3114742).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0565151 – 100Missing in isoform 2. 1 PublicationAdd BLAST100

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M16514 mRNA Translation: AAA03179.1
M36429 mRNA Translation: AAA63264.1
M16538 mRNA Translation: AAA35922.1
AF053356 Genomic DNA Translation: AAC78794.1
AF501883 mRNA Translation: AAM15919.1
AK056750 mRNA Translation: BAG51803.1
AC009488 Genomic DNA No translation available.
BC010073 mRNA Translation: AAH10073.1
BC012348 mRNA Translation: AAH12348.1
BC068003 mRNA Translation: AAH68003.1
CCDSiCCDS5703.1 [P62879-1]
PIRiB26617 RGHUB2
RefSeqiNP_005264.2, NM_005273.3 [P62879-1]
UniGeneiHs.185172

Genome annotation databases

EnsembliENST00000303210; ENSP00000305260; ENSG00000172354 [P62879-1]
ENST00000393924; ENSP00000377501; ENSG00000172354 [P62879-1]
ENST00000393926; ENSP00000377503; ENSG00000172354 [P62879-1]
ENST00000419828; ENSP00000390543; ENSG00000172354 [P62879-2]
ENST00000427895; ENSP00000400286; ENSG00000172354 [P62879-2]
GeneIDi2783
KEGGihsa:2783
UCSCiuc064ggx.1 human [P62879-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M16514 mRNA Translation: AAA03179.1
M36429 mRNA Translation: AAA63264.1
M16538 mRNA Translation: AAA35922.1
AF053356 Genomic DNA Translation: AAC78794.1
AF501883 mRNA Translation: AAM15919.1
AK056750 mRNA Translation: BAG51803.1
AC009488 Genomic DNA No translation available.
BC010073 mRNA Translation: AAH10073.1
BC012348 mRNA Translation: AAH12348.1
BC068003 mRNA Translation: AAH68003.1
CCDSiCCDS5703.1 [P62879-1]
PIRiB26617 RGHUB2
RefSeqiNP_005264.2, NM_005273.3 [P62879-1]
UniGeneiHs.185172

3D structure databases

ProteinModelPortaliP62879
SMRiP62879
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109045, 166 interactors
IntActiP62879, 51 interactors
MINTiP62879
STRINGi9606.ENSP00000305260

PTM databases

iPTMnetiP62879
PhosphoSitePlusiP62879
SwissPalmiP62879

Polymorphism and mutation databases

BioMutaiGNB2
DMDMi51317304

2D gel databases

OGPiP62879
REPRODUCTION-2DPAGEiP62879

Proteomic databases

EPDiP62879
PaxDbiP62879
PeptideAtlasiP62879
PRIDEiP62879
ProteomicsDBi57444
TopDownProteomicsiP62879-1 [P62879-1]

Protocols and materials databases

DNASUi2783
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000303210; ENSP00000305260; ENSG00000172354 [P62879-1]
ENST00000393924; ENSP00000377501; ENSG00000172354 [P62879-1]
ENST00000393926; ENSP00000377503; ENSG00000172354 [P62879-1]
ENST00000419828; ENSP00000390543; ENSG00000172354 [P62879-2]
ENST00000427895; ENSP00000400286; ENSG00000172354 [P62879-2]
GeneIDi2783
KEGGihsa:2783
UCSCiuc064ggx.1 human [P62879-1]

Organism-specific databases

CTDi2783
EuPathDBiHostDB:ENSG00000172354.9
GeneCardsiGNB2
HGNCiHGNC:4398 GNB2
HPAiCAB010032
HPA040736
MIMi139390 gene
neXtProtiNX_P62879
OpenTargetsiENSG00000172354
PharmGKBiPA28778
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0286 Eukaryota
ENOG410XQUX LUCA
GeneTreeiENSGT00760000119239
HOGENOMiHOG000176356
HOVERGENiHBG000188
InParanoidiP62879
KOiK04537
OMAiLYCHDNI
OrthoDBiEOG091G0A7T
PhylomeDBiP62879
TreeFamiTF106149

Enzyme and pathway databases

ReactomeiR-HSA-1296041 Activation of G protein gated Potassium channels
R-HSA-163359 Glucagon signaling in metabolic regulation
R-HSA-202040 G-protein activation
R-HSA-381676 Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
R-HSA-392170 ADP signalling through P2Y purinoceptor 12
R-HSA-392451 G beta:gamma signalling through PI3Kgamma
R-HSA-392851 Prostacyclin signalling through prostacyclin receptor
R-HSA-400042 Adrenaline,noradrenaline inhibits insulin secretion
R-HSA-4086398 Ca2+ pathway
R-HSA-416476 G alpha (q) signalling events
R-HSA-416482 G alpha (12/13) signalling events
R-HSA-418217 G beta:gamma signalling through PLC beta
R-HSA-418555 G alpha (s) signalling events
R-HSA-418592 ADP signalling through P2Y purinoceptor 1
R-HSA-418594 G alpha (i) signalling events
R-HSA-418597 G alpha (z) signalling events
R-HSA-420092 Glucagon-type ligand receptors
R-HSA-428930 Thromboxane signalling through TP receptor
R-HSA-432040 Vasopressin regulates renal water homeostasis via Aquaporins
R-HSA-456926 Thrombin signalling through proteinase activated receptors (PARs)
R-HSA-500657 Presynaptic function of Kainate receptors
R-HSA-6814122 Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
R-HSA-997272 Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
SignaLinkiP62879
SIGNORiP62879

Miscellaneous databases

ChiTaRSiGNB2 human
GeneWikiiGNB2
GenomeRNAii2783
PROiPR:P62879
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000172354 Expressed in 224 organ(s), highest expression level in blood
CleanExiHS_GNB2
ExpressionAtlasiP62879 baseline and differential
GenevisibleiP62879 HS

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR020472 G-protein_beta_WD-40_rep
IPR001632 Gprotein_B
IPR016346 Guanine_nucleotide-bd_bsu
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PANTHERiPTHR19850 PTHR19850, 1 hit
PfamiView protein in Pfam
PF00400 WD40, 7 hits
PRINTSiPR00319 GPROTEINB
PR00320 GPROTEINBRPT
SMARTiView protein in SMART
SM00320 WD40, 7 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 3 hits
PS50082 WD_REPEATS_2, 6 hits
PS50294 WD_REPEATS_REGION, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGBB2_HUMAN
AccessioniPrimary (citable) accession number: P62879
Secondary accession number(s): B3KPU1, P11016, P54312
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: January 23, 2007
Last modified: November 7, 2018
This is version 157 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
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