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Entry version 138 (29 Sep 2021)
Sequence version 2 (23 Jan 2007)
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Protein

40S ribosomal protein S15

Gene

Rps15

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-156827, L13a-mediated translational silencing of Ceruloplasmin expression
R-MMU-1799339, SRP-dependent cotranslational protein targeting to membrane
R-MMU-6791226, Major pathway of rRNA processing in the nucleolus and cytosol
R-MMU-72649, Translation initiation complex formation
R-MMU-72689, Formation of a pool of free 40S subunits
R-MMU-72695, Formation of the ternary complex, and subsequently, the 43S complex
R-MMU-72702, Ribosomal scanning and start codon recognition
R-MMU-72706, GTP hydrolysis and joining of the 60S ribosomal subunit
R-MMU-975956, Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-MMU-975957, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
40S ribosomal protein S15
Alternative name(s):
RIG protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Rps15
Synonyms:Rig
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:98117, Rps15

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSMUSG00000063457

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedBy similarity
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001300292 – 14540S ribosomal protein S15Add BLAST144

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki108Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P62843

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P62843

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P62843

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P62843

PeptideAtlas

More...
PeptideAtlasi
P62843

PRoteomics IDEntifications database

More...
PRIDEi
P62843

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
299937

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
P62843

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P62843

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P62843

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000063457, Expressed in forelimb bud and 290 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P62843, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
203003, 61 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-5261, 40S cytosolic small ribosomal subunit

Protein interaction database and analysis system

More...
IntActi
P62843, 4 interactors

Molecular INTeraction database

More...
MINTi
P62843

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000069004

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P62843, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P62843

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0898, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000000475

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P62843

Identification of Orthologs from Complete Genome Data

More...
OMAi
VIRTHCR

Database of Orthologous Groups

More...
OrthoDBi
1390881at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P62843

TreeFam database of animal gene trees

More...
TreeFami
TF318650

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.860.10, 1 hit

HAMAP database of protein families

More...
HAMAPi
MF_00531, Ribosomal_S19, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002222, Ribosomal_S19
IPR020934, Ribosomal_S19_CS
IPR023575, Ribosomal_S19_S15_SF
IPR005713, Ribosomal_S19A/S15e

The PANTHER Classification System

More...
PANTHERi
PTHR11880, PTHR11880, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00203, Ribosomal_S19, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF002144, Ribosomal_S19, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00975, RIBOSOMALS19

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF54570, SSF54570, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR01025, uS19_arch, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00323, RIBOSOMAL_S19, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P62843-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAEVEQKKKR TFRKFTYRGV DLDQLLDMSY EQLMQLYSAR QRRRLNRGLR
60 70 80 90 100
RKQHSLLKRL RKAKKEAPPM EKPEVVKTHL RDMIILPEMV GSMVGVYNGK
110 120 130 140
TFNQVEIKPE MIGHYLGEFS ITYKPVKHGR PGIGATHSSR FIPLK
Length:145
Mass (Da):17,040
Last modified:January 23, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCA2C682302C7B387
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3YTQ9D3YTQ9_MOUSE
40S ribosomal protein S15
Rps15
118Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M33330 mRNA Translation: AAA40055.1
BC010763 mRNA Translation: AAH10763.1
BC094409 mRNA Translation: AAH94409.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS35978.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A34823

NCBI Reference Sequences

More...
RefSeqi
NP_033117.1, NM_009091.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000068408; ENSMUSP00000069004; ENSMUSG00000063457

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
20054

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:20054

UCSC genome browser

More...
UCSCi
uc007gcn.2, mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M33330 mRNA Translation: AAA40055.1
BC010763 mRNA Translation: AAH10763.1
BC094409 mRNA Translation: AAH94409.1
CCDSiCCDS35978.1
PIRiA34823
RefSeqiNP_033117.1, NM_009091.2

3D structure databases

SMRiP62843
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi203003, 61 interactors
ComplexPortaliCPX-5261, 40S cytosolic small ribosomal subunit
IntActiP62843, 4 interactors
MINTiP62843
STRINGi10090.ENSMUSP00000069004

PTM databases

iPTMnetiP62843
PhosphoSitePlusiP62843

Proteomic databases

EPDiP62843
jPOSTiP62843
MaxQBiP62843
PaxDbiP62843
PeptideAtlasiP62843
PRIDEiP62843
ProteomicsDBi299937
TopDownProteomicsiP62843

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
22700, 214 antibodies

The DNASU plasmid repository

More...
DNASUi
20054

Genome annotation databases

EnsembliENSMUST00000068408; ENSMUSP00000069004; ENSMUSG00000063457
GeneIDi20054
KEGGimmu:20054
UCSCiuc007gcn.2, mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
6209
MGIiMGI:98117, Rps15
VEuPathDBiHostDB:ENSMUSG00000063457

Phylogenomic databases

eggNOGiKOG0898, Eukaryota
GeneTreeiENSGT00390000000475
InParanoidiP62843
OMAiVIRTHCR
OrthoDBi1390881at2759
PhylomeDBiP62843
TreeFamiTF318650

Enzyme and pathway databases

ReactomeiR-MMU-156827, L13a-mediated translational silencing of Ceruloplasmin expression
R-MMU-1799339, SRP-dependent cotranslational protein targeting to membrane
R-MMU-6791226, Major pathway of rRNA processing in the nucleolus and cytosol
R-MMU-72649, Translation initiation complex formation
R-MMU-72689, Formation of a pool of free 40S subunits
R-MMU-72695, Formation of the ternary complex, and subsequently, the 43S complex
R-MMU-72702, Ribosomal scanning and start codon recognition
R-MMU-72706, GTP hydrolysis and joining of the 60S ribosomal subunit
R-MMU-975956, Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-MMU-975957, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
20054, 21 hits in 40 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Rps15, mouse

Protein Ontology

More...
PROi
PR:P62843
RNActiP62843, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000063457, Expressed in forelimb bud and 290 other tissues
GenevisibleiP62843, MM

Family and domain databases

Gene3Di3.30.860.10, 1 hit
HAMAPiMF_00531, Ribosomal_S19, 1 hit
InterProiView protein in InterPro
IPR002222, Ribosomal_S19
IPR020934, Ribosomal_S19_CS
IPR023575, Ribosomal_S19_S15_SF
IPR005713, Ribosomal_S19A/S15e
PANTHERiPTHR11880, PTHR11880, 1 hit
PfamiView protein in Pfam
PF00203, Ribosomal_S19, 1 hit
PIRSFiPIRSF002144, Ribosomal_S19, 1 hit
PRINTSiPR00975, RIBOSOMALS19
SUPFAMiSSF54570, SSF54570, 1 hit
TIGRFAMsiTIGR01025, uS19_arch, 1 hit
PROSITEiView protein in PROSITE
PS00323, RIBOSOMAL_S19, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRS15_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P62843
Secondary accession number(s): P11174, Q52KC9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: January 23, 2007
Last modified: September 29, 2021
This is version 138 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Ribosomal proteins
    Ribosomal proteins families and list of entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families
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