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Protein

40S ribosomal protein S26

Gene

RPS26

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • cadherin binding Source: BHF-UCL
  • mRNA binding Source: UniProtKB
  • RNA binding Source: UniProtKB
  • structural constituent of ribosome Source: GO_Central

GO - Biological processi

  • cytoplasmic translation Source: UniProtKB
  • negative regulation of RNA splicing Source: UniProtKB
  • nuclear-transcribed mRNA catabolic process, nonsense-mediated decay Source: Reactome
  • SRP-dependent cotranslational protein targeting to membrane Source: Reactome
  • translation Source: UniProtKB
  • translational initiation Source: Reactome

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-HSA-156902 Peptide chain elongation
R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane
R-HSA-192823 Viral mRNA Translation
R-HSA-2408557 Selenocysteine synthesis
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol
R-HSA-72649 Translation initiation complex formation
R-HSA-72689 Formation of a pool of free 40S subunits
R-HSA-72695 Formation of the ternary complex, and subsequently, the 43S complex
R-HSA-72702 Ribosomal scanning and start codon recognition
R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit
R-HSA-72764 Eukaryotic Translation Termination
R-HSA-9010553 Regulation of expression of SLITs and ROBOs
R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Names & Taxonomyi

Protein namesi
Recommended name:
40S ribosomal protein S26
Alternative name(s):
Small ribosomal subunit protein eS261 Publication
Gene namesi
Name:RPS26
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000197728.9
HGNCiHGNC:10414 RPS26
MIMi603701 gene
neXtProtiNX_P62854

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum

Pathology & Biotechi

Involvement in diseasei

Diamond-Blackfan anemia 10 (DBA10)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of Diamond-Blackfan anemia, a congenital non-regenerative hypoplastic anemia that usually presents early in infancy. Diamond-Blackfan anemia is characterized by a moderate to severe macrocytic anemia, erythroblastopenia, and an increased risk of malignancy. 30 to 40% of Diamond-Blackfan anemia patients present with short stature and congenital anomalies, the most frequent being craniofacial (Pierre-Robin syndrome and cleft palate), thumb and urogenital anomalies.
See also OMIM:613309
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06358033D → N in DBA10. 1 PublicationCorresponds to variant dbSNP:rs267607023EnsemblClinVar.1
Natural variantiVAR_063581115M → T in DBA10. 1 Publication1

Keywords - Diseasei

Diamond-Blackfan anemia, Disease mutation

Organism-specific databases

DisGeNETi6231
GeneReviewsiRPS26
MalaCardsiRPS26
MIMi613309 phenotype
OpenTargetsiENSG00000197728
Orphaneti124 Blackfan-Diamond anemia
PharmGKBiPA34818

Polymorphism and mutation databases

BioMutaiRPS26
DMDMi51338650

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00002045092 – 11540S ribosomal protein S26Add BLAST114

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei54PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiP62854
MaxQBiP62854
PaxDbiP62854
PeptideAtlasiP62854
PRIDEiP62854
ProteomicsDBi57438
TopDownProteomicsiP62854

PTM databases

iPTMnetiP62854
PhosphoSitePlusiP62854
SwissPalmiP62854

Expressioni

Gene expression databases

BgeeiENSG00000197728
CleanExiHS_RPS26
ExpressionAtlasiP62854 baseline and differential
GenevisibleiP62854 HS

Organism-specific databases

HPAiHPA043961
HPA055803

Interactioni

Subunit structurei

Component of the 40S small ribosomal subunit.3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
TSR2Q969E812EBI-353438,EBI-746981

GO - Molecular functioni

Protein-protein interaction databases

BioGridi112145, 139 interactors
3193504, 66 interactors
CORUMiP62854
IntActiP62854, 27 interactors
MINTiP62854
STRINGi9606.ENSP00000348849

Structurei

3D structure databases

ProteinModelPortaliP62854
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1768 Eukaryota
COG4830 LUCA
GeneTreeiENSGT00390000002517
HOGENOMiHOG000108824
HOVERGENiHBG079147
InParanoidiP62854
KOiK02976
OMAiDKAICVT
OrthoDBiEOG091G19WY
PhylomeDBiP62854
TreeFamiTF300234

Family and domain databases

Gene3Di3.30.1740.20, 1 hit
InterProiView protein in InterPro
IPR000892 Ribosomal_S26e
IPR038551 Ribosomal_S26e_sf
PANTHERiPTHR12538 PTHR12538, 1 hit
PfamiView protein in Pfam
PF01283 Ribosomal_S26e, 1 hit
PROSITEiView protein in PROSITE
PS00733 RIBOSOMAL_S26E, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P62854-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTKKRRNNGR AKKGRGHVQP IRCTNCARCV PKDKAIKKFV IRNIVEAAAV
60 70 80 90 100
RDISEASVFD AYVLPKLYVK LHYCVSCAIH SKVVRNRSRE ARKDRTPPPR
110
FRPAGAAPRP PPKPM
Length:115
Mass (Da):13,015
Last modified:January 23, 2007 - v3
Checksum:iF60DF98F8900D968
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti78A → V in CAA54808 (PubMed:7945460).Curated1
Sequence conflicti109R → A in CAA49345 (PubMed:8464749).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06358033D → N in DBA10. 1 PublicationCorresponds to variant dbSNP:rs267607023EnsemblClinVar.1
Natural variantiVAR_063581115M → T in DBA10. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X69654 mRNA Translation: CAA49345.1
X77770 mRNA Translation: CAA54808.1
X79236 Genomic DNA Translation: CAA55818.1
U41448 Genomic DNA Translation: AAC26987.1
BC002604 mRNA Translation: AAH02604.1
BC015832 mRNA Translation: AAH15832.1
BC070220 mRNA Translation: AAH70220.1
BC105276 mRNA Translation: AAI05277.1
BC105798 mRNA Translation: AAI05799.1
CCDSiCCDS31832.1
PIRiS55545
T50824
RefSeqiNP_001020.2, NM_001029.3
XP_005276741.1, XM_005276684.3
UniGeneiHs.447562
Hs.567235
Hs.711461

Genome annotation databases

EnsembliENST00000356464; ENSP00000348849; ENSG00000197728
ENST00000552361; ENSP00000450339; ENSG00000197728
ENST00000646449; ENSP00000496643; ENSG00000197728
GeneIDi6231
KEGGihsa:101929876
hsa:6231
UCSCiuc001sjf.4 human

Similar proteinsi

Entry informationi

Entry nameiRS26_HUMAN
AccessioniPrimary (citable) accession number: P62854
Secondary accession number(s): P02383
, P70394, Q06722, Q3MHD8, Q6IRY4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: January 23, 2007
Last modified: July 18, 2018
This is version 143 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Ribosomal proteins
    Ribosomal proteins families and list of entries
  7. SIMILARITY comments
    Index of protein domains and families

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