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Protein

GTP-binding nuclear protein Ran

Gene

RAN

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

GTPase involved in nucleocytoplasmic transport, participating both to the import and the export from the nucleus of proteins and RNAs (PubMed:10400640, PubMed:8276887, PubMed:8896452, PubMed:8636225, PubMed:8692944, PubMed:9351834, PubMed:9428644, PubMed:9822603, PubMed:26272610). Switches between a cytoplasmic GDP- and a nuclear GTP-bound state by nucleotide exchange and GTP hydrolysis (PubMed:7819259, PubMed:8896452, PubMed:8636225, PubMed:8692944, PubMed:9351834, PubMed:9428644, PubMed:9822603, PubMed:29040603, PubMed:11336674, PubMed:26272610). Nuclear import receptors such as importin beta bind their substrates only in the absence of GTP-bound RAN and release them upon direct interaction with GTP-bound RAN, while export receptors behave in the opposite way. Thereby, RAN controls cargo loading and release by transport receptors in the proper compartment and ensures the directionality of the transport (PubMed:8896452, PubMed:9351834, PubMed:9428644). Interaction with RANBP1 induces a conformation change in the complex formed by XPO1 and RAN that triggers the release of the nuclear export signal of cargo proteins (PubMed:20485264). RAN (GTP-bound form) triggers microtubule assembly at mitotic chromosomes and is required for normal mitotic spindle assembly and chromosome segregation (PubMed:10408446, PubMed:29040603). Required for normal progress through mitosis (PubMed:8421051, PubMed:12194828, PubMed:29040603). The complex with BIRC5/survivin plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules (PubMed:18591255). Acts as a negative regulator of the kinase activity of VRK1 and VRK2 (PubMed:18617507). Enhances AR-mediated transactivation. Transactivation decreases as the poly-Gln length within AR increases (PubMed:10400640).1 Publication17 Publications

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+1 PublicationNote: Mg2+ interacts primarily with the phosphate groups of the bound guanine nucleotide.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei68GTP; via amide nitrogenCombined sources11 Publications1
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei69Essential for GTP hydrolysis3 Publications1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi18 – 25GTPCombined sources11 Publications8
Nucleotide bindingi36 – 42GTPCombined sources9 Publications7
Nucleotide bindingi122 – 125GTPCombined sources11 Publications4
Nucleotide bindingi150 – 152GTPCombined sources11 Publications3

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell cycle, Cell division, Host-virus interaction, Mitosis, Protein transport, Transport
LigandGTP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-165054 Rev-mediated nuclear export of HIV RNA
R-HSA-1655829 Regulation of cholesterol biosynthesis by SREBP (SREBF)
R-HSA-168333 NEP/NS2 Interacts with the Cellular Export Machinery
R-HSA-180746 Nuclear import of Rev protein
R-HSA-203927 MicroRNA (miRNA) biogenesis
R-HSA-5578749 Transcriptional regulation by small RNAs
R-HSA-6784531 tRNA processing in the nucleus

SignaLink: a signaling pathway resource with multi-layered regulatory networks

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SignaLinki
P62826

SIGNOR Signaling Network Open Resource

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SIGNORi
P62826

Protein family/group databases

Transport Classification Database

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TCDBi
9.A.60.1.1 the small nuclear rna exporter (snrna-e)

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
GTP-binding nuclear protein Ran
Alternative name(s):
Androgen receptor-associated protein 241 Publication
GTPase Ran
Ras-like protein TC43 Publications
Ras-related nuclear protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RAN
Synonyms:ARA241 Publication
ORF Names:OK/SW-cl.81
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000132341.11

Human Gene Nomenclature Database

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HGNCi
HGNC:9846 RAN

Online Mendelian Inheritance in Man (OMIM)

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MIMi
601179 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P62826

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi19G → V: Blocks DNA replication; when associated with L-69. 1 Publication1
Mutagenesisi24T → L: Has low binding affinity for GTP and GDP. Almost completely abolishes interaction with BIRC5. 1 Publication1
Mutagenesisi24T → N: Has low binding affinity for GTP and GDP. Decreases nuclear import of proteins and RNA. Stabilizes the interaction with RCC1. No effect on nuclear location during interphase. Loss of activity in triggering microtubule assembly at mitotic chromosomes. 5 Publications1
Mutagenesisi25T → A: Minor effect on the interaction with the alpha phosphate group of bound GTP. 1 Publication1
Mutagenesisi39Y → A: Abolishes steric hindrance that traps the essential Q-69 in an unreactive position, and causes slow GTP hydrolysis in wild-type. Loss of one hydrogen bond with the gamma phosphate group of bound GTP. 1 Publication1
Mutagenesisi69Q → L: Strongly decreased GTPase activity. Probably locked in the GTP-bound form. Loss of interaction with NUTF2. Decreases nuclear location and leads to cytoplasmic location during interphase. Loss of function in importin-mediated protein nuclear import. High activity in triggering microtubule assembly at mitotic chromosomes. Blocks DNA replication; when associated with V-19. 8 Publications1
Mutagenesisi69Q → N: Unable to hydrolyze GTP. Increases binding to BIRC5 and promotes exaggerated spindle formation. 1 Publication1
Mutagenesisi70E → A: Strongly decreases the relase of bound GDP. 1 Publication1
Mutagenesisi76R → E: Probable loss of interaction with NUTF2. Loss of transport to the nucleus. 1 Publication1
Mutagenesisi134K → Q: Loss of normal mitotic chromosome segregation and defective mitotic spindle orientation. 1 Publication1
Mutagenesisi134K → R: Loss of normal mitotic chromosome segregation and formation of sister chromatid bridges. 1 Publication1
Mutagenesisi211 – 216Missing : No effect on GTPase activity. Abolishes interaction with RANBP1. 1 Publication6

Organism-specific databases

DisGeNET

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DisGeNETi
5901

Open Targets

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OpenTargetsi
ENSG00000132341

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA34205

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

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ChEMBLi
CHEMBL3885569

Drug and drug target database

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DrugBanki
DB04315 Guanosine-5'-Diphosphate

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
RAN

Domain mapping of disease mutations (DMDM)

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DMDMi
51338598

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources1 Publication
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002086962 – 216GTP-binding nuclear protein RanAdd BLAST215

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineCombined sources1 Publication1
Modified residuei24PhosphothreonineCombined sources1
Modified residuei60N6-acetyllysineCombined sources1
Modified residuei71N6-acetyllysine; alternateCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki71Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Cross-linki71Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate
Modified residuei99N6-acetyllysineCombined sources1
Modified residuei134N6-acetyllysine1 Publication1
Cross-linki152Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei159N6-acetyllysine; alternateCombined sources1
Modified residuei159N6-succinyllysine; alternateBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Acetylation by KAT5 at Lys-134 is increased during mitosis, impairs RANGRF binding and enhances RCC1 binding.1 Publication

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
P62826

MaxQB - The MaxQuant DataBase

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MaxQBi
P62826

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P62826

PeptideAtlas

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PeptideAtlasi
P62826

PRoteomics IDEntifications database

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PRIDEi
P62826

ProteomicsDB human proteome resource

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ProteomicsDBi
57429

Consortium for Top Down Proteomics

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TopDownProteomicsi
P62826

2D gel databases

USC-OGP 2-DE database

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OGPi
P62826

REPRODUCTION-2DPAGE

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REPRODUCTION-2DPAGEi
P62826

University College Dublin 2-DE Proteome Database

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UCD-2DPAGEi
P62826

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P62826

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P62826

SwissPalm database of S-palmitoylation events

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SwissPalmi
P62826

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in a variety of tissues.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000132341 Expressed in 226 organ(s), highest expression level in testis

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P62826 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P62826 HS

Organism-specific databases

Human Protein Atlas

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HPAi
HPA063353

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer. Interacts with RANGAP1, which promotes RAN-mediated GTP hydrolysis (PubMed:7819259, PubMed:9428644). Interacts with KPNB1 (PubMed:8896452, PubMed:9428644, PubMed:10367892). Interaction with KPNB1 inhibits RANGAP1-mediated stimulation of GTPase activity (PubMed:9428644). Interacts with RCC1 which promotes the exchange of RAN-bound GDP by GTP (PubMed:1961752, PubMed:7819259, PubMed:12194828, PubMed:11336674). Interaction with KPNB1 inhibits RCC1-mediated exchange of RAN-bound GDP by GTP (PubMed:8896452). Interacts (GTP-bound form) with TNPO1; the interaction is direct (PubMed:9351834). Interacts with KPNB1 and with TNPO1; both inhibit RAN GTPase activity (PubMed:8896452, PubMed:9428644). Interacts (via C-terminus) with RANBP1, which alleviates the inhibition of RAN GTPase activity (PubMed:7891706, PubMed:8896452, PubMed:9428644, PubMed:11832950). Interacts with RANGRF, which promotes the release of bound guanine nucleotide (PubMed:29040603). RANGRF and RCC1 compete for an overlapping binding site on RAN (PubMed:29040603). Identified in a complex with KPNA2 and CSE1L; interaction with RANBP1 mediates dissociation of RAN from this complex (PubMed:9428644). Interaction with both RANBP1 and KPNA2 promotes dissociation of the complex between RAN and KPNB1 (PubMed:9428644). Identified in a complex composed of RAN, RANGAP1 and RANBP1 (PubMed:16428860). Identified in a complex that contains TNPO1, RAN and RANBP1 (PubMed:9428644). Identified in a nuclear export complex with XPO1 (PubMed:9323133, PubMed:15574331, PubMed:10209022). Found in a nuclear export complex with RANBP3 and XPO1 (PubMed:11571268, PubMed:11425870). Interacts with RANBP2/NUP358 (PubMed:10078529, PubMed:26272610). Interaction with RANBP1 or RANBP2 induces a conformation change in the complex formed by XPO1 and RAN that triggers the release of the nuclear export signal of cargo proteins (PubMed:20485264). Component of a nuclear export receptor complex composed of KPNB1, RAN, SNUPN and XPO1 (PubMed:10209022, PubMed:19389996). Found in a nuclear export complex with RAN, XPO5 and pre-miRNA (By similarity). Interacts (GTP-bound form) with XPO5 (By similarity). Part of a complex consisting of RANBP9, RAN, DYRK1B and COPS5 (PubMed:14500717). Interacts with RANBP9 and RANBP10 (PubMed:14684163). Interacts in its GTP-bound form with BIRC5/survivin at S and M phases of the cell cycle (PubMed:18591255). Interacts with TERT; the interaction requires hydrogen peroxide-mediated phosphorylation of TERT and transports TERT to the nucleus (PubMed:12808100). Interacts with MAD2L2 (PubMed:19753112). Interacts with VRK1 and VRK3 (PubMed:18617507). Interacts with isoform 1 and isoform 2 of VRK2 (PubMed:18617507). Interacts with NEMP1 and KPNB1 (By similarity). Interacts (GDP-bound form) with NUTF2; regulates RAN nuclear import (PubMed:9822603, PubMed:10679025, PubMed:18266911). Interacts with CAPG; mediates CAPG nuclear import (PubMed:10679025, PubMed:18266911). Interacts with NUP153 (PubMed:18611384, PubMed:19505478). Interacts with the AR N-terminal poly-Gln region; the interaction with AR is inversely correlated with the poly-Gln length (PubMed:10400640). Interacts with MYCBP2, which promotes RAN-mediated GTP hydrolysis (PubMed:26304119).By similarity32 Publications
(Microbial infection) In case of HIV-1 infection, found in a complex with HIV-1 Rev, RNAs containing a Rev response element (RRE) and XPO1.1 Publication
(Microbial infection) Found in a complex with HTLV-1 Rex, RANBP3 and XPO1.1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
111837, 161 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
P62826

Database of interacting proteins

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DIPi
DIP-5929N

Protein interaction database and analysis system

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IntActi
P62826, 104 interactors

Molecular INTeraction database

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MINTi
P62826

STRING: functional protein association networks

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STRINGi
9606.ENSP00000376176

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1216
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P62826

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P62826

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

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EvolutionaryTracei
P62826

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni211 – 216Interaction with RANBP11 Publication6

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the small GTPase superfamily. Ran family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG0096 Eukaryota
ENOG410XNRS LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000153786

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG107376

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P62826

KEGG Orthology (KO)

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KOi
K07936

Database for complete collections of gene phylogenies

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PhylomeDBi
P62826

TreeFam database of animal gene trees

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TreeFami
TF106302

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR027417 P-loop_NTPase
IPR002041 Ran_GTPase
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase

The PANTHER Classification System

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PANTHERi
PTHR24071 PTHR24071, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF00071 Ras, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR00627 GTPRANTC4

Superfamily database of structural and functional annotation

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SUPFAMi
SSF52540 SSF52540, 1 hit

TIGRFAMs; a protein family database

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TIGRFAMsi
TIGR00231 small_GTP, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS51418 RAN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All

P62826-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAQGEPQVQ FKLVLVGDGG TGKTTFVKRH LTGEFEKKYV ATLGVEVHPL
60 70 80 90 100
VFHTNRGPIK FNVWDTAGQE KFGGLRDGYY IQAQCAIIMF DVTSRVTYKN
110 120 130 140 150
VPNWHRDLVR VCENIPIVLC GNKVDIKDRK VKAKSIVFHR KKNLQYYDIS
160 170 180 190 200
AKSNYNFEKP FLWLARKLIG DPNLEFVAMP ALAPPEVVMD PALAAQYEHD
210
LEVAQTTALP DEDDDL
Length:216
Mass (Da):24,423
Last modified:January 23, 2007 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD5C9B7275C34BCE0
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B4DV51B4DV51_HUMAN
GTP-binding nuclear protein Ran
RAN
128Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B5MDF5B5MDF5_HUMAN
GTP-binding nuclear protein Ran
RAN hCG_1744585
233Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KQE5J3KQE5_HUMAN
GTP-binding nuclear protein Ran
RAN
234Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5H018F5H018_HUMAN
GTP-binding nuclear protein Ran
RAN
198Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YFC6H0YFC6_HUMAN
GTP-binding nuclear protein Ran
RAN
103Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087X0W0A0A087X0W0_HUMAN
GTP-binding nuclear protein Ran
RAN
53Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAB93486 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti2A → T in AAH72000 (PubMed:15489334).Curated1
Sequence conflicti181A → C in AAC99400 (PubMed:11042152).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M31469 mRNA Translation: AAA36546.1
AF052578 mRNA Translation: AAC05840.1
AF054183 mRNA Translation: AAC99400.1
AF501887 mRNA Translation: AAM15923.1
BT007271 mRNA Translation: AAP35935.1
CR450347 mRNA Translation: CAG29343.1
AK290763 mRNA Translation: BAF83452.1
AK312466 mRNA Translation: BAG35373.1
CH471054 Genomic DNA Translation: EAW98516.1
BC004272 mRNA Translation: AAH04272.3
BC014518 mRNA Translation: AAH14518.1
BC014901 mRNA Translation: AAH14901.1
BC016654 mRNA Translation: AAH16654.1
BC051908 mRNA Translation: AAH51908.2
BC072000 mRNA Translation: AAH72000.1
AB062399 mRNA Translation: BAB93486.1 Different initiation.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS9271.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A44393 TVHUC3

NCBI Reference Sequences

More...
RefSeqi
NP_001287725.1, NM_001300796.1
NP_001287726.1, NM_001300797.1
NP_006316.1, NM_006325.4

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.10842

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000392369; ENSP00000376176; ENSG00000132341
ENST00000543796; ENSP00000446215; ENSG00000132341

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
5901

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:5901

UCSC genome browser

More...
UCSCi
uc001uir.4 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M31469 mRNA Translation: AAA36546.1
AF052578 mRNA Translation: AAC05840.1
AF054183 mRNA Translation: AAC99400.1
AF501887 mRNA Translation: AAM15923.1
BT007271 mRNA Translation: AAP35935.1
CR450347 mRNA Translation: CAG29343.1
AK290763 mRNA Translation: BAF83452.1
AK312466 mRNA Translation: BAG35373.1
CH471054 Genomic DNA Translation: EAW98516.1
BC004272 mRNA Translation: AAH04272.3
BC014518 mRNA Translation: AAH14518.1
BC014901 mRNA Translation: AAH14901.1
BC016654 mRNA Translation: AAH16654.1
BC051908 mRNA Translation: AAH51908.2
BC072000 mRNA Translation: AAH72000.1
AB062399 mRNA Translation: BAB93486.1 Different initiation.
CCDSiCCDS9271.1
PIRiA44393 TVHUC3
RefSeqiNP_001287725.1, NM_001300796.1
NP_001287726.1, NM_001300797.1
NP_006316.1, NM_006325.4
UniGeneiHs.10842

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1I2MX-ray1.76A/C1-216[»]
1IBRX-ray2.30A/C1-216[»]
1K5DX-ray2.70A/D/G/J1-216[»]
1K5GX-ray3.10A/D/G/J1-216[»]
1QBKX-ray3.00C1-216[»]
1RRPX-ray2.96A/C8-211[»]
2MMCNMR-A1-216[»]
2MMGNMR-A1-216[»]
2N1BNMR-A1-216[»]
3CH5X-ray2.10A1-216[»]
3EA5X-ray2.50A/C1-216[»]
3GJ0X-ray1.48A/B2-216[»]
3GJ3X-ray1.79A2-216[»]
3GJ4X-ray2.15A/C2-216[»]
3GJ5X-ray1.79A/C2-216[»]
3GJ6X-ray2.70A2-216[»]
3GJ7X-ray1.93A/C2-216[»]
3GJ8X-ray1.82A/C2-216[»]
3GJXX-ray2.50C/F1-216[»]
3NBYX-ray3.42C/F5-180[»]
3NBZX-ray2.80C/F5-180[»]
3NC0X-ray2.90C/F5-180[»]
3NC1X-ray3.35C1-180[»]
3ZJYX-ray3.60A/D/F1-180[»]
4C0QX-ray3.42C/D2-216[»]
4GMXX-ray2.10A1-216[»]
4GPTX-ray2.22A1-216[»]
4HATX-ray1.78A1-216[»]
4HAUX-ray2.00A1-216[»]
4HAVX-ray2.00A1-216[»]
4HAWX-ray1.90A1-216[»]
4HAXX-ray2.28A1-216[»]
4HAYX-ray2.30A1-216[»]
4HAZX-ray1.90A1-216[»]
4HB0X-ray2.20A1-216[»]
4HB2X-ray1.80A1-216[»]
4HB3X-ray2.80A1-216[»]
4HB4X-ray2.05A1-216[»]
4OL0X-ray2.90A1-216[»]
4WVFX-ray1.80A1-216[»]
5CIQX-ray1.65A/B1-216[»]
5CITX-ray1.75A/B1-216[»]
5CIWX-ray1.75A/B1-216[»]
5CJ2X-ray1.75A/B/C/D/E/F/G/H1-216[»]
5CLLX-ray2.45A/C1-191[»]
5CLQX-ray3.20A/C1-216[»]
5DH9X-ray2.55A1-216[»]
5DHAX-ray2.95A1-216[»]
5DHFX-ray2.29A1-216[»]
5DI9X-ray2.28A1-216[»]
5DIFX-ray2.09A1-216[»]
5DISX-ray2.85B8-179[»]
5DLQX-ray3.20C/D5-180[»]
5FYQX-ray3.00C/D31-43[»]
5JLJX-ray2.50A1-216[»]
5UWHX-ray2.26A1-216[»]
5UWIX-ray2.14A1-216[»]
5UWJX-ray2.22A1-216[»]
5UWOX-ray2.35A1-216[»]
5UWPX-ray2.05A1-216[»]
5UWQX-ray2.28A1-216[»]
5UWRX-ray2.24A1-216[»]
5UWSX-ray2.40A1-216[»]
5UWTX-ray2.34A1-216[»]
5UWUX-ray2.24A1-216[»]
5UWWX-ray2.15A1-216[»]
6CITX-ray2.03A1-216[»]
ProteinModelPortaliP62826
SMRiP62826
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111837, 161 interactors
CORUMiP62826
DIPiDIP-5929N
IntActiP62826, 104 interactors
MINTiP62826
STRINGi9606.ENSP00000376176

Chemistry databases

ChEMBLiCHEMBL3885569
DrugBankiDB04315 Guanosine-5'-Diphosphate

Protein family/group databases

TCDBi9.A.60.1.1 the small nuclear rna exporter (snrna-e)

PTM databases

iPTMnetiP62826
PhosphoSitePlusiP62826
SwissPalmiP62826

Polymorphism and mutation databases

BioMutaiRAN
DMDMi51338598

2D gel databases

OGPiP62826
REPRODUCTION-2DPAGEiP62826
UCD-2DPAGEiP62826

Proteomic databases

EPDiP62826
MaxQBiP62826
PaxDbiP62826
PeptideAtlasiP62826
PRIDEiP62826
ProteomicsDBi57429
TopDownProteomicsiP62826

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
5901
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000392369; ENSP00000376176; ENSG00000132341
ENST00000543796; ENSP00000446215; ENSG00000132341
GeneIDi5901
KEGGihsa:5901
UCSCiuc001uir.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
5901
DisGeNETi5901
EuPathDBiHostDB:ENSG00000132341.11

GeneCards: human genes, protein and diseases

More...
GeneCardsi
RAN
HGNCiHGNC:9846 RAN
HPAiHPA063353
MIMi601179 gene
neXtProtiNX_P62826
OpenTargetsiENSG00000132341
PharmGKBiPA34205

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0096 Eukaryota
ENOG410XNRS LUCA
GeneTreeiENSGT00940000153786
HOVERGENiHBG107376
InParanoidiP62826
KOiK07936
PhylomeDBiP62826
TreeFamiTF106302

Enzyme and pathway databases

ReactomeiR-HSA-165054 Rev-mediated nuclear export of HIV RNA
R-HSA-1655829 Regulation of cholesterol biosynthesis by SREBP (SREBF)
R-HSA-168333 NEP/NS2 Interacts with the Cellular Export Machinery
R-HSA-180746 Nuclear import of Rev protein
R-HSA-203927 MicroRNA (miRNA) biogenesis
R-HSA-5578749 Transcriptional regulation by small RNAs
R-HSA-6784531 tRNA processing in the nucleus
SignaLinkiP62826
SIGNORiP62826

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
RAN human
EvolutionaryTraceiP62826

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
Ran_(biology)

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
5901

Protein Ontology

More...
PROi
PR:P62826

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000132341 Expressed in 226 organ(s), highest expression level in testis
ExpressionAtlasiP62826 baseline and differential
GenevisibleiP62826 HS

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR002041 Ran_GTPase
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
PANTHERiPTHR24071 PTHR24071, 1 hit
PfamiView protein in Pfam
PF00071 Ras, 1 hit
PRINTSiPR00627 GTPRANTC4
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51418 RAN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRAN_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P62826
Secondary accession number(s): A8K3Z8
, P17080, P28746, P28747, Q6IPB2, Q86V08, Q8NI90, Q9CSP3, Q9CWI7, Q9CZA2, Q9UDJ5, Q9UEU9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: January 23, 2007
Last modified: December 5, 2018
This is version 185 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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