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Entry version 165 (07 Apr 2021)
Sequence version 1 (16 Aug 2004)
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Protein

DNA-directed RNA polymerases I, II, and III subunit RPABC5

Gene

POLR2L

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and a small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, POLR2L/RBP10 is part of the core element with the central large cleft (By similarity).By similarity1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi7ZincBy similarity1
Metal bindingi10ZincBy similarity1
Metal bindingi44ZincBy similarity1
Metal bindingi45ZincBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTranscription
LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
P62875

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-112382, Formation of RNA Pol II elongation complex
R-HSA-113418, Formation of the Early Elongation Complex
R-HSA-167152, Formation of HIV elongation complex in the absence of HIV Tat
R-HSA-167158, Formation of the HIV-1 Early Elongation Complex
R-HSA-167160, RNA Pol II CTD phosphorylation and interaction with CE during HIV infection
R-HSA-167161, HIV Transcription Initiation
R-HSA-167162, RNA Polymerase II HIV Promoter Escape
R-HSA-167172, Transcription of the HIV genome
R-HSA-167200, Formation of HIV-1 elongation complex containing HIV-1 Tat
R-HSA-167238, Pausing and recovery of Tat-mediated HIV elongation
R-HSA-167242, Abortive elongation of HIV-1 transcript in the absence of Tat
R-HSA-167243, Tat-mediated HIV elongation arrest and recovery
R-HSA-167246, Tat-mediated elongation of the HIV-1 transcript
R-HSA-167287, HIV elongation arrest and recovery
R-HSA-167290, Pausing and recovery of HIV elongation
R-HSA-168325, Viral Messenger RNA Synthesis
R-HSA-1834949, Cytosolic sensors of pathogen-associated DNA
R-HSA-203927, MicroRNA (miRNA) biogenesis
R-HSA-427413, NoRC negatively regulates rRNA expression
R-HSA-5250924, B-WICH complex positively regulates rRNA expression
R-HSA-5578749, Transcriptional regulation by small RNAs
R-HSA-5601884, PIWI-interacting RNA (piRNA) biogenesis
R-HSA-5617472, Activation of anterior HOX genes in hindbrain development during early embryogenesis
R-HSA-674695, RNA Polymerase II Pre-transcription Events
R-HSA-6781823, Formation of TC-NER Pre-Incision Complex
R-HSA-6781827, Transcription-Coupled Nucleotide Excision Repair (TC-NER)
R-HSA-6782135, Dual incision in TC-NER
R-HSA-6782210, Gap-filling DNA repair synthesis and ligation in TC-NER
R-HSA-6796648, TP53 Regulates Transcription of DNA Repair Genes
R-HSA-6803529, FGFR2 alternative splicing
R-HSA-6807505, RNA polymerase II transcribes snRNA genes
R-HSA-72086, mRNA Capping
R-HSA-72163, mRNA Splicing - Major Pathway
R-HSA-72165, mRNA Splicing - Minor Pathway
R-HSA-72203, Processing of Capped Intron-Containing Pre-mRNA
R-HSA-73762, RNA Polymerase I Transcription Initiation
R-HSA-73772, RNA Polymerase I Promoter Escape
R-HSA-73776, RNA Polymerase II Promoter Escape
R-HSA-73779, RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
R-HSA-73780, RNA Polymerase III Chain Elongation
R-HSA-73863, RNA Polymerase I Transcription Termination
R-HSA-73980, RNA Polymerase III Transcription Termination
R-HSA-749476, RNA Polymerase III Abortive And Retractive Initiation
R-HSA-75953, RNA Polymerase II Transcription Initiation
R-HSA-75955, RNA Polymerase II Transcription Elongation
R-HSA-76042, RNA Polymerase II Transcription Initiation And Promoter Clearance
R-HSA-76061, RNA Polymerase III Transcription Initiation From Type 1 Promoter
R-HSA-76066, RNA Polymerase III Transcription Initiation From Type 2 Promoter
R-HSA-76071, RNA Polymerase III Transcription Initiation From Type 3 Promoter
R-HSA-77075, RNA Pol II CTD phosphorylation and interaction with CE
R-HSA-8851708, Signaling by FGFR2 IIIa TM
R-HSA-9018519, Estrogen-dependent gene expression
R-HSA-9670095, Inhibition of DNA recombination at telomere

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
DNA-directed RNA polymerases I, II, and III subunit RPABC5
Short name:
RNA polymerases I, II, and III subunit ABC5
Alternative name(s):
DNA-directed RNA polymerase III subunit L
RNA polymerase II 7.6 kDa subunit
Short name:
RPB7.6
RPB10 homolog
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:POLR2L
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:9199, POLR2L

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
601189, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P62875

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000177700.5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

DNA-directed RNA polymerase, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
5441

Open Targets

More...
OpenTargetsi
ENSG00000177700

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA33519

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
P62875, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
POLR2L

Domain mapping of disease mutations (DMDM)

More...
DMDMi
51338657

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001213331 – 67DNA-directed RNA polymerases I, II, and III subunit RPABC5Add BLAST67

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
P62875

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
P62875

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
P62875

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P62875

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P62875

PeptideAtlas

More...
PeptideAtlasi
P62875

PRoteomics IDEntifications database

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PRIDEi
P62875

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
57442

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
P62875

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P62875

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P62875

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P62875

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000177700, Expressed in adipose tissue of abdominal region and 248 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P62875, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000177700, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the RNA polymerase I (Pol I), RNA polymerase II (Pol II) and RNA polymerase III (Pol III) complexes consisting of at least 13, 12 and 17 subunits, respectively.

By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
111437, 128 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
P62875

Database of interacting proteins

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DIPi
DIP-32960N

Protein interaction database and analysis system

More...
IntActi
P62875, 50 interactors

Molecular INTeraction database

More...
MINTi
P62875

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000324124

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P62875, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P62875

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3497, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000007087

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_143122_1_1_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P62875

Identification of Orthologs from Complete Genome Data

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OMAi
YCCRRMF

Database of Orthologous Groups

More...
OrthoDBi
1639063at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P62875

TreeFam database of animal gene trees

More...
TreeFami
TF103046

Family and domain databases

HAMAP database of protein families

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HAMAPi
MF_00250, RNApol_arch_N, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR023580, RNA_pol_su_RPB10
IPR020789, RNA_pol_suN_Zn-BS
IPR000268, RNAP_N/Rpb10

The PANTHER Classification System

More...
PANTHERi
PTHR23431, PTHR23431, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01194, RNA_pol_N, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF005653, RNA_pol_N/8_sub, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46924, SSF46924, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01112, RNA_POL_N_8KD, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P62875-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MIIPVRCFTC GKIVGNKWEA YLGLLQAEYT EGDALDALGL KRYCCRRMLL
60
AHVDLIEKLL NYAPLEK
Length:67
Mass (Da):7,645
Last modified:August 16, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9E8A72F667FE7EC5
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U37690 mRNA Translation: AAA91459.1
CR536565 mRNA Translation: CAG38802.1
AK311997 mRNA Translation: BAG34935.1
BC005903 mRNA Translation: AAH05903.1
BC018649 mRNA Translation: AAH18649.1
Z47729 Genomic DNA Translation: CAA87658.1
Z47728 Genomic DNA Translation: CAA87657.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS7720.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S53015

NCBI Reference Sequences

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RefSeqi
NP_066951.1, NM_021128.4

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000322028; ENSP00000324124; ENSG00000177700
ENST00000534030; ENSP00000432807; ENSG00000177700

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
5441

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:5441

UCSC genome browser

More...
UCSCi
uc001lsc.4, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U37690 mRNA Translation: AAA91459.1
CR536565 mRNA Translation: CAG38802.1
AK311997 mRNA Translation: BAG34935.1
BC005903 mRNA Translation: AAH05903.1
BC018649 mRNA Translation: AAH18649.1
Z47729 Genomic DNA Translation: CAA87658.1
Z47728 Genomic DNA Translation: CAA87657.1
CCDSiCCDS7720.1
PIRiS53015
RefSeqiNP_066951.1, NM_021128.4

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5IY6electron microscopy7.20J1-67[»]
5IY7electron microscopy8.60J1-67[»]
5IY8electron microscopy7.90J1-67[»]
5IY9electron microscopy6.30J1-67[»]
5IYAelectron microscopy5.40J1-67[»]
5IYBelectron microscopy3.90J1-67[»]
5IYCelectron microscopy3.90J1-67[»]
5IYDelectron microscopy3.90J1-67[»]
6DRDelectron microscopy3.90J1-67[»]
6O9Lelectron microscopy7.20J1-67[»]
7ASTelectron microscopy4.00B1-67[»]
SMRiP62875
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi111437, 128 interactors
CORUMiP62875
DIPiDIP-32960N
IntActiP62875, 50 interactors
MINTiP62875
STRINGi9606.ENSP00000324124

PTM databases

iPTMnetiP62875
PhosphoSitePlusiP62875
SwissPalmiP62875

Genetic variation databases

BioMutaiPOLR2L
DMDMi51338657

Proteomic databases

EPDiP62875
jPOSTiP62875
MassIVEiP62875
MaxQBiP62875
PaxDbiP62875
PeptideAtlasiP62875
PRIDEiP62875
ProteomicsDBi57442
TopDownProteomicsiP62875

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
22712, 103 antibodies

The DNASU plasmid repository

More...
DNASUi
5441

Genome annotation databases

EnsembliENST00000322028; ENSP00000324124; ENSG00000177700
ENST00000534030; ENSP00000432807; ENSG00000177700
GeneIDi5441
KEGGihsa:5441
UCSCiuc001lsc.4, human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
5441
DisGeNETi5441

GeneCards: human genes, protein and diseases

More...
GeneCardsi
POLR2L
HGNCiHGNC:9199, POLR2L
HPAiENSG00000177700, Low tissue specificity
MIMi601189, gene
neXtProtiNX_P62875
OpenTargetsiENSG00000177700
PharmGKBiPA33519
VEuPathDBiHostDB:ENSG00000177700.5

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3497, Eukaryota
GeneTreeiENSGT00390000007087
HOGENOMiCLU_143122_1_1_1
InParanoidiP62875
OMAiYCCRRMF
OrthoDBi1639063at2759
PhylomeDBiP62875
TreeFamiTF103046

Enzyme and pathway databases

PathwayCommonsiP62875
ReactomeiR-HSA-112382, Formation of RNA Pol II elongation complex
R-HSA-113418, Formation of the Early Elongation Complex
R-HSA-167152, Formation of HIV elongation complex in the absence of HIV Tat
R-HSA-167158, Formation of the HIV-1 Early Elongation Complex
R-HSA-167160, RNA Pol II CTD phosphorylation and interaction with CE during HIV infection
R-HSA-167161, HIV Transcription Initiation
R-HSA-167162, RNA Polymerase II HIV Promoter Escape
R-HSA-167172, Transcription of the HIV genome
R-HSA-167200, Formation of HIV-1 elongation complex containing HIV-1 Tat
R-HSA-167238, Pausing and recovery of Tat-mediated HIV elongation
R-HSA-167242, Abortive elongation of HIV-1 transcript in the absence of Tat
R-HSA-167243, Tat-mediated HIV elongation arrest and recovery
R-HSA-167246, Tat-mediated elongation of the HIV-1 transcript
R-HSA-167287, HIV elongation arrest and recovery
R-HSA-167290, Pausing and recovery of HIV elongation
R-HSA-168325, Viral Messenger RNA Synthesis
R-HSA-1834949, Cytosolic sensors of pathogen-associated DNA
R-HSA-203927, MicroRNA (miRNA) biogenesis
R-HSA-427413, NoRC negatively regulates rRNA expression
R-HSA-5250924, B-WICH complex positively regulates rRNA expression
R-HSA-5578749, Transcriptional regulation by small RNAs
R-HSA-5601884, PIWI-interacting RNA (piRNA) biogenesis
R-HSA-5617472, Activation of anterior HOX genes in hindbrain development during early embryogenesis
R-HSA-674695, RNA Polymerase II Pre-transcription Events
R-HSA-6781823, Formation of TC-NER Pre-Incision Complex
R-HSA-6781827, Transcription-Coupled Nucleotide Excision Repair (TC-NER)
R-HSA-6782135, Dual incision in TC-NER
R-HSA-6782210, Gap-filling DNA repair synthesis and ligation in TC-NER
R-HSA-6796648, TP53 Regulates Transcription of DNA Repair Genes
R-HSA-6803529, FGFR2 alternative splicing
R-HSA-6807505, RNA polymerase II transcribes snRNA genes
R-HSA-72086, mRNA Capping
R-HSA-72163, mRNA Splicing - Major Pathway
R-HSA-72165, mRNA Splicing - Minor Pathway
R-HSA-72203, Processing of Capped Intron-Containing Pre-mRNA
R-HSA-73762, RNA Polymerase I Transcription Initiation
R-HSA-73772, RNA Polymerase I Promoter Escape
R-HSA-73776, RNA Polymerase II Promoter Escape
R-HSA-73779, RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
R-HSA-73780, RNA Polymerase III Chain Elongation
R-HSA-73863, RNA Polymerase I Transcription Termination
R-HSA-73980, RNA Polymerase III Transcription Termination
R-HSA-749476, RNA Polymerase III Abortive And Retractive Initiation
R-HSA-75953, RNA Polymerase II Transcription Initiation
R-HSA-75955, RNA Polymerase II Transcription Elongation
R-HSA-76042, RNA Polymerase II Transcription Initiation And Promoter Clearance
R-HSA-76061, RNA Polymerase III Transcription Initiation From Type 1 Promoter
R-HSA-76066, RNA Polymerase III Transcription Initiation From Type 2 Promoter
R-HSA-76071, RNA Polymerase III Transcription Initiation From Type 3 Promoter
R-HSA-77075, RNA Pol II CTD phosphorylation and interaction with CE
R-HSA-8851708, Signaling by FGFR2 IIIa TM
R-HSA-9018519, Estrogen-dependent gene expression
R-HSA-9670095, Inhibition of DNA recombination at telomere

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
5441, 802 hits in 987 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
POLR2L, human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
POLR2L

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
5441
PharosiP62875, Tbio

Protein Ontology

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PROi
PR:P62875
RNActiP62875, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000177700, Expressed in adipose tissue of abdominal region and 248 other tissues
GenevisibleiP62875, HS

Family and domain databases

HAMAPiMF_00250, RNApol_arch_N, 1 hit
InterProiView protein in InterPro
IPR023580, RNA_pol_su_RPB10
IPR020789, RNA_pol_suN_Zn-BS
IPR000268, RNAP_N/Rpb10
PANTHERiPTHR23431, PTHR23431, 1 hit
PfamiView protein in Pfam
PF01194, RNA_pol_N, 1 hit
PIRSFiPIRSF005653, RNA_pol_N/8_sub, 1 hit
SUPFAMiSSF46924, SSF46924, 1 hit
PROSITEiView protein in PROSITE
PS01112, RNA_POL_N_8KD, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRPAB5_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P62875
Secondary accession number(s): P52436, Q6FHX3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: August 16, 2004
Last modified: April 7, 2021
This is version 165 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families
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