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Protein

Ras-related protein Rab-1A

Gene

Rab1A

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB1A regulates vesicular protein transport from the endoplasmic reticulum (ER) to the Golgi compartment and on to the cell surface, and plays a role in IL-8 and growth hormone secretion. Regulates the level of CASR present at the cell membrane. Plays a role in cell adhesion and cell migration, via its role in protein trafficking. Plays a role in autophagosome assembly and cellular defense reactions against pathogenic bacteria (By similarity). Plays a role in microtubule-dependent protein transport by early endosomes and in anterograde melanosome transport.By similarity2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi18 – 26GTPBy similarity9
Nucleotide bindingi36 – 43GTPBy similarity8
Nucleotide bindingi66 – 70GTPBy similarity5
Nucleotide bindingi124 – 127GTPBy similarity4
Nucleotide bindingi154 – 156GTPBy similarity3

GO - Molecular functioni

GO - Biological processi

  • autophagosome assembly Source: UniProtKB
  • autophagy Source: UniProtKB
  • cargo loading into COPII-coated vesicle Source: MGI
  • cell migration Source: UniProtKB
  • defense response to bacterium Source: UniProtKB
  • endocytosis Source: UniProtKB
  • ER to Golgi vesicle-mediated transport Source: UniProtKB
  • Golgi organization Source: MGI
  • growth hormone secretion Source: UniProtKB
  • interleukin-8 secretion Source: UniProtKB
  • intracellular protein transport Source: MGI
  • melanosome transport Source: UniProtKB
  • positive regulation of glycoprotein metabolic process Source: MGI
  • substrate adhesion-dependent cell spreading Source: UniProtKB
  • vesicle transport along microtubule Source: UniProtKB
  • virion assembly Source: MGI

Keywordsi

Biological processAutophagy, ER-Golgi transport, Protein transport, Transport
LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-162658 Golgi Cisternae Pericentriolar Stack Reorganization
R-MMU-204005 COPII-mediated vesicle transport
R-MMU-6807878 COPI-mediated anterograde transport
R-MMU-6811434 COPI-dependent Golgi-to-ER retrograde traffic
R-MMU-8873719 RAB geranylgeranylation
R-MMU-8876198 RAB GEFs exchange GTP for GDP on RABs

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rab-1A
Alternative name(s):
YPT1-related protein
Gene namesi
Name:Rab1A
Synonyms:Rab1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:97842 Rab1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum, Endosome, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001210572 – 205Ras-related protein Rab-1AAdd BLAST204

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Modified residuei79O-(2-cholinephosphoryl)serineBy similarity1
Modified residuei194Phosphoserine; by CDK1By similarity1
Lipidationi204S-geranylgeranyl cysteineBy similarity1
Lipidationi205S-geranylgeranyl cysteineBy similarity1

Post-translational modificationi

Phosphorylated by CDK1 kinase during mitosis.By similarity

Keywords - PTMi

Acetylation, Lipoprotein, Phosphoprotein, Prenylation

Proteomic databases

EPDiP62821
PaxDbiP62821
PeptideAtlasiP62821
PRIDEiP62821

PTM databases

iPTMnetiP62821
PhosphoSitePlusiP62821
SwissPalmiP62821

Expressioni

Gene expression databases

BgeeiENSMUSG00000020149
CleanExiMM_RAB1
ExpressionAtlasiP62821 baseline and differential
GenevisibleiP62821 MM

Interactioni

Subunit structurei

May interact with YIPF5 (By similarity). Interacts with C9orf72; the interaction mediates recruitment of RAB1A to the ATG1/ULK1 kinase complex (PubMed:24549040). Interacts with GDI1; this promotes dissociation from membranes (By similarity).By similarity1 Publication

Protein-protein interaction databases

BioGridi202530, 5 interactors
IntActiP62821, 39 interactors
MINTiP62821
STRINGi10090.ENSMUSP00000127330

Structurei

3D structure databases

ProteinModelPortaliP62821
SMRiP62821
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi40 – 48Effector regionBy similarity9

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGiKOG0084 Eukaryota
ENOG410XQN5 LUCA
GeneTreeiENSGT00900000140786
HOVERGENiHBG009351
InParanoidiP62821
KOiK07874
OMAiVTDNDTF
OrthoDBiEOG091G0LA6
PhylomeDBiP62821
TreeFamiTF300097

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51419 RAB, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P62821-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSMNPEYDY LFKLLLIGDS GVGKSCLLLR FADDTYTESY ISTIGVDFKI
60 70 80 90 100
RTIELDGKTI KLQIWDTAGQ ERFRTITSSY YRGAHGIIVV YDVTDQESFN
110 120 130 140 150
NVKQWLQEID RYASENVNKL LVGNKCDLTT KKVVDYTTAK EFADSLGIPF
160 170 180 190 200
LETSAKNATN VEQSFMTMAA EIKKRMGPGA TAGGAEKSNV KIQSTPVKQS

GGGCC
Length:205
Mass (Da):22,678
Last modified:January 23, 2007 - v3
Checksum:iB2A8F4E3B0FB17D6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y00094 mRNA Translation: CAA68284.1
X15744
, X15745, X15746, X15747 Genomic DNA Translation: CAA33760.1
AF226873 mRNA Translation: AAF33844.1
AK034408 mRNA Translation: BAC28697.1
AK159425 mRNA Translation: BAE35072.1
AK166249 mRNA Translation: BAE38660.1
AK167150 mRNA Translation: BAE39292.1
BC002077 mRNA Translation: AAH02077.3
CCDSiCCDS36115.1
PIRiS05551 TVMSYP
RefSeqiNP_033022.1, NM_008996.3
UniGeneiMm.271944

Genome annotation databases

EnsembliENSMUST00000163483; ENSMUSP00000127330; ENSMUSG00000020149
GeneIDi19324
KEGGimmu:19324
UCSCiuc007icv.1 mouse

Similar proteinsi

Entry informationi

Entry nameiRAB1A_MOUSE
AccessioniPrimary (citable) accession number: P62821
Secondary accession number(s): P11476
, Q3TX44, Q811M4, Q96N61, Q9Y3T2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: January 23, 2007
Last modified: July 18, 2018
This is version 140 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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