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Protein

40S ribosomal protein S25

Gene

RPS25

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-HSA-156902 Peptide chain elongation
R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane
R-HSA-192823 Viral mRNA Translation
R-HSA-2408557 Selenocysteine synthesis
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol
R-HSA-72649 Translation initiation complex formation
R-HSA-72689 Formation of a pool of free 40S subunits
R-HSA-72695 Formation of the ternary complex, and subsequently, the 43S complex
R-HSA-72702 Ribosomal scanning and start codon recognition
R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit
R-HSA-72764 Eukaryotic Translation Termination
R-HSA-9010553 Regulation of expression of SLITs and ROBOs
R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Names & Taxonomyi

Protein namesi
Recommended name:
40S ribosomal protein S25
Alternative name(s):
Small ribosomal subunit protein eS251 Publication
Gene namesi
Name:RPS25
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000118181.10
HGNCiHGNC:10413 RPS25
MIMi180465 gene
neXtProtiNX_P62851

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000118181
PharmGKBiPA34817

Polymorphism and mutation databases

BioMutaiRPS25
DMDMi51338648

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001928691 – 12540S ribosomal protein S25Add BLAST125

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei43N6-acetyllysineBy similarity1
Modified residuei52N6-acetyllysine; alternateCombined sources1
Modified residuei52N6-succinyllysine; alternateBy similarity1
Modified residuei60N6-acetyllysineCombined sources1
Modified residuei66N6-acetyllysineCombined sources1
Modified residuei94N6-acetyllysine; alternateCombined sources1
Modified residuei94N6-succinyllysine; alternateBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiP62851
MaxQBiP62851
PaxDbiP62851
PeptideAtlasiP62851
PRIDEiP62851
ProteomicsDBi57437
TopDownProteomicsiP62851

PTM databases

iPTMnetiP62851
PhosphoSitePlusiP62851
SwissPalmiP62851

Expressioni

Gene expression databases

BgeeiENSG00000118181
CleanExiHS_RPS25
ExpressionAtlasiP62851 baseline and differential
GenevisibleiP62851 HS

Organism-specific databases

HPAiHPA031801

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
THAP1Q9NVV93EBI-353054,EBI-741515

Protein-protein interaction databases

BioGridi112144, 163 interactors
CORUMiP62851
IntActiP62851, 40 interactors
MINTiP62851
STRINGi9606.ENSP00000435096

Structurei

3D structure databases

ProteinModelPortaliP62851
SMRiP62851
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1767 Eukaryota
COG4901 LUCA
GeneTreeiENSGT00390000004856
HOGENOMiHOG000203673
HOVERGENiHBG054579
InParanoidiP62851
KOiK02975
OMAiKEVPTFR
OrthoDBiEOG091G134K
PhylomeDBiP62851
TreeFamiTF314909

Family and domain databases

Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR004977 Ribosomal_S25
IPR036388 WH-like_DNA-bd_sf
PANTHERiPTHR12850 PTHR12850, 1 hit
PfamiView protein in Pfam
PF03297 Ribosomal_S25, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD012268 Ribosomal_S25, 1 hit

Sequencei

Sequence statusi: Complete.

P62851-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPPKDDKKKK DAGKSAKKDK DPVNKSGGKA KKKKWSKGKV RDKLNNLVLF
60 70 80 90 100
DKATYDKLCK EVPNYKLITP AVVSERLKIR GSLARAALQE LLSKGLIKLV
110 120
SKHRAQVIYT RNTKGGDAPA AGEDA
Length:125
Mass (Da):13,742
Last modified:August 16, 2004 - v1
Checksum:iB8E05F04FCF2F1A9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M64716 mRNA Translation: AAA16105.1
AB061844 Genomic DNA Translation: BAB79482.1
AK311883 mRNA Translation: BAG34824.1
CH471065 Genomic DNA Translation: EAW67426.1
BC003537 mRNA Translation: AAH03537.1
BC004294 mRNA Translation: AAH04294.1
BC004986 mRNA Translation: AAH04986.1
CCDSiCCDS8406.1
PIRiJQ1347
RefSeqiNP_001019.1, NM_001028.2
UniGeneiHs.512676

Genome annotation databases

EnsembliENST00000527673; ENSP00000435096; ENSG00000118181
ENST00000628770; ENSP00000486392; ENSG00000280831
GeneIDi6230
KEGGihsa:6230
UCSCiuc001pun.4 human

Similar proteinsi

Entry informationi

Entry nameiRS25_HUMAN
AccessioniPrimary (citable) accession number: P62851
Secondary accession number(s): B2R4M7, P25111
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: August 16, 2004
Last modified: July 18, 2018
This is version 145 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Ribosomal proteins
    Ribosomal proteins families and list of entries
  5. SIMILARITY comments
    Index of protein domains and families

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