Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

40S ribosomal protein S30

Gene

FAU

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Miscellaneous

This ribosomal protein is synthesized as a C-terminal extension protein (CEP) of a ubiquitin-like protein.

GO - Molecular functioni

  • RNA binding Source: ProtInc
  • structural constituent of ribosome Source: UniProtKB

GO - Biological processi

  • antibacterial humoral response Source: UniProtKB
  • antimicrobial humoral immune response mediated by antimicrobial peptide Source: UniProtKB
  • defense response to Gram-positive bacterium Source: UniProtKB
  • innate immune response in mucosa Source: UniProtKB
  • nuclear-transcribed mRNA catabolic process, nonsense-mediated decay Source: Reactome
  • SRP-dependent cotranslational protein targeting to membrane Source: Reactome
  • translation Source: UniProtKB
  • translational initiation Source: Reactome

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-HSA-156902 Peptide chain elongation
R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane
R-HSA-192823 Viral mRNA Translation
R-HSA-2408557 Selenocysteine synthesis
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol
R-HSA-72649 Translation initiation complex formation
R-HSA-72689 Formation of a pool of free 40S subunits
R-HSA-72695 Formation of the ternary complex, and subsequently, the 43S complex
R-HSA-72702 Ribosomal scanning and start codon recognition
R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit
R-HSA-72764 Eukaryotic Translation Termination
R-HSA-9010553 Regulation of expression of SLITs and ROBOs
R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Names & Taxonomyi

Protein namesi
Recommended name:
40S ribosomal protein S30
Alternative name(s):
Small ribosomal subunit protein eS301 Publication
Gene namesi
Name:FAU
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000149806.10
HGNCiHGNC:3597 FAU
MIMi134690 gene
neXtProtiNX_P62861

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi2197

Polymorphism and mutation databases

DMDMi51338655

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001739991 – 5940S ribosomal protein S30Add BLAST59

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei51N6-succinyllysineBy similarity1

Proteomic databases

EPDiP62861
MaxQBiP62861
PeptideAtlasiP62861
PRIDEiP62861
ProteomicsDBi57440
TopDownProteomicsiP62861

PTM databases

iPTMnetiP62861
PhosphoSitePlusiP62861
SwissPalmiP62861

Expressioni

Gene expression databases

BgeeiENSG00000149806
CleanExiHS_FAU
ExpressionAtlasiP62861 baseline and differential
GenevisibleiP62861 HS

Organism-specific databases

HPAiHPA059015

Interactioni

Protein-protein interaction databases

CORUMiP62861
IntActiP62861, 21 interactors
MINTiP62861

Structurei

3D structure databases

ProteinModelPortaliP62861
SMRiP62861
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0001 Eukaryota
KOG0009 Eukaryota
ENOG41123KC LUCA
HOGENOMiHOG000233941
HOVERGENiHBG000057
OrthoDBiEOG091G0X8P

Family and domain databases

InterProiView protein in InterPro
IPR006846 Ribosomal_S30
PfamiView protein in Pfam
PF04758 Ribosomal_S30, 1 hit

Sequencei

Sequence statusi: Complete.

P62861-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
KVHGSLARAG KVRGQTPKVA KQEKKKKKTG RAKRRMQYNR RFVNVVPTFG

KKKGPNANS
Length:59
Mass (Da):6,648
Last modified:August 16, 2004 - v1
Checksum:i012AC1FB555B01A4
GO

Sequence cautioni

The sequence AAH33877 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAQ87877 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB15515 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAA46714 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAA46716 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAG46772 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01964319V → M1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X65921 Genomic DNA Translation: CAA46714.1 Different initiation.
X65923 mRNA Translation: CAA46716.1 Different initiation.
AK026639 mRNA Translation: BAB15515.1 Different initiation.
CR541974 mRNA Translation: CAG46772.1 Different initiation.
AY398663 Genomic DNA Translation: AAQ87877.1 Different initiation.
AP003068 Genomic DNA No translation available.
BC033877 mRNA Translation: AAH33877.1 Different initiation.
PIRiJC1278
UniGeneiHs.387208

Genome annotation databases

EnsembliENST00000527548; ENSP00000434440; ENSG00000149806
ENST00000529639; ENSP00000435370; ENSG00000149806
ENST00000531743; ENSP00000431822; ENSG00000149806
UCSCiuc001ocx.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiRS30_HUMAN
AccessioniPrimary (citable) accession number: P62861
Secondary accession number(s): Q05472, Q95261, Q9H5V4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: August 16, 2004
Last modified: July 18, 2018
This is version 128 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Ribosomal proteins
    Ribosomal proteins families and list of entries
  7. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health