UniProtKB - P62869 (ELOB_MOUSE)
Elongin-B
Elob
Functioni
: protein ubiquitination Pathwayi
This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.
GO - Molecular functioni
- protein-containing complex binding Source: MGI
- transcription coactivator activity Source: MGI
- ubiquitin protein ligase binding Source: Ensembl
GO - Biological processi
- positive regulation of transcription by RNA polymerase II Source: MGI
- protein ubiquitination Source: UniProtKB-UniPathway
- transcription elongation from RNA polymerase II promoter Source: InterPro
Keywordsi
Biological process | Transcription, Transcription regulation, Ubl conjugation pathway |
Enzyme and pathway databases
Reactomei | R-MMU-112382, Formation of RNA Pol II elongation complex R-MMU-1234176, Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-MMU-674695, RNA Polymerase II Pre-transcription Events R-MMU-6796648, TP53 Regulates Transcription of DNA Repair Genes R-MMU-75955, RNA Polymerase II Transcription Elongation R-MMU-8951664, Neddylation R-MMU-983168, Antigen processing: Ubiquitination & Proteasome degradation |
UniPathwayi | UPA00143 |
Names & Taxonomyi
Protein namesi | Recommended name: Elongin-BShort name: EloB Alternative name(s): Elongin 18 kDa subunit RNA polymerase II transcription factor SIII subunit B SIII p18 Transcription elongation factor B polypeptide 2 |
Gene namesi | |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1914923, Elob |
Subcellular locationi
Nucleus
- Nucleus Curated
Nucleus
- elongin complex Source: UniProtKB
Other locations
- Cul2-RING ubiquitin ligase complex Source: Ensembl
- Cul5-RING ubiquitin ligase complex Source: Ensembl
- transcription regulator complex Source: MGI
- VCB complex Source: MGI
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000114915 | 1 – 118 | Elongin-BAdd BLAST | 118 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 1 | N-acetylmethionineBy similarity | 1 | |
Modified residuei | 84 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 108 | PhosphoserineCombined sources | 1 | |
Modified residuei | 111 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | P62869 |
jPOSTi | P62869 |
MaxQBi | P62869 |
PaxDbi | P62869 |
PeptideAtlasi | P62869 |
PRIDEi | P62869 |
2D gel databases
REPRODUCTION-2DPAGEi | P62869 |
PTM databases
iPTMneti | P62869 |
PhosphoSitePlusi | P62869 |
SwissPalmi | P62869 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000055839, Expressed in testis and 67 other tissues |
ExpressionAtlasi | P62869, baseline and differential |
Genevisiblei | P62869, MM |
Interactioni
Subunit structurei
Heterotrimer of an A (ELOA, ELOA2 or ELOA3P), ELOB and ELOC subunit (PubMed:16498413). The elongin BC complex interacts with EPOP; leading to recruit the elongin BC complex to Polycomb group (PcG) target genes, thereby restricting excessive activity of the PRC2/EED-EZH2 complex (PubMed:27863225, PubMed:27863226). Part of E3 ubiquitin ligase complexes with CUL5 or CUL2, RBX1 and a substrate adapter protein that can be either SOCS1, SOCS5, ELOA, VHL or WSB1.
Interacts with VHL.
Found in a complex composed of LIMD1, VHL, EGLN1/PHD2, ELOB and CUL2.
Interacts with SPSB1.
Interacts with KLHDC10; which may be an E3 ubiquitin ligase complex substrate recognition component. May also interact with DCUN1D1, DCUN1D2, DCUN1D3 and DCUN1D5 (By similarity).
By similarity5 PublicationsGO - Molecular functioni
- ubiquitin protein ligase binding Source: Ensembl
Protein-protein interaction databases
BioGRIDi | 212356, 26 interactors |
CORUMi | P62869 |
IntActi | P62869, 9 interactors |
MINTi | P62869 |
STRINGi | 10090.ENSMUSP00000066210 |
Miscellaneous databases
RNActi | P62869, protein |
Structurei
Secondary structure
3D structure databases
BMRBi | P62869 |
SMRi | P62869 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P62869 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1 – 79 | Ubiquitin-likePROSITE-ProRule annotationAdd BLAST | 79 |
Phylogenomic databases
eggNOGi | KOG4495, Eukaryota |
GeneTreei | ENSGT00390000018316 |
HOGENOMi | CLU_139243_0_0_1 |
InParanoidi | P62869 |
OMAi | FTDAKEC |
OrthoDBi | 1637528at2759 |
PhylomeDBi | P62869 |
TreeFami | TF325964 |
Family and domain databases
IDEALi | IID50216 |
InterProi | View protein in InterPro IPR039049, ELOB IPR000626, Ubiquitin-like_dom IPR029071, Ubiquitin-like_domsf |
PANTHERi | PTHR13248, PTHR13248, 1 hit |
Pfami | View protein in Pfam PF00240, ubiquitin, 1 hit |
SMARTi | View protein in SMART SM00213, UBQ, 1 hit |
SUPFAMi | SSF54236, SSF54236, 1 hit |
PROSITEi | View protein in PROSITE PS50053, UBIQUITIN_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
10 20 30 40 50
MDVFLMIRRH KTTIFTDAKE SSTVFELKRI VEGILKRPPE EQRLYKDDQL
60 70 80 90 100
LDDGKTLGEC GFTSQTARPQ APATVGLAFR ADDTFEALRI EPFSSPPELP
110
DVMKPQDSGG SANEQAVQ
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A3B2WBM3 | A0A3B2WBM3_MOUSE | Elongin-B | Elob | 90 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK019358 mRNA Translation: BAB31677.1 AK002223 mRNA Translation: BAB21946.1 AK002868 mRNA Translation: BAB22417.1 AK003277 mRNA Translation: BAB22684.1 AK008477 mRNA Translation: BAB25690.1 AK008534 mRNA Translation: BAB25727.1 AK012254 mRNA Translation: BAB28121.1 AK019181 mRNA Translation: BAB31590.1 AK019218 mRNA Translation: BAB31608.1 BC051927 mRNA Translation: AAH51927.2 BC056983 mRNA Translation: AAH56983.1 |
CCDSi | CCDS57055.1 |
RefSeqi | NP_080581.1, NM_026305.2 |
Genome annotation databases
Ensembli | ENSMUST00000069579; ENSMUSP00000066210; ENSMUSG00000055839 |
GeneIDi | 67673 |
KEGGi | mmu:67673 |
UCSCi | uc008atr.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK019358 mRNA Translation: BAB31677.1 AK002223 mRNA Translation: BAB21946.1 AK002868 mRNA Translation: BAB22417.1 AK003277 mRNA Translation: BAB22684.1 AK008477 mRNA Translation: BAB25690.1 AK008534 mRNA Translation: BAB25727.1 AK012254 mRNA Translation: BAB28121.1 AK019181 mRNA Translation: BAB31590.1 AK019218 mRNA Translation: BAB31608.1 BC051927 mRNA Translation: AAH51927.2 BC056983 mRNA Translation: AAH56983.1 |
CCDSi | CCDS57055.1 |
RefSeqi | NP_080581.1, NM_026305.2 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2FNJ | X-ray | 1.80 | B | 1-118 | [»] | |
4JGH | X-ray | 3.00 | B | 1-118 | [»] | |
BMRBi | P62869 | |||||
SMRi | P62869 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 212356, 26 interactors |
CORUMi | P62869 |
IntActi | P62869, 9 interactors |
MINTi | P62869 |
STRINGi | 10090.ENSMUSP00000066210 |
PTM databases
iPTMneti | P62869 |
PhosphoSitePlusi | P62869 |
SwissPalmi | P62869 |
2D gel databases
REPRODUCTION-2DPAGEi | P62869 |
Proteomic databases
EPDi | P62869 |
jPOSTi | P62869 |
MaxQBi | P62869 |
PaxDbi | P62869 |
PeptideAtlasi | P62869 |
PRIDEi | P62869 |
Genome annotation databases
Ensembli | ENSMUST00000069579; ENSMUSP00000066210; ENSMUSG00000055839 |
GeneIDi | 67673 |
KEGGi | mmu:67673 |
UCSCi | uc008atr.1, mouse |
Organism-specific databases
CTDi | 6923 |
MGIi | MGI:1914923, Elob |
Phylogenomic databases
eggNOGi | KOG4495, Eukaryota |
GeneTreei | ENSGT00390000018316 |
HOGENOMi | CLU_139243_0_0_1 |
InParanoidi | P62869 |
OMAi | FTDAKEC |
OrthoDBi | 1637528at2759 |
PhylomeDBi | P62869 |
TreeFami | TF325964 |
Enzyme and pathway databases
UniPathwayi | UPA00143 |
Reactomei | R-MMU-112382, Formation of RNA Pol II elongation complex R-MMU-1234176, Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-MMU-674695, RNA Polymerase II Pre-transcription Events R-MMU-6796648, TP53 Regulates Transcription of DNA Repair Genes R-MMU-75955, RNA Polymerase II Transcription Elongation R-MMU-8951664, Neddylation R-MMU-983168, Antigen processing: Ubiquitination & Proteasome degradation |
Miscellaneous databases
BioGRID-ORCSi | 67673, 7 hits in 15 CRISPR screens |
ChiTaRSi | Elob, mouse |
EvolutionaryTracei | P62869 |
PROi | PR:P62869 |
RNActi | P62869, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000055839, Expressed in testis and 67 other tissues |
ExpressionAtlasi | P62869, baseline and differential |
Genevisiblei | P62869, MM |
Family and domain databases
IDEALi | IID50216 |
InterProi | View protein in InterPro IPR039049, ELOB IPR000626, Ubiquitin-like_dom IPR029071, Ubiquitin-like_domsf |
PANTHERi | PTHR13248, PTHR13248, 1 hit |
Pfami | View protein in Pfam PF00240, ubiquitin, 1 hit |
SMARTi | View protein in SMART SM00213, UBQ, 1 hit |
SUPFAMi | SSF54236, SSF54236, 1 hit |
PROSITEi | View protein in PROSITE PS50053, UBIQUITIN_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ELOB_MOUSE | |
Accessioni | P62869Primary (citable) accession number: P62869 Secondary accession number(s): Q63529, Q80W20 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 16, 2004 |
Last sequence update: | August 16, 2004 | |
Last modified: | December 2, 2020 | |
This is version 146 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - PATHWAY comments
Index of metabolic and biosynthesis pathways - PDB cross-references
Index of Protein Data Bank (PDB) cross-references