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UniProtKB - P62857 (RS28_HUMAN)

Entry version 166 (02 Jun 2021)
Sequence version 1 (16 Aug 2004)
Previous versions | rss
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Protein

40S ribosomal protein S28

Gene

RPS28

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P62857

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-156827, L13a-mediated translational silencing of Ceruloplasmin expression
R-HSA-156902, Peptide chain elongation
R-HSA-1799339, SRP-dependent cotranslational protein targeting to membrane
R-HSA-192823, Viral mRNA Translation
R-HSA-2408557, Selenocysteine synthesis
R-HSA-6791226, Major pathway of rRNA processing in the nucleolus and cytosol
R-HSA-72649, Translation initiation complex formation
R-HSA-72689, Formation of a pool of free 40S subunits
R-HSA-72695, Formation of the ternary complex, and subsequently, the 43S complex
R-HSA-72702, Ribosomal scanning and start codon recognition
R-HSA-72706, GTP hydrolysis and joining of the 60S ribosomal subunit
R-HSA-72764, Eukaryotic Translation Termination
R-HSA-9010553, Regulation of expression of SLITs and ROBOs
R-HSA-9633012, Response of EIF2AK4 (GCN2) to amino acid deficiency
R-HSA-975956, Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-HSA-975957, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

SIGNOR Signaling Network Open Resource

More...SIGNORi		P62857

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
40S ribosomal protein S28
Alternative name(s):
Small ribosomal subunit protein eS281 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RPS28
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:10418, RPS28

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		603685, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P62857

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000233927.4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Diamond-Blackfan anemia 15, with mandibulofacial dysostosis (DBA15)1 Publication
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA form of Diamond-Blackfan anemia, a congenital non-regenerative hypoplastic anemia that usually presents early in infancy. Diamond-Blackfan anemia is characterized by a moderate to severe macrocytic anemia, erythroblastopenia, and an increased risk of malignancy. 30 to 40% of Diamond-Blackfan anemia patients present with short stature and congenital anomalies, the most frequent being craniofacial (Pierre-Robin syndrome and cleft palate), thumb and urogenital anomalies.
Related information in OMIM

Keywords - Diseasei

Diamond-Blackfan anemia

Organism-specific databases

DisGeNET

More...DisGeNETi		6234

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...GeneReviewsi		RPS28

MalaCards human disease database

More...MalaCardsi		RPS28
MIMi606164, phenotype

Open Targets

More...OpenTargetsi		ENSG00000233927

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		124, Blackfan-Diamond anemia

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA34825

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P62857, Tbio

Chemistry databases

Drug and drug target database

More...DrugBanki		DB11638, Artenimol

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		RPS28

Domain mapping of disease mutations (DMDM)

More...DMDMi		51338652

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001368221 – 6940S ribosomal protein S28Add BLAST69

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineBy similarity1
Modified residuei41PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		P62857

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P62857

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P62857

MaxQB - The MaxQuant DataBase

More...MaxQBi		P62857

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P62857

PeptideAtlas

More...PeptideAtlasi		P62857

PRoteomics IDEntifications database

More...PRIDEi		P62857

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		57439

Consortium for Top Down Proteomics

More...TopDownProteomicsi		P62857

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P62857

MetOSite database of methionine sulfoxide sites

More...MetOSitei		P62857

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P62857

SwissPalm database of S-palmitoylation events

More...SwissPalmi		P62857

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000233927, Expressed in lower esophagus mucosa and 214 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P62857, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P62857, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000233927, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the 40S small ribosomal subunit.

3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		112148, 172 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...ComplexPortali		CPX-5223, 40S cytosolic small ribosomal subunit

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		P62857

Protein interaction database and analysis system

More...IntActi		P62857, 46 interactors

Molecular INTeraction database

More...MINTi		P62857

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000472469

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P62857, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

169
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P62857

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the eukaryotic ribosomal protein eS28 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3502, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00910000144227

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_178987_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P62857

Identification of Orthologs from Complete Genome Data

More...OMAi		MHGEASQ

Database of Orthologous Groups

More...OrthoDBi		1578965at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P62857

TreeFam database of animal gene trees

More...TreeFami		TF300136

Family and domain databases

Conserved Domains Database

More...CDDi		cd04457, S1_S28E, 1 hit

HAMAP database of protein families

More...HAMAPi		MF_00292, Ribosomal_S28e, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR012340, NA-bd_OB-fold
IPR000289, Ribosomal_S28e
IPR028626, Ribosomal_S28e_CS

The PANTHER Classification System

More...PANTHERi		PTHR10769, PTHR10769, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01200, Ribosomal_S28e, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF50249, SSF50249, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00961, RIBOSOMAL_S28E, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P62857-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDTSRVQPIK LARVTKVLGR TGSQGQCTQV RVEFMDDTSR SIIRNVKGPV 
        60 
REGDVLTLLE SEREARRLR
Length:69
Mass (Da):7,841
Last modified:August 16, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i49902FE9376EB74F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti66R → P AA sequence (PubMed:8706699).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
L05091 mRNA Translation: AAC15855.1
U58682 mRNA Translation: AAB07066.1
AB061846 Genomic DNA Translation: BAB79484.1
CR457055 mRNA Translation: CAG33336.1
BC000354 mRNA Translation: AAH00354.1
BC021239 mRNA Translation: AAH21239.1
BC070217 mRNA Translation: AAH70217.1
BC070218 mRNA Translation: AAH70218.1
AB007164 Genomic DNA Translation: BAA28594.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS45953.1

Protein sequence database of the Protein Information Resource

More...PIRi		S68914

NCBI Reference Sequences

More...RefSeqi		NP_001022.1, NM_001031.4

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000600659; ENSP00000472469; ENSG00000233927

Database of genes from NCBI RefSeq genomes

More...GeneIDi		6234

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:6234

UCSC genome browser

More...UCSCi		uc002mjn.4, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L05091 mRNA Translation: AAC15855.1
U58682 mRNA Translation: AAB07066.1
AB061846 Genomic DNA Translation: BAB79484.1
CR457055 mRNA Translation: CAG33336.1
BC000354 mRNA Translation: AAH00354.1
BC021239 mRNA Translation: AAH21239.1
BC070217 mRNA Translation: AAH70217.1
BC070218 mRNA Translation: AAH70218.1
AB007164 Genomic DNA Translation: BAA28594.1
CCDSiCCDS45953.1
PIRiS68914
RefSeqiNP_001022.1, NM_001031.4

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4UG0electron microscopy-Sc1-69[»]
4V6Xelectron microscopy5.00Ac1-69[»]
5A2Qelectron microscopy3.90c8-68[»]
5AJ0electron microscopy3.50Bc1-69[»]
5FLXelectron microscopy3.90c1-69[»]
5LKSelectron microscopy3.60Sc1-69[»]
5OA3electron microscopy4.30c8-68[»]
5T2Celectron microscopy3.60AF1-69[»]
5VYCX-ray6.00c1/c2/c3/c4/c5/c61-69[»]
6EK0electron microscopy2.90Sc1-69[»]
6FECelectron microscopy6.30l5-68[»]
6G18electron microscopy3.60c1-69[»]
6G4Selectron microscopy4.00c1-69[»]
6G4Welectron microscopy4.50c1-69[»]
6G51electron microscopy4.10c1-69[»]
6G53electron microscopy4.50c1-69[»]
6G5Helectron microscopy3.60c1-69[»]
6G5Ielectron microscopy3.50c1-69[»]
6IP5electron microscopy3.903D1-69[»]
6IP6electron microscopy4.503D1-69[»]
6IP8electron microscopy3.903D1-69[»]
6OLEelectron microscopy3.10Sc5-68[»]
6OLFelectron microscopy3.90Sc5-68[»]
6OLGelectron microscopy3.40Bc7-68[»]
6OLIelectron microscopy3.50Sc5-68[»]
6OLZelectron microscopy3.90Bc7-68[»]
6OM0electron microscopy3.10Sc5-68[»]
6OM7electron microscopy3.70Sc5-68[»]
6QZPelectron microscopy2.90Sc5-68[»]
6XA1electron microscopy2.80Sc8-68[»]
6Y0Gelectron microscopy3.20Sc1-69[»]
6Y2Lelectron microscopy3.00Sc1-69[»]
6Y57electron microscopy3.50Sc1-69[»]
6YBSelectron microscopy3.10n1-69[»]
6Z6Lelectron microscopy3.00Sc1-69[»]
6Z6Melectron microscopy3.10Sc1-69[»]
6Z6Nelectron microscopy2.90Sc1-69[»]
6ZLWelectron microscopy2.60d1-69[»]
6ZM7electron microscopy2.70Sc1-69[»]
6ZMEelectron microscopy3.00Sc1-69[»]
6ZMIelectron microscopy2.60Sc1-69[»]
6ZMOelectron microscopy3.10Sc1-69[»]
6ZMTelectron microscopy3.00d1-69[»]
6ZMWelectron microscopy3.70n1-69[»]
6ZN5electron microscopy3.20d8-68[»]
6ZOJelectron microscopy2.80c8-68[»]
6ZOLelectron microscopy2.80c8-68[»]
6ZONelectron microscopy3.00S1-69[»]
6ZP4electron microscopy2.90S1-69[»]
6ZVHelectron microscopy2.90c5-68[»]
6ZVJelectron microscopy3.80S8-68[»]
6ZXDelectron microscopy3.20c1-69[»]
6ZXEelectron microscopy3.00c1-69[»]
6ZXFelectron microscopy3.70c1-69[»]
6ZXGelectron microscopy2.60c1-69[»]
6ZXHelectron microscopy2.70c1-69[»]
7A09electron microscopy3.50S1-69[»]
7K5Ielectron microscopy2.90c1-69[»]
SMRiP62857
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi112148, 172 interactors
ComplexPortaliCPX-5223, 40S cytosolic small ribosomal subunit
CORUMiP62857
IntActiP62857, 46 interactors
MINTiP62857
STRINGi9606.ENSP00000472469

Chemistry databases

DrugBankiDB11638, Artenimol

PTM databases

iPTMnetiP62857
MetOSiteiP62857
PhosphoSitePlusiP62857
SwissPalmiP62857

Genetic variation databases

BioMutaiRPS28
DMDMi51338652

Proteomic databases

EPDiP62857
jPOSTiP62857
MassIVEiP62857
MaxQBiP62857
PaxDbiP62857
PeptideAtlasiP62857
PRIDEiP62857
ProteomicsDBi57439
TopDownProteomicsiP62857

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		24844, 69 antibodies

The DNASU plasmid repository

More...DNASUi		6234

Genome annotation databases

EnsembliENST00000600659; ENSP00000472469; ENSG00000233927
GeneIDi6234
KEGGihsa:6234
UCSCiuc002mjn.4, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		6234
DisGeNETi6234

GeneCards: human genes, protein and diseases

More...GeneCardsi		RPS28
GeneReviewsiRPS28
HGNCiHGNC:10418, RPS28
HPAiENSG00000233927, Low tissue specificity
MalaCardsiRPS28
MIMi603685, gene
606164, phenotype
neXtProtiNX_P62857
OpenTargetsiENSG00000233927
Orphaneti124, Blackfan-Diamond anemia
PharmGKBiPA34825
VEuPathDBiHostDB:ENSG00000233927.4

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3502, Eukaryota
GeneTreeiENSGT00910000144227
HOGENOMiCLU_178987_1_0_1
InParanoidiP62857
OMAiMHGEASQ
OrthoDBi1578965at2759
PhylomeDBiP62857
TreeFamiTF300136

Enzyme and pathway databases

PathwayCommonsiP62857
ReactomeiR-HSA-156827, L13a-mediated translational silencing of Ceruloplasmin expression
R-HSA-156902, Peptide chain elongation
R-HSA-1799339, SRP-dependent cotranslational protein targeting to membrane
R-HSA-192823, Viral mRNA Translation
R-HSA-2408557, Selenocysteine synthesis
R-HSA-6791226, Major pathway of rRNA processing in the nucleolus and cytosol
R-HSA-72649, Translation initiation complex formation
R-HSA-72689, Formation of a pool of free 40S subunits
R-HSA-72695, Formation of the ternary complex, and subsequently, the 43S complex
R-HSA-72702, Ribosomal scanning and start codon recognition
R-HSA-72706, GTP hydrolysis and joining of the 60S ribosomal subunit
R-HSA-72764, Eukaryotic Translation Termination
R-HSA-9010553, Regulation of expression of SLITs and ROBOs
R-HSA-9633012, Response of EIF2AK4 (GCN2) to amino acid deficiency
R-HSA-975956, Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-HSA-975957, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
SIGNORiP62857

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		6234, 764 hits in 930 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		RPS28, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		RPS28

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		6234
PharosiP62857, Tbio

Protein Ontology

More...PROi		PR:P62857
RNActiP62857, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000233927, Expressed in lower esophagus mucosa and 214 other tissues
ExpressionAtlasiP62857, baseline and differential
GenevisibleiP62857, HS

Family and domain databases

CDDicd04457, S1_S28E, 1 hit
HAMAPiMF_00292, Ribosomal_S28e, 1 hit
InterProiView protein in InterPro
IPR012340, NA-bd_OB-fold
IPR000289, Ribosomal_S28e
IPR028626, Ribosomal_S28e_CS
PANTHERiPTHR10769, PTHR10769, 1 hit
PfamiView protein in Pfam
PF01200, Ribosomal_S28e, 1 hit
SUPFAMiSSF50249, SSF50249, 1 hit
PROSITEiView protein in PROSITE
PS00961, RIBOSOMAL_S28E, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRS28_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P62857
Secondary accession number(s): P25112
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: August 16, 2004
Last modified: June 2, 2021
This is version 166 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Ribosomal proteins
    Ribosomal proteins families and list of entries
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
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