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Protein

40S ribosomal protein S15

Gene

RPS15

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • DNA binding Source: UniProtKB
  • RNA binding Source: UniProtKB
  • structural constituent of ribosome Source: GO_Central

GO - Biological processi

  • nuclear-transcribed mRNA catabolic process, nonsense-mediated decay Source: Reactome
  • osteoblast differentiation Source: UniProtKB
  • ribosomal small subunit assembly Source: GO_Central
  • ribosomal small subunit biogenesis Source: UniProtKB
  • ribosomal small subunit export from nucleus Source: UniProtKB
  • rRNA processing Source: UniProtKB
  • SRP-dependent cotranslational protein targeting to membrane Source: Reactome
  • translation Source: UniProtKB
  • translational initiation Source: Reactome

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-HSA-156902 Peptide chain elongation
R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane
R-HSA-192823 Viral mRNA Translation
R-HSA-2408557 Selenocysteine synthesis
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol
R-HSA-72649 Translation initiation complex formation
R-HSA-72689 Formation of a pool of free 40S subunits
R-HSA-72695 Formation of the ternary complex, and subsequently, the 43S complex
R-HSA-72702 Ribosomal scanning and start codon recognition
R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit
R-HSA-72764 Eukaryotic Translation Termination
R-HSA-9010553 Regulation of expression of SLITs and ROBOs
R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Names & Taxonomyi

Protein namesi
Recommended name:
40S ribosomal protein S15
Alternative name(s):
RIG protein
Small ribosomal subunit protein uS191 Publication
Gene namesi
Name:RPS15
Synonyms:RIG
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000115268.9
HGNCiHGNC:10388 RPS15
MIMi180535 gene
neXtProtiNX_P62841

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi6209
MalaCardsiRPS15
OpenTargetsiENSG00000115268
PharmGKBiPA34787

Polymorphism and mutation databases

BioMutaiRPS15
DMDMi51338641

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00001300272 – 14540S ribosomal protein S15Add BLAST144

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Cross-linki108Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Acetylation, Isopeptide bond, Ubl conjugation

Proteomic databases

EPDiP62841
MaxQBiP62841
PaxDbiP62841
PeptideAtlasiP62841
PRIDEiP62841
ProteomicsDBi57433
TopDownProteomicsiP62841

PTM databases

iPTMnetiP62841
PhosphoSitePlusiP62841
SwissPalmiP62841

Miscellaneous databases

PMAP-CutDBiP62841

Expressioni

Gene expression databases

BgeeiENSG00000115268
CleanExiHS_RPS15
ExpressionAtlasiP62841 baseline and differential
GenevisibleiP62841 HS

Organism-specific databases

HPAiHPA054510
HPA057793

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi112123, 153 interactors
CORUMiP62841
IntActiP62841, 23 interactors
MINTiP62841
STRINGi9606.ENSP00000467676

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4UG0electron microscopy-SP1-145[»]
4V6Xelectron microscopy5.00AP1-145[»]
5A2Qelectron microscopy3.90P1-145[»]
5AJ0electron microscopy3.50BP1-145[»]
5FLXelectron microscopy3.90P1-145[»]
5LKSelectron microscopy3.60SP1-145[»]
5OA3electron microscopy4.30P1-145[»]
5T2Celectron microscopy3.60Ax1-145[»]
5VYCX-ray6.00P1/P2/P3/P4/P5/P61-145[»]
6EK0electron microscopy2.90SP1-145[»]
6FECelectron microscopy6.30n4-130[»]
ProteinModelPortaliP62841
SMRiP62841
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP62841

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0898 Eukaryota
COG0185 LUCA
GeneTreeiENSGT00390000000475
HOGENOMiHOG000111561
HOVERGENiHBG000709
InParanoidiP62841
KOiK02958
PhylomeDBiP62841

Family and domain databases

Gene3Di3.30.860.20, 1 hit
HAMAPiMF_00531 Ribosomal_S19, 1 hit
InterProiView protein in InterPro
IPR002222 Ribosomal_S19
IPR020934 Ribosomal_S19_CS
IPR023575 Ribosomal_S19_SF
IPR005713 Ribosomal_S19A/S15e
PANTHERiPTHR11880 PTHR11880, 1 hit
PfamiView protein in Pfam
PF00203 Ribosomal_S19, 1 hit
PIRSFiPIRSF002144 Ribosomal_S19, 1 hit
PRINTSiPR00975 RIBOSOMALS19
SUPFAMiSSF54570 SSF54570, 1 hit
TIGRFAMsiTIGR01025 uS19_arch, 1 hit
PROSITEiView protein in PROSITE
PS00323 RIBOSOMAL_S19, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P62841-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEVEQKKKR TFRKFTYRGV DLDQLLDMSY EQLMQLYSAR QRRRLNRGLR
60 70 80 90 100
RKQHSLLKRL RKAKKEAPPM EKPEVVKTHL RDMIILPEMV GSMVGVYNGK
110 120 130 140
TFNQVEIKPE MIGHYLGEFS ITYKPVKHGR PGIGATHSSR FIPLK
Length:145
Mass (Da):17,040
Last modified:January 23, 2007 - v2
Checksum:iCA2C682302C7B387
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J02984 mRNA Translation: AAA36036.1
M32405 Genomic DNA Translation: AAA36568.1
AF145025 mRNA Translation: AAP97277.1
BC064908 mRNA Translation: AAH64908.1
BC105810 mRNA Translation: AAI05811.1
BC141832 mRNA Translation: AAI41833.1
CCDSiCCDS12067.1
PIRiA35908 R3HU15
RefSeqiNP_001009.1, NM_001018.4
UniGeneiHs.406683

Genome annotation databases

EnsembliENST00000592588; ENSP00000467466; ENSG00000115268
GeneIDi6209
KEGGihsa:6209
UCSCiuc002lsp.2 human

Similar proteinsi

Entry informationi

Entry nameiRS15_HUMAN
AccessioniPrimary (citable) accession number: P62841
Secondary accession number(s): A5D8V9
, P11174, Q3KRA1, Q9UDC2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: January 23, 2007
Last modified: June 20, 2018
This is version 150 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Ribosomal proteins
    Ribosomal proteins families and list of entries
  5. SIMILARITY comments
    Index of protein domains and families

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