RAP1A

Functionⁱ

Induces morphological reversion of a cell line transformed by a Ras oncogene. Counteracts the mitogenic function of Ras, at least partly because it can interact with Ras GAPs and RAF in a competitive manner. Together with ITGB1BP1, regulates KRIT1 localization to microtubules and membranes. Plays a role in nerve growth factor (NGF)-induced neurite outgrowth. Plays a role in the regulation of embryonic blood vessel formation. Involved in the establishment of basal endothelial barrier function. May be involved in the regulation of the vascular endothelial growth factor receptor KDR expression at endothelial cell-cell junctions.2 Publications

Enzyme regulationⁱ

Activated by guanine nucleotide-exchange factors (GEF) EPAC and EPAC2 in a cAMP-dependent manner, and GFR.

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Binding siteⁱ	60	GTP; via amide nitrogen2 Publications		1

Regions

Feature key	Position(s)	DescriptionActions	Length
Nucleotide bindingⁱ	10 – 18	GTP2 Publications	9
Nucleotide bindingⁱ	29 – 35	GTP2 Publications	7
Nucleotide bindingⁱ	116 – 119	GTP2 Publications	4

GO - Molecular functionⁱ

GTPase activity
Source: ProtInc
Traceable author statementⁱ
- 10777492
GTP binding Source: UniProtKB-KW
protein-containing complex binding
Source: UniProtKB
Inferred from direct assayⁱ
- 17916086
protein transporter activity
Source: UniProtKB
Inferred from direct assayⁱ
- 17916086
Rap guanyl-nucleotide exchange factor activity Source: UniProtKB

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cellular response to cAMP
Source: UniProtKB
Inferred from direct assayⁱ
- 21840392
cellular response to drug Source: Ensembl
cellular response to glucose stimulus Source: Ensembl
cellular response to nerve growth factor stimulus Source: UniProtKB
establishment of endothelial barrier
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 21840392
liver regeneration Source: Ensembl
negative regulation of collagen biosynthetic process Source: Ensembl
negative regulation of synaptic vesicle exocytosis Source: Ensembl
nerve growth factor signaling pathway Source: UniProtKB
neutrophil degranulation Source: Reactome
positive regulation of ERK1 and ERK2 cascade Source: UniProtKB
positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis Source: Ensembl
positive regulation of glucose import Source: Ensembl
positive regulation of GTPase activity Source: UniProtKB
positive regulation of neuron projection development Source: UniProtKB
positive regulation of protein kinase activity Source: UniProtKB
positive regulation of vasculogenesis Source: UniProtKB
protein transport
Source: UniProtKB
Inferred from direct assayⁱ
- 17916086
Rap protein signal transduction
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 21840392
regulation of cell junction assembly
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 21840392
regulation of insulin secretion Source: Reactome
response to antineoplastic agent Source: Ensembl
signal transduction
Source: ProtInc
Traceable author statementⁱ
- 2642744

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Neurogenesis
Ligand	GTP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactomeⁱ	R-HSA-170968 Frs2-mediated activation R-HSA-170984 ARMS-mediated activation R-HSA-354192 Integrin alphaIIb beta3 signaling R-HSA-354194 GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-372708 p130Cas linkage to MAPK signaling for integrins R-HSA-381676 Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-392517 Rap1 signalling R-HSA-5674135 MAP2K and MAPK activation R-HSA-6798695 Neutrophil degranulation R-HSA-6802946 Signaling by moderate kinase activity BRAF mutants R-HSA-6802948 Signaling by high-kinase activity BRAF mutants R-HSA-6802949 Signaling by RAS mutants R-HSA-6802952 Signaling by BRAF and RAF fusions R-HSA-6802955 Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-8875555 MET activates RAP1 and RAC1
SignaLinkⁱ	P62834
SIGNORⁱ	P62834

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Ras-related protein Rap-1A Alternative name(s): C21KG G-22K GTP-binding protein smg p21A Ras-related protein Krev-1
Gene namesⁱ	Name:RAP1A Synonyms:KREV1
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 1

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000116473.14
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:9855 RAP1A
MIMⁱ	179520 gene
neXtProtⁱ	NX_P62834

Keywords - Cellular componentⁱ

Cell junction, Cell membrane, Cytoplasm, Endosome, Membrane

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

Tumor suppressor

Organism-specific databases

DisGeNET More...DisGeNETⁱ	5906
MalaCards human disease database More...MalaCardsⁱ	RAP1A
Open Targets More...OpenTargetsⁱ	ENSG00000116473
PharmGKBⁱ	PA34217

Chemistry databases

ChEMBLⁱ	CHEMBL1255139

ChEMBLⁱ

CHEMBL1255139

Polymorphism and mutation databases

BioMutaⁱ	RAP1A
DMDMⁱ	51338607

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000030199	1 – 181	Ras-related protein Rap-1AAdd BLAST		181
PropeptideⁱPRO_0000030200	182 – 184	Removed in mature form		3

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	181	Cysteine methyl ester1 Publication		1
Lipidationⁱ	181	S-geranylgeranyl cysteine1 Publication		1

Keywords - PTMⁱ

Lipoprotein, Methylation, Prenylation

Proteomic databases

EPDⁱ	P62834
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P62834
PaxDbⁱ	P62834
PeptideAtlas More...PeptideAtlasⁱ	P62834
PRIDEⁱ	P62834
ProteomicsDBⁱ	57431
TopDownProteomicsⁱ	P62834

2D gel databases

USC-OGP 2-DE database More...OGPⁱ	P62834

OGPⁱ

P62834

PTM databases

iPTMnetⁱ	P62834
PhosphoSitePlusⁱ	P62834
SwissPalmⁱ	P62834

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000116473
CleanExⁱ	HS_RAP1A
ExpressionAtlasⁱ	P62834 baseline and differential
Genevisibleⁱ	P62834 HS

Interactionⁱ

Subunit structureⁱ

Found in a complex, at least composed of ITGB1BP1, KRIT1 and RAP1A. Interacts (active GTP-bound form preferentially) with KRIT1 (via C-terminus FERM domain); the interaction does not induce the opening conformation of KRIT1. In its GTP-bound form interacts with PLCE1 and RADIL. Interacts with SGSM1, SGSM2 and SGSM3. Interacts (via GTP-bound active form) with RAPGEF2 (via Ras-associating domain).7 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
RAF1	P04049	2	EBI-491414,EBI-365996
RASSF5	Q8WWW0-2	3	EBI-491414,EBI-960502
Rassf5	Q5EBH1	3	EBI-491414,EBI-960530	From Mus musculus.

Show more details

GO - Molecular functionⁱ

Rap guanyl-nucleotide exchange factor activity Source: UniProtKB

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	111841, 88 interactors
CORUMⁱ	P62834
Database of interacting proteins More...DIPⁱ	DIP-29106N
IntActⁱ	P62834, 24 interactors
Molecular INTeraction database More...MINTⁱ	P62834
STRINGⁱ	9606.ENSP00000348786

Chemistry databases

BindingDBⁱ

P62834

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Show more details

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	2 – 9	Combined sources	8
Helixⁱ	16 – 25	Combined sources	10
Beta strandⁱ	36 – 46	Combined sources	11
Beta strandⁱ	49 – 58	Combined sources	10
Helixⁱ	66 – 74	Combined sources	9
Beta strandⁱ	76 – 83	Combined sources	8
Helixⁱ	87 – 91	Combined sources	5
Helixⁱ	93 – 104	Combined sources	12
Beta strandⁱ	111 – 116	Combined sources	6
Helixⁱ	121 – 123	Combined sources	3
Helixⁱ	128 – 137	Combined sources	10
Turnⁱ	138 – 140	Combined sources	3
Beta strandⁱ	142 – 145	Combined sources	4
Turnⁱ	148 – 150	Combined sources	3
Helixⁱ	154 – 166	Combined sources	13

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1C1Y	X-ray	1.90	A	1-167	[»]
	1GUA	X-ray	2.00	A	1-167	[»]
	3KUC	X-ray	1.92	A	1-167	[»]
	4KVG	X-ray	1.65	A/C	1-167	[»]
ProteinModelPortalⁱ	P62834
SMRⁱ	P62834
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P62834

EvolutionaryTraceⁱ

P62834

Family & Domainsⁱ

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	32 – 40	Effector regionCurated		9

Sequence similaritiesⁱ

Belongs to the small GTPase superfamily. Ras family.Curated

Phylogenomic databases

eggNOGⁱ	KOG0395 Eukaryota COG1100 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00860000133678
HOGENOMⁱ	HOG000233973
HOVERGENⁱ	HBG009351
InParanoidⁱ	P62834
KEGG Orthology (KO) More...KOⁱ	K04353
OMAⁱ	QINRQMP
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0OOG
PhylomeDBⁱ	P62834
TreeFamⁱ	TF313014

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd04175 Rap1, 1 hit
InterProⁱ	View protein in InterPro IPR027417 P-loop_NTPase IPR038851 Rap1 IPR005225 Small_GTP-bd_dom IPR001806 Small_GTPase IPR020849 Small_GTPase_Ras-type
PANTHERⁱ	PTHR24070 PTHR24070, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00071 Ras, 1 hit
SUPFAMⁱ	SSF52540 SSF52540, 1 hit
TIGRFAMsⁱ	TIGR00231 small_GTP, 1 hit
PROSITEⁱ	View protein in PROSITE PS51421 RAS, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

P62834-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MREYKLVVLG SGGVGKSALT VQFVQGIFVE KYDPTIEDSY RKQVEVDCQQ 
        60         70         80         90        100
CMLEILDTAG TEQFTAMRDL YMKNGQGFAL VYSITAQSTF NDLQDLREQI 
       110        120        130        140        150
LRVKDTEDVP MILVGNKCDL EDERVVGKEQ GQNLARQWCN CAFLESSAKS 
       160        170        180 
KINVNEIFYD LVRQINRKTP VEKKKPKKKS CLLL

Length:184

Mass (Da):20,987

Last modified:August 16, 2004 - v1

Checksum:ⁱ42C39290C98E0A92

GO

Sequence cautionⁱ

The sequence CAB55685 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X12533 mRNA Translation: CAA31051.1 M22995 mRNA Translation: AAA36150.1 AF493912 mRNA Translation: AAM12626.1 AL049557 Genomic DNA Translation: CAB55685.2 Sequence problems. BC014086 mRNA Translation: AAH14086.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS840.1
PIRⁱ	A32342
NCBI Reference Sequences More...RefSeqⁱ	NP_001010935.1, NM_001010935.2 NP_001278825.1, NM_001291896.1 NP_002875.1, NM_002884.3 XP_016857451.1, XM_017001962.1 XP_016857452.1, XM_017001963.1 XP_016857453.1, XM_017001964.1
UniGeneⁱ	Hs.190334 Hs.586618

Genome annotation databases

Ensemblⁱ	ENST00000356415; ENSP00000348786; ENSG00000116473 ENST00000369709; ENSP00000358723; ENSG00000116473
GeneIDⁱ	5906
KEGGⁱ	hsa:5906
UCSC genome browser More...UCSCⁱ	uc001ebi.4 human

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length
P62834	Ras-related protein Rap-1A		BOVIN		184
Ras-related protein Rap-1A		MOUSE		184
Ras-related protein Rap-1A		RAT		184
Ras-related protein Rap-1A		HUMAN		184
RAP1A isoform 1		PANTR		184
+283

Protein	Similar proteins		Species	Score	Length
P62834	Ras-related protein Rap-1A		BOVIN		184
Ras-related protein Rap-1A		MOUSE		184
Ras-related protein Rap-1A		RAT		184
Ras-related protein Rap-1A		HUMAN		184
RAP1A isoform 1		PANTR		184
+405

Cross-referencesⁱ

Web resourcesⁱ

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X12533 mRNA Translation: CAA31051.1 M22995 mRNA Translation: AAA36150.1 AF493912 mRNA Translation: AAM12626.1 AL049557 Genomic DNA Translation: CAB55685.2 Sequence problems. BC014086 mRNA Translation: AAH14086.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS840.1
PIRⁱ	A32342
NCBI Reference Sequences More...RefSeqⁱ	NP_001010935.1, NM_001010935.2 NP_001278825.1, NM_001291896.1 NP_002875.1, NM_002884.3 XP_016857451.1, XM_017001962.1 XP_016857452.1, XM_017001963.1 XP_016857453.1, XM_017001964.1
UniGeneⁱ	Hs.190334 Hs.586618

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1C1Y	X-ray	1.90	A	1-167	[»]
	1GUA	X-ray	2.00	A	1-167	[»]
	3KUC	X-ray	1.92	A	1-167	[»]
	4KVG	X-ray	1.65	A/C	1-167	[»]
ProteinModelPortalⁱ	P62834
SMRⁱ	P62834
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	111841, 88 interactors
CORUMⁱ	P62834
Database of interacting proteins More...DIPⁱ	DIP-29106N
IntActⁱ	P62834, 24 interactors
Molecular INTeraction database More...MINTⁱ	P62834
STRINGⁱ	9606.ENSP00000348786

Chemistry databases

BindingDBⁱ	P62834
ChEMBLⁱ	CHEMBL1255139

PTM databases

iPTMnetⁱ	P62834
PhosphoSitePlusⁱ	P62834
SwissPalmⁱ	P62834

Polymorphism and mutation databases

BioMutaⁱ	RAP1A
DMDMⁱ	51338607

2D gel databases

USC-OGP 2-DE database More...OGPⁱ	P62834

OGPⁱ

P62834

Proteomic databases

EPDⁱ	P62834
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P62834
PaxDbⁱ	P62834
PeptideAtlas More...PeptideAtlasⁱ	P62834
PRIDEⁱ	P62834
ProteomicsDBⁱ	57431
TopDownProteomicsⁱ	P62834

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	5906
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000356415; ENSP00000348786; ENSG00000116473 ENST00000369709; ENSP00000358723; ENSG00000116473
GeneIDⁱ	5906
KEGGⁱ	hsa:5906
UCSC genome browser More...UCSCⁱ	uc001ebi.4 human

Organism-specific databases

CTDⁱ	5906
DisGeNET More...DisGeNETⁱ	5906
EuPathDBⁱ	HostDB:ENSG00000116473.14
GeneCardsⁱ	RAP1A
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:9855 RAP1A
MalaCards human disease database More...MalaCardsⁱ	RAP1A
MIMⁱ	179520 gene
neXtProtⁱ	NX_P62834
Open Targets More...OpenTargetsⁱ	ENSG00000116473
PharmGKBⁱ	PA34217
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0395 Eukaryota COG1100 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00860000133678
HOGENOMⁱ	HOG000233973
HOVERGENⁱ	HBG009351
InParanoidⁱ	P62834
KEGG Orthology (KO) More...KOⁱ	K04353
OMAⁱ	QINRQMP
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0OOG
PhylomeDBⁱ	P62834
TreeFamⁱ	TF313014

Enzyme and pathway databases

Reactomeⁱ	R-HSA-170968 Frs2-mediated activation R-HSA-170984 ARMS-mediated activation R-HSA-354192 Integrin alphaIIb beta3 signaling R-HSA-354194 GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-372708 p130Cas linkage to MAPK signaling for integrins R-HSA-381676 Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-392517 Rap1 signalling R-HSA-5674135 MAP2K and MAPK activation R-HSA-6798695 Neutrophil degranulation R-HSA-6802946 Signaling by moderate kinase activity BRAF mutants R-HSA-6802948 Signaling by high-kinase activity BRAF mutants R-HSA-6802949 Signaling by RAS mutants R-HSA-6802952 Signaling by BRAF and RAF fusions R-HSA-6802955 Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-8875555 MET activates RAP1 and RAC1
SignaLinkⁱ	P62834
SIGNORⁱ	P62834

Miscellaneous databases

ChiTaRSⁱ	RAP1A human
EvolutionaryTraceⁱ	P62834
GeneWikiⁱ	RAP1A
GenomeRNAiⁱ	5906
Protein Ontology More...PROⁱ	PR:P62834
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000116473
CleanExⁱ	HS_RAP1A
ExpressionAtlasⁱ	P62834 baseline and differential
Genevisibleⁱ	P62834 HS

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd04175 Rap1, 1 hit
InterProⁱ	View protein in InterPro IPR027417 P-loop_NTPase IPR038851 Rap1 IPR005225 Small_GTP-bd_dom IPR001806 Small_GTPase IPR020849 Small_GTPase_Ras-type
PANTHERⁱ	PTHR24070 PTHR24070, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00071 Ras, 1 hit
SUPFAMⁱ	SSF52540 SSF52540, 1 hit
TIGRFAMsⁱ	TIGR00231 small_GTP, 1 hit
PROSITEⁱ	View protein in PROSITE PS51421 RAS, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	RAP1A_HUMAN
Accessionⁱ	P62834Primary (citable) accession number: P62834 Secondary accession number(s): P10113
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	August 16, 2004
	Last sequence update:	August 16, 2004
	Last modified:	June 20, 2018
	This is version 163 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
SIMILARITY comments
Index of protein domains and families

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P62834 (RAP1A_HUMAN)

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Ras-related protein Rap-1A

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the ‘Function’ section describes an enzyme regulatory mechanism and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/enzyme_regulation' target='_top'>More...</a></p>Enzyme regulationi

Sites

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Endosome

Plasma membrane

Other locations

Cytosol

Endosome

Extracellular region or secreted

Plasma Membrane

Other locations

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

2D gel databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Motif

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

2D gel databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

UniProt is an ELIXIR core data resource

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Functionⁱ

Enzyme regulationⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequence cautionⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ