UniProtKB - P62857 (RS28_HUMAN)
Protein
40S ribosomal protein S28
Gene
RPS28
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- RNA binding Source: UniProtKB
- structural constituent of ribosome Source: GO_Central
GO - Biological processi
- cytoplasmic translation Source: UniProtKB
- maturation of SSU-rRNA Source: GO_Central
- nuclear-transcribed mRNA catabolic process, nonsense-mediated decay Source: Reactome
- ribosomal small subunit assembly Source: GO_Central
- ribosomal small subunit biogenesis Source: UniProtKB
- ribosome biogenesis Source: UniProtKB
- rRNA processing Source: UniProtKB
- SRP-dependent cotranslational protein targeting to membrane Source: Reactome
- translation Source: UniProtKB
- translational initiation Source: Reactome
- viral transcription Source: Reactome
Keywordsi
Molecular function | Ribonucleoprotein, Ribosomal protein |
Enzyme and pathway databases
PathwayCommonsi | P62857 |
Reactomei | R-HSA-156827, L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156902, Peptide chain elongation R-HSA-1799339, SRP-dependent cotranslational protein targeting to membrane R-HSA-192823, Viral mRNA Translation R-HSA-2408557, Selenocysteine synthesis R-HSA-6791226, Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-72649, Translation initiation complex formation R-HSA-72689, Formation of a pool of free 40S subunits R-HSA-72695, Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72702, Ribosomal scanning and start codon recognition R-HSA-72706, GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72764, Eukaryotic Translation Termination R-HSA-9010553, Regulation of expression of SLITs and ROBOs R-HSA-9633012, Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-975956, Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975957, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) |
Names & Taxonomyi
Protein namesi | Recommended name: 40S ribosomal protein S28Alternative name(s): Small ribosomal subunit protein eS281 Publication |
Gene namesi | Name:RPS28 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000233927.4 |
HGNCi | HGNC:10418, RPS28 |
MIMi | 603685, gene |
neXtProti | NX_P62857 |
Subcellular locationi
Cytosol
- cytosol 1 Publication
Endoplasmic reticulum
- Rough endoplasmic reticulum By similarity
Other locations
- Cytoplasm 2 Publications
Note: Detected on cytosolic polysomes (PubMed:25957688). Detected in ribosomes that are associated with the rough endoplasmic reticulum (By similarity).By similarity1 Publication
Cytosol
- cytosol Source: Reactome
- cytosolic small ribosomal subunit Source: UniProtKB
Endoplasmic reticulum
- cytoplasmic side of rough endoplasmic reticulum membrane Source: UniProtKB
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
Nucleus
- nucleoplasm Source: Reactome
Other locations
- polysomal ribosome Source: UniProtKB
- small ribosomal subunit Source: UniProtKB
Keywords - Cellular componenti
Cytoplasm, Endoplasmic reticulumPathology & Biotechi
Involvement in diseasei
Diamond-Blackfan anemia 15, with mandibulofacial dysostosis (DBA15)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of Diamond-Blackfan anemia, a congenital non-regenerative hypoplastic anemia that usually presents early in infancy. Diamond-Blackfan anemia is characterized by a moderate to severe macrocytic anemia, erythroblastopenia, and an increased risk of malignancy. 30 to 40% of Diamond-Blackfan anemia patients present with short stature and congenital anomalies, the most frequent being craniofacial (Pierre-Robin syndrome and cleft palate), thumb and urogenital anomalies.
Related information in OMIMKeywords - Diseasei
Diamond-Blackfan anemiaOrganism-specific databases
DisGeNETi | 6234 |
GeneReviewsi | RPS28 |
MalaCardsi | RPS28 |
MIMi | 606164, phenotype |
OpenTargetsi | ENSG00000233927 |
Orphaneti | 124, Blackfan-Diamond anemia |
PharmGKBi | PA34825 |
Miscellaneous databases
Pharosi | P62857, Tbio |
Chemistry databases
DrugBanki | DB11638, Artenimol |
Polymorphism and mutation databases
BioMutai | RPS28 |
DMDMi | 51338652 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000136822 | 1 – 69 | 40S ribosomal protein S28Add BLAST | 69 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 1 | N-acetylmethionineBy similarity | 1 | |
Modified residuei | 41 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | P62857 |
jPOSTi | P62857 |
MassIVEi | P62857 |
MaxQBi | P62857 |
PaxDbi | P62857 |
PeptideAtlasi | P62857 |
PRIDEi | P62857 |
ProteomicsDBi | 57439 |
TopDownProteomicsi | P62857 |
PTM databases
iPTMneti | P62857 |
MetOSitei | P62857 |
PhosphoSitePlusi | P62857 |
SwissPalmi | P62857 |
Expressioni
Gene expression databases
Bgeei | ENSG00000233927, Expressed in lower esophagus mucosa and 214 other tissues |
ExpressionAtlasi | P62857, baseline and differential |
Genevisiblei | P62857, HS |
Organism-specific databases
HPAi | ENSG00000233927, Low tissue specificity |
Interactioni
Subunit structurei
Component of the 40S small ribosomal subunit.
3 PublicationsBinary interactionsi
Hide detailsP62857
Protein-protein interaction databases
BioGRIDi | 112148, 158 interactors |
ComplexPortali | CPX-5223, 40S cytosolic small ribosomal subunit |
CORUMi | P62857 |
IntActi | P62857, 40 interactors |
MINTi | P62857 |
STRINGi | 9606.ENSP00000472469 |
Miscellaneous databases
RNActi | P62857, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P62857 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Sequence similaritiesi
Belongs to the eukaryotic ribosomal protein eS28 family.Curated
Phylogenomic databases
eggNOGi | KOG3502, Eukaryota |
GeneTreei | ENSGT00910000144227 |
HOGENOMi | CLU_178987_1_0_1 |
InParanoidi | P62857 |
OMAi | MHGEASQ |
OrthoDBi | 1578965at2759 |
PhylomeDBi | P62857 |
TreeFami | TF300136 |
Family and domain databases
CDDi | cd04457, S1_S28E, 1 hit |
HAMAPi | MF_00292, Ribosomal_S28e, 1 hit |
InterProi | View protein in InterPro IPR012340, NA-bd_OB-fold IPR000289, Ribosomal_S28e IPR028626, Ribosomal_S28e_CS |
PANTHERi | PTHR10769, PTHR10769, 1 hit |
Pfami | View protein in Pfam PF01200, Ribosomal_S28e, 1 hit |
SUPFAMi | SSF50249, SSF50249, 1 hit |
PROSITEi | View protein in PROSITE PS00961, RIBOSOMAL_S28E, 1 hit |
i Sequence
Sequence statusi: Complete.
P62857-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDTSRVQPIK LARVTKVLGR TGSQGQCTQV RVEFMDDTSR SIIRNVKGPV
60
REGDVLTLLE SEREARRLR
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 66 | R → P AA sequence (PubMed:8706699).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L05091 mRNA Translation: AAC15855.1 U58682 mRNA Translation: AAB07066.1 AB061846 Genomic DNA Translation: BAB79484.1 CR457055 mRNA Translation: CAG33336.1 BC000354 mRNA Translation: AAH00354.1 BC021239 mRNA Translation: AAH21239.1 BC070217 mRNA Translation: AAH70217.1 BC070218 mRNA Translation: AAH70218.1 AB007164 Genomic DNA Translation: BAA28594.1 |
CCDSi | CCDS45953.1 |
PIRi | S68914 |
RefSeqi | NP_001022.1, NM_001031.4 |
Genome annotation databases
Ensembli | ENST00000600659; ENSP00000472469; ENSG00000233927 |
GeneIDi | 6234 |
KEGGi | hsa:6234 |
UCSCi | uc002mjn.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L05091 mRNA Translation: AAC15855.1 U58682 mRNA Translation: AAB07066.1 AB061846 Genomic DNA Translation: BAB79484.1 CR457055 mRNA Translation: CAG33336.1 BC000354 mRNA Translation: AAH00354.1 BC021239 mRNA Translation: AAH21239.1 BC070217 mRNA Translation: AAH70217.1 BC070218 mRNA Translation: AAH70218.1 AB007164 Genomic DNA Translation: BAA28594.1 |
CCDSi | CCDS45953.1 |
PIRi | S68914 |
RefSeqi | NP_001022.1, NM_001031.4 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
4UG0 | electron microscopy | - | Sc | 1-69 | [»] | |
4V6X | electron microscopy | 5.00 | Ac | 1-69 | [»] | |
5A2Q | electron microscopy | 3.90 | c | 8-68 | [»] | |
5AJ0 | electron microscopy | 3.50 | Bc | 1-69 | [»] | |
5FLX | electron microscopy | 3.90 | c | 1-69 | [»] | |
5LKS | electron microscopy | 3.60 | Sc | 1-69 | [»] | |
5OA3 | electron microscopy | 4.30 | c | 8-68 | [»] | |
5T2C | electron microscopy | 3.60 | AF | 1-69 | [»] | |
5VYC | X-ray | 6.00 | c1/c2/c3/c4/c5/c6 | 1-69 | [»] | |
6EK0 | electron microscopy | 2.90 | Sc | 1-69 | [»] | |
6FEC | electron microscopy | 6.30 | l | 5-68 | [»] | |
6G18 | electron microscopy | 3.60 | c | 1-69 | [»] | |
6G4S | electron microscopy | 4.00 | c | 1-69 | [»] | |
6G4W | electron microscopy | 4.50 | c | 1-69 | [»] | |
6G51 | electron microscopy | 4.10 | c | 1-69 | [»] | |
6G53 | electron microscopy | 4.50 | c | 1-69 | [»] | |
6G5H | electron microscopy | 3.60 | c | 1-69 | [»] | |
6G5I | electron microscopy | 3.50 | c | 1-69 | [»] | |
6IP5 | electron microscopy | 3.90 | 3D | 1-69 | [»] | |
6IP6 | electron microscopy | 4.50 | 3D | 1-69 | [»] | |
6IP8 | electron microscopy | 3.90 | 3D | 1-69 | [»] | |
6OLE | electron microscopy | 3.10 | Sc | 5-68 | [»] | |
6OLF | electron microscopy | 3.90 | Sc | 5-68 | [»] | |
6OLG | electron microscopy | 3.40 | Bc | 7-68 | [»] | |
6OLI | electron microscopy | 3.50 | Sc | 5-68 | [»] | |
6OLZ | electron microscopy | 3.90 | Bc | 7-68 | [»] | |
6OM0 | electron microscopy | 3.10 | Sc | 5-68 | [»] | |
6OM7 | electron microscopy | 3.70 | Sc | 5-68 | [»] | |
6QZP | electron microscopy | 2.90 | Sc | 5-68 | [»] | |
6Y0G | electron microscopy | 3.20 | Sc | 1-69 | [»] | |
6Y2L | electron microscopy | 3.00 | Sc | 1-69 | [»] | |
6Y57 | electron microscopy | 3.50 | Sc | 1-69 | [»] | |
6Z6L | electron microscopy | 3.00 | Sc | 1-69 | [»] | |
6Z6M | electron microscopy | 3.10 | Sc | 1-69 | [»] | |
6Z6N | electron microscopy | 2.90 | Sc | 1-69 | [»] | |
6ZLW | electron microscopy | 2.60 | d | 1-69 | [»] | |
6ZM7 | electron microscopy | 2.70 | Sc | 1-69 | [»] | |
6ZME | electron microscopy | 3.00 | Sc | 1-69 | [»] | |
6ZMI | electron microscopy | 2.60 | Sc | 1-69 | [»] | |
6ZMO | electron microscopy | 3.10 | Sc | 1-69 | [»] | |
6ZMT | electron microscopy | 3.00 | d | 1-69 | [»] | |
6ZN5 | electron microscopy | 3.20 | d | 8-68 | [»] | |
6ZOJ | electron microscopy | 2.80 | c | 8-68 | [»] | |
6ZOL | electron microscopy | 2.80 | c | 8-68 | [»] | |
6ZON | electron microscopy | 3.00 | S | 1-69 | [»] | |
6ZP4 | electron microscopy | 2.90 | S | 1-69 | [»] | |
6ZVH | electron microscopy | 2.90 | c | 5-68 | [»] | |
SMRi | P62857 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 112148, 158 interactors |
ComplexPortali | CPX-5223, 40S cytosolic small ribosomal subunit |
CORUMi | P62857 |
IntActi | P62857, 40 interactors |
MINTi | P62857 |
STRINGi | 9606.ENSP00000472469 |
Chemistry databases
DrugBanki | DB11638, Artenimol |
PTM databases
iPTMneti | P62857 |
MetOSitei | P62857 |
PhosphoSitePlusi | P62857 |
SwissPalmi | P62857 |
Polymorphism and mutation databases
BioMutai | RPS28 |
DMDMi | 51338652 |
Proteomic databases
EPDi | P62857 |
jPOSTi | P62857 |
MassIVEi | P62857 |
MaxQBi | P62857 |
PaxDbi | P62857 |
PeptideAtlasi | P62857 |
PRIDEi | P62857 |
ProteomicsDBi | 57439 |
TopDownProteomicsi | P62857 |
Protocols and materials databases
Antibodypediai | 24844, 68 antibodies |
DNASUi | 6234 |
Genome annotation databases
Ensembli | ENST00000600659; ENSP00000472469; ENSG00000233927 |
GeneIDi | 6234 |
KEGGi | hsa:6234 |
UCSCi | uc002mjn.4, human |
Organism-specific databases
CTDi | 6234 |
DisGeNETi | 6234 |
EuPathDBi | HostDB:ENSG00000233927.4 |
GeneCardsi | RPS28 |
GeneReviewsi | RPS28 |
HGNCi | HGNC:10418, RPS28 |
HPAi | ENSG00000233927, Low tissue specificity |
MalaCardsi | RPS28 |
MIMi | 603685, gene 606164, phenotype |
neXtProti | NX_P62857 |
OpenTargetsi | ENSG00000233927 |
Orphaneti | 124, Blackfan-Diamond anemia |
PharmGKBi | PA34825 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3502, Eukaryota |
GeneTreei | ENSGT00910000144227 |
HOGENOMi | CLU_178987_1_0_1 |
InParanoidi | P62857 |
OMAi | MHGEASQ |
OrthoDBi | 1578965at2759 |
PhylomeDBi | P62857 |
TreeFami | TF300136 |
Enzyme and pathway databases
PathwayCommonsi | P62857 |
Reactomei | R-HSA-156827, L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156902, Peptide chain elongation R-HSA-1799339, SRP-dependent cotranslational protein targeting to membrane R-HSA-192823, Viral mRNA Translation R-HSA-2408557, Selenocysteine synthesis R-HSA-6791226, Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-72649, Translation initiation complex formation R-HSA-72689, Formation of a pool of free 40S subunits R-HSA-72695, Formation of the ternary complex, and subsequently, the 43S complex R-HSA-72702, Ribosomal scanning and start codon recognition R-HSA-72706, GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72764, Eukaryotic Translation Termination R-HSA-9010553, Regulation of expression of SLITs and ROBOs R-HSA-9633012, Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-975956, Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975957, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) |
Miscellaneous databases
BioGRID-ORCSi | 6234, 746 hits in 821 CRISPR screens |
ChiTaRSi | RPS28, human |
GeneWikii | RPS28 |
GenomeRNAii | 6234 |
Pharosi | P62857, Tbio |
PROi | PR:P62857 |
RNActi | P62857, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000233927, Expressed in lower esophagus mucosa and 214 other tissues |
ExpressionAtlasi | P62857, baseline and differential |
Genevisiblei | P62857, HS |
Family and domain databases
CDDi | cd04457, S1_S28E, 1 hit |
HAMAPi | MF_00292, Ribosomal_S28e, 1 hit |
InterProi | View protein in InterPro IPR012340, NA-bd_OB-fold IPR000289, Ribosomal_S28e IPR028626, Ribosomal_S28e_CS |
PANTHERi | PTHR10769, PTHR10769, 1 hit |
Pfami | View protein in Pfam PF01200, Ribosomal_S28e, 1 hit |
SUPFAMi | SSF50249, SSF50249, 1 hit |
PROSITEi | View protein in PROSITE PS00961, RIBOSOMAL_S28E, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | RS28_HUMAN | |
Accessioni | P62857Primary (citable) accession number: P62857 Secondary accession number(s): P25112 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 16, 2004 |
Last sequence update: | August 16, 2004 | |
Last modified: | December 2, 2020 | |
This is version 163 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM - Ribosomal proteins
Ribosomal proteins families and list of entries