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Protein

Ubiquitin-conjugating enzyme E2 D2

Gene

Ube2d2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-linked polyubiquitination. Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Mediates ubiquitination of PEX5 and autoubiquitination of STUB1 and TRAF6. Involved in the signal-induced conjugation and subsequent degradation of NFKBIA, FBXW2-mediated GCM1 ubiquitination and degradation, MDM2-dependent degradation of p53/TP53 and the activation of MAVS in the mitochondria by DDX58/RIG-I in response to viral infection. Essential for viral activation of IRF3.By similarity

Catalytic activityi

S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.PROSITE-ProRule annotationBy similarity
S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-cysteine + N6-monoubiquitinyl-[acceptor protein]-L-lysine.By similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.PROSITE-ProRule annotation
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei85Glycyl thioester intermediatePROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processUbl conjugation pathway
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-1234176 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
R-MMU-202424 Downstream TCR signaling
R-MMU-2871837 FCERI mediated NF-kB activation
R-MMU-5607764 CLEC7A (Dectin-1) signaling
R-MMU-8866652 Synthesis of active ubiquitin: roles of E1 and E2 enzymes
R-MMU-8866654 E3 ubiquitin ligases ubiquitinate target proteins
R-MMU-8951664 Neddylation
R-MMU-9033241 Peroxisomal protein import
R-MMU-937041 IKK complex recruitment mediated by RIP1
R-MMU-983168 Antigen processing: Ubiquitination & Proteasome degradation
UniPathwayi
UPA00143

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin-conjugating enzyme E2 D2 (EC:2.3.2.23)
Alternative name(s):
(E3-independent) E2 ubiquitin-conjugating enzyme D2 (EC:2.3.2.24)
E2 ubiquitin-conjugating enzyme D2
Ubiquitin carrier protein D2
Ubiquitin-conjugating enzyme E2(17)KB 2
Ubiquitin-conjugating enzyme E2-17 kDa 2
Ubiquitin-protein ligase D2
Gene namesi
Name:Ube2d2
Synonyms:Ubc4, Ubch4, Ubch5b, Ube2d2a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 18

Organism-specific databases

MGIiMGI:1930715 Ube2d2a

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000824631 – 147Ubiquitin-conjugating enzyme E2 D2Add BLAST147

Proteomic databases

EPDiP62838
PaxDbiP62838
PeptideAtlasiP62838
PRIDEiP62838

PTM databases

iPTMnetiP62838
PhosphoSitePlusiP62838

Expressioni

Gene expression databases

BgeeiENSMUSG00000091896 Expressed in 286 organ(s), highest expression level in thymus
CleanExiMM_UBE2D2
ExpressionAtlasiP62838 baseline and differential
GenevisibleiP62838 MM

Interactioni

Subunit structurei

Interacts with SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex. Interacts with CNOT4 (via RING domain). Interacts with E3 ubiquitin-protein ligases CBLC, PJA1 and PJA2. Interacts with PDZRN3. Interacts with PPP1R11 (PubMed:27805901).By similarity3 Publications

GO - Molecular functioni

Protein-protein interaction databases

BioGridi208052, 4 interactors
IntActiP62838, 1 interactor
MINTiP62838
STRINGi10090.ENSMUSP00000131206

Structurei

3D structure databases

ProteinModelPortaliP62838
SMRiP62838
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ubiquitin-conjugating enzyme family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0417 Eukaryota
COG5078 LUCA
GeneTreeiENSGT00910000143990
HOGENOMiHOG000233455
HOVERGENiHBG063308
InParanoidiP62838
KOiK06689
OMAiQNDSPYQ
OrthoDBiEOG091G0GF8
PhylomeDBiP62838
TreeFamiTF101108

Family and domain databases

CDDicd00195 UBCc, 1 hit
Gene3Di3.10.110.10, 1 hit
InterProiView protein in InterPro
IPR000608 UBQ-conjugat_E2
IPR023313 UBQ-conjugating_AS
IPR016135 UBQ-conjugating_enzyme/RWD
PfamiView protein in Pfam
PF00179 UQ_con, 1 hit
SUPFAMiSSF54495 SSF54495, 1 hit
PROSITEiView protein in PROSITE
PS00183 UBIQUITIN_CONJUGAT_1, 1 hit
PS50127 UBIQUITIN_CONJUGAT_2, 1 hit

Sequencei

Sequence statusi: Complete.

P62838-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MALKRIHKEL NDLARDPPAQ CSAGPVGDDM FHWQATIMGP NDSPYQGGVF
60 70 80 90 100
FLTIHFPTDY PFKPPKVAFT TRIYHPNINS NGSICLDILR SQWSPALTIS
110 120 130 140
KVLLSICSLL CDPNPDDPLV PEIARIYKTD REKYNRIARE WTQKYAM
Length:147
Mass (Da):16,735
Last modified:August 16, 2004 - v1
Checksum:iC942BE7853CBC355
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U62483 mRNA Translation: AAB05772.1
BC003923 mRNA Translation: AAH03923.1
CCDSiCCDS50254.1
RefSeqiNP_064296.1, NM_019912.2
UniGeneiMm.180052
Mm.316489

Genome annotation databases

EnsembliENSMUST00000167406; ENSMUSP00000131206; ENSMUSG00000091896
ENSMUST00000170693; ENSMUSP00000132446; ENSMUSG00000091896
GeneIDi56550
KEGGimmu:56550
UCSCiuc012bbj.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U62483 mRNA Translation: AAB05772.1
BC003923 mRNA Translation: AAH03923.1
CCDSiCCDS50254.1
RefSeqiNP_064296.1, NM_019912.2
UniGeneiMm.180052
Mm.316489

3D structure databases

ProteinModelPortaliP62838
SMRiP62838
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi208052, 4 interactors
IntActiP62838, 1 interactor
MINTiP62838
STRINGi10090.ENSMUSP00000131206

PTM databases

iPTMnetiP62838
PhosphoSitePlusiP62838

Proteomic databases

EPDiP62838
PaxDbiP62838
PeptideAtlasiP62838
PRIDEiP62838

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000167406; ENSMUSP00000131206; ENSMUSG00000091896
ENSMUST00000170693; ENSMUSP00000132446; ENSMUSG00000091896
GeneIDi56550
KEGGimmu:56550
UCSCiuc012bbj.1 mouse

Organism-specific databases

CTDi56550
MGIiMGI:1930715 Ube2d2a

Phylogenomic databases

eggNOGiKOG0417 Eukaryota
COG5078 LUCA
GeneTreeiENSGT00910000143990
HOGENOMiHOG000233455
HOVERGENiHBG063308
InParanoidiP62838
KOiK06689
OMAiQNDSPYQ
OrthoDBiEOG091G0GF8
PhylomeDBiP62838
TreeFamiTF101108

Enzyme and pathway databases

UniPathwayi
UPA00143

ReactomeiR-MMU-1234176 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
R-MMU-202424 Downstream TCR signaling
R-MMU-2871837 FCERI mediated NF-kB activation
R-MMU-5607764 CLEC7A (Dectin-1) signaling
R-MMU-8866652 Synthesis of active ubiquitin: roles of E1 and E2 enzymes
R-MMU-8866654 E3 ubiquitin ligases ubiquitinate target proteins
R-MMU-8951664 Neddylation
R-MMU-9033241 Peroxisomal protein import
R-MMU-937041 IKK complex recruitment mediated by RIP1
R-MMU-983168 Antigen processing: Ubiquitination & Proteasome degradation

Miscellaneous databases

PROiPR:P62838
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000091896 Expressed in 286 organ(s), highest expression level in thymus
CleanExiMM_UBE2D2
ExpressionAtlasiP62838 baseline and differential
GenevisibleiP62838 MM

Family and domain databases

CDDicd00195 UBCc, 1 hit
Gene3Di3.10.110.10, 1 hit
InterProiView protein in InterPro
IPR000608 UBQ-conjugat_E2
IPR023313 UBQ-conjugating_AS
IPR016135 UBQ-conjugating_enzyme/RWD
PfamiView protein in Pfam
PF00179 UQ_con, 1 hit
SUPFAMiSSF54495 SSF54495, 1 hit
PROSITEiView protein in PROSITE
PS00183 UBIQUITIN_CONJUGAT_1, 1 hit
PS50127 UBIQUITIN_CONJUGAT_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiUB2D2_MOUSE
AccessioniPrimary (citable) accession number: P62838
Secondary accession number(s): P51669
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: August 16, 2004
Last modified: November 7, 2018
This is version 133 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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